Search Results 1-20 of 4647

  • Clinical, histopathological, and immunohistochemical studies of histiocytic sarcoma in four-toed hedgehogs (<i>Atelerix albiventris</i>): a retrospective study

    MAKISHIMA Risa , KONDO Hirotaka , SHIBUYA Hisashi

    … Immunohistochemically, neoplastic cells of spindle cell type showed stronger reactivity against human leukocyte antigen-DR than round-polygonal cell type. … Regardless of morphological classification, most tumor cells were negative for CD163, suggesting that this marker is less effective for the diagnosis of histiocytic sarcoma. …

    Journal of Veterinary Medical Science, 2021

    J-STAGE 

  • Pharmacological and clinical study results of trastuzumab deruxtecan (T-DXd, ENHERTU<sup>®</sup>)  [in Japanese]

    Saito Kaku , Kaneko Reina , Kamio Takahiro , Kamiyama Emi , Muto Ryo , Sugihara Masahiro

    … <p>Antibody-drug conjugates (ADCs) combine the specific antibody and cytotoxic agent by a linker and represent a promising drug class with a wider therapeutic window than conventional chemotherapeutic agents by substantiating efficient and specific drug delivery to antigen-expressing tumor cells. …

    Folia Pharmacologica Japonica 156(1), 47-51, 2021

    J-STAGE 

  • Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes

    Kumagai-Takei Naoko , Nishimura Yasumitsu , Maeda Megumi , Hayashi Hiroaki , Matsuzaki Hidenori , Lee Suni , Yoshitome Kei , Ito Tatsuo , Otsuki Takemi

    Environmental Health and Preventive Medicine 25(1), 2020-10-08

    DOI 

  • SEMINAL VESICLE CYSTADENOMA WITH CONCURRENT PROSTATE CANCER : A CASE REPORT  [in Japanese]

    石田 雅宣 , 井上 高光 , 小泉 淳 , 山本 竜平 , 奈良 健平 , 神田 壮平 , 沼倉 一幸 , 齋藤 満 , 成田 伸太郎 , 佐藤 滋 , 羽渕 友則

    … This case report documents seminal vesicle cystadenoma with concurrent prostate cancer in a 49-yearold man evaluated at follow-up for a high prostate-specific antigen level (12 ng/ml). … A possible diagnosis of primary malignant tumor of the seminal vesicle with concurrent organ-confined prostate cancer was considered. …

    泌尿器科紀要 = Acta urologica Japonica 66(10), 351-355, 2020-10

    IR  DOI 

  • Dysfunction of CD8+PD-1+T cells in type 2 diabetes caused by the impairment of metabolism-immune axis

    Nojima Ichiro , Eikawa Shingo , Tomonobu Nahoko , Hada Yoshiko , Kajitani Nobuo , Teshigawara Sanae , Miyamoto Satoshi , Tone Atsuhito , Uchida Haruhito A. , Nakatsuka Atsuko , Eguchi Jun , Shikata Kenichi , Udono Heiichiro , Wada Jun

    … The metabolic changes and dysfunction in CD8+T cells may be involved in tumor progression and susceptibility to virus infection in type 2 diabetes (T2D). … In C57BL/6JJcl mice fed with high fat-high sucrose chow (HFS), multifunctionality of CD8+splenic and tumor-infiltrating lymphocytes (TILs) was impaired and associated with enhanced tumor growth, which were inhibited by metformin. …

    Scientific Reports 10(1), 14928, 2020-09-10

    IR 

  • METACHRONOUS PUBIC BONE METASTASES FROM SYNCHRONOUS DOUBLE CANCER WITH PROSTATE AND ASCENDING COLON CANCERS : A CASE REPORT  [in Japanese]

    伊藤 裕基 , 菱田 勢始 , 谷口 友規 , 加藤 大貴 , 高井 学 , 飯沼 光司 , 村松(前川) 由佳 , 加藤 卓 , 中根 慶太 , 水谷 晃輔 , 土屋 朋大 , 高橋 孝夫 , 酒々井 夏子 , 宮崎 龍彦 , 古家 琢也

