Search Results 1-20 of 1261

  • Protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes.

    YOSHIBAYASHI Mamoru , KUME Shinji , YASUDA-YAMAHARA Mako , YAMAHARA Kosuke , TAKEDA Naoko , OSAWA Norihisa , Chin-Kanasaki Masami , Nakae Yuki , YOKOI Hideki , MUKOYAMA Masashi , ASANUMA Katsuhiko , MAEGAWA Hiroshi , ARAKI Shin-ichi

    … To examine the cell-protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes, we analyzed the renal phenotype of tamoxifen (TM)-inducible podocyte-specific Atg5-deficient (iPodo-Atg5-/-) mice with experimental endothelial dysfunction. …

    Biochemical and biophysical research communications 525(2), 319-325, 2020-04-30

    IR 

  • Aggravated brain injury after neonatal hypoxic ischemia in microglia-depleted mice.

    TSUJI Shunichiro , DI MARTINO Elena , MUKAI Takeo , TSUJI Shoko , MURAKAMI Takashi , HARRIS Robert A , BLOMGREN Klas , ÅDEN Ulrika

    … RESULTS:At P10, tamoxifen administration induced > 99% microglial depletion in DTA+ mice. …

    Journal of neuroinflammation 17(1), 111, 2020-04-11

    IR 

  • Recurring radiation-induced angiosarcoma of the breast that was treated with paclitaxel chemotherapy: a case report

    Suzuki Yoko , Taniguchi Kohei , Hatono Minami , Kajiwara Yukiko , Abe Yuko , Kawada Kengo , Tsukioki Takahiro , Kochi Mariko , Nishiyama Keiko , Iwamoto Takayuki , Ikeda Hirokuni , Shien Tadahiko , Taira Naruto , Tabata Masahiro , Yanai Hiroyuki , Doihara Hiroyoshi

    … She had a history of right breast cancer and had undergone breast-conserving surgery, RT, and tamoxifen therapy 8 years previously. …

    Surgical Case Reports 6(1), 25, 2020-01-16

    IR 

  • c-MAF deletion in adult C57BL/6J mice induces cataract formation and abnormal differentiation of lens fiber cells

    Fujino Mitsunori , Tagami Asuka , Ojima Masami , Mizuno Seiya , Abdellatif Ahmed M. , Kuno Akihiro , Takahashi Satoru

    … floxed (<i>c-Maf<sup>fl/fl</sup></i>) C57BL/6J mice and established tamoxifen-inducible <i>c-Maf</i> … After tamoxifen injection, adult <i>c-Maf<sup>ΔTAM</sup></i> …

    Experimental Animals 69(2), 242-249, 2020

    J-STAGE 

  • Chicken ovalbumin upstream promoter-transcription factor II protects against cisplatin-induced acute kidney injury

    Ishii Sumiyasu , Yamada Masanobu , Koibuchi Noriyuki

    … Male tamoxifen-inducible <i>COUP-TFII</i>-knockout mice or control mice were intraperitoneally treated with 30 mg/kg body weight of cisplatin at 12 weeks old to induce AKI. …

    Endocrine Journal 67(3), 283-293, 2020

    J-STAGE 

  • The claustrum neuronal ensembles that were activated by social defeat stress mediate anxiety-like behavior through regulating the activation of multiple stress-responsive nuclei  [in Japanese]

    Niu Misaki , Kasai Atsushi , Kuwaki Takahiro , Tanuma Masato , Seiriki Kaoru , Takanobu Nakazawa , Yamanaka Akihiro , Hashimoto Hitoshi

    … We bilaterally co-injected adeno-associated virus vectors expressing the tamoxifen-dependent recombinase <sup>ERT2</sup>Cre<sup>ERT2</sup> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-289, 2020

    J-STAGE 

  • Endothelial LOX-1 plays a critical role in inflammatory thrombosis  [in Japanese]

    Kakino Akemi , Fujita Yoshiko , Sawamura Tatsuya

    … To analyze which tissue is responsible in LOX-1-supported thrombosis, tamoxifen-inducible endothelial cell-specific LOX-1KO mice (EC-LOX-1KO) were generated and employed. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-O-123, 2020

    J-STAGE 

  • Protective role of an NAD<sup>+</sup>-dependent deacetylase SIRT1 in doxorubicin-induced cardiotoxicity.  [in Japanese]

