CiNii Articles - Structural biology

1

Solution structure of multi-domain protein ER-60 studied by aggregation-free SAXS and coarse-grained-MD simulation

Okuda Aya , Shimizu Masahiro , Morishima Ken , Inoue Rintaro , Sato Nobuhiro , Urade Reiko , Sugiyama Masaaki

… Furthermore, structural modelling with coarse-grained molecular dynamics simulation indicated that the distance between the two edge domains of oxidized ER-60 is longer than that of reduced ER-60. …

Scientific Reports (11), 2021-03-11

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2

Recent structural insights into the mechanism of lysozyme hydrolysis

Tanaka Ichiro , Nishinomiya Ryota , Goto Ryosuke , Shimazaki Shun , Chatake Toshiyuki

… More recently, high-resolution X-ray structural analysis was used to study the complex of lysozyme with an N-acetylglucosamine tetramer. …

Acta Crystallographica Section D Structural Biology 77(3), 288-292, 2021-03

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3

Laboratory of Protein Structural Biology [in Japanese]

津下英明 , 吉田徹

京都産業大学タンパク質動態研究所年報 = Institute for Protein Dynamics Kyoto Sangyo University (2019年), 53-57, 2021-01-28

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4

ZP4 Is Present in Murine Zona Pellucida and Is Not Responsible for the Specific Gamete Interaction

Mª José Izquierdo-Rico , Carla Moros-Nicolás , Míriam Pérez-Crespo , Ricardo Laguna-Barraza , Alfonso Gutiérrez-Adán , Frédéric Veyrunes , José Ballesta , Vincent Laudet , Pascale Chevret , Manuel Avilés

… This study identifies the existence of several mouse species with four ZPs that can be considered suitable for use as an experimental animal model to understand the structural and functional roles of the four ZP proteins in other species, including human. …

Frontiers in Cell and Developmental Biology (8), 626679, 2021-01-18

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5

Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants

Jin Shuyu , Vu Hue Thi , Hioki Kou , Noda Naotaka , Yoshida Hiroki , Shimane Toru , Ishizuka Shigenari , Takashima Ippei , Mizuhata Yoshiyuki , Pe Kathleen Beverly , Ogawa Tetsuya , Nishimura Naoya , Packwood Daniel , Tokitoh Norihiro , Kurata Hiroki , Yamasaki Sho , Ishii Ken J , Uesugi Motonari

自己集合性ワクチンアジュバントの発見. 京都大学プレスリリース. 2020-10-07.Vaccine ingredients could be hiding in small molecule libraries. 京都大学プレスリリース. 2020-10-07.

Angewandte Chemie International Edition 60(2), 961-969, 2021-01-11

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6

Synthetic Biology Based Construction of Fungal Diterpenoid Pyrone Library [in Japanese]

Asai Teigo

… A synthetic biology method based on heterologous biosynthesis coupled with genome mining is a promising approach to translate tremendous amount of genomic information to richly diverse natural products in the post-genomic era. … In addition, this approach increases the opportunities to rationally access not only novel skeletal natural products but also new structural analogues of bioactive natural products. …

Journal of Synthetic Organic Chemistry, Japan 79(4), 322-332, 2021

J-STAGE
7

Bioinformatics analysis of dysregulated exosomal microRNAs derived from oral squamous cell carcinoma cells

Masaoka Tadashi , Shinozuka Keiji , Ohara Kenshin , Tsuda Hiromasa , Imai Kenichi , Tonogi Morio

Purpose: The present study aimed to identify dysregulated exosomal miRNAs associated with diagnostic and therapeutic biomarkers in oral squamous cell carcinoma (OSCC).</ …

Journal of Oral Science 63(2), 174-178, 2021

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8

The use of micro-computed tomography to determine the accuracy of electronic working length with two apex locators

Suguro Hisashi , Nishihara Anna , Tamura Takahito , Nakamura Takeshi , Toyama Yurika , Takeichi Osamu

Purpose: This study evaluated the precision of electronic working length by microcomputed tomography using two electronic apex locators (EALs).M …

Journal of Oral Science 63(2), 167-169, 2021

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9

The Topological Distribution of the Chromocenter in Panstrongylus megistus (Burmeister) Malpighian Tubule Cells Examined by Confocal Microscopy

Imperador Carlos Henrique L. , Rodrigues Vera L. C. C. , Mello Maria Luiza S.

… Despite the differences in chromocenter composition, structural pattern, and size between P. …

CYTOLOGIA 86(1), 47-54, 2021

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10

The structural basis of class B GPCR activation and signalling [in Japanese]

Wootten Denise

… Combining novel structural information with molecular pharmacology, biophysical studies and molecular dynamics simulations, we are gaining substantial insights into how ligands and accessory proteins interact with this receptor family to facilitate G protein coupling and downstream signaling. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-JAL, 2021

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11

Quantitative evaluation of PTPN22 copy number variation by digital droplet PCR and association with type 2 diabetes risk

Li Jiajun , Wang Yue , Zheng Xiao , Sheng Jie , Guo Hui , Long Wenlin , Xu Yao

… Structural alteration in genome, that is, copy number variation (CNV) is emerging as the inherent marker for disease identification. …

Endocrine Journal 68(2), 153-162, 2021

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12

Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP

Browning Christopher , McEwen Alastair G. , Mori Kotaro , Yokoi Taiyo , Moras Dino , Nakagawa Yoshiaki , Billas Isabelle M. L.

