Search Results 1-20 of 151

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Combined laser capture microdissection and mass spectrometry (LCM-MS) to identify, localize and quantify biologics in specific anatomic microenvironments [in Japanese]

HASHIDA Satoko Nonaka , WEI Benjamin , QUAZI Shakey , DUFIELD Dawn , PERCIVAL Karen , O'NEIL Shawn

<p>[in Japanese] </p>

Annual Meeting of the Japanese Society of Toxicology 46.1(0), P-163, 2019

J-STAGE
2

BmGr10 is a putative functional gustatory receptor in the myo-inositol neuron in the epipharyngeal sensillum

Tsuneto Kana , Takada Tomoyuki , Kasubuchi Mayu , Yamagishi Takayuki , Adegawa Satomi , Sato Ryoichi

… Here, we established a method to isolate a bundle of GRNs in a gustatory sensillum and a single GRN using micromanipulation and laser-capture microdissection to investigate the gustatory receptor expression pattern in a bundle of GRNs and a single GRN in an epipharyngeal sensillum. …

Journal of Insect Biotechnology and Sericology 88(1), 1_007-1_015, 2019

J-STAGE
3

PAXgene-fixed paraffin-embedded sample is applicable to laser capture microdissection with well-balanced RNA quality and tissue morphology

Yamazaki Masaki , Yabuki Nami , Suzuki Yasunori , Ito Mayumi , Ikeda Asuka , Natori Osamu , Suzuki Masami , Kato Atsuhiko

… Assessing how gene expression analysis by RNA sequencing (RNA-Seq) correlates to a unique morphology is increasingly necessary, and laser capture microdissection (LCM) is a critical research tool for discovering the genes responsible in a region of interest (ROI). …

Journal of Toxicologic Pathology 31(3), 213-220, 2018

J-STAGE Ichushi Web
4

PAXgene-fixed paraffin-embedded sample is applicable to laser capture microdissection with well-balanced RNA quality and tissue morphology

YAMAZAKI Masaki , YABUKI Nami , SUZUKI Yasunori , ITO Mayumi , IKEDA Asuka , NATORI Osamu , SUZUKI Masami , KATO Atsuhiko

… <p>Assessing how gene expression analysis by RNA sequencing (RNA-Seq) correlates to a unique morphology is increasingly necessary, and laser capture microdissection (LCM) is a critical research tool for discovering the genes responsible in a region of interest (ROI). …

Journal of Toxicologic Pathology, 2018

J-STAGE
5

Response Predictors of S-1, Cisplatin, and Docetaxel Combination Chemotherapy for Metastatic Gastric Cancer : Microarray Analysis of Whole Human Genes

Kitamura Shinji , Tanahashi Toshihito , Aoyagi Eriko , Nakagawa Tadahiko , Okamoto Koichi , Kimura Tetsuo , Miyamoto Hiroshi , Mitsui Yasuhiro , Rokutan Kazuhito , Muguruma Naoki , Takayama Tetsuji

… Laser capture microdissection was performed, and total cellular RNA was extracted from each microdissected sample. …

Oncology 93(2), 127-135, 2017-05-17

IR
6

Nociceptor-Enriched Genes Required for Normal Thermal Nociception

Honjo Ken , Mauthner StephanieE. , Wang Yu , Skene J.H.Pate , Tracey W.Daniel , 本庄賢

… Using laser capture microdissection and microarray analyses of nociceptive and non-nociceptive neurons, we identified 275 nociceptor-enriched genes. …

Cell reports 16(2), 295-303, 2016-07

IR
7

Green tea extract attenuates MNU-induced photoreceptor cell apoptosis via suppression of heme oxygenase-1

Emoto Yuko , Yoshizawa Katsuhiko , Kinoshita Yuichi , Yuki Michiko , Yuri Takashi , Tsubura Airo

… Expression of oxidant marker, heme oxygenase (HO)-1, mRNA levels in outer nuclear cells was assessed by laser capture microdissection (LCM). …

Journal of Toxicologic Pathology 29(1), 61-65, 2016

J-STAGE Ichushi Web
8

The pathological and biochemical identification of possible seed-lesions of transmitted transthyretin amyloidosis after domino liver transplantation.

Yoshinaga Tsuneaki , Yazaki Masahide , Sekijima Yoshiki , Kametani Fuyuki , Miyashita Kana , Hachiya Naomi , Tanaka Tomohiro , Kokudo Norihiro , Higuchi Keiichi , Ikeda Shu‐ichi

… The amyloid was analyzed using a laser microdissection system and tandem mass spectrometry. … This is the first study to successfully capture the pathological and biochemical features of initial‐stage amyloid lesions in DLT recipients. …

The Journal of Pathology 2(2), 72-79, 2015-12-28

IR
9

Cytokeratin 13, Cytokeratin 17, Ki-67 and p53 Expression in Upper Layers of Epithelial Dysplasia Surrounding Tongue Squamous Cell Carcinoma

Matsuhira Akiko , Noguchi Sunaki , Sato Kazumichi , Tanaka Yoichi , Yamamoto Gou , Mishima Kenji , Katakura Akira

Early detection of oral squamous cell carcinoma (OSCC) improves its prognosis and aids in selecting the appropriate treatment, which may also have a positive effect on quality of life. Early detection …

The Bulletin of Tokyo Dental College 56(4), 223-231, 2015

J-STAGE Ichushi Web
10

Characterization of Motor Neuron Prostaglandin E2 EP3 Receptor Isoform in a Mouse Model of Amyotrophic Lateral Sclerosis

Kosuge Yasuhiro , Ito Yoshihisa , Miyagishi Hiroko , Shinomiya Takashi , Nishiyama Kenta , Suzuki Satomi , Osada Nobuhiro , Ishige Kumiko , Okubo Migiwa , Kawaguchi Mitsuru

