Search Results 1-20 of 234

  • Climbing Fibers Provide Graded Error Signals in Cerebellar Learning

    Yunliang Zang , Erik De Schutter

    … According to the classical cerebellar learning theory, depression of parallel fiber synapses instructed by error signals from climbing fibers, drives cerebellar learning. … In Purkinje cells, long-term potentiation (LTP) of parallel fiber synapses is now well established and it can be achieved with or without climbing fiber signals, making the role of climbing fiber input more puzzling. …

    Frontiers in Systems Neuroscience (13), 46, 2019-09-11


  • Possible Involvement ROS-Dependent Inhibition of Protein S-nitrosylation in Physiological Aging of Mouse Cerebellum  [in Japanese]

    Kakizawa Sho

    … </p><p>In the cerebellar parallel fiber (PF)-to-Purkinje cell (PC) synapse (PF synapse), nitric oxide (NO)-dependent long-term potentiation (PF-LTP) is characterized. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-S12-4, 2019


  • CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration

    Ageta-Ishihara Natsumi , Konno Kohtarou , Yamazaki Maya , Abe Manabu , Sakimura Kenji , Watanabe Masahiko , Kinoshita Makoto

    … Here, we find anomalous configuration of the tripartite synapses comprising the parallel fiber boutons, dendritic spines of Purkinje cells, and Bergmann glial processes in Cdc42ep4^−/− mice. … Paradoxically, however, Cdc42ep4^−/− cerebellum contained significantly more MYH10 and N-cadherin, which is attributed to secondary neuronal response mainly in Purkinje cells. …

    Neurochemistry International (119), 190-198, 2018-10


  • Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells

    Yunliang Zang , Stéphane Dieudonné , Erik De Schutter

    … Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. …

    Cell Reports 24(6), 1536-1549, 2018-08-07


  • Cerebellar Modules and Their Role as Operational Cerebellar Processing Units

    Richard Apps , Richard Hawkes , Sho Aoki , Fredrik Bengtsson , Amanda M. Brown , Gang Chen , Timothy J. Ebner , Philippe Isope , Henrik Jörntell , Elizabeth P. Lackey , Charlotte Lawrenson , Bridget Lumb , Martijn Schonewille , Roy V. Sillitoe , Ludovic Spaeth , Izumi Sugihara , Antoine Valera , Jan Voogd , Douglas R. Wylie , Tom J. H. Ruigrok

    … Furthermore, it has become clear that chemical diversity of Purkinje cells also results in diversity of information processing between cerebellar modules. … An additional important consideration is the relation between modular compartmentalization and the organization of the mossy fiber system, resulting in the concept of modular plasticity. …

    The Cerebellum 17(5), 654-682, 2018-06-06


  • Occurrence of long-term depression in the cerebellar flocculus during adaptation of optokinetic response

    Inoshita Takuma , Hirano Tomoo

    … Long-term depression (LTD) at parallel fiber (PF) to Purkinje cell (PC) synapses has been considered as a main cellular mechanism for motor learning. …

    eLife (7), 2018-03-27


  • Switching On Depression and Potentiation in the Cerebellum

    Andrew R. Gallimore , Taegon Kim , Keiko Tanaka-Yamamoto , Erik De Schutter

    … Using a unified model of LTD and LTP at the cerebellar parallel fiber-Purkinje cell (PF-PC) synapse, we delineate the coordinated pre- and postsynaptic signaling that determines the direction of plasticity. …

    Cell Reports 22(3), 722-733, 2018-01-16


  • Involvement of ROS/8-nitro-cGMP signals in cerebellar synaptic plasticity in mice

    Kakizawa Sho , Endo Shogo

    … Long-term depression at parallel fiber-Purkinje cell synapse (PF-LTD) is considered to be the cellular substrate of cerebellar-dependent motor learning such as eyeblink conditioning and opto-kinetic reflex. … Acute cerebellar slices were prepared from young-adult mice, and excitatory postsynaptic currents of PF synapses (PF-EPSC) were recorded from Purkinje cells. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-1-6, 2018


  • RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

    Valnegri Pamela , Huang Ju , Yamada Tomoko , Yang Yue , Mejia Luis A. , Cho Ha Y. , Oldenborg Anna , Bonni Azad , 山田 朋子

    … Here, we report that in vivo knockdown or conditional knockout of the autism-linked ubiquitin ligase RNF8 or associated ubiquitin-conjugating enzyme UBC13 in rodent cerebellar granule neurons robustly increases the number of parallel fiber presynaptic boutons and functional parallel fiber/Purkinje cell synapses. …

    Nature communications (8), 1271, 2017-11


  • A perisynaptic glial scaffold that facilitates glutamate buffering and clearance  [in Japanese]

    Kinoshita Makoto

    … Electrophysiological analysis of the prarallel fiber-Purkinje cell synapses revealed protracted decay time constant in the excitatory postsynaptic current, and excessive baseline inward current in response to a subthreshold dose of a nonselective inhibitor of the glutamate transporters. …

    Japanese Journal of Biological Psychiatry 28(2), 84-86, 2017

    J-STAGE  Ichushi Web 

  • GluD2 Endows Parallel Fiber-Purkinje Cell Synapses with a High Regenerative Capacity

    Ichikawa Ryoichi , Sakimura Kenji , Watanabe Masahiko

    Journal of neuroscience 36(17), 4846-4858, 2016-04-27


  • Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination

    Ichikawa Ryoichi , Hashimoto Kouichi , Miyazaki Taisuke , Uchigashima Motokazu , Yamasaki Miwako , Aiba Atsu , Kano Masanobu , Watanabe Masahiko

    Proceedings of the National Academy of Sciences of the United States of America (PNAS) 113(8), 2282-2287, 2016-02-23


  • Intracellular Ca2+ thresholds for induction of excitatory long-term depression and inhibitory long-term potentiation in a cerebellar Purkinje neuron

    Nakamura Yoji , Hirano Tomoo

    … In particular, long-term depression at excitatory parallel fiber - Purkinje neuron synapses has been intensively studied as a primary cellular mechanism for motor learning. … Recent studies showed that synaptic plasticity other than long-term depression such as long-term potentiation at inhibitory interneuron - Purkinje neuron synapses called rebound potentiation is also involved in motor learning. …

    Biochemical and Biophysical Research Communications 469(4), 803-808, 2016-01-22


  • Role of Glutamate Receptor GluD2 in Development, Maintenance, and Regeneration of Cerebellar Synaptic Circuits  [in Japanese]

    Watanabe Masahiko

    … <p>Mono-innervation by single climbing fibers and segregated dendritic innervation by climbing fibers and parallel fibers are the two distinguishing features of synaptic circuits in cerebellar Purkinje cells. … In the process, GluD2 or GluRd2, which is selective to parallel fiber-Purkinje cell synapses, plays key roles in development, maintenance, and regeneration of Purkinje cell circuits through its involvement in the strengthening of synaptic connectivity. …

    KENBIKYO 51(3), 159-164, 2016

    J-STAGE  Ichushi Web 

  • Electrical Storm Associated with Inherited Arrhythmia Syndromes : Cardiac Purkinje Fiber Arrhythmogenesis  [in Japanese]

    Tsuji Yukiomi , Harrell Daniel Toshio , Ishikawa Taisuke , Makita Naomasa

    … るが,致死性不整脈が繰り返し発生するメカニズムやその遺伝学的背景は,依然明らかではない.心臓Purkinje線維は不整脈の発生に深く関与し,そのイオンチャネル・プロファイルは心室筋細胞と大きく異なることが知られている.本稿では,致死性不整脈の反復発生に寄与する因子として,Purkinje細胞の電気生理学的特殊性に着目し,遺伝性不整脈疾患に伴うelectrical stormの発生メカニズムを考察す …

