Search Results 1-20 of 2741

  • Supramolecular polymer gels formed from polyamidine and random copolymer of n‐butyl acrylate and acrylic acid.

    FURUSHO Yoshio , ENDO Takeshi , 古荘 義雄

    We have prepared the amidinium‐carboxylate salt bridge‐based supramolecular polymer gels from random copolymer of n‐butyl acrylate and acrylic acid and a linear polyamidine having N,N′‐di‐substituted …

    Journal of Polymer Science, 2021-03-03


  • Mechanisms of productive folding and endoplasmic reticulum-associated degradation of glycoproteins and non-glycoproteins

    Ninagawa Satoshi , George Ginto , Mori Kazutoshi

    … BACKGROUND: The quality of proteins destined for the secretory pathway is ensured by two distinct mechanisms in the endoplasmic reticulum (ER): productive folding of newly synthesized proteins, which is assisted by ER-localized molecular chaperones and in most cases also by disulfide bond formation and transfer of an oligosaccharide unit; …

    Biochimica et biophysica acta (BBA) -General subjects 1865(3), 2021-03


  • Preparation of affinity membranes using polymer phase separation and azido-containing surfactants

    Morita Kenta , Takeda Shinano , Yunoki Ayumi , Tsuchii Takane , Tanaka Tsutomu , Maruyama Tatsuo

    Colloids and Surfaces A: Physicochemical and Engineering Aspects (611), 125802, 2021-02-20


  • A Novel Artificially Humanized Anti-Cripto-1 Antibody Suppressing Cancer Cell Growth

    Ishii Hiroko , Zahra Maram H. , Takayanagi Atushi , Seno Masaharu

    … We designed a novel anti-Cripto-1 artificial antibody and assessed the recognition to the antigen and the potential to suppress the growth of cancer stem cells. …

    International Journal of Molecular Sciences 22(4), 1709, 2021-02-08


  • Molecular Shape Selectivity for Polycyclic Aromatic Compoundson a Poly(4-vinylpyridine) Stationary Phase in Liquid Chromatography

    NAKAGAMI Koki , SHIMIZU Keiichi , SUMIYA Ohjiro , UETA Ikuo , SAITO Yoshihiro

    … On the P4VP phase, a good linear relationship between the logarithmic retention factor and the molecular size of planar PACs was obtained, however, a unique selectivity for some planar PACs was also observed. … molecular shape were strongly retained. … In addition, compared to the typical ODS and PBS phases, the P4VP phase showed a good molecular shape recognition capability for planar/non-planar PACs with a similar two-dimensional molecular size. …



  • Relationship between AGE scavenging and angiogenesis in endothelial cell  [in Japanese]

    Nishinaka Takashi , Hatipoglu Omer Faruk , Wake Hidenori , Mori Shuji , Nishibori Masahiro , Takahashi Hideo

    … Exposure to AGEs in endothelial cells lead to excess angiogenesis, however, molecular mechanisms underlying AGE-elicited angiogenesis remain unclear. … Scavenger receptors has been thought to play a significant role in the recognition and elimination of AGEs from the circulation. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-S26-1, 2021


  • Identification and characterization of a novel G-quadruplexes binding protein DNAPTP6 in mouse brain  [in Japanese]

    Kawasaki Moe , Asamitsu Sefan , Yabuki Yasushi , Shioda Norifumi

    … Here we show the biological function of a novel G4 binding protein DNAPTP6 in LC-MS/MS analysis on immunoprecipitates of mouse brain tissues using G4 recognition antibody. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-O-B1-1, 2021


  • Effects of a Rho-kinase inhibitor, fasudil on schizophrenia-like behavior and neurotransmitter release in MK-801-treated mice  [in Japanese]

    Tanaka Rinako , Yamada Kiyofumi , Sawahata Masahito , Takase Saeko , Liu Yue , Hada Kazuhiro , Mizoguchi Hiroyuki , Nagai Taku , Nabeshima Toshitaka , Ozaki Norio

    … We performed locomotor activity test, novel object recognition test (NORT), social interaction test (SI), and pre-pulse inhibition test (PPI). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-Y-F3-4, 2021


  • Natural antibodies as a safeguard against exposome  [in Japanese]

    Uchida Koji

    … Most of NAbs are poly-reactive (multi-specific or cross-reactive) in nature and recognize specific molecular patterns with no apparent structural similarity. … In addition, based on the findings that these modified proteins have several properties different from native proteins, including an elevated electronegative potential due to modification of the positively charged amino acid residues, we have proposed that the electronegative potential of antigens might be involved, at least in part, in the recognition by Nabs. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-S10-2, 2021


  • Deficit of cognitive function induced by the reduction of mice hippocampal Shati/Nat8l  [in Japanese]

    Daiki Ikejima , Muramatsu Shin-ichi , Nitta Atsumi

    … Long-term potentiation (LTP) is considered one of the cellular and molecular mechanisms of memory.</p><p>Shati / Nat8l is localized in neuronal cells and is ubiquitously present throughout a brain. … Two behavioral experiments were performed, novel object recognition test and Y-maze test, to evaluate cognitive function by using Shati cKD mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-LB50, 2021


  • Mass Spectrometry-Based Steroid Profiling: Meeting Unmet Clinical Needs

    Choi Man Ho

    <p>Despite ongoing concerns regarding its clinical application, mass spectrometry (MS)-based steroid assay represents a promising tool in endocrine research. Recent studies indicate that monito …

