Search Results 1-20 of 1619

  • Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis

    Jiang Qing , Qin Xin , Yoshida Carolina Andrea , Komori Hisato , Yamana Kei , Ohba Shinsuke , Hojo Hironori , Croix Brad St. , Kawata-Matsuura Viviane K. S. , Komori Toshihisa

    … In skeletal development, the process of endochondral ossification proceeded similarly in wild-type and Antxr1–/– mice. …

    International Journal of Molecular Sciences 21(7), 2425, 2020-03-31


  • The C-terminal region including the MH6 domain of Msx1 regulates skeletal development

    Ichihara Aki , Yasue Akihiro , Mitsui Silvia Naomi , Arai Daishi , Minegishi Yoshiyuki , Oyadomari Seiichi , Imoto Issei , Tanaka Eiji

    … These findings suggest that the C-terminal region including the MH6 domain of MSX1 plays important roles not only in tooth development and palatal fusion, but also in postnatal bone formation. …

    Biochemical and Biophysical Research Communications 526(1), 62-69, 2020-03-16


  • Retrotransposons Manipulating Mammalian Skeletal Development in Chondrocytes

    Kubota Satoshi , Ishikawa Takanori , Kawata Kazumi , Hattori Takako , Nishida Takashi

    … thus, their contribution to mammalian skeletal evolution and development is also unquestionable. … In mammals, most of the skeletal parts are formed and grown through a process entitled endochondral ossification, in which chondrocytes play central roles. … In this review, current knowledge on the evolutional, physiological, and pathological roles of retrotransposons in mammalian chondrocyte differentiation and cartilage development is summarized. …

    International Journal of Molecular Sciences 21(5), 1564, 2020-02-25


  • Osteochondritis Dissecans of the Capitellum :Review of the Literature

    Matsuura Tetsuya , Iwame Toshiyuki , Iwase Jyoji , Sairyo Koichi

    … Elbow pain and a longer playing history might be related to progression of capitellar OCD but do not in themselves increase the risk of development of the condition. … Treatment has conventionally included both operative and nonoperative measures based on the stage and size of the lesion, skeletal maturity, subjective symptoms, and structural integrity of the cartilage. …

    The Journal of Medical Investigation 67(3.4), 217-221, 2020


  • Mesenchymal Stem Cells Alter the Inflammatory Response of C2C12 Mouse Skeletal Muscle Cells

    Kono Yusuke , Miyamoto Akihiro , Hiraoka Serina , Negoro Ryosuke , Fujita Takuya

    … <p>Mesenchymal stem cells (MSCs) are capable of repairing skeletal muscle <i>via</i> … This regenerative effect of MSCs on skeletal muscle is based on promoting the proliferation and differentiation of myogenic cells and inhibiting the inflammatory response of immune cells. … However, it is unclear whether MSCs affect the inflammatory response of skeletal muscle cells. …

    Biological and Pharmaceutical Bulletin 43(11), 1785-1791, 2020


  • Differences in Breast Muscle Mitochondrial Respiratory Capacity, Reactive Oxygen Species Generation, and Complex Characteristics between 7-week-old Meat- and Laying-type Chickens

    Hakamata Yuki , Toyomizu Masaaki , Kikusato Motoi

    … <p>The skeletal muscle growth rate is a major feature differentiating meat- and laying-type chickens. … A large amount of ATP is required during skeletal muscle synthesis, in which mitochondrial energy production capacities play a significant role. … Furthermore, the lower reactive oxygen species generation rate in meat-type chickens might have implications for rapid muscle development, which is possibly related to their lower muscle protein degradation rates.</p> …

    The Journal of Poultry Science 57(4), 319-327, 2020


  • Castration-Induced Pelvic Floor Muscle Specific Atrophy and the Effect of Voluntary Wheel-Running Exercise  [in Japanese]

    YOSHIOKA Kiyoshi , MATSUMOTO Tomohiro , NAKAMURA Kodai , TSUCHIYA Yoshifumi , SEKO Daiki , KITAJIMA Yasuo , SAWADA Yuichiro , ONO Yusuke

    <p>【目的】アンドロゲン低下による球海綿体筋・肛門挙筋の筋萎縮に対する自走運動の効果を検証し,併せて,アンドロゲン低下による筋萎縮が他の骨盤底の筋にも共通する特徴であるかを検証する。【方法】3 ヵ月齢雄性マウスを対象とし,去勢術を施す群,去勢術後に自走ケージで飼育する群,偽手術群に無作為に分けた。手術から8 週間後に,後肢筋および骨盤底筋の重量,筋線維直径を測定した。【結果】後肢筋の …