    … The following tumor marker levels were found : prostate-specific antigen (PSA) 20.57 ng/ml, carcinoembryonic antigen (CEA) 108.5 ng/ml, carbohydrate antigen 19-9 (CA19-9) 1, 002.1 U/ml. …

    泌尿器科紀要 = Acta urologica Japonica 66(8), 273-277, 2020-08

    IR  DOI 

  • Early Change in the Plasma Levels of Circulating Soluble Immune Checkpoint Proteins in Patients with Unresectable Hepatocellular Carcinoma Treated by Lenvatinib or Transcatheter Arterial Chemoembolization

    Odagiri Naoshi , Hoang Hai , Le Thi Thanh Thuy , Dong Minh Phuong , Suoh Maito , Kotani Kohei , Hagihara Atsushi , Uchida-Kobayashi Sawako , Tamori Akihiro , Enomoto Masaru , Kawada Norifumi

    … 0.001), levels of sHVEM (soluble herpesvirus entry mediator) (p = 0.003), sTLR-2 (soluble Toll-like receptor 2) (p = 0.009), sCD80 (p = 0.036), sCTLA-4 (soluble cytotoxic T-lymphocyte antigen 4) (p = 0.005), sGITR (soluble glucocorticoid-induced tumor necrosis factor receptor) (p = 0.030), sGITRL (soluble glucocorticoid-induced TNFR-related ligand) (p = 0.090), and sPD-L1 (soluble programmed death-ligand 1) (p = 0.070) also increased. …

    Cancers 12(8), 2045, 2020-07-24

    IR 

  • Progress and challenges for CAR-T cell therapy  [in Japanese]

    草場 香那 , 渡邊 慶介

    腫瘍内科 = Clinical oncology 26(1), 63-70, 2020-07

    Ichushi Web 

  • Increased tumor-associated macrophages in the prostate cancer microenvironment predicted patients' survival and responses to androgen deprivation therapies in Indonesian patients cohort

    Yuri Prahara , Shigemura Katsumi , Kitagawa Koichi , Hadibrata Exsa , Risan Muhammad , Zulfiqqar Andy , Soeroharjo Indrawarman , Hendri Ahmad Z. , Danarto Raden , Ishii Aya , Yamasaki Saya , Yan Yongmin , Heriyanto Didik S. , Fujisawa Masato

    … Background: Tumor-associated macrophages (TAMs) and microvessel density (MVD) play an essential role for tumor progression in prostate cancer (PCa). … In this study, we evaluated the association between TAMs, the infiltration with tumor angiogenesis and the response to androgen deprivation therapies (ADTs) in PCa to evaluate TAM infiltration as a predictive factor for PCa survival. …

    Prostate International 8(2), 62-69, 2020-06

    IR 

  • Development of cancer immunotherapy using CTLs regenerated from iPS cells : To target solid tumor expressing WT1 antigen  [in Japanese]

    嘉島 相輝 , 増田 喬子 , 河本 宏

    医学のあゆみ 273(5), 450-459, 2020-05-02

    Ichushi Web 

  • Influence of human adipose stem cells on prostate cancer cell growth

    Yamamoto Tokunori , Gotoh Momokazu , Koide Naoshi , Funahashi Yasuhito , Shimizu Shinobu , Takei Yoshifumi

    … The LNCaP (human prostate cancer cell line) cells and ASCs were co-cultured, and prostate-specific antigen (PSA) concentration in their culture medium supernatant was measured at 48 and 96 h. … After subcutaneous transplantation of LNCaP cells, with or without ASCs, in immunodeficient mice, tumor growth was compared. … The growth of LNCaP xenograft tumor in immunodeficient mice was significantly suppressed by ASC addition. …

