Search Results 1-20 of 742

  • Magnesium Deficiency Causes Transcriptional Downregulation of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT Interval Prolongation

    Shimaoka Toru , Wang Yan , Morishima Masaki , Miyamoto Shinji , Ono Katsushige

    … <p><b><i>Background:</i></b>Mechanisms for QT interval prolongation and cardiac arrhythmogenesis in hypomagnesemia are poorly understood. …

    Circulation Journal, 2020


  • A case of Torsade de Pointes during and after total laparoscopic hysterectomy  [in Japanese]

    Takamatsu Ai , Ogasawara Sakura , Matsukawa Yasushi , Kimura Naomi , Higuchi Kazuhiro , Takeuchi Kiyotake

    … <p><b>Introduction: </b>Long QT syndrome (LQTS) is divided into congenital and acquired LQTS. … Some studies report that pneumoperitoneum can prolong the QT interval. … When she entered the operating room, the QT interval on the ECG monitor was already prolonged; … More attention should be paid to prevent QTc interval prolongation and TdP during laparoscopic surgery, even when preoperative ECG findings are normal.</p><p></p> …



  • Clinical Implications of Ventricular Repolarization Parameters on Long-Term Risk of Atrial Fibrillation ― Longitudinal Follow-up Data From a General Ambulatory Korean Population ―

    Cho Min Soo , Nam Gi-Byoung , Kim Yu Na , Kim Jun , Choi Kee-Joon , Kim You-Ho

    … study investigated 12-lead electrocardiogram (ECG) predictors associated with atrial fibrillation (AF) or flutter (AFL), specifically whether ventricular repolarization abnormalities in surface ECG (i.e., non-specific ST-T abnormalities [NSSTTA], QT prolongation, early repolarization [ER]) were associated with the development of AF or AFL.</p><p><b><i>Methods and Results:</i></b>This study included 16,793 ambulatory Koreans (mean age 48.2 years, 62.3% male) who underwent …

    Circulation Journal, 2020


  • Clinical pharmacology of cardio-oncology: a novel interdisciplinary platform for basic and translational research  [in Japanese]

    Sase Kazuhiro

    <p>超高齢社会を迎え,がんは身近な病気となったものの,医学の進歩に伴いがんサバイバーの数が急増しつつある.従来から抗がん薬や放射線治療による心毒性には細心の注意が払われてきたが,新たに登場した分子標的薬や免疫チェックポイント阻害薬等では多種多様な病態が報告されるようになり,がん治療関連心血管疾患(cancer treatment-related cardiovascular dise …

    Folia Pharmacologica Japonica 155(3), 179-184, 2020


  • Personalized medicine diagnostics for cardiac safety  [in Japanese]

    Blinova Ksenia

    … The delay in iPSC-CMs repolarization and QT interval prolongation induced by these hERG potassium channel blockers were used as surrogate end points of proarrhythmic risk. … Comparative results showed no significant correlation between the subject‐specific in vitro repolarization prolongation slopes and clinical QT response slopes to either moxifloxacin (P = 0.75) or dofetilide (P = 0.69). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S29-4, 2020


  • Utility of isoflurane-anesthetized guinea pigs for the assessment of the QT-interval prolongation induced by drugs with positive chronotropic action  [in Japanese]

    Kusama Naoto , Nagasawa Yoshinobu , Kawakami Satoshi , Aimoto Megumi , Takahara Akira

    … The QT interval can be shortened by tachycardia, which may underestimate risks of the drug-induced QT-interval prolongation in the safety pharmacology studies. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-333, 2020


  • Ventricular Fibrillation Induced by Takotsubo Syndrome with Congenital Long QT Syndrome

    Taguchi Mamoru , Sasa Tomoki , Izuhara Masayasu , Shioji Keisuke , Iwamuro Ayumi , Uegaito Takashi , Matsuda Mitsuo

