Search Results 1-20 of 1938

  • Insight into innate immune response in "Yusho": The impact of natural killer cell and regulatory T cell on inflammatory prone diathesis of Yusho patients

    Kamio Yoshiyuki , Gunge Yumi , Koike Yuta , Kuwatsuka Yutaka , Tsuruta Kazuto , Yanagihara Katsunori , Furue Masutaka , Murota Hiroyuki

    … Immune cell (e.g. natural killer and regulatory T cell) populations were analyzed by flow cytometry. … Results: The relative proportion of natural killer cells was higher in Yusho patients than in healthy subjects, while the proportion of regulatory T cells did not differ between groups. …

    Environmental Research (185), 109415, 2020-03-21

    IR 

  • Amelioration of experimental autoimmune myocarditis through activation of invariant natural killer T cells by administration of α-galactosylceramide

    Yoshino Kazuhisa , Satoh Masashi , Iwayama Toshitsugu , Kobayashi Shusaku , Okamoto Hirotsugu , Eshima Koji , Watarai Hiroshi , Iwabuchi Kazuya

    The Kitasato medical journal 50(1), 60-72, 2020-03

  • Killer Immunoglobulin-Like Receptor 2DL4 (CD158d) Regulates Human Mast Cells both Positively and Negatively: Possible Roles in Pregnancy and Cancer Metastasis

    Kataoka Tatsuki R. , Ueshima Chiyuki , Hirata Masahiro , Minamiguchi Sachiko , Haga Hironori

    Killer immunoglobulin-like receptor (KIR) 2DL4 (CD158d) was previously thought to be a human NK cell-specific protein. … Mast cells are involved in allergic reactions via their KIT-mediated and FcɛRI-mediated responses. … We recently detected the expression of KIR2DL4 in human cultured mast cells established from peripheral blood of healthy volunteers (PB-mast), in the human mast cell line LAD2, and in human tissue mast cells. …

    International Journal of Molecular Sciences 21(3), 2020-01-31

    IR 

  • iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity

    Suzuki Daisuke , Flahou Charlotte , Yoshikawa Norihide , Stirblyte Ieva , Hayashi Yoshikazu , Sawaguchi Akira , Akasaka Marina , Nakamura Sou , Higashi Natsumi , Xu Huaigeng , Matsumoto Takuya , Fujio Kosuke , Manz Markus G. , Hotta Akitsu , Takizawa Hitoshi , Eto Koji , Sugimoto Naoshi

    … Here, we developed human induced pluripotent cell-derived HLA-I-deficient platelets (HLA-KO iPLATs) in a clinically applicable imMKCL system by genetic manipulation and assessed their immunogenic properties including natural killer (NK) cells, which reject HLA-I downregulated cells. …

    Stem Cell Reports 14(1), 49-59, 2020-01-14

    IR 

  • Infiltrating and peripheral immune cell analysis in advanced gastric cancer according to the Lauren classification and its prognostic significance

    Pernot Simon , Terme Magali , Radosevic-Robin Nina , Castan Florence , Badoual Cecile , Marcheteau Elie , Penault-Llorca Frederique , Bouche Olivier , Bennouna Jaafar , Francois Eric , Ghiringhelli Francois , De La Fouchardiere Christelle , Samalin Emmanuelle , Bachet Jean Baptiste , Borg Christophe , Boige Valerie , Voron Thibault , Stanbury Trevor , Tartour Eric , Gourgou Sophie , Malka David , Taieb Julien

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 23(1), 73-81, 2020

  • Mushroom <i>Sparassis crispa</i> (Hanabiratake) Fermented with Lactic Acid Bacteria Significantly Enhances Innate Immunity of Mice

    Nishioka Junji , Hiramoto Keiichi , Suzuki Koji

    … studies using mice, oral administration of SC or SCL enhanced the accumulation of macrophages, neutrophils, natural killer (NK) cells, and C–C chemokine receptor type 2- or phospho-Syk-expressing cells in the jejunum epithelial villi and spleen, with significantly higher cell numbers in the SCL group than in the SC group. …

    Biological and Pharmaceutical Bulletin 43(4), 629-638, 2020

    J-STAGE 

  • The influence of sarcopenia on immune homeostasis  [in Japanese]

