Search Results 1-20 of 1157

  • Age-related changes in energy metabolism and skeletal muscle function of Sprague-Dawley rats

    Ma Yun , Maruta Hitomi , Sun Baojun , Yamashita Hiromi

    … In this study,we examined age-related changes,including O2 consumption volume (VO2), spontaneous locomotor activity,tissue weight, blood biochemical index, and gene expression in skeletal muscle of Sprague-Dawley (SD) rats,aged 32 to 92 weeks. … Our findings suggest that the aging process might contribute to a decline in the VO2,spontaneous locomotor activity, and glucose oxidation of rats aged 90 weeks compared to that of rats aged32 weeks. …

    岡山県立大学保健福祉学部紀要 = BULLETIN OF FACULTY OF HEALTH AND WELFARE SCIENCE, OKAYAMA PREFECTURAL UNIVERSITY (27), 83-92, 2021-03-12

    IR  DOI 

  • Locomotor activity and growth response of glass eel Anguilla marmorata exposed to different salinity levels

    Aquino Goldyn Anne G. , Cabaitan Patrick C. , Secor David H.

    Fisheries science 87(2), 253-262, 2021-03

  • Motor Dyscoordination and Alteration of Functional Correlation Between DGKγ and PKCγ in Senescence-Accelerated Mouse Prone 8 (SAMP8)

    Tsumagari Ryosuke , Maruo Kenta , Nakao Takaaki , Ueda Shuji , Yamanoue Minoru , Shirai Yasuhito

    … We have recently reported that DGKγ-regulated PKCγ activity is important for cerebellar motor coordination. … Furthermore, 24 weeks old SAMP8 showed the higher locomotor activity in open field test and Y-maze test. … These results suggest that SAMP8 is a useful model of age-related motor dysfunction and that the DGKγ-regulated PKCγ activity is involved in the age-related motor dyscoordination. …

    Frontiers in Aging Neuroscience (13), 573966, 2021-01-28

    IR 

  • Amplitude of circadian rhythms becomes weaken in the north, but there is no cline in the period of rhythm in a beetle

    Abe Masato S. , Matsumura Kentarou , Yoshii Taishi , Miyatake Takahisa

    … Many species show rhythmicity in activity, from the timing of flowering in plants to that of foraging behavior in animals. … However, reports of positive correlations between latitude or longitude and circadian rhythm traits, including free-running periods, the power of the rhythm and locomotor activity, are limited to certain taxonomic groups. …

    PLoS ONE 16(1), e0245115, 2021-01-14

    IR 

  • Specific inhibition of α5 subunit-containing GABA<sub>A</sub> receptors enhances locomotor activity and neuronal activity in the motor cortex

    INOUE Takahiro , TAKAMATSU Yasuyuki , OKAMURA Misato , MANI Hiroki , HASEGAWA Naoya , MAEJIMA Hiroshi

    … receptors (α5GABA<sub>A</sub>R) on the behavioral profile and neuronal activity of the CNS using a compound called L-655,708, which is a selective negative allosteric modulator of α5GABA<sub>A</sub>R. … L-655,708 administration significantly increased locomotor activity without anxiety-related behavior. …

    Biomedical Research 42(3), 103-108, 2021

    J-STAGE 

  • Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice

    MAEDA Mizuki , YOKOYAMA Toshifumi , HOSHI Nobuhiko , KITAUCHI Sayaka , HIRANO Tetsushi , IKENAKA Yoshinori , NISHI Misaki , SHODA Asuka , MURATA Midori , MANTANI Youhei , TABUCHI Yoshiaki

    … Significant increases in anxiety-like behavior and locomotor activity were observed in juveniles and adults, respectively, and neuronal activity and neurogenesis in the hippocampal dentate gyrus were affected in both stages. …

    Journal of Veterinary Medical Science 83(3), 542-548, 2021

    IR  J-STAGE 

  • Behavioral Characterization of Dopamine D<sub>5</sub> Receptor Knockout(D<sub>5</sub>KO) Mice  [in Japanese]

    Sugiura Chiaki

    … Because normal locomotor activity and working memory are required to learn the impulsivity measurement task, we also checked those.</p><p>We used adult D<sub>5</sub>KO mice or wild-type littermates. … An open field test and a home cage locomotor test were used as measures of locomotor activity. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-P1-27, 2021

