CiNii Articles - Total synthesis

1

Total Synthesis of Saxitoxins [in Japanese]

Nagasawa Kazuo

… For the synthesis of the core structure, we have developed a neighboring acyl group assisted cyclization strategy to give tricycle with a fully protected form of saxitoxinol under quite mild conditions. … This key intermediate allows us total synthesis of (＋)-decarbamoyl saxitoxin (dcSTX), (＋)-gonyautoxin 3 (GTX3) including and STX. …

Journal of Synthetic Organic Chemistry, Japan 79(1), 43-53, 2021

J-STAGE
2

Synthesis of 2-Azabicyclo[3.3.1]nonanes: Lessons from Synthetic Studies of Macrocyclic Diamine Alkaloids

Yokoshima Satoshi

This highlight review describes the syntheses of 2-azabicyclo[3.3.1]nonanes, focusing on synthetic studies of the macrocyclic diamine alkaloids, sarain A and madangamines. These alkaloids hav …

Chemistry Letters 50(1), 96-102, 2021

J-STAGE
3

Chemical Activation of Nitrogen-doped Carbon Derived from Chitosan with ZnCl2 to Produce a High-performance Gas Diffusion-type Oxygen Electrode

OKUDA Ryunosuke , NAKANO Kota , SUEMATSU Koichi , WATANABE Ken , ILNICKA Anna , ŁUKASZEWICZ Jerzy P. , SHIMANOE Kengo

… In this study, we fabricated nitrogen-doped carbons (NDCs) derived from chitosan using a new synthesis method that combines the thermal decomposition of chitosan and chemical activation with ZnCl2. … The surface area and total pore volume of the fabricated NDCs tended to increase with activation temperature, despite decreasing nitrogen content. …

Electrochemistry 89(1), 36-42, 2021

J-STAGE
4

Effects of the built environment on physical activity: a systematic review of longitudinal studies taking sex/gender into account

Tcymbal Antonina , Demetriou Yolanda , Kelso Anne , Wolbring Laura , Wunsch Kathrin , Wäsche Hagen , Woll Alexander , Reimers Anne K.

Environmental Health and Preventive Medicine 25(1), 2020-11-27

DOI
5

Total Synthesis of Zephycarinatines via Photocatalytic Reductive Radical ipso‐Cyclization

Takeuchi Haruka , Inuki Shinsuke , Nakagawa Kohei , Kawabe Takaaki , Ichimura Atsuhiko , Oishi Shinya , Ohno Hiroaki

… We report herein a nonbiomimetic strategy for the total synthesis of the plicamine‐type alkaloids zephycarinatines C and D. … The key feature of the synthesis is a stereoselective reductive radical ipso‐cyclization using visible‐light‐mediated photoredox catalysis. …

Angewandte Chemie - International Edition 59(47), 21210-21215, 2020-11-16

IR
6

Exploring the Complexity of Protein-Level Dosage Compensation that Fine-Tunes Stoichiometry of Multiprotein Complexes

Ishikawa Koji , Ishihara Akari , Moriya Hisao

… Proper stoichiometry of multiprotein complexes is achieved by the balance between protein synthesis and degradation. … To better understand the landscape of the stoichiometry control system, we examined genetic interactions between 18 subunits and 12 quality control factors (E3 ubiquitin ligases and N-acetyltransferases), in total 114 combinations. …

PLoS Genetics 16(10), e1009091, 2020-10-28

IR
7

Total Synthesis of (-)-Sigillin A: A Polychlorinated and Polyoxygenated Natural Product

Yamaoka Yousuke , Nakayama Takamori , Kawai Shota , Takasu Kiyosei

… The total synthesis of (−)-sigillin A, a highly chlorinated and oxygenated octahydroisocoumarin, is described herein. … Stereoselective installation of two hydroxy groups and formation of gem-dichloroalkene from the corresponding ketone led to the total synthesis of (−)-sigillin A in a total of 16 steps. …

Organic Letters 22(19), 7721-7724, 2020-10-02

IR
8

RECENT ADVANCES IN THE TOTAL SYNTHESIS OF CLAVILACTONES

Ogura Akihiro , Takao Ken-ichi

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry 100(9), 1355-1370, 2020-09-01
9

Stereoselective Synthesis of 1,1′-Disaccharides by Organoboron Catalysis

Izumi Sanae , Kobayashi Yusuke , Takemoto Yoshiji

… The highly stereoselective synthesis of 1, 1′‐disaccharides was achieved by using 1, 2‐dihydroxyglycosyl acceptors and glycosyl donors in the presence of a tricyclic borinic acid catalyst. …

