Search Results 1-20 of 977

  • Intrapulmonary Pharmacokinetics and Drug Distribution Characteristics for the Treatment of Respiratory Diseases  [in Japanese]

    Togami Kohei

    … The time course of the uptake of these agents in ELF and AMs, following oral administration to rats, resulted in markedly higher concentrations than that in plasma. … multidrug resistance protein 1 and to high uptake by AMs themselves <i>via</i> … active transport mechanisms and trapping and/or binding in acidic organelles. …

    YAKUGAKU ZASSHI 140(3), 345-354, 2020


  • Active Participation in Outpatient Cardiac Rehabilitation Is Associated With Better Prognosis After Coronary Artery Bypass Graft Surgery ― J-REHAB CABG Study ―

    Origuchi Hideki , Nagayama Masatoshi , Omiya Kazuto , Adachi Hitoshi , Goto Yoichi , Itoh Haruki , Momomura Shin-ichi , Nohara Ryuji , Daida Hiroyuki , Masuda Takashi , Kohzuki Masahiro , Makita Shigeru , Ueshima Kenji

    … They formed the Active (n=240) and Non-Active (n=106) CR participation groups and were followed for 3.5 years. … Peak oxygen uptake at 3–5 months from baseline was significantly more increased in Active than in Non-Active patients (+26±24% vs. +19±20%, respectively; … P<0.05), and the MACE rate was significantly lower in Active than Non-Active patients (3.4% vs. 10.5%, respectively; …

    Circulation Journal 84(3), 427-435, 2020


  • Reactive arthritis induced by active extra-articular tuberculosis

    Endo Yushiro , Kawashiri Shin-ya , Koga Tomohiro , Okamoto Momoko , Tsuji Sosuke , Takatani Ayuko , Shimizu Toshimasa , Sumiyoshi Remi , Igawa Takashi , Iwamoto Naoki , Ichinose Kunihiro , Tamai Mami , Nakamura Hideki , Origuchi Tomoki , Kawakami Atsushi

    … RATIONALE: Rare cases of reactive arthritis induced by active extra-articular tuberculosis (Poncet disease) have been reported. … Complete response to antitubercular treatment and evidence of active extra-articular tuberculosis are the most important clinical features of Poncet disease. … We report the case of successfully treated a patient with reactive arthritis induced by active extra-articular tuberculosis with a TNF inhibitor after sufficient antitubercular treatment. …

    Medicine 98(49), e18008, 2019-12


  • The Effect of Estrogen on Neuronal Cell Disorders Elicited by Amyloid β  [in Japanese]

    西田 昌司 , Masashi NISHIDA

    … We investigated three research questions regarding the relationship between the amyloid hypothesis as an etiology of AD and the epidemiological gender difference, using cultured PC-12 neuronal cells loaded with amyloid β: (1) whether PC-12 cells uptake amyloid β, (2) whether incorporated amyloid β produces active oxygen species in PC-12, and (3) whether female hormones suppress the production of reactive oxygen by amyloid β. …

    神戸女学院大学論集 = Kobe College studies 66(1), 15-25, 2019-06

    IR  DOI 

  • Rheumatoid arthritis-like active synovitis with T-cell activation in a case of idiopathic multicentric Castleman disease

    Otsuka Mizuna , Koga Tomohiro , Sumiyoshi Remi , Okamoto Momoko , Endo Yushiro , Tsuji Sosuke , Takatani Ayuko , Shimizu Toshimasa , Igawa Takashi , Kawashiri Shin-ya , Iwamoto Naoki , Ichinose Kunihiro , Tamai Mami , Nakamura Hideki , Origuchi Tomoki , Niino Daisuke , Kawakami Atsushi

    … The levels of both rheumatoid factor and anticitrullinated protein antibody were negative.F-fluorodeoxyglucose/positron emission tomography-computed tomography showed lymphadenopathy with increased fluoro-2-deoxy-D-glucose uptake. … Magnetic resonance imaging and musculoskeletal ultrasonography revealed active synovitis in the hands which was consistent with RA. …

    Medicine 98(18), e15237, 2019-05-01


  • Intracellular localization of vitellogenin receptor mRNA and protein during oogenesis of a parthenogenetic tick, Haemaphysalis longicornis

    Umemiya-Shirafuji Rika , Mihara Ryo , Fujisaki Kozo , Suzuki Hiroshi

    … To elucidate the timing of the onset of Vg uptake, RNA interference (RNAi)-mediated gene silencing of HlVgR was performed. … CONCLUSIONS: These results suggest that active uptake of Vg is required for development from stage III to stage IV during oogenesis. …

