Search Results 1-20 of 266

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Effect of genotype-based personalized nutrition guidance on serum folate and homocysteine concentrations in male workers [in Japanese]

平岡真実 , 坂本香織 , 百合本真弓 , 香川靖雄 , Mami Hiraoka , Kaori Sakamoto , Mayumi Yurimoto , Yasuo Kagawa

… 【目的】葉酸摂取不足や葉酸代謝関連酵素の遺伝子多型MTHFR C677Tは高ホモシステイン（Hcy）血症を招き、動脈硬化性疾患のリスクを高める。 …

淑徳大学看護栄養学部紀要 = Journal of the School of Nursing and Nutrition Shukutoku University (13), 1-11, 2021-03-16

IR
2

Effect of genotype-based personalized nutrition guidance on serum folate and homocysteine concentrations in male workers [in Japanese]

平岡真実 , 坂本香織 , 百合本真弓 , 香川靖雄

淑徳大学看護栄養学部紀要 = Journal of the School of Nursing and Nutrition, Shukutoku University (13), 1-11, 2021
3

Perspectives on urological care in spina bifida patients

Moussa Mohamad , Papatsoris Athanasios G. , Abou Chakra Mohamad , Fares Youssef , Dabboucy Baraa , Dellis Athanasios

… The methylenetetrahydrofolate reductase (MTHFR) gene has been implicated as a risk factor for NTDs. …

Intractable & Rare Diseases Research 10(1), 1-10, 2021

J-STAGE
4

Effects of Simulated Weightlessness on Metabolizing Enzymes and Pharmacokinetics of Folic Acid in SD Rats

Zhang Yang , Wang Qingwei , Zhao Jun , Jing Juan , Zhang Ruitao , Zhou Xuejiao , Gao Jianyi , Wang Jiaping , Li Yongzhi , Liu Xueying

… Proteins expression of such FA metabolic enzymes as Methyltetrahydrofolate reductase (MTHFR), Cystathionine beta synthase (CBS) and Methionine synthase (MS) in a variety of organs was analyzed with Western-Blot, and mRNA expression was detected by RT-PCR. …

Biological and Pharmaceutical Bulletin 44(2), 162-168, 2021

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5

Effect of Maternal Folate Deficiency on Growth Performance, Slaughter Performance, and Serum Parameters of Broiler Offspring

Zhang Yujie , Jing Wenqian , Zhang Ningbo , Hao Jiwei , Xing Jinyi

… Serum concentrations of MTHFR, DHFR, LEP, IGF2, LPL and HCY in the 21-day-old broilers were not affected by maternal FD (P>0.05), but those of HSL at 21 days of age was enhanced by maternal FD (P<0.05). …

The Journal of Poultry Science 57(4), 270-276, 2020

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6

Association Between MTHFR C677T Polymorphism and Congenital Heart Disease:A PRISMA-Compliant Meta-Analysis

Liu Peng-Fei , Ding Bing , Zhang Jun-Yi , Mei Xiao-Fei , Li Fei , Wu Peng , Mei Chun-Hao , Zhou Ya-Feng , Chen Tan

… Many published studies have evaluated the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) polymorphism and the risk of congenital heart disease (CHD); …

International Heart Journal 61(3), 553-561, 2020

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7

Effect of Chlorella Food on Folate Metabolism [in Japanese]

藤島雅基

Vegetarian research = ベジタリアン・リサーチ 20(1・2), 11-15, 2019
8

Association of Intake Folate and Related Gene Polymorphisms with Breast Cancer

CHEN Xiang , AHAMADA Hadji , ZHANG Ting , BAI Zhonghu , WANG ChunXin

… are key elements of the one-carbon metabolism pathway where methylenetetrahydrofolate reductase (MTHFR) plays a significant role. … Though many molecular and epidemiological studies have been performed to explore the relationship between intake folate, vitamin B12, MTHFR gene polymorphism and breast cancer risk, there is no consensus to date. …

Journal of Nutritional Science and Vitaminology 65(6), 459-469, 2019

J-STAGE Ichushi Web
9

Polymorphisms in folic acid metabolism genes do not associate with cancer cachexia in Japanese gastrointestinal patients

