CiNii Articles - Parkinson's disease

1

Protective Effect of Nervonic Acid Against 6-Hydroxydopamine-Induced Oxidative Stress in PC-12 Cells

Umemoto Hiroki , Yasugi Saika , Tsuda Shinji , Yoda Minoru , Ishiguro Takashi , Kaba Naoko , Itoh Tatsuki

… <p>Increased oxidative stress in the human brain is observed in neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD), and is considered to be a major cause of progression of these disease states. … NA plays an important role in forming the plasma membrane's lipid bilayer and in maintaining normal myelin function. …

Journal of Oleo Science 70(1), 95-102, 2021

J-STAGE
2

Anti-oxidants in astrocytes as target of neuroprotection for Parkinson's disease [in Japanese]

Asanuma Masato , Miyazaki Ikuko

… We previously revealed that several antiepileptic drugs, serotonin 5-HT1A receptor agonists, plant-derived chemicals (phytochemicals) increased xCT expression, Nrf2 activation, GSH or MT expression and release in/from astrocytes, and exerted a neuroprotective effect against dopaminergic neurodegeneration in Parkinson's disease model. …

Folia Pharmacologica Japonica 156(1), 14-20, 2021

J-STAGE
3

Mechanism of glutathione production in neurons [in Japanese]

Matsumura Nobuko , Kinoshita Chisato , Aoyama Koji

… In neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, GSH levels in the brain would be decreased before the onset, and GSH dysregulation is considered to be involved in the development of these neurodegenerative diseases. …

Folia Pharmacologica Japonica 156(1), 26-30, 2021

J-STAGE
4

Effectiveness of Levodopa in Patients with Multiple System Atrophy and Associated Clinicopathological Features

Ishida Chiho , Takahashi Kazuya , Kato-Motozaki Yuko , Tagami Atsuro , Komai Kiyonobu

… <p><b>Objective </b>To determine the clinicopathological features of levodopa or dopamine agonist (DA) responders with multiple system atrophy (MSA), an autopsy-confirmed diagnosis is vital due to concomitant cases of MSA and Parkinson's disease (PD). … Additionally, they exhibited bilateral hyperintense putaminal rims in MRIs after six and nine years, respectively, after disease onset. …

Internal Medicine, 2021

J-STAGE
5

Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection

Kikuoka Ryo , Miyazaki Ikuko , Kubota Natsuki , Maeda Megumi , Kagawa Daiki , Moriyama Masaaki , Sato Asuka , Murakami Shinki , Kitamura Yoshihisa , Sendo Toshiaki , Asanuma Masato

… Here, we evaluated the neuroprotective effects of mirtazapine against dopaminergic neurodegeneration in models of Parkinson's disease (PD). … Our study suggests that mirtazapine could be an effective disease-modifying drug for PD and highlights that astrocytic 5-HT1A receptors may be a novel target for the treatment of PD. …

Scientific Reports 10(1), 20698, 2020-11-26

IR
6

Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation

Nakano-Kobayashi A. , Fukumoto A. , Morizane A. , Nguyen D. T. , Le T. M. , Hashida K. , Hosoya T. , Takahashi R. , Takahashi J. , Hori O. , Hagiwara M.

… Here, we identified novel therapeutic candidate ALGERNON2 (altered generation of neurons 2) and demonstrate that ALGERNON2 suppressed the production of proinflammatory cytokines and rescued neurodegeneration in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)–induced Parkinson's disease model. …

Science Advances 6(46), 2020-11-11

IR
7

Triad TMS of Human Motor Cortex [in Japanese]

花島律子 , 宇川義一

Brain and nerve 72(11), 1247-1253, 2020-11
8

TMS Intervention of Human Neuronal Network [in Japanese]

宇川義一

Brain and nerve 72(11), 1239-1246, 2020-11
9

Parkinson's Disease as a Network Disorder [in Japanese]

南部篤 , 知見聡美

Brain and nerve 72(11), 1159-1171, 2020-11
10

Diagnosis and Treatment of Parkinson's Disease：Including the Latest Insights [in Japanese]

藤田裕明 , 鈴木圭輔

Dokkyo Journal of Medical Sciences 47(3), 201-211, 2020-10-25

IR
11

Metabolic biomarkers of Parkinson's disease [in Japanese]

医学のあゆみ 275(4), 362-364, 2020-10-24

Ichushi Web
12

Relationship between Parkinson's disease and gastrointestinal tract dysfunction [in Japanese]

福島幸樹 , 山田睦人 , 榊原隆次

消化器・肝臓内科 = Gastroenterology & hepatology 8(4), 349-354, 2020-10
13

Difference in cardiovascular response during orthostatic stress in Parkinson's disease and multiple system atrophy

Nakamura Tomohiko , Suzuki Masashi , Ueda Masamichi , Harada Yumiko , Hirayama Masaaki , Katsuno Masahisa

… Although orthostatic hypotension is more prominent in multiple system atrophy (MSA) than in Parkinson's disease (PD), there is no study comparing the degree of decrease in total peripheral resistance and cardiac response during orthostatic stress between both diseases. …

Journal of Neural Transmission 127(10), 1377-1386, 2020-10

IR
14

Survey on Difficulty in Excretion-related Motions in Parkinson's Disease Patients [in Japanese]

大野洋一

日本在宅ケア学会誌 = Journal of Japan Academy of Home Health Care 24(1), 102-106, 2020-09
15

Two Cases of Parkinson's Disease Accompanied with Nasogastric Tube Syndrome [in Japanese]

古澤恭平 , 杉江正行 , 大内崇弘 , 伊藤まり , 水越元気 , 矢﨑俊二

Brain and nerve 72(9), 993-997, 2020-09
16

Regional medical cooperation of early Parkinson's disease diagnosis using dopamine transporter scintigraphy (DAT scan) effectively [in Japanese]

山脇泰秀 , 三船啓文 , 笠井肇

広島医学 73(8), 487-491, 2020-08
17

Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson's disease

Doi Daisuke , Magotani Hiroaki , Kikuchi Tetsuhiro , Ikeda Megumi , Hiramatsu Satoe , Yoshida Kenji , Amano Naoki , Nomura Masaki , Umekage Masafumi , Morizane Asuka , Takahashi Jun

… Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies for Parkinson's disease (PD). …

Nature Communications (11), 2020-07-06

IR
18

Cell transplantation therapy for Parkinson's disease [in Japanese]

菊地哲広 , 髙橋淳

Precision medicine = プレシジョンメディシン 3(8臨増), 700-703, 2020-07

Ichushi Web
19

Role of inflammation in Parkinson's disease [in Japanese]

斉木臣二

老年精神医学雑誌 31(7), 743-749, 2020-07

Ichushi Web
20

Relationship between Drug Metabolism and Intestinal Microbiota in Parkinson's Disease [in Japanese]

平山正昭 , 大野欽司 , 勝野雅央

Brain and nerve 72(7), 805-809, 2020-07

Ichushi Web

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