Search Results 1-20 of 746

  • Structure Activity Relationship Study of Polymethoxylated Flavones Targeted Retinal Müller Cells for Prevention of Retinal Diseases  [in Japanese]

    Miyata Yoshiki

    … In DR, they attribute to increased vascular permeability by degrading the junction proteins, such as occuldin and cadherin that are important to maintain the BRB junction complex. … In this symposium review, I present the molecular mechanism of MMP expression in retinal Müller cells. …

    YAKUGAKU ZASSHI 141(1), 41-45, 2021


  • Key Molecules to Decipher the Mechanisms of Intractable Neurological Diseases  [in Japanese]

    吉良 潤一

    … We used molecular immunopathology of autopsied materials to identify marked alterations in glial connexins (Cxs) in acute and chronic demyelinating lesions of MS as well as neuromyelitis optica (NMO) and Balóʼs concentric sclerosis. … Similar changes were also observed in acute and chronic experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Glial Cxs form gap junction (GJ) channels, which connect glial cells constituting the glial syncytium. …

    福岡醫學雜誌 111(3), 93-112, 2020-09-25


  • On the motion of slightly rarefied gas induced by a discontinuous surface temperature

    Taguchi Satoshi , Tsuji Tetsuro

    … More precisely, the channel is longitudinally divided into two parts and each part is kept at a uniform temperature different from each other, so that the surface temperature of the whole channel has a jump discontinuity at the junction. …

    Journal of Fluid Mechanics (897), 2020-08-25


  • Structural insights into gap junction channels boosted by cryo-EM

    Oshima Atsunori

    … Gap junction channels are the major components mediating this function, but the molecular mechanisms underlying their opening and closing remain unclear. … Single-particle cryo-electron microscopy (cryo-EM) is a powerful tool for investigating high-resolution protein structures that are difficult to crystallize, such as gap junction channels. … This review focuses on recent reports of gap junction channel structures visualized by cryo-EM. …

    Current Opinion in Structural Biology (63), 42-48, 2020-08


  • STM apparent height measurements of molecular wires with different physical length attached on 2-D phase separated templates for evaluation of single molecular conductance

    Iizuka Tomoya , Shimizu Daiki , Matsuda Kenji

    … Single molecular conductance of molecular wires is effectively evaluated by the combination of STM apparent height measurement and a 2-D phase separation technique. … Previously the method was only applied to a set of molecular wires with the same physical length, but herein we applied the method to thienylene-based and phenylene-based molecular wires with different physical lengths. …

    RSC Advances (10), 22054-22057, 2020-06-09


  • Single-molecular bridging in static metal nanogap electrodes using migrations of metal atoms  [in Japanese]

    Naitoh Yasuhisa , Tani Yosuke , Koyama Emiko , Nakamura Tohru , Sumiya Touru , Ogawa Takuji

    … <p>The realization of molecular devices via metal-molecule-metal junctions necessitates the fabrication of a steady molecular bridging structure, where the number of bridging structures should be fixed. … This study investigated a new molecular bridging method using migrations of gold atoms on static nanogap electrodes. …

    Abstract book of Annual Meeting of the Japan Society of Vacuum and Surface Science 2020(0), 269, 2020


  • Formation of the molecular junction in Ta<sub>2</sub>O<sub>5</sub> thin layer  [in Japanese]

    Aiba Akira , Kaneko Satoshi , Nishino Tomoaki

    … <p>Metal/molecule/metal junction has been attracted to wide attention due to the potential application for molecular electronics. … In this study, we aimed to fabricate the molecular junction in a solid electrolyte to improve the stability of the molecular junction. …

    Abstract book of Annual Meeting of the Japan Society of Vacuum and Surface Science 2020(0), 259, 2020


  • Temperature measurement of 1,4-benzendithiol single molecular junction by surface enhanced Raman scattering  [in Japanese]

    Yasuraoka Koji , Kaneko Satoshi , Nishino Tomoaki

    … <p>The single molecular junction(SMJ) has wide attention due to potential application tomolecular devices. …

    Abstract book of Annual Meeting of the Japan Society of Vacuum and Surface Science 2020(0), 263, 2020


  • Analysis of Raman spectra of spiropyran single-molecule junction using PCA  [in Japanese]

    Kobayashi Shuji , Kaneko Satoshi , Tamaki Takashi , Tsukagoshi Kazuhito , Nishino Tomoaki

    … <p>Single-molecule junction(SMJ)s with the functional molecule is expected to apply for the molecular devices because their electric property can be controlled by the external stimulation. … We found that the change in conductance is due to the change in molecular structure.</p> …

    Abstract book of Annual Meeting of the Japan Society of Vacuum and Surface Science 2020(0), 264, 2020


  • Bottom-up Growth of Graphene Nanoribbons for Application to Electronic Devices  [in Japanese]

    OHTOMO Manabu , HAYASHI Hironobu , JIPPO Hideyuki , HARADA Naoki , YAMAGUCHI Junichi , HAYASHI Kenjiro , OHFUCHI Mari , YAMADA Hiroko , SATO Shintaro

