Search Results 1-20 of 181

  • A Case Report of a Pathological Complete Response to Hilar Cholangiocarcinoma Due to Prior Treatment for Synchronous Gastric Cancer  [in Japanese]

    Kanazawa Ayumi , Ohnuma Hiroyuki , Yoshida Makoto , Kato Junji , Sugawara Taro , Sugita Shintaro , Takemasa Ichiro , Kimura Yasutoshi , Imamura Masafumi , Nagayama Minoru , Yamaguchi Hiroshi , Ito Tatsuya , Nobuoka Takayuki , Fujino Hiroki , Yoshida Eiji

    <p>重複胃癌に対する術前治療が著効し，病理学的完全奏効を得られた肝門部領域胆管癌の1例を経験したので報告する．症例は36歳の男性で，肝門部領域胆管癌（Bismuth-IV，cT3N1M0，cStage IIIB），噴門部胃癌（cT3N1M0，cStage IIB）の重複癌と診断された．残肝容積率が過少であり経皮経門脈塞栓術（percutaneous transhepatic port …

    The Japanese Journal of Gastroenterological Surgery 54(2), 107-117, 2021

    J-STAGE 

  • Preoperative endoscopic biliary drainage in patients with resectable pancreatic cancer  [in Japanese]

    ICHIKAWA Hironao , IWASHITA Takuji , SHIMIZU Masahito

    … <p>切除企図膵癌については術前化学療法（neoadjuvant chemotherapy：NAC）の有用性が認識されるようになり，閉塞性黄疸を伴う症例ではNACを予定通り安全に行うために内視鏡的術前胆道ドレナージの重要性が増している．術前胆道ドレナージは，以前はプラスチックステント（plastic stent：PS）が使用されていたが，ステントの開存期間延長を期待してメタリック …

    Suizo 36(1), 42-48, 2021

    J-STAGE 

  • Adverse events after treatment with neoadjuvant gemcitabine plus S-1 and their management in patients with resectable T3 pancreatic cancer  [in Japanese]

    SAITO Kei , NAKAI Yousuke , ARITA Junichi , ISHIGAKI Kazunaga , TAKAHARA Naminatsu , ISHIZAWA Takeaki , WATADANI Takeyuki , HASEGAWA Kiyoshi , KOIKE Kazuhiko

    <p>本邦で行われたPrep-02/JSAP05試験の結果をもとに，切除可能膵癌に対する術前化学療法が広く行われるようになり，無再発生存期間，生存期間の延長が期待される一方で，有害事象による治療延期から切除の機会を逸する可能性もあり，術前治療を安全に施行することが重要である．当院のT3切除可能膵癌に対する術前ゲムシタビン＋S-1（GS）併用療法22例の検討では，術前化学療法のGrade …

    Suizo 36(1), 29-35, 2021

    J-STAGE 

  • The outcomes of endoscopic ultrasound-guided fine needle aspiration and neoadjuvant chemotherapy for patients with resectable pancreatic cancer  [in Japanese]

    HISADA Yuya , SATAKE Tomoyuki , YOSHINARI Motohiro , MARUKI Yuta , OHBA Akihiro , NAGASHIO Yoshikuni , KONDO Shunsuke , MORIZANE Chigusa , UENO Hideki , YOSHINO Jun , MIZUI Takahiro , HIJIOKA Susumu , TAKAMOTO Takeshi , NARA Satoshi , BAN Daisuke , ESAKI Minoru , SHIMADA Kazuaki , OKUSAKA Takuji , KAWAHARA Shun , KOGA Takehiko , MURASHIMA Yumi , KAWASAKI Yuki , KITAMURA Hidetoshi , HARAI Shota , MAEHARA Kosuke

    … <p>Prep-02/JSAP-05 trialで術前補助化学療法（NAC）としてのゲムシタビン＋S-1療法（GS療法）による有用性が示されて以降，切除可能膵癌（R膵癌）の周術期治療は大きく変化しつつある．これまでR膵癌は手術先行が基本であったが，Prep-02/JSAP-05 trial以降は全国的に術前GS療法が広がりつつある．またそれに伴い組織学的診断の必要性が高まり，超音波内視鏡下穿刺吸引法（EUS-FNA）の必要性が増している．当院におけるR膵 …

    Suizo 36(1), 20-28, 2021

    J-STAGE 

  • Clinical outcomes of neoadjuvant chemotherapy for patients with breast cancer: Tri-weekly nanoparticle albumin-bound paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide: a retrospective observational study.