The ecdysone receptor (EcR) possesses the remarkable capacity to adapt structurally to different types of ligands. EcR binds ecdysteroids, including 20-hydroxyecdysone (20E), as well as nonst …

Journal of Pesticide Science 46(1), 88-100, 2021

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13

Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo

Koiwai Kotaro , Fujikawa Yuuta , Inoue Hideshi , Yumoto Fumiaki , Senda Toshiya , Niwa Ryusuke , Morohashi Kana , Inaba Kazue , Ebihara Kana , Kojima Hirotatsu , Okabe Takayoshi , Yoshino Ryunosuke , Hirokawa Takatsugu , Nampo Taiki

… However, to develop IGRs with a greater Nobo inhibitory activity than 17β-estradiol, further structural information is warranted. …

Journal of Pesticide Science 46(1), 75-87, 2021

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14

Microstructural Properties and Surface Properties of a New Resin Composite Employing Structural Color Technology

Maesako Mayumi , Kishimoto Takafumi , Horie Taku , Suzuki Miki , Inoue Kazuho , Mizuno Ayaka , Tomoda Shigetaka , Fujitani Morioki

… Our aim was to identify factors that affect the matching of various shades of teeth using structural color technology. … The effect of these structural properties on the surface properties of the resin composite was also investigated. … We found that the structural properties of the new composite included a wide distribution of many spherical organic fillers of various sizes. …

Journal of Hard Tissue Biology 30(1), 7-12, 2021

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15

Lipopolysaccharide and High Concentrations of Glucose Enhances Zoledronate-induced Increase in RANKL/OPG Ratio by Upregulating PGE2 Production in Osteoblasts

Nagasaki Maki , Tonogi Morio , Nakai Kumiko , Tanaka Hideki , Ozaki Manami , Kato Kengo , Koshi Ryosuke , Maeno Masao , Nishikubo Shuichi , Kawato Takayuki

Preexisting diseases, such as diabetes and chronic inflammation in periodontal tissue, are risk factors associated with bisphosphonate-related osteonecrosis of the jaw. Osteoblasts produce pr …

Journal of Hard Tissue Biology 30(1), 37-44, 2021

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16

Development of Biological Response Modifiers Based on Unique Medicinal Chemical Strategy [in Japanese]

Hashimoto Yuichi

… Chemical biology and structural development studies performed at The University of Tokyo during 1977-2020 are outlined chronologically. …

YAKUGAKU ZASSHI 141(1), 1-13, 2021

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17

Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone

Im Dohyun , Inoue Asuka , Fujiwara Takaaki , Nakane Takanori , Yamanaka Yasuaki , Uemura Tomoko , Mori Chihiro , Shiimura Yuki , Kimura Terakado Kanako , Asada Hidetsugu , Nomura Norimichi , Tanaka Tomoyuki , Yamashita Ayumi , Nango Eriko , Tono Kensuke , Kadji Francois Marie Ngako , Aoki Junken , Iwata So , Shimamura Tatsuro

統合失調症に関わるドパミン受容体の構造解明 --副作用を抑えた薬の迅速な探索・設計が可能に--. 京都大学プレスリリース. 2020-12-24.

Nature Communications (11), 2020-12-22

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18

Organelle membrane-specific chemical labeling and dynamic imaging in living cells

Tamura Tomonori , Fujisawa Alma , Tsuchiya Masaki , Shen Yuying , Nagao Kohjiro , Kawano Shin , Tamura Yasushi , Endo Toshiya , Umeda Masato , Hamachi Itaru

狙った細胞内小器官脂質の可視化に成功 --オートファゴソーム形成機構解明に貢献--. 京都大学プレスリリース. 2020-09-28.

Nature Chemical Biology 16(12), 1361-1367, 2020-12

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19

High-Throughput Analysis and Engineering of Ribozymes and Deoxyribozymes by Sequencing

Yohei Yokobayashi

… On the practical side, catalytic nucleic acids have been extensively engineered for various applications, such as biosensors and genetic devices for synthetic biology. … Furthermore, these newly available data are motivating researchers to employ more rigorous computational methods to extract additional insights such as structural information and nonlinear effects of multiple mutations. …

Accounts of Chemical Research 53(12), 2903-2912, 2020-11-09

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20

Involvement of the transcription factor E75 in adult cuticular formation in the red flour beetle Tribolium castaneum

Sapin Gelyn D. , Tomoda Kai , Tanaka Sayumi , Shinoda Tetsuro , Miura Ken , Minakuchi Chieka

ファイル公開：2021-11-01

Insect Biochemistry and Molecular Biology (126), 103450, 2020-11

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