Search Results 1-15 of 15

  • Development of a Method for Generation of Immune Competent Dendritic Cells in a Large Scale by Using Human Peripheral Blood Monocytes with Gene Modifications  [in Japanese]

    Imamura Yuya , Haruta Miwa , Tomita Yusuke , Matsumura Keiko , Ikeda Tokunori , Takamatsu Koutaro , Nishimura Yasuharu , Senju Satoru

    癌免疫療法ではHLA抗原により提示された癌抗原ペプチド特異的なT細胞を誘導することが最も重要であり,これを誘導するために樹状細胞(DC)が有用である。そこで我々はヒトの単球を生体外で増殖させることにより,少量の末梢血から大量のDCを作成する方法を開発した。末梢血より分離したCD14<sup>+</sup>単球にレンチウイルスで<i>cMYC</i>と …

    Major Histocompatibility Complex 22(1), 37-43, 2015

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  • Diallyl disulfide administration increases the number of B-lymphocytes in the rat spleen

    Hashizume Yoko , Shirato Ken , Tachiyashiki Kaoru , Imaizumi Kazuhiko

    … Diallyl disulfide (DADS), the major sulfur compound in garlic, reduces the number of circulating T-lymphocytes, B-lymphocytes, and monocytes via activation of the hypothalamus-pituitary-adrenal axis. … However, the translocation of those cells that migrate in response to DADS administration is still unclear. …

    Fundamental Toxicological Sciences 1(4), 115-121, 2014

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  • CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes

    Komura Takuya , Sakai Yoshio , Honda Masao , Takamura Toshinari , Matsushima Kouji , Kaneko Shuichi

    … We assessed how immune-mediating peripheral blood mononuclear cells (PBMCs) are affected in diabetes. … RESULTS - In a subpopulation of PBMCs, monocytes derived from patients with diabetes were more susceptible to apoptosis than monocytes from healthy volunteers. …

    Diabetes 59(3), 634-643, 2010-03-01

    IR  Cited by (2)

  • The presence of mature granulocytes/monocytes derived from leukemic cells in MLL-associated leukemia

    KOBAYASHI Shoichi , OBATA Masato , HAGIHARA Maki , MOTOHASHI Kenji , ITO Satomi , OHSHIMA Rika , SAKAI Rika , MARUTA Atsuo , KANAMORI Heiwa

    International journal of hematology 90(5), 591-596, 2009-12-15

    References (16)

  • Macrophage colony-stimulating factor enhances rituximab-dependent cellular cytotoxicity by monocytes

    SHIMADOI Shigeru , TAKAMI Akiyoshi , KONDO Yukio , OKUMURA Hirokazu , NAKAO Shinji

    … 医薬保健研究域医学系Recent studies suggest that monocytes are the dominant effectors by which rituximab induces cell death in B-cell lymphoma. … Because macrophage colony-stimulating factor (M-CSF) can enhance the cytotoxicity of monocytes, the authors examined whether this growth factor can enhance their ability to kill lymphoma cells in vitro. …

    Cancer Science 98(9), 1368-1372, 2007-09-10

    IR  Ichushi Web  References (35) Cited by (1)

  • Phagocytic Activation of Monocytes by C-UP III Herbal Polysaccharides in Calves and Cows  [in Japanese]

    YOSHIDA Satoshi , NAKANISHI Nobuo , YAMADA Koji

    植物多糖体C-UP IIIを投与した成牛および子牛の単球のラテックスビーズ貪食能 (貪食数および貪食率) について検討した. C-UP IIIを5, 10, 20, 509/日連続3日間投与した成牛の単球の貪食能は, 全投与群で投与開始3日後から増加し, 7日後にピークとなり, 2週後まで高いレベルを維持した. 10~50g/日投与群の貪食能は同値を示した. 子牛にC-UP IIIを3gまたは6g …

    Journal of the Japan Veterinary Medical Association 59(5), 315-319, 2006-05-20

    J-STAGE  JASI  Ichushi Web  References (24) Cited by (2)

  • MOLECULAR PATHOGENESIS IN TUBERCULOSIS COMPLICATED WITH AIDS  [in Japanese]

    NAKATA Koh , HOSHINO Yoshihiko , HONDA Yoshihiro , TANAKA Naohiko , HEBISAWA Akira , WEIDEN Michael

    … infection of monocytes derived macrophages (MDM) or differentiated monocytic THP-1 cells. … We observed that HIV-15' LTR function was repressed in PMA differentiated THP-1 cells after co-infection with <I>M. … Monocyte-derived macrophages and differentiated THP-1 cells increased expression of the 16kDa inhibitory form of C/EBP after <I>M. …

    Kekkaku(Tuberculosis) 79(11), 659-667, 2004-11-15

    J-STAGE  Ichushi Web  References (10)

  • TUBERCULOSIS IN PATIENTS WITH ACQUIRED IMMUNE DEFICIENCY SYNDROME:The 75th Annual Meeting Lunch-Time Seminar