    Nagoya Journal of Medical Science 82(2), 217-224, 2020-05

    IR  DOI 

  • Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model

    Kashima Soki , Maeda Takuya , Masuda Kyoko , Nagano Seiji , Inoue Takamitsu , Takeda Masashi , Kono Yuka , Kobayashi Takashi , Saito Shigeyoshi , Higuchi Takahiro , Ichise Hiroshi , Kobayashi Yuka , Iwaisako Keiko , Terada Koji , Agata Yasutoshi , Numakura Kazuyuki , Saito Mitsuru , Narita Shintaro , Yasukawa Masaki , Ogawa Osamu , Habuchi Tomonori , Kawamoto Hiroshi

    … To address these issues, we developed a strategy in which cytotoxic T lymphocytes (CTLs) are regenerated from iPSCs that were originally derived from T cells and succeeded in regenerating CTLs specific for the WT1 antigen, which exhibited therapeutic efficacy in a xenograft model of leukemia. … The regenerated CTLs antigen-specifically suppressed tumor growth in a patient-derived xenograft model of RCC, demonstrating the feasibility of our strategy against solid tumors. …

    iScience 23(4), 100998, 2020-04-24

    IR 

  • Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model

    Kashima Soki , Maeda Takuya , Masuda Kyoko , Nagano Seiji , Inoue Takamitsu , Takeda Masashi , Kono Yuka , Kobayashi Takashi , Saito Shigeyoshi , Higuchi Takahiro , Ichise Hiroshi , Kobayashi Yuka , Iwaisako Keiko , Terada Koji , Agata Yasutoshi , Numakura Kazuyuki , Saito Mitsuru , Narita Shintaro , Yasukawa Masaki , Ogawa Osamu , Habuchi Tomonori , Kawamoto Hiroshi

    … To address these issues, we developed a strategy in which cytotoxic T lymphocytes (CTLs) are regenerated from iPSCs that were originally derived from Tcells and succeeded in regenerating CTLs specific for the WT1 antigen, which exhibited therapeutic efficacy in a xenograft model of leukemia. … The regenerated CTLs antigen-specifically suppressed tumor growth in a patient-derived xenograft model of RCC, demonstrating the feasibility of our strategy against solid tumors. …

    iScience 23(4), 2020-04-24

    IR 

  • THE EFFICACY OF AMRUBICIN THERAPY AS A SECOND LINE TREATMENT IN PATIENTS WITH SMALL CELL CARCINOMA OF THE PROSTATE : A CASE REPORT  [in Japanese]

    大澤 華織 , 柚原 一哉 , 小鷹 博人 , 加藤 大貴 , 高井 学 , 飯沼 光司 , 中根 慶太 , 岡本 清尚 , 古家 琢也

    … A 68-year-old man was diagnosed with prostate cancer (initial serum prostate specific antigen [PSA] 389 ng/ml, stage cT4N1M1c, Gleason score 5+4), and androgen deprivation therapy was initiated. … Serum levels of neuron-specific enolase and pro-gastrinreleasing peptide (tumor markers) were elevated. … Liver metastases showed partial remission, and serum tumor marker levels were temporarily reduced. …

    泌尿器科紀要 = Acta urologica Japonica 66(4), 121-125, 2020-04

    IR  DOI  Ichushi Web 

  • NEOAJUVANT CHEMOTHERAPY WITH GEMCITABINE AND CISPLATIN PLUS S-1 FOR PRIMARY FEMALE URETHRAL ADENOCARCINOMA  [in Japanese]

    西川 武友 , 杉野 友亮 , 大和 俊介 , 北野 剛士 , 佐々木 豪 , 加藤 学 , 舛井 覚 , 西川 晃平 , 吉尾 裕子 , 神田 英輝 , 有馬 公伸 , 杉村 芳樹 , 内田 克典

    … Contrast-enhanced computed tomography revealed a tumor surrounding the urethra. … Magnetic resonance imaging showed that the tumor had invaded the bladder neck on the anterior aspect of the urethra. … The serum carbohydrate antigen 19-9 level was elevated. …

