Search Results 1-20 of 221

  • Toll -like receptor ligand-dependent inflammatory responses in chick skeletal muscle myoblasts

    Nihashi Yuma , Ono Tamao , Kagami Hiroshi , Takaya Tomohide

    … Epub 2018 Oct 30Toll-like receptors (TLRs) are a group of sensory receptors which are capable of recognizing a microbial invasion and activating innate immune system responses, including inflammatory responses, in both immune and non immune cells. …

    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (91), 115-122, 2019-02

    IR 

  • Effects of <i>Salmonella enteritidis</i> Vaccination on the Expression of Innate Immune Molecules and Histone Modifications in the Follicular Theca of Laying Hens

    Kang Ye , Nii Takahiro , Isobe Naoki , Yoshimura Yukinori

    … Gene expression levels of immune molecules (Toll-like receptors [TLRs], cytokines, and avian β-defensins [AvBDs]), and histone modifications in the follicular thecal tissues, were examined using real-time PCR and western blot, respectively. …

    The Journal of Poultry Science, 2019

    J-STAGE 

  • Toll-like receptor homolog TOL-1 regulates <i>Bifidobacterium infantis</i>–elicited longevity and behavior in <i>Caenorhabditis elegans</i>

    SUN Simo , MIZUNO Yasuko , KOMURA Tomomi , NISHIKAWA Yoshikazu , KAGE-NAKADAI Eriko

    … homolog of Toll-like receptors (TLRs). …

    Bioscience of Microbiota, Food and Health, 2019

    J-STAGE 

  • Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia

    Nishimoto Sachiko , Aini Kunduziayi , Fukuda Daiju , Higashikuni Yasutomi , Tanaka Kimie , Hirata Yoichiro , Yagi Shusuke , Kusunose Kenya , Yamada Hirotsugu , Soeki Takeshi , Shimabukuro Michio , Sata Masataka

    … Ischemic tissue injury releases various endogenous ligands for Toll-like receptors (TLRs), suggesting the involvement of TLRs in blood flow recovery. …

    Frontiers in Cardiovascular Medicine (5), 144, 2018-10-16

    IR 

  • The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation

    Nie Xiang , Kitaoka Shiho , Tanaka Kohei , Segi-Nishida Eri , Imoto Yuki , Ogawa Atsubumi , Nakano Fumitake , Tomohiro Ayaka , Nakayama Kazuki , Taniguchi Masayuki , Mimori-Kiyosue Yuko , Kakizuka Akira , Narumiya Shuh , Furuyashiki Tomoyuki

    … Innate immune receptors, such as Toll-like receptors (TLRs), are activated by exogenous or endogenous ligands to evoke inflammation. …

    Neuron 99(3), 464-479e7, 2018-08-08

    IR 

  • Nucleic acid-sensing TLRs are the efficacious targets for disease treatment by the antibody drug  [in Japanese]

    村上 祐輔

    医学のあゆみ 265(13), 1263-1270, 2018-06-30

    Ichushi Web 

  • Structures and ligand recognition mechanism of TLRs  [in Japanese]

    大戸 梅治

    医学のあゆみ 265(13), 1061-1066, 2018-06-30

    Ichushi Web 

  • Ecrg4 peptide is the ligand of multiple scavenger receptors

    Moriguchi Tetsuo , Takeda Shuji , Iwashita Shinzo , Enomoto Kei , Sawamura Tatsuya , Koshimizu Uichi , Kondo Toru

    … This activation was dependent on MyD88, an adaptor protein that recruits signalling proteins to Toll-like receptors (TLRs), with the consequent induction of various immune responses. … These data suggest that multiple scavenger receptors recognise Ecrg4(71-132) and transduce its signals, together with TLRs, in microglia. …

    Scientific reports 8, 4048, 2018-03-06

    IR  DOI 

  • The study on structure-activity relationship of pyrimidoindoles TLR4 ligands  [in Japanese]