… Laser capture microdissection was used to dissect out motor neurons from frozen samples of lumbar spinal cord in these mice for analysis by real-time PCR. …

Biological and Pharmaceutical Bulletin 38(12), 1964-1968, 2015

J-STAGE Ichushi Web
11

Chemoarchitecture of glial fibrillary acidic protein (GFAP) and glutamine synthetase in the rat optic nerve: An immunohistochemical study

KAWANO June

An immunohistochemical analysis of the chemoarchitecture of glial fibrillary acidic protein (GFAP) and glutamine synthetase (GS) was conducted in the rat optic nerve. The optic nerve has been divided …

Okajimas Folia Anatomica Japonica 92(1), 11-30, 2015

J-STAGE Ichushi Web
12

The PFA-AMeX method achieves a good balance between the morphology of tissues and the quality of RNA content in DNA microarray analysis with laser-capture microdissection samples

Watanabe Takeshi , Kato Atsuhiko , Terashima Hiromichi , Matsubara Koichi , Chen Yu Jau , Adachi Kenji , Mizuno Hideaki , Suzuki Masami

… In the present study, we investigated 30 human prostate tissues using the PFA-AMeX method (fixation using paraformaldehyde (PFA) followed by embedding in paraffin by AMeX) with a DNA microarray combined with laser-capture microdissection. …

Journal of Toxicologic Pathology 28(1), 43-49, 2015

J-STAGE Ichushi Web
13

Comparison of depth-specific gene expression levels in primary tumors in advanced gastric cancer

Naruke Akira , Azuma Mizutomo , Takeuchi Atsuko [他]

The Kitasato medical journal 44(2), 125-133, 2014-09

Ichushi Web
14

Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes

Honda Masao , Shirasaki Takayoshi , Shimakami Tetsuro , Sakai Akito , Horii Rika , Arai Kuniaki , Yamashita Tatsuya , Sakai Yoshio , Yamashita Taro , Okada Hikari , Nakamura Mikiko , Mizukoshi Eishiro , Kaneko Shuichi

This article has Supplemental materrial and methods.

Hepatology 59(3), 828-838, 2014-03-01

IR
15

High Expression of Dihydropyrimidine Dehydrogenase in Lung Adenocarcinoma is Associated With Mutations in Epidermal Growth Factor Receptor: Implications for the Treatment of Non–Small-Cell Lung Cancer Using 5-Fluorouracil

Mochinaga Koji , Tsuchiya Tomoshi , Nagasaki Toshiya , Arai Junichi , Tominaga Tetsuro , Yamasaki Naoya , Matsumoto Keitaro , Miyazaki Takuro , Nanashima Atsushi , Hayashi Tomayoshi , Tsukamoto Kazuhiro , Nagayasu Takeshi

… Here, we focus on clinicopathologic factors and in vitro correlations between DPD expression and EGFR mutation status. Patients and Methods EGFR mutations and messenger RNA (mRNA) levels of DPD and thymidylate synthase (TS) were analyzed in 47 resected NSCLC tumors by laser-capture microdissection. …

Clinical Lung Cancer 15(2), 136-144, 2014-03

IR
16

Proteomic analysis of proteins related to prognosis of lung adenocarcinoma [in Japanese]

Okayama Akiko , Miyagi Yohei , Oshita Fumihiro , Nishi Mayuko , Nakamura Yoshiyasu , Nagashima Yoji , Akimoto Kazunori , Ryo Akihide , Hirano Hisashi

Abstracts for Annual Meeting of Japanese Proteomics Society 2014(0), 51-51, 2014

J-STAGE
17

Perfusion fixation method is critical for immunoelectron microscopy and ultrastructural evaluation on changes of caveolin-1 and caveolae relates with capillarization of liver sinusoidal endothelial cells in human cirrhotic liver

Yokomori Hiroaki , Han Jing-Yan , Oda Masaya

… CAV-1 protein and gene expression was examined by immunohistochemistry, Western blotting, laser-capture microdissection (LCM)-PCR. …

Microvascular Reviews and Communications 7(1), 32-32, 2014

J-STAGE Ichushi Web
18

A Histopathological Study of Multi-hormone Producing Proliferative Lesions in Estrogen-induced Rat Pituitary Prolactinoma

Takekoshi Susumu , Yasui Yuzo , Inomoto Chie , Kitatani Kanae , Nakamura Naoya , Osamura Robert Yoshiyuki

… We studied these neoplastic nodules obtained by laser microdissection to acquire findings similar to those of the immunohistochemical analysis. …

ACTA HISTOCHEMICA ET CYTOCHEMICA 47(4), 155-164, 2014

J-STAGE Ichushi Web
19

Inhibition of the Fibroblast Growth Factor Receptor 2 Signaling Pathway as a Novel Therapeutic Approach for Clear Cell Adenocarcinoma of the Ovary [in Japanese]

ITAMOCHI Hiroaki

… Methods: Epithelial cells were isolated from endometriomas, endometriomas adjacent to CCC, and CCC by laser capture microdissection. …

日本産科婦人科學會雜誌 66(11), 2751-2760, 2014

NDL Digital Collections Ichushi Web
20

The molecular mechanism by which the short-term intervention of anti-diabetic drugs preserves pancreatic β-cells in db/db mice : comparison of their straightforward effects between early and advanced stage of diabetes [in Japanese]

Kimura Tomohiko

We compared the protective effects of pioglitazone, PPARγ agonist, and/or liraglutide, GLP-1 receptor agonist, on pancreatic β-cells between early and advanced stage of diabetes. Male db/db mice were …

Kawasaki medical journal 40(2), 77-88, 2014

IR Ichushi Web

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