Search Results 1-20 of 1617

  • Identification of novel cell subsets which induce lung fibrotic response  [in Japanese]

    青木 亜美 , 平原 潔 , 中山 俊憲

    臨床免疫・アレルギー科 = Clinical immunology & allergology 73(6), 652-657, 2020-06

  • Right single lung transplantation using an inverted left donor lung: interposition of pericardial conduit for pulmonary venous anastomosis-a case report

    Yamamoto Haruchika , Miyoshi Kentaroh , Otani Shinji , Kurosaki Takeshi , Sugimoto Seiichiro , Yamane Masaomi , Toyooka Shinichi , Kobayashi Motomu , Oto Takahiro

    … BACKGROUND:<br/>Lung transplantation (LTx) is still limited by the shortage of suitable donor lungs. … We report a case in which a successful left-to-right inverted LTx was completed using the interposition of a pericardial conduit for pulmonary venous anastomosis.<br/>CASE PRESENTATION:<br/>A left lung graft was offered to a 59-year-old male who had idiopathic pulmonary fibrosis with predominant damage in the right lung. …

    BMC Pulmonary Medicine 20(1), 46, 2020-02-19

    IR 

  • Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transition

    Rinastiti Pranindya , Ikeda Koji , Rahardini Elda Putri , Miyagawa Kazuya , Tamada Naoki , Kuribayashi Yuko , Hirata Ken-ichi , Emoto Noriaki

    … Pulmonary hypertension is a progressive lung disease with poor prognosis due to the consequent right heart ventricular failure. … Previous genome-wide association studies revealed a significant correlation between the genetic locus of family with sequence similarity 13, member A (FAM13A) and various lung diseases such as chronic obstructive pulmonary disease and pulmonary fibrosis; …

    PLoS ONE 15(2), e0226049, 2020-02-13

    IR 

  • Pathogenic activity of secretory IgA on lung fibrosis  [in Japanese]

    鈴川 真穂

    臨床免疫・アレルギー科 = Clinical immunology & allergology 73(1), 82-88, 2020-01

    Ichushi Web 

  • A case of unilateral upper lung field fibrosis consistent with pleuroparenchymal fibroelastosis after thoracotomy  [in Japanese]

    Nosaka Seishi , Morita Katsuhiko , Murayama Masaki

    … We encountered a postoperative patient with upper lung field fibrosis that was radiologically consistent with PPFE, but limited to the unilateral lung. … His medical history included a middle and lower lobectomy under thoracotomy for a lung squamous cell carcinoma seven years ago. … Chest CT conducted 7 years after surgery showed subpleural consolidations with bronchiectases and parenchymal lesions in the remaining right lung. …

    The Journal of the Japanese Association for Chest Surgery 34(5), 348-352, 2020

    J-STAGE 

  • Exosome-Derived <i>microRNA</i>-<i>22</i> Ameliorates Pulmonary Fibrosis by Regulating Fibroblast-to-Myofibroblast Differentiation <i>in Vitro</i> and <i>in Vivo</i>

    Kuse Naoyuki , Atsumi Kenichiro , Hayashi Hiroki , Saito Yoshinobu , Seike Masahiro , Gemma Akihiko , Kamio Koichiro , Azuma Arata , Matsuda Kuniko , Inomata Minoru , Usuki Jiro , Morinaga Akemi , Tanaka Toru , Kashiwada Takeru

    … <p><b>Background: </b>Although aberrant proliferation and activation of lung fibroblasts are implicated in the initiation and progression of idiopathic pulmonary fibrosis (IPF), the underlying mechanisms are not well characterized. … In this study, we attempted to identify exosome-derived miRNAs relevant to fibrosis development. …

    Journal of Nippon Medical School 87(3), 118-128, 2020

    J-STAGE 

  • Pristane/Hypoxia (PriHx) Mouse as a Novel Model of Pulmonary Hypertension Reflecting Inflammation and Fibrosis

    Mori Hiroyoshi , Ishibashi-Ueda Hatsue , Kumanogoh Atsushi , Nakaoka Yoshikazu , Ishibashi Tomohiko , Inagaki Tadakatsu , Okazawa Makoto , Masaki Takeshi , Asano Ryotaro , Manabe Yusuke , Ohta-Ogo Keiko , Narazaki Masashi

    … In the pathogenesis of CTD-PAH, inflammation, immune cell abnormality, and fibrosis play important roles. … Pristane administration exacerbated lung fibrosis and elevated the expression of fibrosis-related genes. …

    Circulation Journal 84(7), 1163-1172, 2020

    J-STAGE 

  • Functional analysis of human fibrocytes derived from monocytes reveals their profibrotic phenotype through paracrine effects

