Search Results 1-20 of 1114

  • Efficacy of Oral Care Provided by Interprofessional Collaboration for a Patient with Esophageal Cancer Associated with Post-polio Syndrome during Neoadjuvant Chemotherapy

    Takahashi-Arimasa Keiko , Kohno-Yamanaka Reiko , Soga Yoshihiko , Miura Rumi , Morita Manabu

    … He had poor oral health status and developed oral complications as a side effect of chemotherapy. … However, infection control by oral care provided by an interprofessional collaboration successfully improved his oral hygiene, and his follow-up involved no severe complications. …

    Acta Medica Okayama 73(1), 71-76, 2019-02

    IR  DOI 

  • Kikyo-to vs. Placebo on Sore Throat Associated with Acute Upper Respiratory Tract Infection: A Randomized Controlled Trial

    Ishimaru Naoto , Kinami Saori , Shimokawa Toshio , Kanzawa Yohei

    … No controlled studies have yet demonstrated its effect, however. … Secondary outcomes were the impact of the sore throat on daily life (none, mild, moderate, and severe) at 10 minutes after administration. … Patients reported no side effects. …

    Internal Medicine, 2019


  • Toward Personalized Cancer Therapy with Oral Molecular-targeted Agents  [in Japanese]

    Yamaguchi Hiroaki , Takasaki Shinya , Kikuchi Masafumi , Kawasaki Yoshihide , Arai Yoichi , Mano Nariyasu

    … However, even when treatment is started at the dosage indicated in the medical package insert, we have experienced many cases in which treatment had to be stopped early owing to the occurrence of serious side effects or an insufficient therapeutic effect. … In recent years, a wide range of studies has been conducted on the therapeutic drug monitoring (TDM) of oral molecular-targeted therapeutic agents to prevent serious side effects and maximize the therapeutic effect. …

    YAKUGAKU ZASSHI 139(6), 911-915, 2019


  • A Case of Solitary Fibrous Tumor from the Greater Omentum Presenting with Severe Abdominal Pain Caused by Torsion  [in Japanese]

    Suzuki Yumi , Hiramatsu Kiyoshi , Amemiya Takeshi , Seki Takashi , Arai Toshiyuki

    <p>今回,我々は捻転による腹痛を契機に診断されたまれな大網原発の孤立性線維性腫瘍(solitary fibrous tumor;以下,SFTと略記)の症例を経験したので報告する.症例は45歳の女性で,下腹部痛を主訴に当院を紹介受診した.CTで子宮体部腹側に6.6×5.1 cm大の内部に不均一な造影効果を示す楕円形腫瘤を認め,栄養血管は左胃大網動脈の大網枝と考えられた.大網腫瘍捻転の術 …

    The Japanese Journal of Gastroenterological Surgery 52(5), 263-271, 2019


  • The Role of Community Pharmacists in Proper Use of Efinaconazole Topical Solution in Onychomycosis Treatment  [in Japanese]

    Shinohara Yuki , Tanaka Naoya , Kondo Sumiko , Kato Seiichi , Toyoda Akira , Terado Yasushi , Otuka Yoshitaka , Aoki Kazuhisa , Yajima Takehiko

    <p>要旨:服薬率は治療効果に影響を及ぼす.爪白癬治療において,エフィナコナゾール爪外用液が発売され,内服薬の長期服用,副作用,薬物相互作用の問題点が解消され,アドヒアランス低下を回避できると思われた.しかし,エフィナコナゾール単独群の初回脱落率は45.3%であり,内服薬の併用群5.9%に比べて有意に高かった(<i>p</i>=0.002).また,爪白癬治療指導 …

    The Journal of Community Pharmacy and Pharmaceutical Sciences 11(1), 44-52, 2019


  • Treatment of POEMS syndrome with lenalidomide and dexamethasone  [in Japanese]

    GOTO Akari , MURASE Kazuyuki , TAKADA Kohichi , KATO Junji , KOBUNE Masayoshi , IYAMA Satoshi , SUGAMA Yusuke , YOSHIDA Masahiro , IBATA Soshi , TATEKOSHI Ayumi , FUJITA Chisa , KIKUCHI Shohei , IKEDA Hiroshi

    <p>POEMS症候群に対してlenalidomide(Len)-dexamethasone(Dex)(Ld)療法を施行した3例を報告する。症例は,69歳女性,51歳男性,59歳男性の3例で,末梢神経障害を主訴に受診した。全例でvascular endothelial growth factor(VEGF)の異常高値を認めた。重篤な末梢神経障害を有することから,神経毒性の少ないLd療法 …