    … <p>We herein report a case of congenital long QT syndrome (LQTS) in which the QT interval was prolonged by Takotsubo syndrome (TTS), inducing ventricular fibrillation (VF). … An electrocardiogram showed marked QT prolongation and large negative T waves. …

    Internal Medicine 59(6), 789-792, 2020


  • Progress on Safety-Related ICH Activities  [in Japanese]

    MAKI Kazushige , NONAKA Mizuho , NISHIMURA Jihei , MIKASHIMA Fumito , TSUNODA Satoshi , NAOTA Misaki , NISHIMURA Takuya , HIRABAYASHI Keiji

    … また, ICH S7B (ヒト用医薬品の心室再分極遅延 (QT間隔延長) の潜在的可能性に関する非臨床評価) およびICH M7 (R2)〔潜在的発がんリスクを低減するための医薬品中DNA反応性 (変異原性) 不純物の評価及び管理〕のQ & …

    Regulatory Science of Medical Products 10(1), 15-22, 2020


  • Establishment of a new formula for QT interval correction using a large colony of cynomolgus monkeys

    Nakayama Shunya , Koie Hiroshi , Kato-Tateishi Miyoko , Pai Chungyu , Ito-Fujishiro Yasuyo , Kanayama Kiichi , Sankai Tadashi , Yasutomi Yasuhiro , Ageyama Naohide

    … The QT interval is the distance between the Q wave and T wave, but this interval is affected by heart rate. … Therefore, QT correction methods are commonly used in clinical settings. … However, an accurate correction formula for the QT interval in cynomolgus monkeys has not been reported. …

    Experimental Animals 69(1), 18-25, 2020


  • QT prolongation  [in Japanese]

    町野 毅 , 青沼 和隆

    臨床精神薬理 = Japanese journal of clinical psychopharmacology 22(9), 871-876, 2019-09

    Ichushi Web 

  • Cardiac conduction failure by psychotropic drugs  [in Japanese]

    有波 浩 , 鈴木 雄太郎

    精神科治療学 34(5), 571-576, 2019-05

    Ichushi Web 

  • Clinical and Genetic Characteristics in Patients With Gitelman Syndrome

    Fujimura Junya , Nozu Kandai , Yamamura Tomohiko , Minamikawa Shogo , Nakanishi Keita , Horinouchi Tomoko , Nagano China , Sakakibara Nana , Nakanishi Koichi , Shima Yuko , Miyako Kenichi , Nozu Yoshimi , Morisada Naoya , Nagase Hiroaki , Ninchoji Takeshi , Kaito Hiroshi , Iijima Kazumoto

    … In one case, QT prolongation was detected. … Patients with GS need attention for developing extrarenal complications, such as short stature, febrile convulsion, thyroid dysfunction, epilepsy, or QT prolongation. …

    Kidney International Reports 4(1), 119-125, 2019-01


  • Cardio-Oncology: Challenges and Opportunities in the New Interdisciplinary Research  [in Japanese]

    Sase Kazuhiro

    … </p><p>Research priorities need to be identified to diagnose, treat, and prevent the previously unknown CTRCD(s), including (1) myocardial dysfunction and heart failure, (2) coronary artery disease, (3) valvular disease, (4) arrhythmias and QT-prolongation, (5) arterial hypertension, (6) thromboembolic disease and others.</p><p>For example, understanding fundamental mechanisms underlying CTRCD is essential to the development of new methods to manage these toxicities. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-S22-4, 2019


  • Reciprocal action of a synthetic estrogen and hERG blockers on the hERG channel  [in Japanese]

    Sugimoto Shintaro , Tamura Fumiya , Iwasaki Nanami , Ieda Masaki , Sakamoto Kazuho , Kurokawa Junko

    … <p>Inhibition of K<sup>+</sup>-conductance through the hERG channel leads QT prolongation and associates with cardiac arrhythmias. … These results suggest that EE2 interacts with E-4031 at the promiscuous drug-binding site of the hERG channel and imply that EE2, an anti-breast cancer drug or an oral contraceptive, is protective against drug-induced QT prolongation.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-SS-80, 2019