    Abe Shuichi , Nishioka Yasuhiko , Sato Seidai , Aono Yoshinori , Azuma Momoyo , Kishi Masami , Koyama Kazuya , Takahashi Naoki , Kagawa Kozo , Kawano Hiroshi

    … <p>Fibrocytes, which are bone marrow-derived collagen-producing cells, were reported to play a role in the pathogenesis of pulmonary fibrosis. … However, their function in pulmonary fibrosis is unclear. … We analyzed their function compared with that of monocytes and localization in fibrotic tissues in patients with idiopathic pulmonary fibrosis (IPF). … The localization of fibrocytes in lung tissues of patients with IPF was determined by immunofluorescence staining. …

    The Journal of Medical Investigation 67(1.2), 102-112, 2020

    J-STAGE 

  • Azithromycin Inhibits Constitutive Airway Epithelial Sodium Channel Activation <i>in Vitro</i> and Modulates Downstream Pathogenesis <i>in Vivo</i>

    Fujikawa Haruka , Nakagata Naomi , Suico Mary Ann , Kai Hirofumi , Shuto Tsuyoshi , Kawakami Taise , Nakashima Ryunosuke , Nasu Aoi , Kamei Shunsuke , Nohara Hirofumi , Eto Yuka , Ueno-Shuto Keiko , Takeo Toru

    … We examined whether macrolides could modulate constitutive ENaC activity and downstream events that typify cystic fibrosis (CF) and chronic obstructive pulmonary diseases (COPD) in <i>in vitro</i> … Although not statistically significant, improvement of pulmonary obstructive parameters such as emphysema and lung dysfunction (FEV0.1%) was observed. …

    Biological and Pharmaceutical Bulletin 43(4), 725-730, 2020

    J-STAGE 

  • Pharmacological aspects of Respiratory Diseases  [in Japanese]

    Yatera Kazuhiro

    … <p>With the recent aging population, pneumonia, lung cancer, and chronic obstructive pulmonary disease (COPD) are leading death causes, and asthma and interstitial pneumonia are common. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S34-2, 2020

    J-STAGE 

  • Diverse roles of nitric oxide synthases in the pathogenesis of lung diseases  [in Japanese]

    Tsutsui Masato , Yatera Kazuhiro

    … the lung under both physiological and pathological conditions. Although the role of NOSs in lung diseases has been examined in pharmacological studies with non-selective NOSs inhibitors, it still remains to be fully elucidated due to non-specificity of the agents. We addressed this point in our mice lacking all three NOSs and in mouse lung disease models. Bleomycin treatment significantly increased pulmonary fibrosis, collagen content in the lung, …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S34-1, 2020

    J-STAGE 

  • Protective effect of a metallothionein inducer on cadmium-induced lung epithelial injury.  [in Japanese]

    Tanaka Ken-ichiro , Kimura Kazuma , Sugizaki Toshifumi , Nakano Yukari , Shimoda Mikako , Kawahara Masahiro

    … Therefore, in this study we examined whether polaprezinc, a chelate compound consisting of carnosine and zinc, can suppress cadmium-induced lung epithelial cell death. … These results indicate that polaprezinc can suppress cadmium-induced lung epithelial cell death and oxidative stress by inducing metallothioneins. … We therefore suggest that polaprezinc may have therapeutic effects against respiratory diseases, such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-310, 2020

    J-STAGE 

  • Identification of B38-CAP as an ACE2-like enzyme to suppress hypertension and cardiac dysfunction in mice.  [in Japanese]

    Kuba Keiji , Minato Takafumi , Nirasawa Satoru , Sato Teruki , Yamaguchi Tomokazu , Watanabe Hiroyuki , Imai Yumiko , Takahashi Saori

    … <p>Angiotensin-converting enzyme 2 (ACE2) is a negative regulator of the renin-angiotensin system, critically involved in blood pressure regulation, heart function, lung injury, or fibrotic kidney disease. … Recombinant human ACE2 protein (rhACE2), currently clinically evaluated to treat acute lung failure, is a glycosylated protein, requiring time- and cost-consuming protein production in mammalian cells. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-314, 2020

    J-STAGE 

  • Ferric chloride induces irreversible pulmonary fibrosis in mice  [in Japanese]

    Mikami Hidekideki , Kim Jundai , Matsuda Shuichi , Ugai Keita , Yoshioka Kento , Hatano Masahiko , Fukamizu Akiyoshi , Tatsumi Koichiro , Kasuya Yoshitoshi