    Rinsho Ketsueki 60(4), 308-313, 2019


  • Dimethyl fumarate ameliorates cisplatin-induced renal tubulointerstitial lesions

    Sasaki Ayaka , Koike Natsumi , Murakami Tomoaki , Suzuki Kazuhiko

    … Dimethyl fumarate (DMF) has an antioxidant effect by activating the nuclear factor erythroid 2-related transcription factor 2 (Nrf2). … Cisplatin (CIS) has nephrotoxicity as a frequently associated side effect that is mainly mediated by oxidative stress. …

    Journal of Toxicologic Pathology 32(2), 79-89, 2019


  • Proton-pump Inhibitor-induced Severe Hypomagnesemia and Hypocalcemia are Clinically Masked by Thiazide Diuretic

    Uehara Atsuko , Kita Yohei , Sumi Hirofumi , Shibagaki Yugo

    … <p>Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. …

    Internal Medicine, 2019



    Kondo Tetsuri , Tanigaki Toshimori , Hibino Makoto , Tajiri Sakurako , Horiuchi Shigeru , Fukuda Minoru , Ohbayashi Hiroyuki

    <p>【背景】エリプタ(EPT),ディスカス(DKS),タービュヘイラー(TBH)は側孔を塞がない指導がされるが,その妥当性は不明である.</p><p>【方法】シミュレーターを用いて側孔閉鎖前後で吸入を行い,最大吸気速度(PIF),最大吸気圧(PIP),放出薬物量を測定した.EPTは実使用に近い不完全閉鎖も行った.</p><p>【結果】側 …

    Japanese Journal of Allergology 68(2), 96-100, 2019

    J-STAGE  Ichushi Web 

  • Effect of combined sublethal X-ray irradiation and cyclosporine A treatment in NOD <i>scid</i> gamma (NSG) mice

    Walcher Lia , Müller Claudia , Hilger Nadja , Kretschmer Anna , Stahl Lilly , Wigge Simone , Rengelshausen Jens , Müller Anne M. , Fricke Stephan

    … GvHD is the most severe side effect of allogeneic HSCT and efficient therapies are lacking. … The effect of CsA (7.5 mg/kg body weight) on sublethally X-ray irradiated (2 Gy) and non-irradiated NSG mice was tested. … Furthermore, combined therapy resulted in severe weight loss (82 ± 6% of initial weight, n=7, day 8), with weight recovery after the CsA application was ceased. …

    Experimental Animals 68(1), 1-11, 2019


  • Sublingual immunotherapy on Japanese cedar pollinosis and mite allergic rhinitis  [in Japanese]

    北村 嘉章

    … Approximately 25% of the Japanese population are affected by Japanese cedar pollinosis and proportion of severe status patients is higher than with grass or ragweed pollinosis, which are the representative condiotions in other countries. … Treatment with SCIT requires special attention because it may cause, as a side effect, anaphylactic shock, which prevents the therapy from becoming popular in Japan. …

    四国医学雑誌 = Shikoku acta medica 74(5・6), 147-152, 2018-12-25


  • Comparison of the effects of polyethylene glycol and hyaluronic acid in prevention of epidural fibrosis

    Karabulut Enis , Karaavci Funda Aksunger , Eroksuz Hatice

    … The aim of this study was to evaluate of the effect of 5% Polyethylene Glycol 4000 in the prevention of epidural fibrosis and to compare the results with hyaluronic acid. … Hemilaminectomy was performed at L5 vertebrae on the right side. … In the hemilaminectomy sites of Group I, severe thickness and tenacious epidural scar adhesions were found between the dura mater and surrounding tissues. …

    Japanese Journal of Veterinary Research 66(3), 133-143, 2018-08

    IR  DOI 

  • Therapeutic effect of hybrid FKO on congenital Mandibular ramus length asymmetric case  [in Japanese]


    … However, in case of congenital facial asymmetry, asymptomatic facial expression becomes severe as a result of only the follow–up observation until the end of the growing period. … Recently, the therapeutic approach has included the use of an asymmetrical FKO (hybrid FKO) tostimulate the growth of the affected side and consequently to improve symmetry of the mandible deficiency. …

    松本歯学 = Journal of the Matsumoto Dental University Society 44(1), 18-30, 2018-06-29

    IR  Ichushi Web 

  • Effects of Cryotherapy on Objective and Subjective Symptoms of Paclitaxel-Induced Neuropathy: Prospective Self-Controlled Trial