    Oyama Shin-ya , B. Cottam Howard , A. Carson Dennis , Suda Yasuo , Wakao Masahiro , Ahmadiiveli Alast , Kakitsubata Yuhei , Yamaguchi Toru , Shinchi Hiroyuki , Chan Michael , M. Shukla Nikunj , Hayashi Tomoko

    … <p> Toll-like receptors (TLRs) are a family of type Ⅰ membrane proteins, classified to pattern recognition receptors (PRR). … TLRs are expressed in cell surface or endosomal compartment of immune cells. … TLRs are activated by recognition of pathogen specific components called pathogen-associated molecular patterns (PAMPs). … Signal of TLRs induces the innate immune response and adaptive immune response. …

    Endotoxin and Innate Immunity 21(0), 42-46, 2018

    J-STAGE  Ichushi Web 

  • TLR-regulatory system of C4b-binding protein (C4BP)  [in Japanese]

    Akashi-Takamura Sachiko , Yamazaki Tatsuya , Morita Naoko

    … These findings indicate that C4BP binds to TLRs on the cell surface and inhibits the interaction between TLRs and the ligands, followed by inhibition of TLR activation.</p><p> Here we explain the function of C4BP to affect complement and TLR, which is called the two major immune systems. …

    Endotoxin and Innate Immunity 21(0), 47-50, 2018

    J-STAGE  Ichushi Web 

  • Regulation of Toll-like receptor signal transduction by Rho guanine nucleotide exchange factors  [in Japanese]

    Hayami Ryo , Sugiyama Tsuyoshi

    … <p> Toll-like receptors (TLRs) trigger innate immune responses by recognizing microbe-associated molecular patterns such as lipopolysaccharides and nucleic acids. … In this review, we will focus on RhoGEFs which affect TLR signal transduction, and further we will discuss about the mechanisms of the cross-talk between TLRs and RhoGEFs. … Future interests in this research field include establishing mechanistic understanding of TLRs and RhoGEFs cross-talk. …

    Endotoxin and Innate Immunity 21(0), 38-41, 2018

    J-STAGE  Ichushi Web 

  • Toll-like receptor (TLR) localization and activation  [in Japanese]

    Saitoh Shin-Ichiroh

    … The other is nucleic acid-sensing TLRs, which localize in endosome or lysosome in immune cells to recognize viral and bacterial nucleic acids. …

    Endotoxin and Innate Immunity 21(0), 1-6, 2018

    J-STAGE  Ichushi Web 

  • Sperm enter bovine uterine glands <i>ex-vivo</i> and initiate a pro-inflammatory response  [in Japanese]

    AKTHAR Ihshan , SUAREZ Susan , MORILLO Vernadyn , EZZ Mohamed , SASAKI Motoki , TAKAHASHI Ken-Ichi , SHIMADA Masayuki , MAREY Mohamed Ali , MIYAMOTO Akio

    … Our BUEC culture model showed that pro-inflammatory response induced by sperm binding involves TLRs signaling pathway <i>via</i> …

    The Journal of Reproduction and Development Supplement 111(0), AW1-2-AW1-2, 2018

    J-STAGE 

  • High-mobility group box1 as an inducer of inflammation in chemical induced rat liver injury  [in Japanese]

    KURAMOCHI Mizuki , IZAWA Takeshi , PERVIN Munmun , KARIM Mohammad Rabiul , KUWAMURA Mitsuru , YAMATE Jyoji

    … <p>【背景・目的】虚血・再灌流による器官障害では,虚血に陥った細胞から放出されるDamage associated molecular patterns(DAMPs)の中でもHigh-mobility group box1 (HMGB1) と,受容体であるToll様受容体(TLRs)や終末糖化産物受容体(RAGE)が炎症を惹起すると考えられている.一方で,薬剤性肝障害におけるDAMPsとその受容体に着目した炎症の進展機序は明らかになっていない.チオアセトアミド(TAA)誘発ラット肝障害モデルを …