Morishita Takuto , Hishida Asahi , Okugawa Yoshinaga , Morimoto Yuuki , Shirai Yumiko , Okamoto Kyoko , Momokita Sachiko , Ogawa Aki , Tanaka Koji , Nishikawa Ryutaro , Toiyama Yuji , Inoue Yasuhiro , Sakurai Hiroyuki , Urata Hisashi , Tanaka Motoyoshi , Miki Chikao

… used clinical data from Iga General Hospital to examine the association between polymorphisms in MTR (methionine synthase) A2756G (rs1805087), MTRR (methionine synthase reductase) His595Tyr (rs10380), MTHFR (methylenetetrahydrofolate reductase) C677T (rs1801133), MTHFR A1298C (rs1801131) and SHMT (serine hydroxymethyltransferase) C1420T (rs1979277), which are genes involved in folate metabolism, and the risk of weight loss in patients with gastrointestinal cancers, with the aim of establishing personalized palliative care for …

Nagoya Journal of Medical Science 80(4), 529-539, 2018-11

IR DOI Ichushi Web
10

Development of Next Generation Sequencing panel including cancer risk gene and drug-metabolizing enzymes

Nguyen Phuong T. T , Jeong Hye-Eun , Kim Ho-Sook , Ghim Jong-Lyul , Shin Jae Gook

… METHODS: Panel was designed a multiplex PCR targeting hotspot region of 20 genes (AKT1, BRAF, EGFR, ERBB2, FOXL2, KIT, KRAS, MET, BRCA1, BRCA2, NRAS, PDGFRA, PIK3CA, RET, TP53, UGT1A1, CYP2D6, TPMT, MTHFR and DPYD) which are for cancer risk assessment, and selection of drug and drug dosage. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO4-10-18, 2018

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11

A case of venous thromboembolism with hyperhomocysteinemia [in Japanese]

Uchida Masato , Numaguchi Kotaro , Murasato Yoshinobu , Nakamura Toshihiro , Takenaka Katsuhiko , Araki Masahiro , Ura Yujiro , Meno Kyohei , Kuwabara Yukimitsu , Ejima Emiko , Aso Akemi , Mori Takahiro

… 7病日に退院した．悪性疾患や環境因子はなく，血液検査では明らかな血栓素因も認めなかった．唯一，血清ホモシステイン濃度のみ61.8 nmol/mLと異常高値であった．遺伝子検査でmethylenetetrahydrofolate reductase（MTHFR）遺伝子多型のホモ変異TT型が判明し，外来で葉酸補充療法を開始し，以降血中ホモシステイン濃度は低下した．静脈血栓塞栓症の再発なく経過している．明らかな血栓素因のない静脈血栓塞栓症に対して， …

Shinzo 50(6), 661-666, 2018

J-STAGE Ichushi Web
12

Risk Factors of Cervical Cancer : Folate Levels and Lifestyle Habits : The Prevention of Cancer and Health Guidance [in Japanese]

川原由佳子 , 吉村彩 , 折戸智恵子 , 横田卓 , 加納崇裕 , 本間理央 , 小西剛 , 橋野聡

Campus health 公益社団法人全国大学保健管理協会機関誌 54(2), 137-142, 2017-05

Ichushi Web
13

Interaction of B vitamins with antiepileptic drugs [in Japanese]

Nagae Akiko , Ao Misora , Kumode Masao

VITAMINS 91(8), 503-505, 2017

J-STAGE Ichushi Web
14

MTHFR promoter hypermethylation may lead to congenital heart defects in Down syndrome

Asim Ambreen , Agarwal Sarita , Panigrahi Inusha , Saiyed Nazia , Bakshi Sonal

… Methylene Tetrahydrofolate Reductase (MTHFR) is one of the major enzymes of the folate metabolism pathway. … MTHFR gene polymorphism has been associated with maternal risk for DS. … Studies have revealed that increased MTHFR promoter methylation results in the reduction of MTHFR protein activity further leading to increased risk of various diseases. …