    … <p>Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease with an unknown cause and poor prognosis. … To precisely know the pathophysiology of lung fibrotic disease, the appropriate animal model correlating to the pathology of IPF is required. … From the transcriptome analysis using lung myofibroblasts derived from the patient with IPF, we found the possible correlation between ferroptosis and lung fibrosis. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-O-073, 2020

    J-STAGE 

  • Reversal of myofibroblast phenotype due to the adhesion of Lung mixed culture-derived epithelial cells (LMDEC)  [in Japanese]

    Matsuda Shuichi , Ugai Keita , Mikami Hideki , Suga Masaki , Tatsumi Koichiro , Hatano Masahiko , Kasuya Yoshitoshi

    … <p>Fibroblast-to-myofibroblast differentiation is recognized as critical process of developing irreversible pulmonary fibrosis through the excessive accumulation of extracellular matrix. … To elucidate the factor that can induce dedifferentiation of myofibroblast phenotype will provide a new therapeutic target for pulmonary fibrosis. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-O-072, 2020

    J-STAGE 

  • Bleomycin-induced pulmonary fibrosis in cynomolgus monkeys  [in Japanese]

    Okabayashi Sachi , Sakuraba Takashi , Yasuda Hitoshi , Yamanouchi Tomohiko , Sasaki Mai , Mitsuoka Chihomi , Yamazaki Noriyuki , Tateda Chiaki , Kitajima Shunichi

    … <p>【Purpose】</p><p>Idiopathic pulmonary fibrosis (IPF) is a progressive and intractable lung disease characterized by the proliferation of fibroblasts and loss of pulmonary function. … Although many bleomycin-induced pulmonary fibrosis has been studied as IPF model in rodent, IPF model in nonhuman primates has not been reported. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-123, 2020

    J-STAGE 

  • A case of thoracoscopic bullectomy with ECMO for secondary pneumothorax with poor pulmonary function  [in Japanese]

    Nakamura Ryuji , Fujiwara Toshiya , Okada Kazuhiro , Kubo Yujiro , Okada Masanori , Matsuura Motoki

    … He underwent left lower lobectomy for lung cancer. … However, his pulmonary function was inadequate because of combined pulmonary fibrosis and emphysema and post-pulmonary resection status associated with lung cancer.</p><p>Therefore, we decided to perform video-assisted thoracoscopic bullectomy with extracorporeal membrane oxygenation (ECMO) to maintain the oxygen levels during the operation in cooperation with the cardiovascular surgery department as well as other departments. …

    The Journal of the Japanese Association for Chest Surgery 34(2), 178-181, 2020

    J-STAGE  Ichushi Web 

  • Pleural translocation and lesions by pulmonary exposed multi-walled carbon nanotubes

    WANG Qiong , WANG Qiqi , ZHAO Ziyue , ALEXANDER David B. , ZHAO Dahai , XU Jiegou , TSUDA Hiroyuki

    … Experimental data indicate that CNTs can induce lung and pleural lesions, inflammation, pleural fibrosis, lung tumors, and malignant mesothelioma upon inhalation in the experimental animals. …

    Journal of Toxicologic Pathology, 2020

    J-STAGE 

  • Protective role of myelocytic nitric oxide synthases in pulmonary hypertension due to lung diseases and/or hypoxia  [in Japanese]

    Ogoshi Takaaki , Tsutsui Masato , Yatera Kazuhiro , Mukae Hiroshi

    … We demonstrated that, in 36 consecutive patients with idiopathic pulmonary fibrosis, pulmonary artery systolic pressure is inversely correlated with NOx levels in the bronchoalveolar lavage fluid, suggesting reduced pulmonary NO production in group III PH. We then revealed that transplantation of BM cells from mice lacking all NOSs aggravates hypoxia-induced PH in wild-type (WT) mice, and transplantation of BM cells from the WT mice ameliorates hypoxia-induced PH in the NOSs<sup>−/−</sup> …

    Folia Pharmacologica Japonica 155(2), 69-73, 2020

    J-STAGE  Ichushi Web 

  • Intrapulmonary Pharmacokinetics and Drug Distribution Characteristics for the Treatment of Respiratory Diseases  [in Japanese]

    Togami Kohei

    … <p>This study was designed to clarify the intrapulmonary pharmacokinetics and distribution characteristics of drugs in order to develop better therapies for respiratory diseases, including respiratory infections and pulmonary fibrosis. … The distribution characteristics of three macrolide antimicrobial agents—clarithromycin, azithromycin, and telithromycin—in plasma, lung epithelial lining fluid (ELF), and alveolar macrophages (AMs), were examined for the optimization of antimicrobial therapy. …

    YAKUGAKU ZASSHI 140(3), 345-354, 2020

    J-STAGE  Ichushi Web 

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