    Physical Therapy Japan 47(5), 385-392, 2020


  • Protective effects of low-intensity exercise on metabolic oxidative capacity and capillarization in skeletal muscle of non-obese diabetic rats

    QATAMISH Mohammad A. , AL-NASSAN Saad M. , KONDO Hiroyo , FUJINO Hidemi

    … <p>Diabetes mellitus induces skeletal muscle dysfunction, such as decreased metabolic activity and capillarization. … This study aimed to investigate the effects of aerobic low intensity exercise training on metabolic oxidative capacity and capillarization in skeletal muscle of non-obese diabetic rats. … Sedentary SDT rats resulted in hyperglycemia, reduction of metabolic oxidative enzyme, and low percentage of oxidative fibers in the skeletal muscles. …

    Biomedical Research 41(5), 227-236, 2020


  • Function Integrated Diagnostic Assistance Based on Multidisciplinary Computational Anatomy Models  [in Japanese]

    FUJITA Hiroshi , HARA Takeshi , ZHOU Xiangrong , TERAMOTO Atsushi , KAMIYA Naoki

    <p>本解説では,文部科学省科学研究費補助金新学術領域研究「医用画像に基づく計算解剖学の多元化と高度知能化診断・治療への展開」(略称:多元計算解剖学,2014年度から約5年間実施)における計画班の一つである「多元計算解剖モデルを利用した臓器・組織機能診断支援システム」の開発に関する研究の成果の一部を紹介する.まず,1)多元画像における多臓器・組織の自動検出・セグメンテーション・位置合わ …

    Medical Imaging Technology 38(4), 155-162, 2020


  • Reefal microbial crusts found in Middle Holocene reef from Okinawa Island, the Ryukyu Archipelago

    FUJITA Kazuhiko , SASAKI Toru , KOYANO Sho , CHINEN Masaaki , HONGO Chuki , WEBSTER Jody M. , IRYU Yasufumi

    … <p>Reefal microbial crusts (RMCs) are fine-grained, non-skeletal carbonate crusts coating coralgal reef frameworks, and are locally common in late Quaternary reef deposits. … Here we report the first occurrence of brownish, few-centimeter-thick, fine-grained, non-skeletal crusts in a Middle Holocene reef core recovered at Naha New Port Pier, off the western coast of Okinawa Island, the Ryukyu Archipelago. …

    Galaxea, Journal of Coral Reef Studies 22(1), 9-25, 2020


  • Clinical characteristics of cytochrome P450 oxidoreductase deficiency: a nationwide survey in Japan

    Yatsuga Shuichi , Fujiwara Ikuma , Minamitani Kanshi , Hasegawa Tomonobu , Tajima Toshihiro , Amano Naoko , Nakamura-Utsunomiya Akari , Kobayashi Hironori , Takasawa Kei , Nagasaki Keisuke , Nakamura Akie , Nishigaki Satsuki , Numakura Chikahiko

    … <p>Cytochrome P450 oxidoreductase deficiency (PORD) is a disorder of steroidogenesis that causes various symptoms such as skeletal malformations, disorders of sex development, and adrenal insufficiency. …

    Endocrine Journal 67(8), 853-857, 2020


  • INHAND: International Harmonization of Nomenclature and Diagnostic Criteria for Lesions - an update - 2020  [in Japanese]


    Development of harmonized terminology for each rodent organ system or non-rodent species is the responsibility of the Organ Working Groups (OWG) or Non-rodent Working Groups (NRWG) respectively, drawing upon experts from North America, Europe and Japan.</p><p></p><p>Great progress has been made with 15 rodent organ systems published to date-Respiratory, Hepatobiliary, Urinary, Central/Peripheral Nervous Systems, Male Reproductive and Mammary, Zymbals, Clitoral and Preputial Glands and Hematolymphoid System in Toxicologic Pathology …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-238, 2020


  • Nonheme Iron- and 2-Oxoglutarate-Dependent Dioxygenases in Fungal Meroterpenoid Biosynthesis

    Abe Ikuro

    … This enzyme class activates a selective C–H bond of the substrate and catalyzes a wide range of chemical reactions, from simple hydroxylation to dynamic carbon skeletal rearrangements, thereby significantly contributing to the structural diversification and complexification of the molecules. … Structure–function studies of these enzymes provide an excellent platform for the development of useful biocatalysts for synthetic biology to create novel molecules for future drug discovery.</p> …

