Search Results 1-20 of 1094

  • HTLV-1-asasociated myelopathy : a retrovirus induced neurological disease  [in Japanese]

    山野 嘉久

    医学のあゆみ 277(1), 71-77, 2021-04-03

  • Transcription of Endogenous Retrovirus Group K Members and Their Neighboring Genes in Chicken Skeletal Muscle Myoblasts

    Takaya Tomohide , Nihashi Yuma , Ono Tamao , Kagami Hiroshi

    … Based on the RNA-seq data, we herein report that chicken myoblasts transcribe endogenous retrovirus group K member (ERVK) genes. …

    The Journal of Poultry Science 58(2), 79-87, 2021

    J-STAGE 

  • Lipid droplets are formed in 2-cell-like cells

    FURUTA Asuka , NAKAMURA Toshinobu

    … In mice, totipotent 2-cell stage embryo-like (2-cell-like) cells, which are identified by reactivation of murine endogenous retrovirus with leucin transfer RNA primer (MuERV-L), arise at a very few frequencies in ES cell cultures. …

    Journal of Reproduction and Development 67(2), 79-81, 2021

    J-STAGE 

  • PHF24 is expressed in the inhibitory interneurons in rats

    Numakura Yuki , Serikawa Tadao , Kuwamura Mitsuru , Uemura Risa , Tanaka Miyuu , Izawa Takeshi , Yamate Jyoji , Kuramoto Takashi , Kaneko Takehito , Mashimo Tomoji , Yamamoto Takashi

    … but it is detected an insertion of an endogenous retrovirus sequence in intron 2 of the PHD finger protein 24 (<i>Phf24</i>) gene, encoding Gαi-interacting protein (GINIP). …

    Experimental Animals 70(1), 137-143, 2021

    J-STAGE 

  • Fecal Microbiome Composition in Healthy Adults in Ghana

    Parbie Prince Kofi , Ofori Sampson Badu , Uematsu Satoshi , Imoto Seiya , Kimura Yasumasa , Kiyono Hiroshi , Ishikawa Koichi , Ampofo William Kwabena , Matano Tetsuro , Mizutani Taketoshi , Ishizaka Aya , Kawana-Tachikawa Ai , Runtuwene Lucky Ronald , Seki Sayuri , Abana Christopher Zaab-Yen , Kushitor Dennis , Bonney Evelyn Yayra

    <p>Recent studies have indicated an association between gut microbiome composition and various disorders, including infectious diseases. The composition of the microbiome differs among ethniciti …

    Japanese Journal of Infectious Diseases 74(1), 42-47, 2021

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  • Interferon regulatory factor 7 mediates obesity-associated MCP-1 transcription

    Kuroda Masashi , Nishiguchi Misa , Ugawa Naho , Ishikawa Etsuko , Kawabata Yasuyo , Okamoto Saya , Sasaki Waka , Miyatake Yumiko , Sebe Mayu , Masumoto Saeko , Tsutsumi Rie , Harada Nagakatsu , Sakaue Hiroshi

    … To investigate the role of IRF7 in adipocytes, we examined gene expression patterns in 3T3-L1 cells infected with a retrovirus carrying the IRF7 gene and found that enforced IRF7 expression induced the expression of monocyte chemoattractant protein-1 (MCP-1), a key initial adipokine in the chronic inflammation of obesity. …

    PLOS ONE 15(5), e0233390, 2020-05-21

    IR 

  • Retrotransposons Manipulating Mammalian Skeletal Development in Chondrocytes

    Kubota Satoshi , Ishikawa Takanori , Kawata Kazumi , Hattori Takako , Nishida Takashi

    Retrotransposons are genetic elements that copy and paste themselves in the host genome through transcription, reverse-transcription, and integration processes. Along with their proliferation in the g …

    International Journal of Molecular Sciences 21(5), 1564, 2020-02-25

    IR 

  • Investigation of Drug Interaction Based on CYP Inhibitory Effect between Anti-Retrovirus Therapeutic Agents and Glucocorticoids  [in Japanese]

    嶺 豊春 , 室 高広 , 兒玉 幸修 , 中村 忠博 , 佐々木 均

    日本エイズ学会誌 = The journal of AIDS research 22(1), 51-56, 2020

  • [OPINION]Infectious diseases and the future of human society  [in Japanese]

    Matsushita Shuzo

    Drug Delivery System 35(5), 354-354, 2020

    J-STAGE 

  • Viral safety testing for biopharmaceuticals: Current and future prospects

    YUSA Keisuke , YUSA Yuzhe , UCHIDA Kazuhisa

    <p>Biopharmaceuticals produced from animal cells and raw materials pose a risk of pathogen contamination. Thus, it is essential to pay special attention to contamination with i …

    Translational and Regulatory Sciences 2(3), 94-99, 2020

    J-STAGE 

  • Methylmercury-induced neuronal hyperactivation and site-specific neurodegeneration  [in Japanese]

    FUJIMURA Masatake , USUKI Fusako

    <p>メチル水銀の成人期暴露は、脳において部位特異的な神経毒性を誘発する。本研究では、成人水俣病患者と同様に大脳皮質の深層部 (特に第IV層) に特異的な神経変性を示すメチル水銀中毒マウスモデルを用いて、神経活動に関連するシグナル伝達経路の部位特異的発現について研究を行った。まず、免疫組織学的手法を用いて、神経活動マーカーであるc-fosおよび脳由来神経栄養因子(BDNF)の脳内各部位 …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), S19-3, 2020