Intractable & Rare Diseases Research 6(4), 295-298, 2017

J-STAGE Ichushi Web
15

Association between oxidative stress-related genes polymorphisms and metabolic abnormalities among schizophrenia patients

Oniki Kentaro , Otake Koji , Ogata Yasuhiro , Saruwatari Junji , Yasui-Furukori Norio , Ishioka Masamichi , Osaki Natsumi , Sakamoto Yuki , Yoshimori Yuki , Tomita Tetsu , Kamihashi Ryoko , Tsuchimine Shoko , Sugawara Norio

… The effects of the polymorphisms of methylenetetrahydrofolate reductase (MTHFR) (rs1801133, C677T; … (rs1917760, G-1308T) on the risk for metabolic abnormalities were investigated by structural equation modeling.Results: Among the female schizophrenia patients, the MTHFR … MTHFR …

Clinical Neuropsychopharmacology and Therapeutics 8(0), 25-37, 2017

J-STAGE Ichushi Web
16

Associations of folate consumption with serum folate concentrations and plasma homocysteine levels according to methylenetetrahydrofolate reductase C677T genotype in Japanese female university students : a single-arm intervention study using fermented milk with pteroylmonoglutamic acid [in Japanese]

三ツ口千代菊 , 熊谷佳子 , 安友裕子 , 伊藤勇貴 , 北川元二 , 藤木理代 , 徳留裕子

… 【目的】葉酸添加発酵乳を付加し、メチレンテトラヒドロ還元酵素遺伝子多型別（MTHFR）C677T別に葉酸摂取量、血清葉酸値および血漿ホモシステイン値との関連を検討した。 …

Nagoya journal of nutritional sciences = 名古屋栄養科学雑誌 (3), 25-38, 2017

IR DOI Ichushi Web
17

Association of Mycobacterium infections in patients with Mendelian susceptibility to mycobacterial disease with venous thromboembolism

Alinejad Dizaj Maryam , Mahdaviani Seyed Alireza , Tabarsi Payam , Ahari Hamed , Ebrahimi Ahmad , Nadji Seyed Alireza , Emami Habib , Mortaz Esmaeil

Microbiology and immunology 60(10), 678-686, 2016-10
18

5．椎体骨折のリスクを考慮した，MTHFR 遺伝子多型別の血液中ビタミンB12 及びホモシステイン濃度基準値の検討(第444 回研究協議会研究発表要旨、ビタミンB 研究委員会） [in Japanese]

田中清 , 青未空

VITAMINS 90(9), 452-453, 2016

J-STAGE
19

The Independent and Joint Association of Blood Pressure, Serum Total Homocysteine, and Fasting Serum Glucose Levels With Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults:Associations of SBP, Hcy and FBG With baPWV

Liu Xiaoyun , Li Jianping , Qin Xianhui , Hou Fanfan , Xu Xiping , Yang Xinchun , Chen Yundai , Wang Xiaobin , Huo Yong , Sun Ningling , Yu Tao , Fan Fangfang , Zheng Meili , Qian Geng , Wang Binyan , Wang Yu , Tang Genfu

This study aimed to investigate the independent and joint association of blood pressure (BP), homocysteine (Hcy), and fasting blood glucose (FBG) levels with brachial-ankle pulse wave velocit …

International Heart Journal 57(5), 627-633, 2016

J-STAGE Ichushi Web
20

Folate Deficiency Was Associated with Increased Alanine Aminotransferase and Glutamyl Transpeptidase Concentrations in a Chinese Hypertensive Population: A Cross-Sectional Study

LI Wen-Xing , HUANG Jing-Fei , LIU Dahai , LI Wei , CAO Jia-Qian , YAN Haiyue , SUN Yuanyuan , ZHANG Hong , ZHANG Qiang , TANG Ling , WANG Manman

… The results showed that the MTHFR … C677T mutation was related a decreased serum AST level (r=−0.11, p=0.026), whereas the MTHFR … Our data suggested that hepatic functions were affected by MTHFR …

Journal of Nutritional Science and Vitaminology 62(4), 265-271, 2016

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