Search Results 1-20 of 1173

  • IL-33-amphiregulin-axis directs type 2 inflammation-mediated fibrosis via eosinophilic reprogramming to produce osteopontin  [in Japanese]

    森本 侑樹

    臨床免疫・アレルギー科 = Clinical immunology & allergology 71(1), 14-18, 2019-01

  • Amelioration of CIA by Asarinin is associated to a downregulation of TLR9/NF-κB and regulation of Th1/Th2/Treg expression

    Dai Qiaomei , Wang Meiqiao , Li Yaozhang , Li Ji

    … <p>To study the role of asarinin on collagen-induced arthritis (CIA) and its treatment mechanism on dendritic cells (DCs) and T cells. … The CD11c MicroBeads were employed to isolate CD11c+ cells from the spleen. … Asarinin treatment suppressed the expression of Th1 cytokines and increased the levels of Th2 cytokines (IL-10), TGF-β and Foxp3 in the synovium and hindpaw, however T-bet mRNA levels in synovium decreased. …

    Biological and Pharmaceutical Bulletin, 2019

    J-STAGE

  • Suppressive effect of dietary resistant maltodextrin on systemic immunity in a mouse model of food allergy

    MIYAZATO Shoko , TSUDA Masato , KISHIMOTO Yuka , HOSONO Akira

    … While RMD was shown to contribute to an increase in goblet cells, RMD did not change the overall inflammatory status when ingested with the egg-white diet. … RMD suppressed IL-4 and IL-10 production from splenocytes but not cells from mesenteric lymph nodes. … RMD also downregulated the serum levels of OVA-specific Th1- and Th2-related antibodies, which were elevated in the food-allergic condition. …

    Bioscience of Microbiota, Food and Health, 2019

    J-STAGE

  • Th2 and Th17 Induce Dry Skin in a Mouse Model of Arthritis

    Goto Kenji , Hiramoto Keiichi , Ooi Kazuya

    … We hypothesized that T helper (Th)2 and Th17 cells mediate this process. … A mouse model of DBA/1JJmsSlc collagen-induced arthritis was treated with Th2 or Th17 cell inhibitor, and transepidermal water loss (TEWL) and the expression of markers associated with allergic reaction and inflammation were evaluated. … Administration of Th2 cell inhibitor abolished the increase in TEWL, IL-6, and TNF-α levels, whereas Th17 cell inhibitor reversed TEWL and decreased IL-17 level. …

    Biological and Pharmaceutical Bulletin 42(3), 468-474, 2019

    J-STAGE

  • Hepatoprotective immune response during <i>Trichinella spiralis</i> infection in mice

    FARID Ayman Samir , FATH Eman Mohamed , MIDO Shogo , NONAKA Nariaki , HORII Yoichiro

    … <p>Infections with gastrointestinal nematodes provoke immune and inflammatory responses mediated by cytokines released from T-helper type-2 (Th2) cells. …

    Journal of Veterinary Medical Science 81(2), 169-176, 2019

    J-STAGE

  • Bidirectional roles of IL-22 in the pathogenesis of allergic airway inflammation

    Ito Takashi , Hirose Koichi , Nakajima Hiroshi

    … Although these pathognomonic features are mainly mediated by antigen-specific Th2 cells and their cytokines, such as IL-4, IL-5, and IL-13, recent studies have revealed that other inflammatory cells, including Th17 cells and innate lymphoid cells (ILCs), also play a critical role in the pathogenesis of asthma. …

    Allergology International 68(1), 4-8, 2019

    J-STAGE

  • Airway innate lymphoid cells in the induction and regulation of allergy

    Doherty Taylor A. , Broide David H.

    … <p>The recent discovery of innate lymphoid cells has revolutionized our understanding of the pathogenesis of immune diseases including allergy and asthma. … Innate lymphoid cells (ILCs) are a heterogeneous collection of lymphocytes that lack antigen-specificity (non-T, non-B cells) and potently produce characteristic cytokines of T cell subsets (Th1, Th2, Th17). …

    Allergology International 68(1), 9-16, 2019

    J-STAGE

  • Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis  [in Japanese]

    Iinuma T. , Okamoto Y. , Morimoto Y. , Arai T. , Sakurai T. , Yonekura S. , Sakurai D. , Hirahara K. , Nakayama T.

    Allergy : European journal of allergy and clinical immunology : official journal of the European Academy of Allergy and Clinical Immunology : highlights from the official journal of the European Academy of Allergy and Clinical Immunology 4(2), 14-25, 2018-08

  • The impact of pathogenic Th2 cells on the allergic disease of upper airway  [in Japanese]

    飯沼 智久 , 岡本 美孝

    医学のあゆみ 265(9), 801-805, 2018-06-02

    Ichushi Web

  • Control of allergic responses by regulatory T cells  [in Japanese]

    村上 龍一 , 堀 昌平

    医学のあゆみ 265(9), 724-728, 2018-06-02

    Ichushi Web

  • The crosstalk between Tpash2 cells and epithelial cells via IL-33 is crucial for the pathology of chronic airway inflammation  [in Japanese]

    平原 潔 , 中山 俊憲

    医学のあゆみ 265(9), 707-712, 2018-06-02

  • Clinical features of severe eosinophilic asthma  [in Japanese]