    Tada Kohei , Kuno Atsushi , Hosoda Ryusuke , Horio Yoshiyuki

    …  Here, we investigated whether and how SIRT1 protects the heart from DOX-induced cardiotoxicity in mice.</p><p><b>Methods and Results</b>: Wild type (WT) and tamoxifen-inducible cardiomyocyte-specific SIRT1 knockout (cKO) mice were treated with vehicle (Veh) or DOX (4 IP injections of 5 mg/kg/week) starting at 3 months of age. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-064, 2020

    J-STAGE 

  • Pharmacogenomic–pharmacokinetic study of selective estrogen-receptor modulators with intra-patient dose escalation in breast cancer

    坂東 裕子 , Hiroshi Ishiguro , Shinji Ohno , Yutaka Yamamoto , Shintaro Takao , Nobuaki Sato , Tomomi Fujisawa , Takayuki Kadoya , Katsumasa Kuroi , Hiroko BANDO , Yasufumi Teramura , Hiroji Iwata , Shiro Tanaka , Masakazu Toi

    … BackgroundAn association between CYP2D6 polymorphisms and tamoxifen (TAM) efficacy has not been confirmed, partly due to unreliable prediction of active metabolite exposure solely by CYP2D6 activity. …

    Breast cancer 26(5), 535-543, 2019-09

    IR 

  • Role of PPARG, a Transcriptional Factor on Hypertension  [in Japanese]

    Mukohda Masashi

    … We then generated double transgenic mice (termed S-RhoBTB1) with tamoxifen-inducible, Cre-dependent expression of RhoBTB1 in SMC. … S-RhoBTB1 mice were crossed with S-DN to produce mice (S-DN/S-RhoBTB1) in which tamoxifen-treatment restored RhoBTB1 expression in aorta to normal. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-S30-2, 2019

    J-STAGE 

  • Cardiotoxicity induced by doxorubicin is exacerbated by deletion of SIRT1 in mice.  [in Japanese]

    Kuno Atsushi , Hosoda Ryusuke , Horio Yoshiyuki

    … SIRT1 is an NAD<sup>+</sup>-dependent protein deacetylase that plays a crucial role in cell survival.</p><p><b>Hypothesis</b>: SIRT1 protects against doxorubicin-induced cardiotoxicity.</p><p><b>Methods and Results</b>: In wild type (WT) and tamoxifen-inducible cardiomyocyte-specific SIRT1 knockout (SIRT1 cKO) mice, either DOX or PBS was administered (4 injections of 5 mg/kg/wk) starting at 3 months of age. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-P-063, 2019

    J-STAGE 

  • Role of TRPM7 channel in pancreatic stellate cells  [in Japanese]

    Hirano Tatsuya , Kuwamura Takashi , Sakaguchi Reiko , Numata Tomohiro , Mori Yasuo

    … To investigate the function of TRPM7 in PSCs, we constructed TRPM7 conditional knock out (cKO) mouse using the Tamoxifen (Tam)-inducible Cre / loxP system. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-P-107, 2019

    J-STAGE 

  • A Case of Intracystic Spindle Cell Carcinoma of the Breast  [in Japanese]

    KOIKE Yasuo , HIRAGA Risako , TAKAGI Satoshi

    … The remains of fine DCIS were found and one lymphnode metastasis which was stained positive by cytokeratin staining.<br>Adjuvant chemotherapy was administerd with 4 cycles of FEC (Fluorouracil, Epirubicin hydrochloride, Cyclophosphamide) and Docetaxel, and was followed by adjuvant endocrine therapy with Tamoxifen citrate. …

    THE SHINSHU MEDICAL JOURNAL 67(5), 307-313, 2019

    IR  J-STAGE 

  • A case of recurrent extramammary Paget's disease treated with several chemotherapies  [in Japanese]

    KAJIHARA Ikko , URATA Kazumi , TANAKA Kenichiro , SAKAMOTO Ryoko , OTSUKA Saki , KANAZAWA Saori , INOUE Kuniko , IHN Hironobu

    <p>58歳,女性。10年前に乳房外Paget病に対して切除術を施行した。根治術10年後に当院再診,PET/CTにて多発リンパ節転移および多発骨転移を認めた。1st lineとしてS-1/ドセタキセル療法を行い,15ヵ月間奏功した。以降,ゲムシタビン,エトポシド,タモキシフェンによる加療を行ったが効果を認めなかった。免疫染色にてホルモン受容体陽性HER2陰性且つCDK4陽性であったため …