    Chemical and Pharmaceutical Bulletin 68(9), 823-831, 2020


  • Zinc-α2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice

    Fan Guoqiang , Li Yanfei , Ma Fuli , Zhao Ruqian , Yang Xiaojing

    … <p>Skeletal muscle is the most abundant tissue in the adult body and plays an essential role in maintaining heat production for the entire body. … We used ZAG knock-out (ZAG KO) and wild-type (WT) mice to investigate the effect of ZAG on the lipid metabolism of skeletal muscle upon exposure to a low temperature (6°C) for one week. … These results indicate that ZAG promotes lipid-related metabolism in the skeletal muscle when the animals are exposed to low temperatures. …

    Endocrine Journal, 2020


  • Preventive effects of medium-chain triglycerides supplementation on the oxidative capacity in skeletal muscle under cachectic condition

    HIRABAYASHI Takumi , TANAKA Minoru , MATSUMOTO Tomohiro , MAESHIGE Noriaki , KONDO Hiroyo , FUJINO Hidemi

    … <p>Cachexia is a multifactorial condition characterized by muscle mass loss and induces metabolic dysfunction of the skeletal muscles. … The preventive effects of medium-chain triglycerides (MCT) supplementation on the oxidative capacity in skeletal muscle under cachectic condition were investigated in the present study. …

    Biomedical Research 41(4), 179-186, 2020


  • Molecular network regulating development and homeostasis of musculoskeletal system  [in Japanese]

    Asahara Hiroshi

    … <p>筋・腱・骨格・関節の形態形成と恒常性を理解するため(Hum Mol Genet 2015, PloS Genet 2016, Sci Rep 2017)、転写因子の発現データベースEMBRYSを作成(Dev Cell 2009)、腱の転写因子Mkxを同定し(PNAS 2010)、その生理学的な機能を解明した(PNAS 2016, Nat Commun 2016, Mol Cell Biol 2016, Development 2017, Nat Rev Rheumatol 2020)。 …

    Transactions of Japanese Society for Medical and Biological Engineering Annual58(Abstract), 181-181, 2020


  • Mechano-protective roles of sugar chain in skeletal muscle  [in Japanese]

    Kanagawa Motoi

    <p> 骨格筋は絶えず筋収縮というメカニカルストレスにさらされる組織であり、それゆえに機械的な細胞障害や運動負荷に適応すべき仕組みを備える必要がある。細胞外マトリクス受容体であるジストログリカンは、基底膜と細胞骨格を結ぶ分子で、糖鎖修飾がマトリクス結合活性に必須とされる。糖鎖の異常は筋ジストロフィーなどヒト疾患につながることが知られている。我々は、ジストログリカンに修飾される糖鎖の中か …

    Transactions of Japanese Society for Medical and Biological Engineering Annual58(Abstract), 197-197, 2020


  • Transcription of Endogenous Retrovirus Group K Members and Their Neighboring Genes in Chicken Skeletal Muscle Myoblasts

    Takaya Tomohide , Nihashi Yuma , Ono Tamao , Kagami Hiroshi

    … <p>Skeletal muscle myoblasts are myogenic precursor cells that generate myofibers during muscle development and growth. …

    The Journal of Poultry Science, 2020


  • Recent progress in and future perspectives on orthodontic materials  [in Japanese]

    IIJIMA Masahiro , KAWAMURA Naohiko , ENAMI Yumiko

    <p>Dr. E. Angleによって考案されたマルチブラケット装置は,これまでの約100年間で,原材料,デザインおよび適用方法について進化を遂げてきた.本装置による治療では,エナメル質の脱灰を防ぐためにフッ化物等が添加されたブラケット用接着材料やエラスティックリガチャーが用いられるが,それらの臨床的有効性については不明な点が多い.近年の歯科矯正治療では,アンカースクリューやミニプレー …



  • Circadian rhythms and exercise/physical activity  [in Japanese]

    Takahashi Masaki , Aoyama Shinya

    … These functions are controlled by circadian clock genes, and the circadian clock system in the body is classified into two clocks which are the central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks in peripheral tissues such as the liver and skeletal muscle. … On the other hand, it has been shown that abnormal circadian rhythms and disturbance of circadian rhythms can lead to the development of several diseases such as diabetes, cancer, sarcopenia, depression, and dementia. …

    Japanese Journal of Physical Fitness and Sports Medicine 69(4), 351-358, 2020


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