Search Results 1-20 of 414

  • Adjacent Bilateral Pedicle Fractures 5 Years after PLIF in a Patient with Parkinson's Disease : A Case Report  [in Japanese]

    藤田 進世 , 河村 直洋 , 林 宏

    日本職業・災害医学会会誌 = Japanese journal of occupational medicine and traumatology 69(2), 76-80, 2021-03

  • Differences in Home Health Nursing Care for Patients with Parkinson's Disease by Stage of Progress: Patients in Hoehn and Yahr Stages III, IV, and V

    Iwasa Yumi , Saito Izumi , Suzuki Miyoko

    … As societal aging progresses globally, the number of people with Parkinson's disease (PD) is expected to increase worldwide. … We aimed to clarify the clinical care provided by nurses to homebound patients in each Hoehn and Yahr (HY) stage of the disease. … The nurses visited each patient nine times per month, on average. …

    Parkinson's Disease (2021), 8834998, 2021-02-22

    IR 

  • Analysis of Responses of a Healthy Subject and Subjects with Cerebellar Hemorrhage and Parkinson's Disease in Eye–Hand Coordination Pointing with Pencil Test

    Saito Kazuo , Koyama Maki , Ishida Atsuko , Futaki Toshiko

    … The objectives of this study were to quantitatively analyze the reaction patterns of ataxia and Parkinson's disease cases that are cognitively harmless and to examine the characteristics of pathological reactions, such as ataxia, rigidity, and motor control, compared to the patterns of a healthy subject.</p><p><b>Methods:</b> …

    Asian Journal of Occupational Therapy 17(1), 31-35, 2021

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  • Inherited Creutzfeldt–Jakob disease with four-octapeptide repeat insertional mutation in the prion gene  [in Japanese]

    M.D. Douzono Mika , M.D. Ph.D. Nobuhara Yasuyuki , M.D. Ph.D. Maruta Kyouko , M.D. Ph.D. Okamoto Yuji , M.D. Ph.D. Sonoda Yoshito , M.D. Ph.D. Takashima Hiroshi

    <p>症例は男性,60歳から物忘れ,歩行障害,動作緩慢が出現,パーキンソン病や多系統萎縮症として近医加療受けていたが,軽度の意識障害も加わり入院となった.意識障害が1年の経過で悪化し無動無反応となった.臨床症状ではミオクローヌスはみられず,四肢の粗大な振戦の不随意運動があり,脳波で周期性同期性放電(periodic synchronous discharge)及び頭部MRI拡散強調画像 …

    Rinsho Shinkeigaku, 2021

    J-STAGE 

  • Elucidation of the mechanisms of intractable neurologic diseases by applying techniques for the differentiation of iPS cells and reverse translational neuroscience research  [in Japanese]

    Kuzumaki Naoko , Suda Yukari , Kato Takahiro , Okano Hideyuki , Narita Minoru

    … Thus, we have been able to analyze the mechanisms of disease in specific cells that are targets for disease. … By connecting human disease-specific iPS cell research and <i>in vivo</i> … In the present study, we focused on genetic and sporadic intractable neurologic diseases and applied these techniques to the analysis of disease mechanisms. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-S09-4, 2021

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  • Effects of Lee Silverman Voice Treatment (LSVT LOUD) on Swallowing in Patients with Progressive Supranuclear Palsy: A Pilot Study

    Nozaki Sonoko , Yorifuji Shiro , Fujiu-kurachi Masako , Tanimura Takako , Ishizuka Kimiyo , Miyata Eri , Sugishita Shuhei , Imai Takahisa , Nishiguchi Maiko , Furuta Mitsuru

    … <p><b>Objectives: </b>Progressive supranuclear palsy (PSP) is an uncommon progressive neurodegenerative disease with no effective cure at present. … The initial symptoms resemble those of Parkinson's disease; … however, the prevalence of PSP is about one-tenth that of Parkinson's disease. …