    Skin Cancer 34(2), 182-185, 2019

    J-STAGE  Ichushi Web 

  • Ocular Side Effects are Associated with Anticancer Drugs in Neuro-Ophthalmology  [in Japanese]

    Kashiwagi Hiroya

    現在2人に1人ががんになる時代である.そのため近年の抗がん剤の開発は目覚ましい.それに伴い眼の副作用の報告が増加している.この副作用は,眼部の多岐にわたり,神経眼科領域では,視力低下,視野障害,複視,羞明感などの症状があり,障害部位は,視神経,網膜,外眼筋,脳神経などにわたる.代表的な原因薬剤は,殺菌性製剤(パクリタキセル,ドセタキセル,シスプラチン,5-FUなど),ホルモン製剤(タモキシフェンな …

    Neuro-Ophthalmology Japan 36(3), 297-303, 2019

    J-STAGE 

  • Role of Angiogenesis and Chronic Inflammation in Fat Hypertrophy in NASH Pathology  [in Japanese]

    Wada Tsutomu , Tsuneki Hiroshi , Sasaoka Toshiyasu

    … On the other hand, AT of tamoxifen-induced systemic PDGF receptor-β knockout mice showed decreased detachment of PCs from vessels in obesity, thereby attenuating hypertrophy of AT mediated by neoangiogenesis, resulting in protection from the development of chronic AT inflammation and systemic insulin resistance. …

    YAKUGAKU ZASSHI 139(9), 1163-1167, 2019

    J-STAGE 

  • A Case of Invasive Ductal Carcinoma Occurring in a Breast Fibroadenoma  [in Japanese]

    ITO Sayaka , SONODA Norio , KAYANO Hidekazu

    <p>症例は41歳,女性.左乳房にしこりを自覚して自治体検診を受診し,マンモグラフィーで石灰化の集簇を認めた.針生検を行い線維腺腫内に発生した浸潤性乳管癌と診断した.通常の乳癌に準じて左乳房部分切除術+センチネルリンパ節生検を行った.病理組織診断では,線維腺腫内に増生する浸潤性乳管癌でER陽性,PgR陽性,HER2 0,Ki67 low(<10%)であった.術後はタモキシフェン内服を実 …

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 80(2), 266-270, 2019

    J-STAGE  Ichushi Web 

  • Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain

    Iwasawa Takumi , Shinomiya Takahisa , Ota Nozomi , Shibata Natsumi , Nakata Kenya , Shiina Isamu , Nagahara Yukitoshi

    … <p>Ridaifen (RID)-B is an analog derived from tamoxifen (TAM). …

    Biological and Pharmaceutical Bulletin 42(3), 401-410, 2019

    J-STAGE  Ichushi Web 

  • A case of pre-menopausal woman with recurrent breast cancer showing an excellent response to endocrine therapy with palbociclib  [in Japanese]

    田中 克浩 , 惣田 麻衣 , 太田 裕介 , 岸野 瑛美 , 小池 良和 , 野村 長久 , 紅林 淳一

    パルボシクリブ併用内分泌療法が著効した閉経前再発乳癌の1例を報告する.8年前に乳房温存手術を受け,残存乳房への放射線治療後に化学内分泌補助療法(シクロフォスファミド+エピルビシン(CE 90)を4サイクル後に毎週パクリタキセルを4サイクル施行.化学療法終了後からLH-RH アゴニスト2年間とタモキシフェン5年間)を行った.治療継続中も含め定期で外来受診を継続しており,年1回の画像検査(肺,肝,骨を …

    川崎医学会誌 = Kawasaki medical journal (45), 75-80, 2019

    IR 

  • Genome-wide screen reveals important roles for ESCRT proteins in drug/ion resistance of fission yeast

    Yang Yikun , Liu Qiannan , Jiang Guanglie , Chen Si , Zhou Lina , Sakamoto Norihiro , Kuno Takayoshi , Fang Yue , Yao Fan

    … While these ESCRT mutants were more or equally sensitive to most of the drugs tested as compared to the wild-type cells, they showed resistance to some drugs such as tamoxifen, fluorouracil and amiodarone. …

    PLoS ONE 13(6), e0198516, 2018-06-01

    IR 

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