Search Results 1-20 of 367

  • Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice

    Ueda Yo , Saegusa Jun , Okano Takaichi , Sendo Sho , Yamada Hirotaka , Nishimura Keisuke , Morinobu Akio

    … Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. … This study investigated how inhibiting both glutamine metabolism with 6-diazo-5-oxo-L-norleucine (DON) and mTOR with rapamycin affects immune cells and the arthritis in a mouse model. … We revealed that rapamycin and DON additively suppressed CD4(+) T cell proliferation, and both of them inhibited Th17 cell differentiation. …

    Scientific Reports (9), 6374, 2019-04-23

    IR

  • Treg cells and rheumatoid arthritis  [in Japanese]

    小松 紀子 , 高柳 広

    医学のあゆみ 268(13), 1217-1222, 2019-03-30

  • T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation

    Lee Jinju , Aoki Tomohiro , Thumkeo Dean , Siriwach Ratklao , Yao Chengcan , Narumiya Shuh

    … PGE2経路による病因細胞Th17の増殖機構を解明 --乾癬の慢性的な皮膚炎症を改善する新しい治療薬開発に向けて--. … 2018-06-20.Background: IL-23 is the key cytokine for generation of pathogenic IL-17–producing helper T (TH17) cells, which contribute critically to autoimmune diseases. … However, how IL-23 generates pathogenic TH17 cells remains to be elucidated. …

    Journal of Allergy and Clinical Immunology 143(2), 631-643, 2019-02

    IR

  • Th17-mediated inflammatory cascade in the development of autoimmune arthritis  [in Japanese]

    廣田 圭司

    臨床免疫・アレルギー科 = Clinical immunology & allergology 71(1), 1-7, 2019-01

  • Clinical and Genetic Aspects of Behçet's Disease in Japan

    Kirino Yohei , Nakajima Hideaki

    … Mechanisms discovered by genome-wide association studies include <i>ERAP1</i>-mediated HLA class I antigen bounding pathway, autoinflammation, Th17 cells, natural killer cells, and polarized macrophages, a similar genetic architecture to Crohn's disease, ankylosing spondylitis, and psoriasis. …

    Internal Medicine 58(9), 1199-1207, 2019

    J-STAGE

  • Th2 and Th17 Induce Dry Skin in a Mouse Model of Arthritis

    Goto Kenji , Hiramoto Keiichi , Ooi Kazuya

    … We hypothesized that T helper (Th)2 and Th17 cells mediate this process. … A mouse model of DBA/1JJmsSlc collagen-induced arthritis was treated with Th2 or Th17 cell inhibitor, and transepidermal water loss (TEWL) and the expression of markers associated with allergic reaction and inflammation were evaluated. … Administration of Th2 cell inhibitor abolished the increase in TEWL, IL-6, and TNF-α levels, whereas Th17 cell inhibitor reversed TEWL and decreased IL-17 level. …

    Biological and Pharmaceutical Bulletin 42(3), 468-474, 2019

    J-STAGE

  • Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1β in Hashimoto's thyroiditis but not in Graves' disease

    Zake Tatjana , Skuja Sandra , Kalere Ieva , Konrade Ilze , Groma Valerija

    … <p>T helper (Th) 17 cells and interleukin (IL)-17 play a significant role in the pathogenesis of autoimmune thyroid disease (AITD). … However, it has recently become clear that Th17 cells are more heterogeneous and exhibit two different phenotypes, whereas IL-23 and IL-1β are crucial for the generation of pathogenic Th17 lymphocytes. …

    Endocrine Journal, 2019

    J-STAGE

  • Interleukin-17: The Role for Pathological Angiogenesis in Ocular Neovascular Diseases

    Li Yuanjun , Zhou Yedi

    … Interleukin (IL)-17, the signature cytokine produced by T helper 17 (Th17) cells, has proven to be involved in ocular neovascularization. …

    The Tohoku Journal of Experimental Medicine 247(2), 87-98, 2019

    J-STAGE

  • Bidirectional roles of IL-22 in the pathogenesis of allergic airway inflammation

    Ito Takashi , Hirose Koichi , Nakajima Hiroshi

    … Although these pathognomonic features are mainly mediated by antigen-specific Th2 cells and their cytokines, such as IL-4, IL-5, and IL-13, recent studies have revealed that other inflammatory cells, including Th17 cells and innate lymphoid cells (ILCs), also play a critical role in the pathogenesis of asthma. …

    Allergology International 68(1), 4-8, 2019

    J-STAGE

  • Airway innate lymphoid cells in the induction and regulation of allergy

    Doherty Taylor A. , Broide David H.

