Search Results 1-20 of 113

  • Dexmedetomidine Protects SK-N-SH Nerve Cells from Oxidative Injury by Maintaining Iron Homeostasis

    Qiu Lingqin , Ge Li , Hu Qionghua

    … Dexmedetomidine (Dex), an extensively used anesthetic, has neuroprotective effects against ROS, but its effect on iron metabolism remains unknown. … <i>t</i>-BHP increased the phosphorylation of c-Jun N-terminal kinase (JNK) and signal transducer and activator of transcription 4 (STAT4), the primary up-stream activators of SP-1, but Dex decreased this. … Dex regulates iron metabolism by regulating iron importers and exporters through JNK/Sp1 and Stat4/Sp1 signaling. …

    Biological and Pharmaceutical Bulletin 43(3), 424-431, 2020

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  • The Purpose and Importance of Air Shots in Self-injection Device for Insulin  [in Japanese]

    Asakura Toshinari , Kondo Takuma , Inagaki Mieko , Kitaoka Masafumi

    <p>インスリンペン型注入器(以下,注入器)は,注射直前に空打ちを行うのが基本である.空打ちには「事前の作動調整・確認」と「薬液排出の確認」の目的がある.「事前の作動調整・確認」のための空打ちは,原則として全ての注入器で行う.「薬液排出の確認」のための空打ちは,投与量の微量調節が必要なインスリンでは行うが,GLP-1受容体作動薬では必ずしも要求されない.空打ちのための薬液排出量には,患 …

    Japanese Journal of Pharmaceutical and Diabetes 8(1), 112-120, 2019

    J-STAGE  Ichushi Web 

  • Does homogenisation of stream bed sediment samples influence their respiration?

    Mendoza-Lera Clara

    Limnology 19(2), 165-169, 2018-04

  • Long-Term Cultivation and Metagenomics Reveal Ecophysiology of Previously Uncultivated Thermophiles Involved in Biogeochemical Nitrogen Cycle

    Kato Shingo , Sakai Sanae , Hirai Miho , Tasumi Eiji , Nishizawa Manabu , Suzuki Katsuhiko , Takai Ken

    … In the present study, we performed long-term continuous cultivation at 65°C and 70°C using a microbial mat sample, collected from a subsurface geothermal stream, as the inoculum, and reconstructed the whole genome of the maintained populations using metagenomics. … Some metagenome-assembled genomes (MAGs), affiliated into phylum-level bacterial and archaeal clades without cultivated representatives, contained genes involved in nitrogen metabolism including nitrification and denitrification. …

    Microbes and Environments 33(1), 107-110, 2018

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  • EFFECTS OF INTAKING WATER DUE TO RUN OF RIVER HYDROPOWER SYSTEMS ON DYNAMICS OF METABOLISM IN MOUNTANEOUS STREAM  [in Japanese]

    田代 喬 , 松谷 隆佑 , 戸田 祐嗣

    水工学論文集 Annual journal of Hydraulic Engineering, JSCE 61, Ⅰ_1123-1128, 2017

  • The study of ghrelin secretion and acyl-modification using mice and ghrelinoma cell lines

    Sakata Ichiro , Gong Zhi , Ikenoya Chika , Takemi Shota , Sakai Takafumi

    … Ghrelin cells are known to be abundantly localized in the gastric mucosa and are released into the blood stream to exert their multifunctional physiological effects. … Furthermore, we recently revealed that the genes involved in fatty acid synthesis and long chain fatty acid metabolism were expressed in ghrelin cells, and that CPT-1 inhibitor treatment dramatically decreased the levels of acyl-modified ghrelin. …

    Endocrine Journal 64(Suppl.), S27-S29, 2017

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  • EFFECTS OF INTAKING WATER DUE TO RUN OF RIVER HYDROPOWER SYSTEMS ON DYANAMICS OF METANBOLISM IN MOUNTANEOUS STREAM  [in Japanese]

    TASHIRO Takashi , MATSUTANI Ryusuke , TODA Yuji

    本研究では,Odumによる溶存酸素の収支を利用した河川生態系の代謝構造モデルを援用し,流れ込み式発電システムを有する山地渓流の代謝動態を記述することを目的とした.夏季から冬季にわたる長期の溶存酸素濃度の連続観測により,取水堰堤上下流における群集呼吸速度,付着藻類による一次生産速度を比較・考察する一方,水位・水質変動の同時期記録を用いて現象記述を試みた.<br> 上下流に位置する2つの取 …