    Progress in Rehabilitation Medicine 6(0), n/a, 2021

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  • Effectiveness of Levodopa in Patients with Multiple System Atrophy and Associated Clinicopathological Features

    Ishida Chiho , Takahashi Kazuya , Kato-Motozaki Yuko , Tagami Atsuro , Komai Kiyonobu

    … <p><b>Objective </b>To determine the clinicopathological features of levodopa or dopamine agonist (DA) responders with multiple system atrophy (MSA), an autopsy-confirmed diagnosis is vital due to concomitant cases of MSA and Parkinson's disease (PD). … DA was mildly effective in one MSA-C patient. …

    Internal Medicine 60(3), 367-372, 2021

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  • Association between toe-grip strength and gait in patient with Parkinsonʼs disease:analysis of temporal and spatial gait parameters in comfortable and fast walking  [in Japanese]

    Soma Masayuki , Murata Shin , Nakae Hideyuki , Nakano Hideki , Ishida Haruhisa , Maruyama Yuumi , Nagara Hitoshi , Nagara Yuko

    <p>〔目的〕本研究は,パーキンソン病者の歩行機能と足趾把持力との関係を明らかにするために,足趾把持力と快適および最速下の時間的・空間的歩行パラメータとの関係を検討した。〔対象・方法〕在宅パーキンソン病者40名とした。測定項目は,足趾把持力と快適および最速下における速度,歩幅,歩行率,歩隔,足角,立脚時間,遊脚時間,両脚支持時間とした。足趾把持力とこれらの項目との関連について,ピアソン …

    Japanese Journal of Health Promotion and Physical Therapy 10(4), 195-198, 2021

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  • S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein

    Fujikawa Kana , Nakahara Kengo , Takasugi Nobumasa , Nishiya Tadashi , Ito Akihiro , Uchida Koji , Uehara Takashi

    S-Nitrosylation of protein cysteine thiol is a post-translational modification mediated by nitric oxide (NO). … We previously reported that S-nitrosylation of protein disulfide isomerase (PDI) and the ER stress sensor inositol-requiring enzyme 1 (IRE1) decreases their enzymatic activities. … We detected that UBE2D1 is S-nitrosylated at its active site, Cys85 by liquid chromatography-tandem mass spectrometry (LC-MS/MS). …

    Biochemical and Biophysical Research Communications 524(4), 910-915, 2020-04-16

    IR 

  • Patients' and families' feelings about treatment and patient education when starting levodopa/carbidopa intestinal gel therapy, and nurses' difficulties when providing patient education  [in Japanese]

    屋久 裕美 , 三原 静花 , 鷲塚 麻衣 , 平島 佳林 , 坂之上 奈々 , 武 亜希子 , 清水 佐智子

    目的:レポドパ・カルビドパ配合経腸用液(LCIG)療法導入指導時の患者・家族の訴えを通しての思いと,看護師が感じた指導上の困難を明らかにする。方法:対象はLCIG 療法導入指導経験がある看護師。半構造化面接を行い,クリッペンドルフの内容分析で分析した。結果:12名に面接を行った。全員女性で看護師経験年数の平均は9年だった。患者・家族の訴えは,5つのカテゴリーに分類され〈導入で病気が治ると思っていた …

    鹿児島大学医学部保健学科紀要 = Bulletin of the School of Health Sciences, Faculty of Medicine, Kagoshima University 30(1), 15-22, 2020-03-31

    IR 

  • Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson's disease modeling

    Tae Hwan Kwak , Ji Hyun Kang , Sai Hali , Jonghun Kim , Kee-Pyo Kim , Chanhyeok Park , Ju-Hyun Lee , Ha Kyun Ryu , Ji Eun Na , Junghyun Jo , Hyunsoo Shawn Je , Huck-Hui Ng , Jeongwoo Kwon , Nam-Hyung Kim , Kwon Ho Hong , Woong Sun , Chi Hye Chung , Im Joo Rhyu , Dong Wook Han