    The Tohoku Journal of Experimental Medicine 253(3), 171-180, 2021


  • Graphene-Based FRET Aptasensors

    UENO Yuko

    … This review describes the principles of the sensor, several applications to microchannel devices, improvement of the sensing performance by molecular design of the aptamer and remarks on future prospects based on an introduction of recent works and achievements, including the author's paper. … The sensor employs DNA modified with graphene/graphene oxide at the terminal as the molecular probe. …

    Analytical Sciences 37(3), 439-446, 2021


  • Inhibition of CASK Expression by Virus-mediated RNA Interference in Medial Prefrontal Cortex Affects Social Behavior in the Adult Mouse

    CAO Xueshan , QIU Wen , PANG Bo , ZHOU Mengyun , MEHTA Anuradha , GUO Qi , SHIRAI Yoshinori , MORI Takuma , TABUCHI Katsuhiko

    … In the three-chamber test, CASK knockdown mice showed more interaction with a novel juvenile mouse than an empty cage at a similar level to control mice, suggesting that social recognition is intact. …

    THE SHINSHU MEDICAL JOURNAL 69(1), 45-52, 2021

    IR  J-STAGE 

  • Multipoint Recognition of Molecular Conformations with Organocatalysts for Asymmetric Synthetic Reactions

    Asano Keisuke

    … The enzyme-like catalytic system is effective for recognizing specific molecular conformations of substrates, which continually change under reaction conditions, through multipoint interactions, thereby leading to high stereoselectivity. … This review provides a comprehensive account of our achievements regarding multipoint recognition of molecular conformations with organocatalysts for asymmetric synthetic reactions.</p> …

    Bulletin of the Chemical Society of Japan 94(2), 694-712, 2021


  • Simultaneous Detection of Two Tumor Marker Proteins Using Dual-Colored Signaling Molecularly Imprinted Polymers Prepared via Multi-Step Post-Imprinting Modifications

    Sunayama Hirobumi , Takamiya Kazuhiro , Takano Eri , Horikawa Ryo , Kitayama Yukiya , Takeuchi Toshifumi

    … <p>We report simultaneous detection of tumor marker proteins using a molecularly imprinted polymer-based fluorescence sensing system, in which prostate-specific antigen (PSA) recognition cavity, labeled with Alexa Fluor 594, and α-fetoprotein (AFP) recognition cavity, labeled with Alexa Fluor 647, exist together in the polymer matrix. …

    Bulletin of the Chemical Society of Japan 94(2), 525-531, 2021


  • Effects of Exogenous Biliverdin Treatment on Neurobehaviors in Mice

    Li Yueyi , Gao Yuan , Dong Yan , Meng Li , Yu Panpan , Zhao Penghui , Gong Miao , Gao Qiang , Shi Haishui , Meng Cuili

    … Novel object recognition (NOR) paradigm was used for memory formation test. …

    Biological and Pharmaceutical Bulletin 44(3), 325-331, 2021


  • Non-steroidal inhibitors of <i>Drosophila melanogaster</i> steroidogenic glutathione <i>S</i>-transferase Noppera-bo

    Koiwai Kotaro , Fujikawa Yuuta , Inoue Hideshi , Yumoto Fumiaki , Senda Toshiya , Niwa Ryusuke , Morohashi Kana , Inaba Kazue , Ebihara Kana , Kojima Hirotatsu , Okabe Takayoshi , Yoshino Ryunosuke , Hirokawa Takatsugu , Nampo Taiki

    … <p>Insect growth regulators (IGRs) can be developed by elucidating the molecular mechanisms of insect-specific biological events. … Our previous study using 17β-estradiol as a molecular probe revealed that Asp113 of <i>Drosophila melanogaster</i> … Among amino acid residues at the substrate-recognition site, conformation of conserved Phe39 was dynamically altered upon inhibitor binding. …

    Journal of Pesticide Science 46(1), 75-87, 2021


  • Design of Supramolecular Sensors and Their Applications to Optical Chips and Organic Devices

    Minami Tsuyoshi

    … <p>In nature, molecular recognition is crucial to induce functions as living systems. … Bioinspired molecular recognition chemistry has been intensively studied for more than half a century since the discovery of crown ethers. … Chemical sensors are a concrete representative example of the application of artificial molecular recognition materials. …

    Bulletin of the Chemical Society of Japan 94(1), 24-33, 2021


  • Urea/Thiourea Based Optical Sensors for Toxic Analytes: A Convenient Path for Detection of First Nerve Agent (Tabun)

    Kumar Vinod

    … <p>In the realm of supramolecular chemistry, the development in synthetic receptors for harmful analytes has attracted substantial attention in recent decades due to the fact that a huge number of chemical and biological processes involve molecular recognition of these species. …

    Bulletin of the Chemical Society of Japan 94(1), 309-326, 2021


  • Combined Analysis Based on a Crystalline Sponge Method

    OHARA Kazuaki , YAMAGUCHI Kentaro

    … <p>The crystalline sponge (CS) method was developed as an X-ray crystallographic molecular structure analysis method that can be performed without the need for crystallization of the analyte. … CS has strong molecular-recognition properties and a highly flexible framework. … Both approaches demonstrate the potential of microanalysis to determine the molecular structure of an unknown sample. …

    Analytical Sciences 37(1), 167-175, 2021


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