    永田 真

    臨床免疫・アレルギー科 = Clinical immunology & allergology 69(5), 457-462, 2018-05

    Ichushi Web

  • Practice for the use of disease–modifying drugs in multiple sclerosis  [in Japanese]

    Matsui Makoto

    … The second step is entry of immune cells into the CNS via the blood–brain barrier (BBB). … Activated T cells can easily cross the BBB using surface α4–integrin as a ligand to VCAM–1, which is expressed on endothelial cells in the CNS. … As the third step, immune reactions occur within the CNS when activated T cells encounter specific antigens presented by microglia. …

    Neurological Therapeutics 35(4), 499-503, 2018

    J-STAGE

  • Effect of collagen peptide ingestion on immunity  [in Japanese]

    Kusubata Masashi , Kuwaba Kumiko

     コラーゲンペプチド経口摂取の効果として免疫系への作用を検討した.ヒト試験においては免疫力を総合的に判定できる免疫力スコアの向上が認められた.卵白アレルギーモデルマウスを使った抗アレルギー試験では,Th1 を優勢にさせることでアレルギーを抑制できる可能性を示した.

    Functional Food Research 14(0), 44-47, 2018

    J-STAGE Ichushi Web

  • Changes of Structures and Functions in the Epidermis of Atopic Dermatitis  [in Japanese]

    Omori-Miyake Miyuki

    … アトピー性皮膚炎を含むアレルギー疾患は, Th2型サイトカイン優位な体内環境を特徴とする。 …

    Nihon Hifu Meneki Arerugy Gakkai Zasshi 1(1), 35-45, 2018

    J-STAGE Ichushi Web

  • The expression and functional analysis of CST1 in intractable nasal polyps  [in Japanese]

    Kato Yukinori , Fujieda Shigeharu , Takabayashi Tetsuji , Sakashita Masafumi , Imoto Yoshimasa , Tokunaga Takahiro , Ninomiya Takahiro , Morikawa Taiyo , Yoshida Kanako , Noguchi Emiko

    … CST1は鼻茸内において,ECRSの鼻茸形成・増悪に関わる様々な因子と相互作用することにより,Th2/好酸球性炎症として作用し,鼻茸の重症化,難治性,再発に関わる。 …

    Journal of Japan Society of Immunology & Allergology in Otolaryngology 36(4), 261-266, 2018

    J-STAGE

  • Relationship between CCL22 Expression by Vascular Smooth Muscle Cells and Macrophage Histamine Receptors in Atherosclerosis

    Kimura Satoshi , Noguchi Hirotsugu , Nanbu Uki , Wang Ke-Yong , Sasaguri Yasuyuki , Nakayama Toshiyuki

    … CCL22 was distributed in sparse areas of vascular smooth muscle cells (VSMCs) and associated with M2-like macrophages. … Moreover, H2R stimulation was associated with CCL22 expression via M2-like macrophage dominant differentiation.</p><p><b>Conclusion: </b>The expression of M1- or M2-like macrophages in atherosclerosis were observed to be dependent on the distribution of VSMCs owing to differences in causal stimuli and the switching of histamine receptors via Th1 or Th2 cytokines. …

    Journal of Atherosclerosis and Thrombosis 25(12), 1240-1254, 2018

    J-STAGE

  • Hepatoprotective immune response during <i>Trichinella spiralis </i>infection in mice

    FARID Ayman Samir , FATH Eman Mohamed , MIDO Shogo , NONAKA Nariaki , HORII Yoichiro

    … <p>Infections with gastrointestinal nematodes provoke immune and inflammatory responses mediated by cytokines released from T-helper type-2 (Th2) cells. …

    Journal of Veterinary Medical Science, 2018

    J-STAGE

  • Maternal Separation as Early-Life Stress Causes Enhanced Allergic Airway Responses by Inhibiting Respiratory Tolerance in Mice

    Ouchi Ryusuke , Kawano Tasuku , Yoshida Hitomi , Ishii Masato , Miyasaka Tomomitsu , Ohkawara Yuichi , Takayanagi Motoaki , Takahashi Tomoko , Ohno Isao

    … We then evaluated the effects of MS on the development of regulatory T (Treg) cells in bronchial lymph nodes (BLN) and on splenocyte proliferation and cytokine expression. … Furthermore, exposure to MS was associated with a lower number of Treg cells in the BLN. … These findings suggest that exposure to early-life stress prevents the acquisition of respiratory tolerance to inhaled antigen due to insufficient Treg cell development, resulting in Th2-biased sensitization and asthma onset. …

    The Tohoku Journal of Experimental Medicine 246(3), 155-165, 2018

    J-STAGE

  • Recent findings on house dust mite allergen components  [in Japanese]

    Nambu Mitsuhiko

    … 1はプロテアーゼ活性によってTh2アジュバントとして作用し, また上皮のバリアを傷害してIL-33を誘導し, さらに上皮細胞や好塩基球, 好酸球なども刺激する可能性が報告されている.</p><p> Der 2はMD-2と相同性を有しており, LPSとともにTLR4を刺激して, 自然免疫反応を誘導する可能性が報告されている.</p><p> Der 3, 6, 9はセリン・プロテアーゼであり, 気道上皮やケラチノサイト, 樹状細胞などのprotease-activ …

    Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 32(4), 698-708, 2018

    J-STAGE Ichushi Web

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