    Kawanami Tomoya

    … The fraction of immunological cells, including T cells, B cells, macrophages, natural killer cells, and neutrophils, was observed. … The T and B cell lineages were significantly suppressed in the sarcopenic model compared with control mice, and the fraction of macrophages and natural killer cells also tended to increase. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-099, 2020

    J-STAGE 

  • Inflammatory Disease (1) What Is Inflammation?  [in Japanese]

    Kato Hidehito

    … Inflammation is caused by a complex influence of various molecules and cells that form networks through inflammatory cytokines. …

    Journal of Tokyo Women's Medical University 90(1), 1-13, 2020

    J-STAGE 

  • Brain Abscess as a Rare Complication of Primary Extranodal Nasal-type Natural Killer/T-cell Lymphoma

    Ohta Nobuo , Waki Takayoshi , Ito Tsukasa , Suzuki Yusuke , Kakehata Seiji , Aoyagi Masaru

    … <p>We present the case of a 58-year-old Japanese woman with a natural killer T (NK/T)-cell lymphoma complicated by brain abscess. … NK/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. …

    Yonago Acta Medica 63(1), 88-91, 2020

    IR  J-STAGE 

  • Endoplasmic Reticulum Aminopeptidase 1 beyond Antigenic Peptide-Processing Enzyme in the Endoplasmic Reticulum

    Tsujimoto Masafumi , Aoki Kazuma , Ohnishi Atsushi , Goto Yoshikuni

    … Besides antigen processing, ERAP1 performs multiple functions in various cells depending on its intracellular and extracellular localization. … Of note is the secretion of ERAP1 into the extracellular milieu in response to inflammatory stimuli, which further activates immune cells including macrophages and natural killer cells. …

    Biological and Pharmaceutical Bulletin 43(2), 207-214, 2020

    J-STAGE 

  • Chemotherapy Improved Pulmonary Arterial Hypertension in a Patient with Chronic-Active Epstein-Barr Virus Infection

    Akagi Satoshi , Miki Takashi , Sando Yasuhisa , Fujii Nobuharu , Sarashina Toshihiro , Nakamura Kazufumi , Ito Hiroshi

    … Laboratory examination showed granular lymphocytes and 91% natural killer cells in lymphocyte subsets in peripheral blood. …

    International Heart Journal 61(1), 191-194, 2020

    J-STAGE 

  • A case of chronic lymphoproliferative disorders of NK cells diagnosed on the basis of lymphocytosis and hyperglobulinemia  [in Japanese]

    NARUMI Natsuki , MORIAI Ryosuke , KONDO Takashi , MOCHIZUKI Maki , ENDOH Akemi , ASANUMA Koichi , YANAGIHARA Nozomi , TAKAHASHI Satoshi

    … <p>Here we report a case of chronic lymphoproliferative disorders (CLPDs) of natural killer (NK) cells (CLPD-NK), which are a very rare group of diseases. …

    Japanese Journal of Medical Technology 69(1), 125-129, 2020

    J-STAGE 

  • Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion

    Taha Eman A. , Ono Kisho , Eguchi Takanori

    … Oncosomes released by tumor cells are a major aspect of the resistance-associated secretory phenotype (RASP) by which immune evasion can be established. … The concepts of RASP are: (i) releases of ex-HSP and HSP-rich oncosomes are essential in RASP, by which molecular co-transfer of HSPs with oncogenic factors to recipient cells can promote cancer progression and resistance against stresses such as hypoxia, radiation, drugs, and immune systems; …

    International Journal of Molecular Sciences 20(18), E4588, 2019-09-17

    IR 

  • Bisecting GlcNAc Is a General Suppressor of Terminal Modification of N-glycan

    Nakano Miyako , Mishra Sushil K. , Tokoro Yuko , Sato Keiko , Nakajima Kazuki , Yamaguchi Yoshiki , Taniguchi Naoyuki , Kizuka Yasuhiko

    … Here we found that bisecting GlcNAc, a branching sugar residue in N-glycan, suppresses the biosynthesis of various types of terminal epitopes in N-glycans, including fucose, sialic acid and human natural killer-1. … Expression of these epitopes in N-glycan was elevated in mice lacking the biosynthetic enzyme of bisecting GlcNAc, GnT-III, and was conversely suppressed by GnT-III overexpression in cells. …

