Search Results 1-12 of 12

  • Direct Cardiac Reprogramming: A Novel Approach for Heart Regeneration

    家田 真樹 , Hidenori Tani , Taketaro Sadahiro , Masaki IEDA

    … We previously reported that fibroblasts can be directly reprogrammed to cardiomyocytes by overexpressing a combination of three cardiac-specific transcription factors (Gata4, Mef2c, Tbx5 (together, GMT)). … We and other groups have promoted cardiac reprogramming by the addition of certain miRNAs, cytokines, and epigenetic factors, and unraveled new molecular mechanisms of cardiac reprogramming. …

    International Journal of Molecular Sciences 19(9), 2629, 2018-09

    IR 

  • Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.

    MAEJIMA Takashi , INOUE Tsuyoshi , KANKI Yasuharu , KOHRO Takahide , LI Guoliang , OHTA Yoshihiro , KIMURA Hiroshi , KOBAYASHI Mika , TAGUCHI Akashi , TSUTSUMI Shuichi , IWANARI Hiroko , YAMAMOTO Shogo , ARUGA Hirofumi , DONG Shoulian , STEVENS Junko F , POH Huay Mei , YAMAMOTO Kazuki , KAWAMURA Takeshi , MIMURA Imari , SUEHIRO Jun-ichi , SUGIYAMA Akira , KANEKI Kiyomi , SHIBATA Haruki , YOSHINAKA Yasunobu , DOI Takeshi , ASANUMA Akimune , TANABE Sohei , TANAKA Toshiya , MINAMI Takashi , HAMAKUBO Takao , SAKAI Juro , NOZAKI Naohito , ABURATANI Hiroyuki , NANGAKU Masaomi , RUAN Xiaoan , TANABE Hideyuki , RUAN Yijun , IHARA Sigeo , ENDO Akira , KODAMA Tatsuhiko , WADA Youichiro

    … Statins exert atheroprotective effects through the induction of specific transcriptional factors in multiple organs. … In endothelial cells, statin-dependent atheroprotective gene up-regulation is mediated by Kruppel-like factor (KLF) family transcription factors. … Myocyte enhancer factor-2 (MEF2) family activation is reported to be involved in pitavastatin-dependent KLF4 induction. …

    PLoS One = PLoS One 9(5), e96005, 2014-05-05

    IR 

  • Direct reprogramming into cardiomyocytes  [in Japanese]

    Miyamoto Kazutaka , Ieda Masaki

    … We and other reported that functional cardiomyocytes can be directly generated from fibroblasts using several combinations of cardiac-specific defined factors. … Mouse fibroblasts can be directly converted into cardiomyocyte-like cells by overexpression of cardiac-specific transcription factors, Gata4, Mef2c, and Tbx5 (GMT), GMT plus Hand2 (GHMT), or Mef2c, Myocd, and Tbx5 <I>in vitro</I>. …

    Inflammation and Regeneration 34(5), 217-223, 2014

    J-STAGE  Ichushi Web 

  • Heart regeneration using reprogramming technology

    IEDA Masaki

    … On the other hand, recent studies demonstrated that a somatic cell could be converted into an alternative differentiated cell type without first becoming a stem cell by overexpression of lineage-specific factors. … We found that functional cardiomyocytes can be directly induced from fibroblasts by a combination of three cardiac transcription factors, Gata4, Mef2c and Tbx5, <i>in vitro</i> …

    Proceedings of the Japan Academy, Series B 89(3), 118-128, 2013

    J-STAGE 

  • Genetic Analysis of Essential Cardiac Transcription Factors in 256 Patients With Non-Syndromic Congenital Heart Defects

    KODO Kazuki , NISHIZAWA Tsutomu , FURUTANI Michiko , ARAI Shoichi , ISHIHARA Kazuaki , ODA Mayumi , MAKINO Shinji , FUKUDA Keiichi , TAKAHASHI Takao , MATSUOKA Rumiko , NAKANISHI Toshio , YAMAGISHI Hiroyuki

    … Genes encoding NKX2.5, GATA4, GATA6, MEF2C, and ISL1, essential for heart development, were analyzed using PCR-based bidirectional sequencing. … A novel sequence variant (A103V in <i>MEF2C</i>) was identified, in addition to 4 unreported non-synonymous sequence variants in 3 known causative genes (A6V in <i>NKX2.5</i>, T330R and S339R in <i>GATA4</i>, and E142K in <i>GATA6</i>) in 5 individuals. …

    Circulation Journal 76(7), 1703-1711, 2012-06-25

    J-STAGE  Ichushi Web  References (45) Cited by (1)

  • Evaluation and comparison the embryotoxicity of mainstream and sidestream smoke on cardiogenesis  [in Japanese]

    CHENG Wei , FENG Lixin , WANG Yan

    … Expression of key transcription factors, such as Gata4, Tbx5, Tbx20 and Mef2c, and transcript myosin heavy chain (MHC) were detected by real-time PCR analysis when the exposure phase ended. …

    Annual Meeting of the Japanese Society of Toxicology 39.2(0), AP-113, 2012

    J-STAGE 

  • Differentiation of cardiomyocyte  [in Japanese]

    OKA Toru , KOMURO Issei

    … Cardiac-specific transcription factors, including Csx/Nkx-2.5, GATA4, MEF2 and dHAND eHAND, play central roles in cardiac development. … Loss-of-function and gain-of-function studies have revealed that these factors regulate heart morphogenesis and cardiac-specific gene expressions. …

    Folia Pharmacologica Japonica 115(6), 337-344, 2000-06-01

    J-STAGE  Ichushi Web  References (42)

  • Ca^<2+>-dependent gene expression mediated by MEF2 transcription factors

    BLAESER F

    J. Biol. Chem. 275, 197-209, 2000

    Cited by (2)

  • Regulation of the MEF2 family of transcription factors by p38

    ZHAO M.

    Mol. Cell Biol. 19, 21-30, 1999

    Cited by (3)

  • Expression of MEF2 Genes during Human Cardiac Development.

    Iida Kazuki , Hidaka Kyoko , Takeuchi Makoto , Nakayama Masahiro , Yutani Chikao , Mukai Tsunehiro , Morisaki Takayuki

    … To better understand the reguratory mechanisms in gene expression of human cardiomyocytes, we studied the expression of MEF2 genes encoding transcription factors during the course of cardiac development. …

    The Tohoku Journal of Experimental Medicine 187(1), 15-23, 1999

    J-STAGE 

  • Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist

    SPICER D. B.

    Science 272, 1476-1480, 1996

    Cited by (3)

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