    … <p>The recent discovery of innate lymphoid cells has revolutionized our understanding of the pathogenesis of immune diseases including allergy and asthma. … Innate lymphoid cells (ILCs) are a heterogeneous collection of lymphocytes that lack antigen-specificity (non-T, non-B cells) and potently produce characteristic cytokines of T cell subsets (Th1, Th2, Th17). …

    Allergology International 68(1), 9-16, 2019

    J-STAGE

  • Clinical and Genetic Aspects of Behçet's Disease in Japan

    Kirino Yohei , Nakajima Hideaki

    … Mechanisms discovered by genome-wide association studies include ERAP1-mediated HLA class I antigen bounding pathway, autoinflammation, Th17 cells, natural killer cells, and polarized macrophages, a similar genetic architecture to Crohn's disease, ankylosing spondylitis, and psoriasis. …

    Internal Medicine, 2019

    J-STAGE

  • Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression

    三輪 佳宏

    … Here we provide evidence implying that Prevotella heparinolytica promotes the differentiation of Th17 cells colonizing the gut and migrating to the bone marrow (BM) of transgenic Vk*MYC mice, where they favor progression of multiple myeloma (MM). … IL-17 induced STAT3 phosphorylation in murine plasma cells, and activated eosinophils. …

    Nature communications 9(1), 4832, 2018-12

    IR

  • Resolvin E1 attenuates murine psoriatic dermatitis

    Sawada Yu , Honda Tetsuya , Nakamizo Satoshi , Otsuka Atsushi , Ogawa Narihito , Kobayashi Yuichi , Nakamura Motonobu , Kabashima Kenji

    … Consistently, RvE1 inhibited IL-23 production by dendritic cells (DCs) in vitro. … Furthermore, RvE1 exerted inhibitory effects on migration of cutaneous DCs and γδ T cells, a major IL-17-producing cell population in mouse, both in vivo and in vitro. … These suppressive effects of RvE1 were mediated by its antagonistic function on BLT1, a receptor of leukotriene B4, and were also observed in human DCs, Th17 and Tc17 cells. …

    Scientific Reports (8), 2018-12

    IR

  • Regulation of Th17 differentiation by the AP-1 transcription factor JunB  [in Japanese]

    山﨑 創

    臨床免疫・アレルギー科 = Clinical immunology & allergology 70(3), 275-282, 2018-09

    Ichushi Web

  • Roles of lung epithelium/dendritic cells and the interaction with environmental factors in asthma pathogenesis  [in Japanese]

    廣瀬 晃一 , 中島 裕史

    医学のあゆみ 265(9), 757-761, 2018-06-02

    Ichushi Web

  • The AP1 transcription factor JunB regulates pathogenicity of Th17 cells  [in Japanese]

    石川 裕規

    生化学 90(2), 230-233, 2018-04

    Ichushi Web

  • Lactobacillus helveticus SBT2171 Attenuates Experimental Autoimmune Encephalomyelitis in Mice

    Yamashita Maya , Ukibe Ken , Matsubara Yumi , Hosoya Tomohiro , Sakai Fumihiko , Kon Shigeyuki , Arima Yasunobu , Murakami Masaaki , Nakagawa Hisako , Miyazaki Tadaaki

    … We recently reported that Lactobacillus helveticus SBT2171 (LH2171) inhibited the proliferation and inflammatory cytokine production of primary immune cells in vitro, and alleviated collagen-induced arthritis (CIA) in mice, a model of human rheumatoid arthritis (RA). … LH2171 also reduced the numbers of pathogenic immune cells, especially Th17 cells, in the spinal cord at the peak stage of disease severity. …

    Frontiers in microbiology 8, 2596, 2018-01-22

    IR DOI

  • Multiple sclerosis  [in Japanese]

    能登 大介 , 三宅 幸子

    臨床免疫・アレルギー科 = Clinical immunology & allergology 69(1), 20-26, 2018-01

    Ichushi Web

  • Practice for the use of disease–modifying drugs in multiple sclerosis  [in Japanese]

    Matsui Makoto

    … The second step is entry of immune cells into the CNS via the blood–brain barrier (BBB). … Activated T cells can easily cross the BBB using surface α4–integrin as a ligand to VCAM–1, which is expressed on endothelial cells in the CNS. … As the third step, immune reactions occur within the CNS when activated T cells encounter specific antigens presented by microglia. …

    Neurological Therapeutics 35(4), 499-503, 2018

    J-STAGE

  • Differential dendritic cell responses to cell wall mannan of <i>Candida albicans</i>, <i>Candida parapsilosis</i>, and <i>Candida dubliniensis </i>

    Nguyen Thu N. Y. , Matangkasombut Oranart , Ritprajak Patcharee

    … cell wall may be the first molecules that interact with host dendritic cells (DCs) and activate immune responses that determine disease outcomes. … The effects of heat-inactivated (HI) yeast cells and soluble mannan of <i>Candida albicans</i>, <i>Candida parapsilosis</i>, and <i>Candida dubliniensis</i> … mannan may skew T helper (Th) responses from protective Th17 toward Th1. …

    Journal of Oral Science 60(4), 557-566, 2018

    J-STAGE

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