    泌尿器科紀要 = Acta urologica Japonica 66(4), 115-119, 2020-04

    IR  DOI  Ichushi Web 

  • A CASE OF NEUROENDCRINE CARCINOMA OF THE PROSTATE DIAGNOSED BY PROSTATE RE-BIOPSY DURING HORMONAL TREATMENT AND EFFECTIVELY TREATED BY MULTIDISCIPLINARY THERAPY  [in Japanese]

    木村 翔一 , 寺田 直樹 , 秋岡 貴弘 , 中原 智子 , 長野 正史 , 山本 昇士 , 秋山 裕 , 佐藤 勇一郎 , 大塚 武 , 木村 友哉 , 飛田 卓哉 , 岡部 洸 , 高森 大樹 , 木田 和貴 , 上村 敏雄 , 向井 尚一郎 , 賀本 敏行

    … His prostate specific antigen (PSA) level was 146.7 ng/ml and he was diagnosed with prostate adenocarcinoma with a Gleason Score of 5+4. … He had gross hematuria in October 2017 and a prostate tumor was detected by computed tomography (CT) and magnetic resonance imaging without increasing PSA levels. … Follow-up CT revealed a left adrenal tumor with a positive positron emission tomographic scan in October 2018. …

    泌尿器科紀要 = Acta urologica Japonica 66(3), 91-96, 2020-03

    IR  DOI  Ichushi Web 

  • Synergistic anti-tumor efficacy by combination therapy of a self-assembled nanogel vaccine with an immune checkpoint anti-PD-1 antibody

    Miura Risako , Sawada Shin-ichi , Mukai Sada-atsu , Sasaki Yoshihiro , Akiyoshi Kazunari

    … For this, we evaluated the therapeutic efficacy of combining an anti-PD-1 antibody as an ICI with an OVA antigen-complexed CHP nanogel vaccine delivery system in a mouse E.G7-OVA tumor model. … Mice were subcutaneously inoculated with E.G7-OVA tumor cells on one side of the back, and subcutaneously injected with OVA or the OVA/CHP nanogel vaccine on the other side of the back. …

    RSC Advances 2020(14), 8074-8079, 2020-02-25

    IR 

  • Potential diagnostic biomarkers for esophageal cancer : recent developments and future directions  [in Japanese]

    三好 人正 , 佐藤 康史 , 六車 直樹 , 高山 哲治

    消化器・肝臓内科 = Gastroenterology & hepatology 7(2), 105-110, 2020-02

    Ichushi Web 

  • A CASE OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA THAT DEVELOPED DURING THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER  [in Japanese]

    弓場 覚 , 中山 雅志 , 栗林 宗平 , 辻 博隆 , 波多野 浩士 , 中井 康友 , 垣本 健一 , 西村 和郎

    … Although enzalutamide lowered the prostate specific antigen value, the patient staggered while walking and developed homonymous hemianopsia. … Magnetic resonance imaging revealed a brain tumor. … Although the brain tumor was considered to have metastasized from the prostate cancer, it was diagnosed as a primary central nervous system lymphoma using open-ended tumor biopsy. … The brain tumor was eliminated with whole-brain irradiation. …

    泌尿器科紀要 = Acta urologica Japonica 66(2), 49-52, 2020-02

    IR  DOI  Ichushi Web 

  • Roles of acetylcholine receptors in regulation of immune function in human monocytic cell line U937 Cells  [in Japanese]

    間下 雅士 , 寺尾 美帆子 , 藤井 健志 , MASHIMO Masato , TERAO Mihoko , FUJII Takeshi

    … It has been reported that α7 type nAChR on Mφ is involved in reducing the release of pro-inflammatory cytokine tumor necrosis factor-α and regulating antigen presentation function. …

    同志社女子大學學術研究年報 = Doshisha Women's College of Liberal Arts annual reports of studies (70), 13-19, 2020-01-08

    IR  DOI 

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