    Hanai Akiko , Ishiguro Hiroshi , Sozu Takashi , Tsuda Moe , Yano Ikuko , Nakagawa Takayuki , Imai Satoshi , Hamabe Yoko , Toi Masakazu , Arai Hidenori , Tsuboyama Tadao

    … 2017-10-16.Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting and disabling side effect of taxane anticancer agents. … Methods: Breast cancer patients treated weekly with paclitaxel (80 mg/m2 for one hour) wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion. …

    JNCI: Journal of the National Cancer Institute 110(2), 141-148, 2018-02


  • Occurrence of Drug Eruption following Tigecycline Treatment in a Japanese Patient  [in Japanese]

    Sakakura Kota , Nakakura Ichiro , Imanishi Kaori , Sako Rumi , Doi Toshiyuki , Yamazaki Kunio

    Side effects such as rash, itching, and other severe drug eruption have all been reported outside of Japan; …

    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 44(1), 24-28, 2018

    J-STAGE  Ichushi Web 

  • Insurance coverage for azathioprine to treat of autoimmune hepatitis  [in Japanese]

    Ohira Hiromasa , Tanaka Atsushi

    Side effects of azathioprine include cholestatic hepatitis, pancreatitis, and opportunistic infections. … gene polymorphism, associated with severe leukopenia, has been reported as an adverse effect of azathioprine. …

    Kanzo 59(11), 653-654, 2018


  • <b>Successful Treatment of Painful Trigeminal Neuropathy Caused by a Basilar Artery Aneurysm, Using Combined Analgesic and Kampo Therap</b><b>y</b>  [in Japanese]

    ISHIDA Kazuyuki , SATO Hiroshi

    <p>半夏白朮天麻湯が奏功したpainful trigeminal neuropathy の1例を報告した。症例は76歳女性。脳底動脈の大型脳動脈瘤のため脳幹が圧排され,難治性の顔面痛を呈していた。鎮痛薬としてgabapentin(GPT と略す)がある程度有効であったが,GPT 増量によりふらつきが悪化し,歩行困難となるため,増量は困難であった。GPT に半夏白朮天麻湯を併用した結果 …

    Kampo Medicine 69(2), 145-149, 2018

    J-STAGE  Ichushi Web 

  • Severe heart failure after low-dose doxorubicin administration in a 3-year-old girl with nephroblastoma  [in Japanese]

    Sawada Sari , Uemoto Shinji , Motoyama Hideki , Adachi Souichi , Umeda Katsutsugu , Tanaka Kuniaki , Kato Itaru , Hirata Takuya , Baba Shiro , Hiramatsu Hidefumi , Yoshizawa Atsushi , Okajima Hideaki

    <p>腎芽腫の3歳女児に対してdoxorubicin(DOX)を含む術後化学療法と全腹部照射10.5 Gyを施行した.治療開始25週目(DOX累積投与量116 mg/m<sup>2</sup>)に多呼吸,SpO<sub>2</sub>低下を認め,胸部レントゲンで著明な心拡大と肺門部のうっ血像・胸水貯留,心臓超音波検査で左室駆出率低下(36 …

    The Japanese Journal of Pediatric Hematology / Oncology 55(3), 309-314, 2018

    J-STAGE  Ichushi Web 

  • A case of severe stomatitis associated with pancytopenia that developed during methotrexate therapy for rheumatoid arthritis  [in Japanese]

    SEINO Sayaka , ONO Shigehiro , MURODUMI Hiroshi , SHIMASUE Hiroshi , MIZUTA Kuniko , TAKECHI Masaaki

    … Pancytopenia is an adverse side effect of MTX that is often fatal, while stomatitis is considered a prodromal symptom of pancytopenia. …

    Japanese Journal of Oral and Maxillofacial Surgery 64(8), 497-501, 2018

    J-STAGE  Ichushi Web 

  • Amlodipine induced hepatic enzyme elevation following mitral valve repair in a dog  [in Japanese]

    Takahashi Arane , Takeuchi Sayaka , Uechi Masami

    <p>症例は、フランスのクリニックにて僧帽弁閉鎖不全症を診断され、JASMINEどうぶつ循環器病センターにて僧帽弁修復術(MVR)を受けるために来日した18.5 kg、ハウンド系のミックス犬、11 歳6 ヵ月(初診時)、未去勢雄であった。MVR 後の入院観察中に重度の肝酵素上昇を認めた。術後の合併症として入院中投与薬剤の影響及び血栓塞栓症が鑑別候補として挙がったが、検査の結果としてアム …

    Journal of Veterinary Cardiovascular Medicine 2(1), 13-17, 2018

    J-STAGE  Ichushi Web 

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