    … Furthermore, our MOs exhibit mDA neuron-specific cell death upon treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, indicating that MOs could be a proper human model system for studying the in vivo pathology of Parkinson's disease (PD). … Our optimized conditions for producing homogeneous and mature MOs might provide an advanced patient-specific platform for in vitro disease modeling as well as for drug screening for PD. …

    STEM CELLS 38(6), 727-740, 2020-02-28

    IR 

  • A Case of Emergency Operation of Pneumatosis Cystoides Intestinalis with a Diagnosis of Gastrointestinal Perforation  [in Japanese]

    Chinen Yoshinao , Yamada Terumasa , Tsuda Yujiro , Kato Ryo , Ueda Masami , Iede Kiyotsugu , Nakashima Shinsuke , Ohta Katsuya , Matsuyama Jin , Ikenaga Masakazu

    <p>症例は80歳台女性で,パーキンソン病で入院加療中に突然の心窩部痛が出現した.顔面冷汗著明,腹部は平坦・軟で心窩部に著明な圧痛を認めた.血液検査所見で炎症反応の上昇を認めた.腹部造影CTで,上行結腸周囲に腹腔内遊離ガス像と腸間膜内ガス像を認めた.臨床症状と画像所見より上行結腸穿孔と診断し,緊急手術を行った.開腹時,汚染腹水や腸管の虚血性変化は認めず,盲腸から上行結腸にかけて漿膜下気 …

    Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) 45(1), 46-50, 2020

    J-STAGE  Ichushi Web 

  • Clinical Evaluation of Strabismus in Elderly Individuals with Emphasis on the Differences between Sagging Eye Syndrome and Ocular Movement Nerve Paralysis  [in Japanese]

    Oka Mayumi , Hoshihara-Fukuda Noriko , Kawahara Masaaki

    … 非共同性斜視のうち、年齢区分が高くなるにつれて増加傾向にあったのは滑車神経麻痺、SES、Parkinson 病関連疾患であった。 …

    JAPANESE ORTHOPTIC JOURNAL 49(0), 13-20, 2020

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  • Factors Associated with Heating Efficiency in Transcranial Focused Ultrasound Therapy

    YAMAMOTO Kazuaki , ITO Hisashi , FUKUTAKE Shigeru , ODO Takashi , KAMEI Tetsumasa , YAMAGUCHI Toshio , TAIRA Takaomi

    … Therefore, maximizing the heating efficiency is critical in cases where high temperature cannot be achieved because of patient-related characteristics. … 18 with essential tremor (ET), 11 with tremor-dominant Parkinson's disease (TDPD), and 1 with Holmes tremor. … This strategy may be particularly beneficial in cases where high ablation temperatures cannot be achieved because of patient-related characteristics. …

    Neurologia medico-chirurgica 60(12), 594-599, 2020

    J-STAGE 

  • Oral function management of Parkinson's disease (PD)  [in Japanese]

    Iida Ryohei

    <p> パーキンソン病は神経変性疾患のなかではアルツハイマー型認知症に次いで多く,訪問歯科診療などの現場では少なからず遭遇する.オーラルジスキネジアや開口保持が困難となれば,種々の歯科治療だけでなく口腔衛生管理に際しても難渋することとなる.姿勢や口腔機能の障害が進行すれば,義歯のコントロールも不良となり,徐々に使用困難となることが多い.摂食嚥下障害は高率に存在するが身体的運動障害とは必 …

    Annals of Japan Prosthodontic Society 12(4), 316-321, 2020

    J-STAGE  Ichushi Web 

  • Implant failure early after combined posetroanterior fusion for osteoporotic lumbar vertebral collapse in a patient with Parkinson's disease: a case report  [in Japanese]