    Shizuku Masato , Shibata Masahiro , Shimizu Yoshimi , Takeuchi Dai , Mizuno Yutaka

    … Neoadjuvant chemotherapy (NAC) using the combination of anthracycline and taxanes is the standard regimen for patients with primary breast cancer. … Among the taxanes, conventional paclitaxel (PTX) and docetaxel have usually been adopted in the neoadjuvant or adjuvant setting. … We evaluated the efficacy and safety of nab-PTX followed by 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) in the neoadjuvant setting. …

    Nagoya Journal of Medical Science 82(3), 457-467, 2020-08

    IR  DOI 

  • A pathological complete response after neoadjuvant triplet chemotherapy for locally advanced transverse colon cancer

    Tominaga Tetsuro , Nonaka Takashi , Tabata Kazuhiro , Sawai Terumitsu , Nagayasu Takeshi

    … Introduction: Perioperative chemotherapy could improve oncological outcomes for patients with advanced colon cancer. … However, the effectiveness of triplet chemotherapy in the neoadjuvant setting is still unknown. … Then, neoadjuvant chemotherapy (NAC) consisting of a combination of 5-fluorouracil (5-FU), oxaliplatin, irinotecan, and leucovorin (FOLFOXIRI) was planned, followed by primary tumor resection. …

    International Journal of Surgery Case Reports (72), 127-132, 2020-06-06

    IR 

  • A pathological complete response after neoadjuvant triplet chemotherapy for locally advanced transverse colon cancer

    Tominaga Tetsuro , Nonaka Takashi , Tabata Kazuhiro , Sawai Terumitsu , Nagayasu Takeshi

    … Introduction: Perioperative chemotherapy could improve oncological outcomes for patients with advanced colon cancer. … However, the effectiveness of triplet chemotherapy in the neoadjuvant setting is still unknown. … Then, neoadjuvant chemotherapy (NAC) consisting of a combination of 5-fluorouracil (5-FU), oxaliplatin, irinotecan, and leucovorin (FOLFOXIRI) was planned, followed by primary tumor resection. …

    International Journal of Surgery Case Reports (72), 127-132, 2020-06-06

    IR 

  • Indication and outcomes of neoadjuvant chemotherapy for locally advanced rectal cancer  [in Japanese]

    松田 明久 , 山田 岳史 , 進士 誠一 , 太田 竜 , 園田 寛道 , 高橋 吾郎 , 岩井 琢磨 , 原 敬介 , 香中 伸太郎 , 吉田 寛

    外科 = Surgery : 臨床雑誌 82(7), 730-735, 2020-06

    Ichushi Web 

  • The history, present situation, and future directions of neoadjuvant chemotherapy for HER2-negative breast cancer

    Oikawa Masahiro

    … Chemotherapy has played a significant role in breast cancer therapy and dramatically improved the outcome of breast cancer patients. … Neoadjuvant chemotherapy (NAC) is defined as chemotherapy conducted before surgery. …

    Chinese Clinical Oncology 9(3), 29, 2020-06

    IR 

  • The history, present situation, and future directions of neoadjuvant chemotherapy for HER2-negative breast cancer

    Oikawa Masahiro

    … Chemotherapy has played a significant role in breast cancer therapy and dramatically improved the outcome of breast cancer patients. … Neoadjuvant chemotherapy (NAC) is defined as chemotherapy conducted before surgery. …

    Chinese Clinical Oncology 9(3), 29, 2020-06

    IR 

  • Clinical analysis of locally advanced squamous cell carcinoma of the tongue along with the transition of neoadjuvant therapy  [in Japanese]