    Annual Meeting of the Japanese Society of Toxicology 45.1(0), P-55, 2018

    J-STAGE 

  • Low Molecular-Weight Curdlan, (1→3)-β-Glucan Suppresses TLR2-Induced RANKL-Dependent Bone Resorption

    Aizawa Maki , Watanabe Kenta , Tominari Tsukasa , Matsumoto Chiho , Hirata Michiko , Grundler Florian M. W. , Inada Masaki , Miyaura Chisato

    … Toll-like receptors (TLRs) play critical roles in innate immunity, and various ligands for TLRs are thought to regulate the host defense mechanisms against pathogens. …

    Biological and Pharmaceutical Bulletin 41(8), 1282-1285, 2018

    J-STAGE  Ichushi Web 

  • Microbiome and intestinal ischemia/reperfusion injury

    Nadatani Yuji , Watanabe Toshio , Shimada Sunao , Otani Koji , Tanigawa Tetsuya , Fujiwara Yasuhiro

    … This review focuses on our current understanding of the impact of the microbiome, including the roles of the TLRs, oxidative stress, and nitric oxide, on intestinal ischemia/reperfusion injury.</p> …

    Journal of Clinical Biochemistry and Nutrition 63(1), 26-32, 2018

    J-STAGE  Ichushi Web 

  • Microbiome and intestinal ischemia/reperfusion injury

    Nadatani Yuji , Watanabe Toshio , Shimada Sunao , Otani Koji , Tanigawa Tetsuya , Fujiwara Yasuhiro

    … This review focuses on our current understanding of the impact of the microbiome, including the roles of the TLRs, oxidative stress, and nitric oxide, on intestinal ischemia/reperfusion injury.</p> …

    Journal of Clinical Biochemistry and Nutrition, 2018

    J-STAGE 

  • Effects of TLR Ligands on the Expression of Cytokines and Possible Role of NFκB in its Process in the Theca of Chicken Follicles

    Kang Ye , Nii Takahiro , Isobe Naoki , Yoshimura Yukinori

    … In experiment 1, the expression of TLRs in the theca interna and externa was confirmed using RT-PCR. … TLRs. … The results of experiment 1 revealed that all TLRs, namely TLR1 (type 1 and 2), TLR2 (type 1 and 2), 3-5, 7, 15, and 21, were expressed in the follicular theca, although the PCR products of TLR1 (type 2) and TLR21 were faint. … These results suggest that the innate immune system, including pattern recognition by TLRs and cytokine synthesis, occur in the theca; …

    The Journal of Poultry Science, 2018

    J-STAGE 

  • Toll-Like Receptors 2 and 4 Predict New-Onset Atrial Fibrillation in Acute Myocardial Infarction Patients

    Zhang Ping , Shao Liang , Ma Jun

    … Toll-like receptors (TLRs) have been shown to participate in the process of myocardial infarction as innate immune factors.</p><p>The subjects were divided into 3 groups: healthy controls (<i>n</i> … Western blot was used to analyze PBMC TLRs and their downstream signal protein expression. …

    International Heart Journal 59(1), 64-70, 2018

    J-STAGE  Ichushi Web 

  • The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis

    Moroi Hiroaki , Li Hua , Sumigama Seiji , Yamamoto Eiko , Iwase Akira , Kikkawa Fumitaka , Kotani Tomomi , Miki Rika , Tsuda Hiroyuki , Mizuno Masako , Ito Yumiko , Ushida Takafumi , Imai Kenji , Nakano Tomoko

    … Toll-like receptors (TLRs) have a role in the response of the innate immune system. … The role of TLR5 in chorioamnionitis remains unclear: however, TLR5 was reported to have a significantly stronger effect on the induction of interleukin (IL)-6 when compared with other TLRs in amniotic epithelial cells. …

    Journal of Clinical Biochemistry and Nutrition 62(1), 63-67, 2018

    J-STAGE  Ichushi Web 

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