    Funayama Toru , Koda Masao , Yamazaki Masashi , Mataki Kentaro , Sato Kosuke , Miura Kousei , Abe Tetsuya , Noguchi Hiroshi , Nagashima Katsuya , Shibao Yosuke , Kumagai Hiroshi

    … <p><b>はじめに:</b>パーキンソン病患者の脆弱性椎体骨折に対する手術法は統一されていない.</p><p><b>症例:</b>70歳男性,10年来のパーキンソン病.L4椎体圧潰に対して生検とL2-S1後方固定術を行い,2週間後に側方椎体置換術を追加した.しかし早期に椎体ケージの脱転を呈しT6から腸骨までの固定延長によりケージは安定し骨癒合した.</p><p><b>結語:</b>パーキンソン病 …

    Journal of Spine Research 11(10), 1252-1258, 2020

    J-STAGE  Ichushi Web 

  • Physical Therapy for a Patient with Parkinson's Disease Treated With Levodopa/Carbidopa Intestinal Gel: A Case Report  [in Japanese]

    HAKOMORI Masaki , TOYODA Kazunori , HAYASAKA Miku , TOMIMITSU Hiroyuki

    レボドパ/カルビドパ配合経腸用液療法(以下,LCIG)を導入した60歳代女性のパーキンソン病患者の理学療法(以下,PT)を経験した。LCIG導入前は,日中Off時間が約6時間で,Off時の無動に対する不安の為,6年間外出できなかった。Hospital Anxiety and Depression Scale(以下,HADS)におけるDepression(以下,D)は14点,Anxiety(以下,A …

    JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE 69(2), 148-154, 2020

    J-STAGE  Ichushi Web 

  • A novel variant c.3706C>T p.(Avg 1236Cys) in the <i>ABCA7</i> gene in a Saudi patient with susceptibility to Alzheimer's disease 9

    Algahtani Hussein , Shirah Bader , Alshareef Alhusain , Al-Qahtani Mohammad H. , Abdulkareem Angham Abdulrahman , Naseer Muhammad Imran

    … <p>Alzheimer's disease (AD) is the most common cause of dementia with around 50 million people suffering from this disease worldwide. … in a Saudi patient with susceptibility to AD 9 and a strong family history of neurodegenerative disorders, which may be explained by the same variant. …

    Intractable & Rare Diseases Research 9(3), 151-155, 2020

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  • Progressive Parkinsonism Three Years after Shunt Surgery in a Patient with Idiopathic Normal Pressure Hydrocephalus

    Shimada Hitoshi , Shimada Yasuo

    … His clinical symptoms, including resting tremor and rapid eye movement sleep behavior disorder, responsiveness to levodopa, and abnormal findings on <sup>123</sup>I-meta-iodobenzylguanidine myocardial scintigraphy and dopamine transporter imaging, indicated that his pathological background of parkinsonism included concomitant synucleinopathy, such as Parkinson's disease or dementia with Lewy bodies, in addition to iNPH. …

    Internal Medicine 59(17), 2183-2186, 2020

    J-STAGE 

  • Heart rate response analysis in Parkinson's disease patients with sleep apnea  [in Japanese]

    Yoshino Kohzoh , Kawaguchi Ayano , Yata Shogo , Iyama Akinori , Sakoda Saburo

    <p>パーキンソン病では早期より交感神経の変性が見られる一方,睡眠時無呼吸障害では交感神経の亢進が見られる.本研究では,パーキンソン病のある睡眠時無呼吸障害患者(PD+SAS)とパーキンソン病のない睡眠時無呼吸障害患者(PD-SAS)の睡眠時無呼吸イベントに対する心拍応答を比較することにより,両患者群間の自律神経系応答性の違いを明らかにすることを目的とする.国立病院機構大阪刀根山医療セ …

    Transactions of Japanese Society for Medical and Biological Engineering Annual58(Abstract), 304-304, 2020

    J-STAGE 

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