    Japanese Journal of Electrocardiology 35(2), 104-115, 2015

    J-STAGE  Ichushi Web 

  • Investigating Mechanisms of Ventricular Arrhythmias Induced in the Purkinje Fiber Network Using Computer Simulation  [in Japanese]

    INADA Shin , HARRELL Daniel T. , HARAGUCHI Ryo , ASHIHARA Takashi , MAKITA Naomasa , NAKAZAWA Kazuo

    … The Purkinje fiber network is one of the specialized excitation conduction systems that ensure coordinated contraction of the ventricles due to faster excitation conduction than other regions of the heart. … A recent study identified a mutation in connexin 40 (Cx40), a gap junction isoform predominantly expressed in the His-Purkinje system, in patients with progressive cardiac conduction defect associated with lethal ventricular arrhythmias. …

    Transactions of Japanese Society for Medical and Biological Engineering 53(3), 106-114, 2015


  • Clinical and Electrocardiographic Characteristics of Electrical Storms Due to Monomorphic Ventricular Tachycardia Refractory to Intravenous Amiodarone

    Murata Hiroshige , Takahashi Kenta , Yamamoto Teppei , Maruyama Mitsunori , Akutsu Koichi , Yamamoto Takeshi , Kobayashi Yoshinori , Tanaka Keiji , Atarashi Hirotsugu , Katoh Takao , Shimizu Wataru , Miyauchi Yasushi , Hayashi Meiso , Iwasaki Yu-ki , Yodogawa Kenji , Ueno Akira , Hayashi Hiroshi , Tsuboi Ippei , Uetake Shunsuke

    … In the Refractory group, additional administration of IV-mexiletine and/or Purkinje potential-guided catheter ablation was effective.<b><i>Conclusions:</i></b>IV-amiodarone-refractory VT exhibited a relatively narrow QRS tachycardia. … The narrow triggering PVCs, suggesting a Purkinje fiber origin, may be treated by additional IV-mexiletine and endocardial catheter ablation. …

    Circulation Journal 79(10), 2130-2137, 2015

    J-STAGE  Ichushi Web 

  • Morphometric analysis of progressive changes in hereditary cerebellar cortical degenerative disease (abiotrophy) in rabbits caused by abnormal synaptogenesis

    Sato Junko , Yamada Naoaki , Kobayashi Ryosuke , Tsuchitani Minoru , Kobayashi Yoshiyasu

    … We previously investigated rabbit hereditary cerebellar cortical degenerative disease, called cerebellar cortical abiotrophy in the veterinary field, and determined that the pathogenesis of this disease is the result of failed synaptogenesis between parallel fibers and Purkinje cells. … Although 26% to 36% of parallel fiber terminals formed synaptic junctions with Purkinje cell spines, the remainder did not at PD 15 and 42. …

    Journal of Toxicologic Pathology 28(2), 73-78, 2015

    J-STAGE  Ichushi Web 

  • Around LTD hypothesis in motor learning.

    Hirano Tomoo

    … Long-term depression (LTD) at parallel fiber-Purkinje neuron synapses has been regarded as a primary cellular mechanism for motor learning. …

    Cerebellum 13(5), 645-650, 2014-06-29


  • Regulation and functional roles of rebound potentiation at cerebellar stellate cell—Purkinje cell synapses

    Hirano Tomoo , Kawaguchi Shin-ya

    Purkinje cells receive both excitatory and inhibitory synaptic inputs and send sole output from the cerebellar cortex. … Long-term depression (LTD), a type of synaptic plasticity, at excitatory parallel fiberPurkinje cell synapses has been studied extensively as a primary cellular mechanism of motor learning. … On the other hand, at inhibitory synapses on a Purkinje cell, postsynaptic depolarization induces long-lasting potentiation of GABAergic synaptic transmission. …

    Frontiers in Cellular Neuroscience (8), 2014-02-18


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