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  • Histone H3 methylation orchestrates transcriptional program in mouse spermatogenic cell line

    WANG Xiao-fei , TIAN Qing , QIN Wei-bing , YIN Ying , ZENG Ling , TANG Yun-ge , SU Ping , ZHOU Li-quan

    … Moreover, the H3.3 K-to-M transgenes, especially H3.3 K36M, impacted the expression of endogenous retrovirus ERVK. …

    Journal of Reproduction and Development 66(3), 223-230, 2020

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  • Prediction of Contact Residues in Anti-HIV Neutralizing Antibody by Deep Learning

    Kaku Yu , Kuwata Takeo , Gorny Miroslaw K. , Matsushita Shuzo

    <p>The monoclonal antibody 1C10 targets the V3 loop of HIV-1 and neutralizes a broad range of clade B viruses. However, the mode of interaction between 1C10 and the V3 loop remains unclear becau …

    Japanese Journal of Infectious Diseases 73(3), 235-241, 2020

    J-STAGE  Ichushi Web 

  • Inefficient Tax-Specific T-Cell Responses in Mice after Syngeneic Transplantation with <i>tax</i>-Transgenic Mouse-Derived Adult T-Cell Leukemia Cells

    Nakamura-Hoshi Midori , Suzuki Tadaki , Ainai Akira , Hasegawa Hideki , Ishii Hiroshi , Matano Tetsuro

    <p>Adult T-cell leukemia (ATL) is induced by chronic latent infection with human T-cell leukemia virus type 1 (HTLV-1). HTLV-1 Tax is an oncogenic factor that can be targeted by host T-cell resp …

    Japanese Journal of Infectious Diseases 73(3), 221-225, 2020

    J-STAGE  Ichushi Web 

  • Survey of bovine foamy virus infection among cattle in Japan and comparison with bovine leukemia virus infection

    IWASAKI Ryoji , NAKAGIRI Yu , YAGUCHI Yuji , OGUMA Keisuke , ONO Mamiko , HORIKITA Tetsuya , SENTSUI Hiroshi

    <p>The prevalence of bovine foamy virus (BFV) infections in cattle on farms in the Kanto region of Japan was determined using agar gel immunodiffusion (AGID) test and polymerase chain reaction ( …

    Journal of Veterinary Medical Science 82(5), 615-618, 2020

    J-STAGE  Ichushi Web 

  • The initial symptom as a clinical parameter for rapid progression of HAM/TSP  [in Japanese]

    Furuzono Mai , Takashima Hiroshi , Matsumoto Riku , Mayumi Hanako , Tashiro Yuichi , Arata Hitoshi , Yamano Yoshihisa , Tanaka Masakazu , Kubota Ryuji , Matsuura Eiji

    <p>【要旨】HAM 患者データベース『HAM ねっと』に登録されている 527 例において、疾患進行速度の予測因子としての初発症状の意義を検討した。初発症状は歩行障害、下肢感覚障害、排尿障害の三分類とした。初発症状の出現から車椅子使用レベルである納の運動障害重症度分類(OMDS)で Grade 6 にいたるまでの期間を疾患進行速度の指標とした。検討の結果、初発症状が下肢感覚障害であれ …

    NEUROINFECTION 25(1), 146, 2020

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  • The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos

    Hirata Maki , Wittayarat Manita , Hirano Takayuki , Nguyen Nhien Thi , Le Quynh Anh , Namula Zhao , Fahrudin Mokhamad , Tanihara Fuminori , Otoi Takeshige

    … Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation. …

    Animals 9(9), 593, 2019-08-22

    IR 

  • A screening for DNA damage response molecules that affect HIV-1 infection

    Yoshinaga Noriyoshi , Shindo Keisuke , Matsui Yusuke , Takiuchi Yoko , Fukuda Hirofumi , Nagata Kayoko , Shirakawa Kotaro , Kobayashi Masayuki , Takeda Shunichi , Takaori-Kondo Akifumi

    Host DNA damage response molecules affect retroviral infection, as DNA intermediates of the viruses play essential roles in the viral life cycles. Although several such molecules have been reported, i …

    Biochemical and Biophysical Research Communications 513(1), 93-98, 2019-05-21

    IR 

  • HTLV-1-associated myelopathy  [in Japanese]

    YAMANO Yoshihisa

    HTLV-1関連脊髄症(HAM)は,ヒトT細胞白血病ウイルス1型(HTLV-1)の感染者の一部に発症する神経難病である.HTLV-1はTリンパ球を宿主細胞とするレトロウイルスで,感染者の多くは無症候性キャリアのまま生涯をおくるが,感染者の一部にHAMや成人T細胞白血病リンパ腫(Adult T cell leukemia/lymphoma : ATL)などの重篤な疾患を起こすという特徴をもつ.本稿で …

    Uirusu 69(1), 29-36, 2019

    J-STAGE 

  • Astute strategies of HTLV-1 with driven viral genes  [in Japanese]

    TOYODA Kosuke , YASUNAGA Jun-ichirou , MATSUOKA Masao

    ヒトT細胞白血病ウイルス1型(human T-cell leukemia virus type 1:HTLV-1)はヒトレトロウイルスとして世界で初めて同定され,予後不良な造血器悪性腫瘍である成人T細胞白血病・リンパ腫(adult T-cell leukemia-lymphoma:ATL)の他,HTLV-1関連脊髄症やHTLV-1ブドウ膜炎などの種々の炎症性疾患を引き起こす.HTLV-1は生きた感 …

    Uirusu 69(1), 37-46, 2019

    J-STAGE 

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