    Molecular & Cellular Proteomics 18(10), 2044-2057, 2019-08-02

    IR 

  • Safety, tolerability, pharmacokinetics, and pharmacodynamics of the afucosylated, humanized anti-EPHA2 antibody DS-8895a: a first-in-human phase I dose escalation and dose expansion study in patients with advanced solid tumors

    兵頭 一之介 , Kohei Shitara , Taroh Satoh , Satoru Iwasa , Kensei Yamaguchi , Kei Muro , Yoshito Komatsu , Tomohiro Nishina , Taito Esaki , Jun Hasegawa , Yasuyuki Kakurai , Emi Kamiyama , Tomoko Nakata , Kota Nakamura , Hayato Sakaki , Ichinosuke HYODO

    … The proportion of CD16-positive natural killer (NK) cells (CD3-CD56+CD16+) decreased 4 h after the start of DS-8895a administration, and the ratio of CD3-CD56+CD137+ to CD3-CD56+CD16+ cells increased on day 3.CONCLUSIONS:Twenty mg/kg DS-8895a infused intravenously every 2 weeks was generally safe and well tolerated in patients (n = 21) with advanced solid tumors. …

    Journal for ImmunoTherapy of Cancer (7), 219, 2019-08

    IR 

  • Cationized liposomal keto-mycolic acids isolated from Mycobacterium bovis bacillus Calmette-Guérin induce antitumor immunity in a syngeneic murine bladder cancer model

    木村 友和 , Takayuki Yoshino , Jun Miyazaki , Takahiro Kojima , Shuya KANDORI , Masanobu Shiga , Takashi Kawahara , Tomokazu Kimura , Takashi Naka , Hideyasu Kiyohara , Miyuki Watanabe , Sho Yamasaki , Hideyuki Akaza , Ikuya Yano , Hiroyuki Nishiyama

    … Interestingly, Lip-kMA(D12), which was made of D12 instead of D22, did not exhibit antitumor activity in the murine syngeneic graft model using MB49 cells, although it was successfully taken up by MB49 cells in vitro. … Antitumor effects of Lip-kMA were not observed in nude mice, whereas weak but significant effects were observed in beige mice with natural killer activity deficiency. …

    PLOS ONE 14(1), e0209196, 2019-02

    IR 

  • Immune system observation in a murine sarcopenic model  [in Japanese]

    Kawanami Tomoya , Mogi Masaki , Liu Shuang

    … To investigate the correlation between muscle atrophy and aging-related immune deterioration, a dissected sciatic nerve sarcopenic mouse model was established and the fraction of immunological cells, including T cells, B cells, macrophages, natural killer cells, and neutrophils, was determined. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-SS-54, 2019

    J-STAGE 

  • NKT cell-based immunotherapy for non-small-cell lung cancer  [in Japanese]

    Ishii Ayana , Takami Mariko , Motohashi Shinichiro

    … <p> Invariant natural killer T (iNKT) cells are a unique lymphocyte subpopulation that possess an invariant T cell receptor (TCR) and recognize glycolipid antigens, such as α-Galactosylceramide (αGalCer), presenting on CD1d. …

    Endotoxin and Innate Immunity 22(0), 25-29, 2019

    J-STAGE 

  • Two Opposite Roles of Core 2 <i>O</i>-Glycans in Evasion Mechanisms of Tumor Immunity

    Tsuboi Shigeru

    … <p>Tumor immunity has a two-stage defense system consisting of natural killer (NK) immunity for primary tumor and cytotoxic T lymphocyte (CTL) immunity for the metastatic lesions. … A series of our studies revealed that bladder cancer cells evade each tumor immune system by different evasion strategies using altered <i>O</i>-glycosylation. …

    Trends in Glycoscience and Glycotechnology 31(183), E113-E119, 2019

    J-STAGE 

  • Two Opposite Roles of Core 2 <i>O</i>-Glycans in Evasion Mechanisms of Tumor Immunity  [in Japanese]

    Tsuboi Shigeru

    … <p>Tumor immunity has a two-stage defense system consisting of natural killer (NK) immunity for primary tumor and cytotoxic T lymphocyte (CTL) immunity for the metastatic lesions. … A series of our studies revealed that bladder cancer cells evade each tumor immune system by different evasion strategies using altered <i>O</i>-glycosylation. …

    Trends in Glycoscience and Glycotechnology 31(183), J113-J118, 2019

    J-STAGE 

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