    NAKATA Koh , HONDA Yoshihiro , TANAKA Naohiko , WEIDEN Michael , KEICHO Naoto

    … infection of monocytes derived macrophages (MDM) or differentiated monocytic THP-1 cells. … We observed that HIV-1 5' LTR function was repressed in PMA differentiated THP-1 cells after co-infection with <I>M. … Monocyte-derived macrophages and differentiated THP-1 cells increased expression of the 16 kDa inhibitory form of C/EBP-β …

    Kekkaku(Tuberculosis) 75(9), 547-562, 2000

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  • The expression of inducible nitric oxide messenger RNA in human monocytes and inhibition by TNF.ALPHA. monoclonal antibody.  [in Japanese]

    Tanjoh Katsuhisa , Shima Atsuyuki , Iwata Mitsumasa , Tomita Ryoichi , Kurosu Yasuhiko

    われわれは過去に,単球の誘導型nitric oxide合成酵素(inducible nitric oxide synthase; iNOS)によって産生される多量のnitric oxide (NO)が組織傷害性に作用し得ることを報告した。iNOSは各種サイトカインやlipopolysaccharide (LPS)によって誘導されることが知られているが,その機序は不明である。今回われわれは,in v …

    Nihon Kyukyu Igakukai Zasshi 7(8), 395-400, 1996

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  • Tumor necrosis factor(TNF) production by peripheral monocytes in patients with inflammatory bowel disease(IBD).  [in Japanese]

    Yokoyama M.

    潰瘍性大腸炎, クローン病などの炎症性腸疾患 (IBD) における末梢血単球のtumornecrosisfactor (TNF) 産生能について検討を加えたところ, 潰瘍性大腸炎1086±729U/ml, クローン病1035±682U/mlと健常人130±70U/mlに比較してIBD患者において明らかにy進していることを知ることができた. そこでIBDの病態解明や治療薬の影響, さらには同患者にお …

    Nippon Daicho Komonbyo Gakkai Zasshi 42(2), 169-176, 1989

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  • Disappearance of inhibitory pathway of IL-2 production by phorbol myristate acetate treatment in peripheral monocyte of cancer patients.  [in Japanese]

    Kohgo Yutaka , Niitsu Yoshiro , Sasagawa Yutaka , Sakamaki Sumio , Kanisawa Yuji , Ito Yoshinori , Nojiri Shuichi , Ueno Yoshinori , Urushizaki Ichiro

    各種進行癌患者末梢単核球(PBMC)のIL-2産生低下について単球の果たす役割の面から検討した. LPS刺激による単球のIL-1産生能は健常者よりもむしろ高値を示した.一方, PBMCから単球を除去すると, IL-2産生が上昇することより抑制性単球の関与が示唆された.健常者と癌患者末梢リンパ球を交互に再構成しIL-2産生をみると癌患者単球により強い抑制作用がみられた.この癌患者単球のIL-2産生抑 …

    Japanese Journal of Clinical Immunology 11(2), 106-113, 1988

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  • Studies on Interleukin 2 Production and Non-specific Killer Activity derived from Peripheral Blood Mononuclear Cells in Cancer Patients  [in Japanese]

    笹川 裕

    … Interleukin 2(IL2) production and the nonspecific killer activities of peripheral blood mononuclear cells (PBMC) derived from cancer patients were investigated. … IL2 activity of PHA stimulated lymphocytes derived from control subjects and patients with nontreated advanced carcinoma was 524.1±250.4 nano Jurkat Units (nJ. …

    札幌医学雑誌 = The Sapporo medical journal = The Sapporo medical journal 56(3), 415-428, 1987-06-01

    IR  DOI 

  • Differentiation Induction of Leukemic Cells in Acute Myeloid Leukemia  [in Japanese]

    SUZUKI Kazuo , YOKOYAMA Shinichiro , ASANO Yoji , TOMOYASU Shigeru , TSURUOKA Nobuyoshi , HOZUMI Motoo

    … The differentiation induction of leukemic cells was attempted with drugs in three cases of acute myeloid leukemia. … After the administration of drugs, peripheral and marrow leukemic cells decreased without cytopenia in all patients. …

    Rinsho Ketsueki 25(2), 241-245, 1984

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  • STUDY ON THE EXPERIMENTAL TYPHOID:IN VITRO INTERACTION BETWEEN S. ENTERITIDIS AND MQUSE MONOCYTES

    Tongu Saburo

    … enteritidis and the abdominal monocytes of the mice. … Monocytes were obtained from the abdominal cavity of normal and immune mice which had been given an intraperitoneal injection of glycogen solution as hemotactic agent four to five days prior to the collection. … Cells were washed twice by centrifugation and then resuspended in Hanks's solution.<BR>The attenuated strain SER of S. …

    The KITAKANTO Medical Journal 9(3), 470-478, 1959

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