    Journal of Japan Society of Civil Engineers, Ser. B1 (Hydraulic Engineering) 73(4), I_1123-I_1128, 2017

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  • Significant Association of Serum Adiponectin and Creatine Kinase-MB Levels in ST-Segment Elevation Myocardial Infarction

    Natsukawa Tomoaki , Hayashi Yasuyuki , Funahashi Tohru , Kai Tatsuro , Shimomura Iichiro , Maeda Norikazu , Fukuda Shiro , Yamaoka Masaya , Fujishima Yuya , Nagao Hirofumi , Sato Fumi , Nishizawa Hitoshi , Sawano Hirotaka

    … <p><i><b>Aims</b></i>: Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. …

    Journal of Atherosclerosis and Thrombosis 24(8), 793-803, 2017

    J-STAGE  Ichushi Web 

  • ATMOSPHERIC CONDITIONS, LANDSCAPE CHARACTERISTICS, AND ANTHROPOGENIC FACTORS AFFECTING STREAM WATER TEMPERATURE

    Wu Weijun , Yoshiyama Kohei , Senge Masateru

    … <p>Stream water temperature is a dominant parameter of stream ecosystems, which affects water quality and biogeochemical processes, as well as the growth, metabolism, and behavior of the resident organisms. … Because of growing concern regarding global warming and the impact of anthropogenic activities on the environment, recent intensive research has been conducted to elucidate the factors that control stream water temperature. …

    Reviews in Agricultural Science 3(0), 46-53, 2015

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  • IMPACT OF INTAKING WATER DUE TO RUN-OF-RIVER HYDROPOWER DAM IN THE MOUNTAINOUS STREAM: EVALUATION OF ECOSYSTEM METABOLISM WITH COUTINUOUS MEASUREMENT OF DISSOLVED OXYGEN CONCENTRATION  [in Japanese]

    TASHIRO Takashi , KATAOKA Teruyuki , SUKUKA Jetmir , TSUJIMOTO Tetsuro

    … The concepts of stream metabolism were adopted to clarify the impacts of run-of-river hydropower system on the stream ecosystem. …

    Journal of Japan Society of Civil Engineers, Ser. B1 (Hydraulic Engineering) 71(4), I_1129-I_1134, 2015

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  • Effect of methotrexate on rostral migratory stream in newborn rats

    HIRAKO Ayano , SUN Jin , FURUKAWA Satoshi , TAKEUCHI Takashi , SUGIYAMA Akihiko

    … To our knowledge, this is the first report demonstrating the effect of MTX on the RMS and the necessity of the folic acid metabolism on RMS development in newborn rats. …

    Journal of Veterinary Medical Science 77(12), 1565-1571, 2015

    J-STAGE  Ichushi Web 

  • Novel mechanism for invasion and metastasis involving metabolic enzymes in intractable cancer cells  [in Japanese]

    KONNO Masamitsu , HAMABE Atsushi , DOKI Yuichiro , MORI Masaki , ISHII Hideshi

    がん細胞も正常細胞の派生であると大きくは捉えられるが,その代謝は大きく異なっていることが指摘されている。その1つがWarbarg効果である。このような嫌気性解糖と固形がんの悪性度の根源とも言えるがん転移現象との関わりは十分には解明されてない。本研究では,生化学的なアプローチによりWarbarg効果の鍵酵素とがん転移との関連性につき,若干の知見を得たので最近の報告を踏まえて概説する。

    Rinsho Ketsueki 56(8), 1059-1063, 2015

    J-STAGE  Ichushi Web 

  • Effect of a Humus Soil Side-Stream Reactor (HSR) on the Bacterial Characteristics in Enhanced Biological Phosphorus Removal Process

    Wu Min , Zhu Rui , Ma HuiRong , Zhu Heguang , Dai Xiaohu , Yang Jian

    … Three enhanced phosphorus removal processes, each with a sequencing batch reactor (SBR), one with a humus soil side-stream reactor, one with an anaerobic side-stream reactor, and one without a side stream reactor (used as a conventional SBR process), designated as HS-SBR, A-SBR, and C-SBR, respectively, were operated and compared for the treatment of municipal sewage in laboratory scale. …