    J-STAGE 

  • Lifelong measurement of locomotor activity and body temperature in group-housed laboratory mice by wireless power transmission  [in Japanese]

    Yanai Kazuhiko , Yoshikawa Takeo , Sagara Kenichi , Sasaki Shu

    Locomotor activity is one of the most important factors for the assessment of animal condition such as the circadian rhythm and motor activity. … In the present study, we aimed to develop a novel recording equipment to monitor life-long locomotor activity and body temperature in group-housed mice by wireless power transmission. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-P1-39, 2021

    J-STAGE 

  • Inhibitory effect of SB216763, a selective glycogen synthase kinase-3 inhibitor, on morphine-induced Straub's tail reaction in mice  [in Japanese]

    Kitanaka Junichi , Shiomoto Ami , Watabe Kaname , Nakano Kiyoshi , Takahashi Hitoshi , Nishiyama Nobuyoshi , Sato Tomoaki , Takemura Motohiko , Kitanaka Nobue , Horie Utau , Kawasaki Yumi , Sakamoto Takashi , Yashiro Junya , Tanaka Koh-ichi , Igarashi Kento , Tomita Kazuo

    … The endpoint of the STR can be identified easier than that of locomotor activity, but behavioral measures of STR can only be achieved by skilled observers. … Horizontal locomotor activity was also attenuated by SB216763. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-P1-11, 2021

    J-STAGE 

  • Loss of function in mouse GAD67 leads to emotional impairments  [in Japanese]

    Miyata Shigeo , Watanabe Masahiko , Abe Manabu , Sakimura Kenji , Yanagawa Yuchio , Kakizaki Toshikazu , Fujihara Kazuyuki , Obinata Hideru , Hirano Touko , Nakai Junichi , Tanaka Mika , Itohara Shigeyoshi , Tanaka Kenji

    … mice exhibited hyper-locomotor activity and decreased duration spent in the center region. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-P1-20, 2021

    J-STAGE 

  • Involvement of Dysfunction of Noradrenergic Neuronal System in the Depression-Like Behaviors in MAGE-D1 KO Mice  [in Japanese]

    Mouri Akihiro , Noda Yukihiro , Saito Kuniaki , Nabeshima Toshitaka , Hirakawa Mami , Yokoyama Misato , Watanabe Ken , Kimura Mari , Isobe Ryosuke , Kunisawa Kazuo , Mori Yuko , Yamamoto Yasuko

    … MAGE-D1 KO mice showed decreases in locomotor activity, social interaction time and sucrose preference, but increases in immobility time in the forced swimming test (FST), and feeding latency in the novelty suppression feeding test. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-O-E1-4, 2021

    J-STAGE 

  • Prefrontal cortex miR-874-3p prevents lipopolysaccharide-induced depression-like behavior through inhibition of indoleamine 2,3-dioxygenase 1 expression in mice  [in Japanese]

    Kunisawa Kazuo , Nabeshima Toshitaka , Mouri Akihiro , Suento Willy Jaya , Wulaer Bolati , Kosuge Aika , Iida Tsubasa , Fujigaki Hidetsugu , Yamamoto Yasuko , Tanra Andi Jayalangkara , Saito Kuniaki

    … Its activity is highly inducible by pro-inflammatory cytokines and correlates with the severity of major depressive disorder (MDD). … In the present study, we investigated the role of novel miRNAs in the regulation of IDO1 activity and its effect on lipopolysaccharide (LPS)-induced depression-like behavior in mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-O-E1-3, 2021

    J-STAGE 

  • Roles of TRPC3 and TRPC6 in the medial prefrontal cortex in the antidepressant-like actions of ketamine  [in Japanese]

    Deyama Satoshi , Kaneda Katsuyuki

    … <p>The antidepressant actions of the NMDA receptor antagonist ketamine require activity-dependent release of brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex (mPFC). … These treatments did not significantly affect locomotor activity in LPS-treated mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-O-E3-3, 2021

    J-STAGE 

  • Phenotypic examination of the endocannabinoid-degrading enzyme alpha/beta-hydrolase domain containing 6 (ABHD6) knockout rat  [in Japanese]

    Noguchi Katsuhiko , Sugaya Kimio , Nishijima Saori , Sakanashi Mayuko , Kadekawa Katsumi , Okitsu Shiho , Nakamine Sayomi , Torihara Hidetsugu , Yamamoto Hideyuki

