Search Results 1-14 of 14

  • The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions

    Teramoto Koji , Katoh Hironori

    … The phosphorylation requires the activity of the cystine/glutamate antiporter xCT and reactive oxygen species (ROS)-dependent ERK and RSK activation. …

    Cellular Signalling (62), 2019-10

    IR 

  • TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

    Kitajima Naoyuki , Numaga-Tomita Takuro , Watanabe Masahiko , Kuroda Takuya , Nishimura Akiyuki , Miyano Kei , Yasuda Satoshi , Kuwahara Koichiro , Sato Yoji , Ide Tomomi , Birnbaumer Lutz , Sumimoto Hideki , Mori Yasuo , Nishida Motohiro

    … Reactive oxygen species (ROS) produced by NADPH oxidase 2 (Nox2) function as key mediators of mechanotransduction during both physiological adaptation to mechanical load and maladaptive remodeling of the heart. … We demonstrate that transient receptor potential canonical 3 (TRPC3), a Ca2+-permeable channel, acts as a positive regulator of ROS (PRROS) in cardiomyocytes, and specifically regulates pressure overload-induced maladaptive cardiac remodeling in mice. …

    SCIENTIFIC REPORTS (6), 37001, 2016-11-11

    IR 

  • TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

    Kitajima Naoyuki , Numaga-Tomita Takuro , Watanabe Masahiko , Kuroda Takuya , Nishimura Akiyuki , Miyano Kei , Yasuda Satoshi , Kuwahara Koichiro , Sato Yoji , Ide Tomomi , Birnbaumer Lutz , Sumimoto Hideki , Mori Yasuo , Nishida Motohiro

    … Reactive oxygen species (ROS) produced by NADPH oxidase 2 (Nox2) function as key mediators of mechanotransduction during both physiological adaptation to mechanical load and maladaptive remodeling of the heart. … We demonstrate that transient receptor potential canonical 3 (TRPC3), a Ca2+-permeable channel, acts as a positive regulator of ROS (PRROS) in cardiomyocytes, and specifically regulates pressure overload-induced maladaptive cardiac remodeling in mice. …

    Scientific Reports (6), 2016-11-11

    IR 

  • Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

    Miyake Takahito , Nakamura Saki , Zhao Meng , So Kanako , Inoue Keisuke , Numata Tomohiro , Takahashi Nobuaki , Shirakawa Hisashi , Mori Yasuo , Nakagawa Takayuki , Kaneko Shuji

    人はなぜ「冷たい」を「痛い」と感じるのか ―活性酸素と痛みセンサーTRPA1がカギを握る―. 京都大学プレスリリース. 2016-09-16.

    Nature Communications (7), 2016-09-15

    IR 

  • Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells

    Ishikura Kazuhide , Misu Hirofumi , Kumazaki Masafumi , Takayama Hiroaki , Matsuzawa-Nagata Naoto , Tajima Natsumi , Chikamoto Keita , Lan Fei , Ando Hitoshi , Ota Tsuguhito , Sakurai Masaru , Takeshita Yumie , Kato Kenichiro , Fujimura Akio , Miyamoto Ken-ichi , Saito Yoshiro , Kameo Satomi , Okamoto Yasuo , Takuwa Yoh , Takahashi Kazuhiko , Kidoya Hiroyasu , Takakura Nobuyuki , Kaneko Shuichi , Takamaura Toshinari

    … Here, we investigated the effects of SeP on VEGF signalling and angiogenesis. … We examined the actions of SeP on VEGF signalling and VEGF-induced angiogenesis in HUVECs. … SeP suppressed VEGF-induced reactive oxygen species (ROS) generation and phosphorylation of VEGF receptor 2 (VEGFR2) and extracellular signal-regulated kinase 1/2 (ERK1/2) in HUVECs. …

    Diabetologia 57(9), 1968-1976, 2014-09-01

    IR 

  • Regulation of redox signalling by an electrophilic cyclic nucleotide

    Akaike Takaaki , Nishida Motohiro , Fujii Shigemoto

    The journal of biochemistry 153(2), 131-138, 2013-02

    Ichushi Web 

  • Sulphur Antioxidants Inhibit Oxidative Stress Induced Retinal Ganglion Cell Death by Scavenging Reactive Oxygen Species but Influence Nuclear Factor (Erythroid-Derived 2)-Like 2 Signalling Pathway Differently

    Majid Aman Shah Abdul , Yin Zheng Qin , Ji Dan

    … Cell viability, microscopic evidence for apoptosis, caspase 3 activity, reactive oxygen species (ROS), glutathione (GSH), catalase and gluthathione-<i>S</i>-transferase (GST) were determined. … NAC and sulbutiamine both independently stimulated the GSH and GST production but scavenged different types of ROS with different efficacy. …

