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  • Development of Direct Enantioselective Alkynylation of α-Ketoester and α-Ketiminoesters Catalyzed by Phenylbis(oxazoline)Rh(III) Complexes  [in Japanese]

    Morisaki Kazuhiro , Morimoto Hiroyuki , Mashima Kazushi , Ohshima Takashi

    … In this account, we summarized our studies on direct enantioselective alkynylation reaction of α-ketoester and α-ketiminoesters catalyzed by phenylbis(oxazoline)(phebox)-rhodium(III) complexes, affording enantioenriched propargyl alcohols and propargylamines with a tetrasubstituted carbon stereocenter under proton-transfer conditions. …

    Journal of Synthetic Organic Chemistry, Japan 76(3), 226-240, 2018


  • C1- and C2-Symmetric Rh-Phebox-Catalyzed Asymmetric Alkynylation of Keto Ester  [in Japanese]

    Ohshima Takashi , Kawabata Takahito , Takeuchi Yosuke , Morimoto Hiroyuki , Nishiyama Hisao , Mashima Kazushi

    … Here, we report catalytic asymmetric alkynylation of alfa-keto ester with various aryl and alkyl substituted terminal alkynes catalyzed by as little as 3 mol% of C<SUB>1</SUB>-symmetric Rh-Phebox complexes to afford the corresponding propargylic alcohols with greater than 99% ee. … Because acetate ligand on the Rh complex acted as an internal base, the reactions proceeded at rt without any additives. …

    Proceedings of the Symposium on Progress in Organic Reactions and Syntheses 37(0), 1-1, 2011


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