  • Effects of 12 compounds on field potential signals with xCELLigence CardioECR system using iCell cardiomyocyte<sup>2</sup>  [in Japanese]

    Kato Eriko , Baba Atsushi , Ikegaya Yuji , Sawada Kohei

    … <p>Human iPSC cardiomyocytes (hiPS-CMs) have been used for the risk assessment of drug-induced QT prolongation and ventricular tachycardia called torsade de pointes. … These results suggested that CardioECR can be used as a platform to assess the QT risk with hiPS-CMs. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-P-072, 2019


  • Cardiac safety assessment with motion field imaging analysis of human iPS cell-derived cardiomyocytes is improved by an integrated evaluation with cardiac ion channel profiling

    Isobe Takehito , Honda Masaki , Komatsu Ryuichi , Tabo Mitsuyasu

    … However, 2 internal compounds shortened CRDc despite QTc prolongation in Langendorff heart. … Cardiac ion channel profiling revealed that hiPS-CMs could not be used to detect QTc prolongation when the value of Cav1.2 IC<sub>50</sub> …

    The Journal of Toxicological Sciences 44(12), 859-870, 2019


  • Replacement of an Implantable Cardioverter-Defibrillator (ICD) with a New Standard Subcutaneous ICD System in a Patient with Jervell and Lange-Nielsen Syndrome

    Sato Akinori , Hasegawa Yuki , Haniu Hisanori , Shiraishi Shuichi , Yagihara Nobue , Iijima Kenichi , Izumi Daisuke , Minamino Tohru

    … Implantation of the S-ICD may be considered a reliable and safe option in young patients with JLNS, even if their electrocardiograms show remarkable prolongation of the QT interval and T-wave alternans.</p> …

    International Heart Journal 60(5), 1206-1210, 2019


  • Specific Therapy Based on the Genotype in a Malignant Form of Long QT3, Carrying the V411M Mutation

    Blich Miry , Khoury Asaad , Suleiman Mahmoud , Lorber Avraham , Gepstein Lior , Boulous Monther

    … <p>Congenital long QT syndrome (LQTS) is a cardiac channelopathy that leads to the prolongation of the QT interval. … This prolongation can lead to ventricular tachyarrhythmia, syncope, and sudden cardiac death. …

    International Heart Journal 60(4), 979-982, 2019

    J-STAGE  Ichushi Web 

  • Intraoperative Change in QTc in a Patient with a Prolonged QTc Interval  [in Japanese]

    YAMAMOTO Takeshi , TAKAISHI Kazumi , OTSUKA Ryo , FUJIWARA Shigeki , EGUCHI Satoru , KITAHATA Hiroshi

    … <p>  Long QT syndrome is characterized by a prolongation of the QT interval and a morphological change in the T wave on an electrocardiogram. … Prolongation of the QT interval is associated with serious arrhythmia and may cause syncope and sudden death. …

    Journal of Japanese Dental Society of Anesthesiology 47(2), 53-55, 2019

    J-STAGE  Ichushi Web 

  • The Genetics of Acquired Long QT Syndrome  [in Japanese]

    Itoh Hideki

    … <p>後天性QT延長症候群は薬剤,低カリウム血症,高度徐脈などでQT延長が顕在化し,致死性不整脈が出現する病態である.本研究は日本,フランス,イタリアの計8施設による国際共同研究で,後天性QT延長症候群188症例(55±20歳,女性140例)を対象に,先天性QT延長症候群において頻度の高い5つの責任遺伝子(KCNQ1,KCNH2,SCN5A,KCNE1,KCNE2)の変異を検索し …

    Japanese Journal of Electrocardiology 39(1), 5-15, 2019

    J-STAGE  Ichushi Web 

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