    … First, we show the simulation results suggesting that a GNR backward diode with GNR heterojunction can outperform the state-of-the-art diodes owing to their negligible junction capacitance. … It was revealed that the important design policies for precursors are as follows : molecular design avoiding intramolecular steric hinderance upon polymerization, precursor design considering dehydrogenation path, and precursor design considering intramolecular side reaction. …

    Vacuum and Surface Science 63(9), 492-497, 2020


  • Study of Hybrid Type Two-dimensional Electrochemical Sensor  [in Japanese]

    Maejima Kazuma , Hasegawa Yuki , Uchida Hidekazu

    … <p>In the field of life science such as drug discovery, technological innovation of molecular evolution is required. … Hybrid pn junction LAAS devices are fabricated by combining a plurality of organic materials with different Si types. …

    IEEJ Transactions on Sensors and Micromachines 140(6), 144-149, 2020


  • Investigation of Organic-Based Thermoelectric Materials for Flexible Thermoelectric Generators  [in Japanese]

    NAKAMURA Masakazu , KOJIMA Hirotaka

    … A protein molecular junction is used to suppress the phonon propagation while maintaining the electron transport.</p> …

    Vacuum and Surface Science 63(5), 239-244, 2020


  • Genetic Counseling for Patients with <i>GJB2</i>-Associated Hearing Loss  [in Japanese]

    Abe Satoko , Nishio Shin-ya , Moteki Hideaki , Yokota Yoh , Misawa Takeru , Takeda Hidehiko , Usami Shin-ichi

    … gene, which encodes the gap junction protein connexin26, are known, worldwide, to be frequently responsible for congenital profound hearing loss. … is one of the important standard screening methods for the molecular diagnosis of deafness. …

    Practica Oto-Rhino-Laryngologica 113(4), 223-233, 2020

    J-STAGE  Ichushi Web 

  • The roles of gap junctional intercellular communication in non-alcoholic steatohepatitis (NASH) and liver fibrosis  [in Japanese]

    Naiki-Ito Aya

    … Connexin (Cx)32, a hepatocyte gap-junction protein, plays an important role in liver tissue homeostasis. … We would like to discuss about molecular mechanisms and chemoprevention of NASH and liver fibrosis.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-S22-2, 2020


  • CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum

    Kajiho Hiroaki , Yamamoto Yasunori , Sakisaka Toshiaki

    … Oligomerization of three-way junction protein lunapark (Lnp) is important for its localization and the three-way junction stability. … On the other hand, Lnp has an N-terminal ubiquitin ligase activity domain, which is also important for the three-way junction localization. … CAND1 and Lnp form a higher-molecular-weight complex in vitro, while they do not co-localize at the three-way junctions. …

    Scientific Reports (9), 13152, 2019-09-11


  • Spin-Current Induced Mechanical Torque in a Chiral Molecular Junction

    Sasao Naoki , Okada Hiroki , Utsumi Yasuhiro , Entin-Wohlman Ora , Aharony Amnon

    Journal of the Physical Society of Japan 88(6), 064702-1-9, 2019-06


  • Presynaptic Black Box Opened by Pioneers at Biophysics Department in University College London

    Tomoyuki Takahashi

    … The mechanism of chemical synaptic transmission was elucidated at the frog neuromuscular junction (NMJ) and at the squid giant synapse by Katz, Miledi and other researchers. … Later progress in molecular biology revealed numerous types of proteins in mammalian central synapses. … To establish molecular-functional correlation in synaptic transmission, it now seems essential to re-address the fundamental mechanisms at mammalian central synapses. …

    Neuroscience, 2019-05-18


  • Molecular-scale visualization and surface charge density measurement of Z-DNA in aqueous solution

    Kominami Hiroaki , Kobayashi Kei , Yamada Hirofumi

    … Furthermore, the detailed structures of the interface between B- and Z-DNAs, B-Z junction, was also determined with an atomic resolution. …

    Scientific Reports (9), 2019-05-02


  • Identifying the molecular adsorption site of a single molecule junction through combined Raman and conductance studies

    加納 英明 , Satoshi Kaneko , Enrique Montes , Sho Suzuki , Shintaro Fujii , Tomoaki Nishino , Kazuhito Tsukagoshi , Katsuyoshi Ikeda , Hideaki KANOU , Hisao Nakamura , Héctor Vázquez , Manabu Kiguchi

    … Using this methodology, we determine the interface geometry of these two prototypical molecules at the junction and its time evolution. … By modulating the applied voltage, we can change and monitor the distribution of adsorption sites at the junction. …

    Chemical science 10(25), 6261-6269, 2019-05


  • Molecular changes to tendons after collagenase-induced acute tendon injury in a senescence-accelerated mouse model

    Ueda Yasuhiro , Inui Atsuyuki , Mifune Yutaka , Takase Fumiaki , Kataoka Takeshi , Kurosawa Takashi , Yamaura Kohei , Kokubu Takeshi , Kuroda Ryosuke

    … However, molecular changes in aged tendons under inflammatory conditions are not well understood. … The present study analyzed the molecular changes in collagenase induced acute tendon injury using a senescence-accelerated mouse (SAM) model. … Collagenase I from Clostridium histolyticum (20 μL) was injected percutaneously to the tendon-bone junction of the Achilles tendon. …

    BMC Musculoskeletal Disorders (20), 120, 2019-03-21


Page Top