    Sato Kiminobu , Ono Takeharu , Shin Bu-ichiro , Chitose Shun-ichi , Umeno Hirohito

    … 局所進行舌扁平上皮癌に対する補助療法の治療変遷に伴う治療群を ①術前照射群，②手術群（術前治療なし），③術前化学療法（NAC）群に分け，治療成績を比較した。 … 治療群間での局所領域再発と遠隔再発において有意差を認めなかったが，術前NAC群ではTNともに進行症例の割合が多く，局所領域再発が多い傾向がみられた。 …

    Toukeibu Gan 46(4), 340-346, 2020

    J-STAGE  Ichushi Web 

  • A Case of Gastrointestinal Stromal Tumor（GIST）of the Stomach Causing Threatened Ruptur with Tumor Necrosis and Penetration during Neoadjuvant Chemotherapy  [in Japanese]

    KATO Kazuya , FUJITA Junya , MIKAMI Jota , MAKARI Yoichi , NAKATA Ken , OZATO Hiroki

    <p>症例は64歳，男性．上腹部の膨満感が持続するため近医を受診．腹部エコー検査にて腹部腫瘤を指摘され当院紹介となった．上部消化管内視鏡検査では残胃の噴門下前壁に多発潰瘍を伴う粘膜下腫瘍を認め，生検結果からGISTと診断された．CTでは左上腹部に長径20cmの腫瘤を認め，周囲臓器への浸潤も疑われた．術前化学療法の方針とし，イマチニブ400mg/day投与を開始した．投与開始19日目のC …

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 81(5), 860-865, 2020

    J-STAGE  Ichushi Web 

  • Current Status of Neoadjuvant Chemotherapy for Locally Advanced Colorectal Cancer  [in Japanese]

    Uehara Kay , Aiba Toshisada , Ogura Atsushi , Murata Yuki , Sato Yusuke , Hattori Norifumi , Nakayama Goro , Kodera Yasuhiro , Ebata Tomoki

    … しい薬物療法の進歩を背景に，術前化学療法（NAC）は日常臨床の中で徐々に普及しているが，その長期成績は明らかでない．</p><p>直腸癌に対する術前化学療法（NAC）は欧米では放射線化学療法（CRT）を省略することになり，高リスク症例では受け入れられ難い．しかし，術前治療を一般的に行って来なかった本邦では，NACは単に術後補助化学療法の前倒しであり，可能 …

    Nippon Daicho Komonbyo Gakkai Zasshi 73(10), 417-423, 2020

    J-STAGE 

  • Propensity-score-matching-based analysis of laparoscopic gastrectomy with neoadjuvant chemotherapy for gastric carcinoma

    MD Furuta Shimpei , MD PhD Uyama Ichiro , MD PhD Morise Zenichi

    … Neoadjuvant chemotherapy (NAC) is widely accepted as a potential treatment for advanced gastric cancer (AGC). … In the present study, we compared the feasibility and outcomes of LG in patients with or without NAC in our institution.</p><p><b>Methods:</b> … We assessed patients who underwent LG with (n=185) or without (n=1204) NAC between 1997 and 2013. …

    Fujita Medical Journal, 2020

    J-STAGE 

  • Comparison of diagnostic usefulness of laparoscopic biopsy versus cell block method in body fluid cytology in ovarian cancer or primary peritoneal cancer  [in Japanese]

    TAKAHASHI Ryosuke , SHIMIZU Maho , NAGAMATA Satoshi , MATSUMOTO Masuyo , MURATA Yuka , SUZUKI Kaho , DEGUCHI Masashi , TERAI Yoshito

    … 療法（neoadjuvant chemotherapy；NAC）とその後の減量手術（interval debulking surgery；IDS）の有用性について報告されている．NACを行う際の診断方法として，手術による生検と体腔液の穿刺細胞診があるが，細胞診では組織診断が困難な欠点がある．そこで，われわれは組織型の再現がしやすいcell block法（CB法）を取り入れている．今回，NAC時の診 …