    Biological and Pharmaceutical Bulletin 36(7), 1095-1110, 2013

    J-STAGE  Ichushi Web 

  • Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signaling

    Ahmed Khandaker Ahtesham , Sawa Tomohiro , Ihara Hideshi , Kasamatsu Shingo , Yoshitake Jun , Rahaman Md. Mizanur , Okamoto Tatsuya , Fujii Shigemoto , Akaike Takaaki

    … In the present study, we investigated chemical and biochemical regulatory mechanisms involved in 8-nitro-cGMP formation, with particular focus on the roles of ROS (reactive oxygen species). … The results of the present study suggest that 8-nitro-cGMP can serve as a unique second messenger thatmay be implicated in regulating ROS signalling in the presence of NO. …

    Biochemical Journal 441(2), 719-730, 2012-01-15

    IR 

  • Analysis of nitrogen monoxide (NO) status in cell death of lethal interspecific F<SUB>1</SUB> hybrid of <I>Nicotiana gossei</I> x <I>N. tabacum</I>

    Yamamoto Takumi

    … 我々は、これまでにGTH4の細胞死が活性酸素種(ROS)と一酸化窒素(NO)、特にO<SUB>2</SUB><SUP>-</SUP>とNOの量比バランスおよびH<SUB>2</SUB>O<SUB>2</SUB>とNOの相互作用の制御下にあることを確認し、またROS発生がMAPK経路の制御下にあることを明らかにした。 …

    Plant and Cell Physiology Supplement 2011(0), 0798-0798, 2011

    J-STAGE 

  • S1p3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species

    Takuwa Noriko , Ohkura Sei-Ichiro , Takashima Shin-ichiro , Ohtani Keisuke , Okamoto Yasuo , Tanaka Tamotsu , Hirano Kaoru , Usui Soichiro , Wang Fei , Du Wa , Yoshioka Kazuaki , Banno Yoshiko , Sasaki Motoko , Ichi Ikuyo , Okamura Miwa , Sugimoto Naotoshi , Mizugishi Kiyomi , Nakanuma Yasuni , Ishii Isao , Takamura Masayuki , Kaneko Shuichi , Kojo Shosuke , Satouchi Kiyoshi , Mitumori Kunitoshi , Chun Jerold , Takuwa Yoh

    金沢大学医薬保健研究域医学系

    Cardiovascular Research 85(3), 484-493, 2010-02-01

    IR  Cited by (3)

  • Role of interleukins in testicular physiology and disease

    Ishikawa Tomomoto , O'Bryan Moira K. , Fujisawa Masato , Morris Patricia L.

    … while each subsequently influences developing germ cells and spermatogenesis, little is known about the signalling mechanisms involved. … potently induces reactive oxygen species (ROS) and/or cyclooxygenase-2 (COX-2). … does not generate ROS but does rapidly phosphorylate cJun-NH2-terminal kinase (JNK), but not p44/42 or p38 mitogen-activated protein kinases. … activates FP-PKC signalling. …

    Reproductive Immunology and Biology 25(2), 123-135, 2010

    J-STAGE 

  • Induced defence mechanisms: the binding protein of the PiP elicitor in potato cell was Ca2+ dependent protein kinase  [in Japanese]

    Furuichi Naotaka

    ジャガイモ宿主細胞において過敏感反応が起こるときに一過的に活性酸素が生成される。反応は植物の動的誘導性を誘導するエリシターにより、細胞内へのCa(2+)を引き起こす。Ca(2+)のオシレーションが活性酸素の生成に強く関与している。細胞内Ca(2+)濃度は、Ca(2+)受容型タンパク質を活性化させる。このCa(2+)依存型蛋白質キナーゼ(CDPK1、CDPK2)は、Ca(2+)結合ドメインを有するタ …

    Bulletin of the Faculty of Agriculture, Niigata University 60(2), 91-95, 2008-03

    IR  JASI 

  • ROS as signalling molecules : mechanisms that generate specificity in ROS homeostasis

    D'AUTREAUX B

    Nat. Rev. Mol. Cell Biol. 8, 813-824, 2007

    Cited by (7)

  • The Effects of UVA Irradiation on Human Neutrophil Function  [in Japanese]

    SHIRAISHI Masahiko , NAKAJI Shigeyuki , SUGAWARA Kazuo

    … For measurements of reactive oxygen species (ROS) and serum opsonic activity, chemiluminescence was used. …

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 50(6), 1093-1102, 1996-02-15

    J-STAGE  Ichushi Web  References (39)

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