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 48(6), 498-505, 2015

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  • Catheter-Related Blood Stream Infection (CRBSI)に対する 中心静脈カテーテルエタノールロック療法(CVC-ELT)の展望  [in Japanese]

    日本小児外科代謝研究会 中心静脈カテーテルエタノールロック療法ワーキンググループ , Kuroda Tatsuo , Fukumoto Koji , Yamane Yusuke , YOSHINO Hiroaki , Hebiguchi Tatsuzo , Toki Akira , Yonekura Takeo , KAJI Tatsuru , Chiba Masahiro , Amae Shintaro , Tazuke Yuko , Owari Mitsugu , Obana Kazuko , Nakano Miwako

    The Japanese Journal of SURGICAL METABOLISM and NUTRITION 49(1), 17-26, 2015

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  • Transcriptional Regulation of Vasopressin Gene: Update in 2015

    IWASAKI Yasumasa , ITOI Keiichi

    Arginine vasopressin (AVP) is expressed in discrete regions of a mammalian brain, and is involved in various physiological functions including the maintenance of body fluid osmolality, regulation of t …

    Interdisciplinary Information Sciences 21(3), 267-272, 2015

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  • Home Parenteral Nutrition Therapy in Seven Patients with Anorexia Nervosa: The Role and Indications

    Hotta Mari , Araki Mariko , Urano Ayako , Ohwada Rina

    Home parenteral nutrition (HPN) is a well-established intervention to sustain life in malnourished patients at home. Because it is difficult for patients with anorexia nervosa (AN) to gain weight or s …

    Internal Medicine 53(23), 2695-2699, 2014

    J-STAGE  Ichushi Web 

  • Expression Quantitative Trait Loci Analysis of Carotenoid Metabolism-related Genes in Citrus

    Sugiyama Aiko , Omura Mitsuo , Shimada Takehiko , Fujii Hiroshi , Endo Tomoko , Shimizu Tokurou , Nesumi Hirohisa , Nonaka Keisuke , Ikoma Yoshinori

    カンキツの育種において,カロテノイド代謝酵素遺伝子の発現プロファイルはカロテノイドの含有量と組成を制御する重要な要因の一つである.これらカロテノイド代謝経路に関与する遺伝子の制御因子を明らかにするため,交雑集団を用いて eQTL 解析を行った.この交雑集団において,フィトエン合成酵素(<i>PSY</i>),フィトエン不飽和化酵素(<i>PDS</i> …

    Journal of the Japanese Society for Horticultural Science 83(1), 32-43, 2014

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  • Imidacloprid, a neonicotinoid insecticide, induces insulin resistance

    KIM Jonggun , PARK Yooheon , YOON Kyong Sup Yoon , CLARK J.Marshall , PARK Yeonhwa

    … Thus, the purpose of the study was to determine effects of imidacloprid, a neonicotinoid insecticide, on glucose metabolism. … These results suggest that imidacloprid could induce insulin resistance by affecting the insulin signaling cascade, particularly up-stream of AKT, in adipocytes, liver, and muscle. …

    The Journal of Toxicological Sciences 38(5), 655-660, 2013-10-01

    J-STAGE  Ichushi Web  References (46)

  • Decreased fasting blood glucose is associated with impaired hepatic glucose production in thyroid-stimulating hormone receptor knockout mice

    WANG Tingting , XU Jin , BO Tao , ZHOU Xiaoming , JIANG Xiuyun , GAO Ling , ZHAO Jiajun

    … These findings implied a possible role for TSH in hepatic glucose metabolism. … deletion on hepatic glucose metabolism, and investigated whether the effects of TSH directly regulate hepatic gluconeogenesis in HepG2 cells. … deletion inhibited the protein expression of hepatic phospho-CREB and increased the protein expression of hepatic phospho-AMP-activated protein kinase (p-AMPK), two up-stream regulators of PEPCK and G6P mRNA. …

    Endocrine Journal 60(8), 941-950, 2013-08-01

    J-STAGE  Ichushi Web  References (32)

  • Oxidative Stress and Periodontitis  [in Japanese]

    玉木 直文 , 伊藤 博夫

    … ROS are products of normal cellular metabolism; … When periodontitis develop, ROS produced in the periodontal lesion diffuse into the blood stream, resulting in the oxidation of circulating oxidative stress. …

    四国歯学会雑誌 25(2), 93-99, 2013-01-31

    IR  Ichushi Web 

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