Angewandte Chemie International Edition 59(33), 14054-14059, 2020-08-10

IR
10

Convergent Total Synthesis of Lamellarins and Their Congeners

Morikawa Daiki , Morii Kazuki , Yasuda Yuto , Mori Atsunori , Okano Kentaro

Journal of Organic Chemistry 85(13), 8603-8617, 2020-07-02

IR
11

Relationship among Frailty, Muscle Volume, Protein Intake in Patients with Chronic Kidney Disease (CKD)

Bando Hiroshi , Kato Y

… Insufficient protein intake in each meal or a total of three meals causes a decrease in muscle mass. … For the elderly, protein intake has been insufficient at breakfast and then a large amount of protein is necessary for stimulating muscle protein synthesis. …

Journal of Health Care and Research 1(2), 101-104, 2020-06-27

IR
12

Minimization of Amounts of Catalyst and Solvent in NHC-Catalyzed Benzoin Reactions of Solid Aldehydes: Mechanistic Consideration of Solid-to-Solid Conversion and Total Synthesis of Isodarparvinol B

Iwai Kenta , Ono Masakazu , Nanjo Yoshiko , Ema Tadashi

… The first total synthesis of isodarparvinol B was achieved via the NHC-catalyzed intramolecular benzoin reaction using a small amount of solvent as an additive. …

ACS Omega 5(17), 10207-10216, 2020-04-20

IR
13

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

Tsukada Kento , Shinki Shono , Kaneko Akiho , Murakami Kazuma , Irie Kazuhiro , Murai Masatoshi , Miyoshi Hideto , Dan Shingo , Kawaji Kumi , Hayashi Hironori , Kodama Eiichi N. , Hori Aki , Salim Emil , Kuraishi Takayuki , Hirata Naoya , Kanda Yasunari , Asai Teigo

… A synthetic biology method based on heterologous biosynthesis coupled with genome mining is a promising approach for increasing the opportunities to rationally access natural product with novel structures and biological activities through total biosynthesis and combinatorial biosynthesis. …

Nature Communications (11), 2020-04-14

IR
14

Total Synthesis of Tetrodotoxin

Murakami Keigo , Toma Tatsuya , Fukuyama Tohru , Yokoshima Satoshi

… A total synthesis of tetrodotoxin was accomplished. …

Angewandte Chemie International Edition 59(15), 6253-6257, 2020-04-06

IR
15

Clinical Significance of Cytoplasmic IgE-Positive Mast Cells in Eosinophilic Chronic Rhinosinusitis

Gion Yuka , Okano Mitsuhiro , Koyama Takahisa , Oura Tokie , Nishikori Asami , Orita Yorihisa , Tachibana Tomoyasu , Marunaka Hidenori , Makino Takuma , Nishizaki Kazunori , Sato Yasuharu

… Fc epsilon RI expression and IgE synthesis are, therefore, critical for type 2 inflammatory disease development. … Patients with ECRS exhibited high levels of total IgE serum levels and elevated peripheral blood eosinophil ratios. … A positive correlation was found between the membrane IgE-positive cells and the radiological severity score, the ratio of eosinophils, and the total serum IgE level. …

International Journal of Molecular Sciences 21(5), 1843, 2020-03-07

IR
16

Synthesis of anti-Bredt compounds and structural analysis by 2D NMR [in Japanese]

髙橋希恵 , 飯田博一

… Recently, it was reported that asymmetric total synthesis of cyclocitrinol having bicyclo [4.4.1] skeleton with double bond at the bridgehead position via [5+2] cycloaddition reaction had been achieved. … In this research, we performed the synthesis of anti-Bredt compounds using pyrazole as a starting material. …

研究報告 = Journal of technological researches 63(110), 13-18, 2020-03

IR
17

Total Synthesis of Complex Natural Products via Tandem Reactions [in Japanese]

村田佳亮 , 不破春彦

化學工業 71(2), 117-124, 2020-02
18

Bioinspired Total Synthesis of Natural Product [in Japanese]

榎本賢

化學工業 71(2), 92-98, 2020-02
19

Comprehensive Total Synthesis and Medicinal Chemistry of Dihydroisocoumarin-type Natural Product [in Japanese]

中山淳

化學工業 71(2), 83-91, 2020-02
20

Total Synthesis of Englerin A Utilizing [4+3] Cycloaddition [in Japanese]

萩原秀一 , 花屋賢悟 , 須貝威 , 庄司満

化學工業 71(2), 79-82, 2020-02

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