    ADVANCES IN OBSTETRICS AND GYNECOLOGY 72(3), 211-215, 2020

    J-STAGE  Ichushi Web 

  • Ruptured Gastroduodenal Artery Pseudoaneurysm and Penetration of the Duodenum and Common Bile Duct Caused by Tumor Necrosis: A Case of Resected Pancreatic Head Cancer during Neoadjuvant Chemotherapy  [in Japanese]

    Kitami Chie , Kawachi Yasuyuki , Igarashi Toshihiko , Makino Shigeto , Nishimura Atsushi , Kawahara Mikako , Niikuni Keiya

    <p>術前化学療法中に腫瘍内動脈の仮性動脈瘤破裂，十二指腸，胆管への穿通を認めた膵頭部癌の1例を報告する．症例は70歳の男性で，膵頭部癌と診断された．CTで胃十二指腸動脈（gastroduodenal artery；以下，GDAと略記）が腫瘍内部を走行，狭小化し，胆管，上腸間膜静脈浸潤を認めた．Gemcitabine+nab-paclitaxel 1コース終了後，腫瘍内のGDA仮性動脈 …

    The Japanese Journal of Gastroenterological Surgery 53(7), 583-591, 2020

    J-STAGE  Ichushi Web 

  • Retrospective Study of Immediate Breast Reconstruction after Chemotherapy at Our Institute  [in Japanese]

    Tazo Mizuho , Kojima Yasuyuki , Kajikawa Akiyoshi , Tsugawa Koichiro

    <p>　現在の乳癌診療では化学療法後に乳房再建術を受ける患者が多いが, その安全性に関して明らかなコンセンサスは得られていない。そこで今回, 当施設において2015年から2016年までに片側の一次二期乳房再建術を受けた初発乳癌患者148人を対象とし, 後方視的に検討を行った。術前化学療法を行った21例と化学療法を行わなかった101例において, 手術時間, 術中出血量, ドレーン留置日数 …

    Oncoplastic Breast Surgery 5(2), 30-34, 2020

    J-STAGE  Ichushi Web 

  • Neoadjuvant chemotherapy in the management of advanced ovarian cancer  [in Japanese]

    FUJIWARA Satoe

    ADVANCES IN OBSTETRICS AND GYNECOLOGY 72(2), 108-109, 2020

    J-STAGE  Ichushi Web 

  • Capecitabine + Epirubicin + Cyclophosphamide Combination Therapy (CEX Therapy) as Neoadjuvant Chemotherapy for HER-2-Negative Breast Cancer: A Retrospective, Single-Center Study

    Yokoyama Tadashi , Makino Hiroshi , Seki Natsuki , Ueda Junji , Hosone Masaru , Katayama Hironori , Takei Hiroyuki , Yoshida Hiroshi

    … <p><b>Background: </b>We modified and administered capecitabine + epirubicin + cyclophosphamide combination therapy (CEX) as neoadjuvant chemotherapy (NAC) for HER-2-negative breast cancer and retrospectively analyzed its effectiveness and tolerability at our center. … <b>Results: </b>A clinical benefit was noted in all 18 patients who received CEX as neoadjuvant chemotherapy during the period from 2009 through 2013. …

    Journal of Nippon Medical School 87(2), 73-79, 2020

    J-STAGE  Ichushi Web 

  • High and/or Non-Decreased Systemic Inflammatory Index During Treatment Indicates Poor Prognosis in Patients with Esophageal Cancer

    Murayama Kenji , Suzuki Takashi , Oshima Yoko , Yajima Satoshi , Funahashi Kimihiko , Shimada Hideaki

    … Fifty-nine of the patients received neoadjuvant chemotherapy (NAC); … The impact of clinicopathological factors on the SII and prognosis was also evaluated after stratifying patients by treatment with surgery and NAC or surgery only. … Results: Pre-treatment SII was not associated with prognosis, but pre-operative SII (p = 0.11), post-operative SII (p = 0.07), and post-NAC SII (p < …

    Toho journal of medicine 5(4), 153-160, 2019-12

    IR  DOI  Ichushi Web 

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