    Locomotor activity of 24 hr and light phase significantly increased in Abhd6<sup>−/−</sup> rats compared with WT rats (<i>P</i>&lt;0.05). … We firstly demonstrate that deletion of Abhd6 gene in rats causes increased locomotor activity, frequent urination in stimulated bladder and hyperalgesia to non-noxious mechanical stimuli.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-P1-09, 2021

    J-STAGE 

  • The anti-alcoholism drug disulfiram produces anxiolytic effects in mice.  [in Japanese]

    Yoshifumi Nagayama , Okano Kotaro , Omata Tomoki , Takahashi Hideyo , Matsushima Kouji , Saitoh Akiyoshi , Yamada Daisuke , Terashima Yuya , Makino Kosyo , Takahashi Yoshino , Sano Yoshitake , Toda Etsuko , Ohashi Misaki , Yoshioka Toshinori

    … In contrast to diazepam, DSF produced no effects on the spontaneous locomotor activity in mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P1-32, 2021

    J-STAGE 

  • The effects of chronic administration of methamphetamine on circadian rhythm of mice  [in Japanese]

    Mizuki Nakaya , Sato Ryousuke , Nagasawa Kouki , Yoshida Yukina , Hayashi Juri , Ishi Yuki , Hamada Kazuko , Hamada Toshiyuki

    … <p>The suprachiasmatic nucleus (SCN) orchestrates synchrony among many peripheral oscillators and and is required for circadian rhythms of locomotor activity and many physiological processes. … However, chronic administration of methamphetamine (MAP) treatment dramatically lengthens circadian period of locomotor activity rhythms and induces rhythms in animals lacking SCN. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P1-LB49, 2021

    J-STAGE 

  • Effects of a Rho-kinase inhibitor, fasudil on schizophrenia-like behavior and neurotransmitter release in MK-801-treated mice  [in Japanese]

    Tanaka Rinako , Yamada Kiyofumi , Sawahata Masahito , Takase Saeko , Liu Yue , Hada Kazuhiro , Mizoguchi Hiroyuki , Nagai Taku , Nabeshima Toshitaka , Ozaki Norio

    … We performed locomotor activity test, novel object recognition test (NORT), social interaction test (SI), and pre-pulse inhibition test (PPI). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-Y-F3-4, 2021

    J-STAGE 

  • Real time recording of <i>Period1</i> gene in the central and peripheral tissues of the freely moving streptozotocin-treated diabetic mouse.  [in Japanese]

    Koki Nagasawa , Hamada Toshiyuki , Ishii Yuki , Sato Ryosuke , Nakaya Mizuki , Hayashi Juri , Yoshida Yukina , Ishikawa Masayori , Ozaki Michitaka , Hamada Kazuko

    … expression rhythm and locomotor activity rhythm. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-44, 2021

    J-STAGE 

  • Influence of circadian rhythm on the delayed recovery from isoflurane anesthesia induced by hypnotics in mice  [in Japanese]

    Iba Yoshinori , Sugano Atsunobu , Murai Hiroki , Horiguchi Syunpei , Amano Yuki

    … hypnotics can be affected by circadian rhythm. Using ICR mice and three inbred strains (sighted C57BL/6J and blind FVB/N and C3H/HeN mice), locomotor activity was measured during every 6 hours from zeitgeber time (ZT) 0, and the effects of brotizolam or suvorexant on isoflurane anesthesia were compared during light period and dark period. Although the locomotor activities were highest at ZT12-18 in all the strains examined, there was no significant difference between the activities at ZT0-6, ZT6-12, …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-43, 2021

    J-STAGE 

  • Astrocytic histamine <i>N</i>-methyltransferase controls locomotor activity and vigilance state  [in Japanese]

    Otsuka Rina , Naganuma Fumito , Sato Yuki , Takahashi Yuna , Yanai Kazuhiko , Yoshikawa Takeo

    … In behavioral tests, locomotor activity of cKO mice in novel environment and in their home cages were decreased during the dark phase. … Sleep analysis showed that the power density of delta frequency was increased in cKO mice, indicating the lower cortical activation of cKO mice. These results demonstrate that astrocytic Hnmt is important for locomotor activity and vigilance state, although the impact of Hnmt in astrocytes on histamine concentration was limited.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-O-B3-2, 2021

    J-STAGE 

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