    Parasites & vectors 12(1), 205, 2019-05


  • Detection of Active Inflammation Status Around Ventricular Aneurysms in Patients With Cardiac Sarcoidosis

    Nanno Takuma , Suga Kazuyoshi , Yano Masafumi , Kobayashi Shigeki , Yoshitomi Ryosuke , Fujii Shohei , Kajii Toshiro , Kohno Michiaki , Ishiguchi Hironori , Okuda Shinichi , Okada Munemasa

    … 54 patients with active CS (presence of abnormal <sup>18</sup>F-FDG accumulation in the heart) were subdivided into VA (n=17) and non-VA groups (n=37). … Peak standardized uptake value was higher around the VA than in the VA center (5.1±2.1 vs. 2.2±0.6, P=0.0003) and the VA center had no <sup>18</sup>F-FDG accumulation (VA center: 2.2±0.6 vs. control area: 2.1±0.6, P=0.37). …

    Circulation Journal 83(12), 2494-2504, 2019


  • An Examination of Factors Related to Physical Fitness in 5th and 6th Grade Students, and the Association between Physical Fitness and Bone Mass  [in Japanese]

    NAKAOKA Kanae , NODA Seiko , YAMADA Asako , TOGASHI Yuriko , NAMIKI Naoko , GOSEKI (SONE) Masae

    … Regarding female students, many of those who scored high on the physical test developed a healthy body image and their average time spent being physically active was longer. … In addition, a significant positive correlation was observed between the "maximum oxygen uptake", the parameter used to determine bone mass and whole-body endurance for both male and female students. …

    Journal of Home Economics of Japan 70(10), 672-683, 2019

    J-STAGE  Ichushi Web 

  • Vasculo-Behçet disease complicated by conversion disorder diagnosed with <sup>18</sup>F-fluoro-deoxy-glucose positron emission tomography combined with computed tomography (PET/CT)

    Furuya Makiko Yashiro , Temmoku Jumpei , Fujita Yuya , Matsuoka Naoki , Asano Tomoyuki , Sato Shuzo , Kobayashi Hiroko , Watanabe Hiroshi , Migita Kiyoshi

    … PET/CT showed intense FDG uptake in the left popliteal artery, demonstrating active vasculitis. …


    IR  J-STAGE 

  • Effect of Dietary Oil Rich in Docosahexaenoic Acid-Bound Lysophosphatidylcholine Prepared from Fishery By-Products on Lipid and Fatty Acid Composition in Rat Liver and Brain

    Hosomi Ryota , Fukunaga Kenji , Nagao Toshihiro , Shiba Shunichi , Miyauchi Kazumasa , Yoshida Munehiro , Takahashi Koretaro

    … <p>The possibility of improving brain function coupled with its preferential uptake in the brain has garnered attention for docosahexaenoic acid-bound lysophosphatidylcholine (DHA-LPC). … enzymatic modification of phospholipids (PL) extracted from squid (<i>Todarodes pacificus</i>) meal and purification of active carbon, ion exchange resin, and silica gel. …

    Journal of Oleo Science 68(8), 781-792, 2019

    J-STAGE  Ichushi Web 

  • Involvement of Renal Efflux Transporter MATE1 in Renal Excretion of Flecainide

    Doki Kosuke , Apáti Sándor , Sakata Takeshi , Homma Masato

    … <p>Flecainide, an anti-arrhythmic drug, undergoes renal excretion through active renal tubular secretion in addition to passive glomerular filtration. … The contribution of renal uptake and efflux transporters in active renal tubular secretion of flecainide remains unclear except that flecainide is a substrate of human multidrug resistance protein 1 (MDR1). …

    Biological and Pharmaceutical Bulletin 42(7), 1226-1229, 2019

    J-STAGE  Ichushi Web 

  • Telomerase Inhibition, Telomere Shortening, and Cellular Uptake of the Perylene Derivatives PM2 and PIPER in Prostate Cancer Cells

    Kaewtunjai Navakoon , Summart Ratasark , Wongnoppavich Ariyaphong , Lojanapiwat Bannakij , Lee T. Randall , Tuntiwechapikul Wirote

    … Since prostate cancer is slow-growing, active surveillance for low-risk cancer has been increasingly supported by various guidelines. … therefore, telomerase inhibition is potentially useful for the suppression of prostate cancer progression during this active surveillance or for the prevention of cancer recurrence after conventional therapies. …

    Biological and Pharmaceutical Bulletin 42(6), 906-914, 2019

    J-STAGE  Ichushi Web 

  • Successful Inflammation Imaging of Non-Human Primate Hearts Using an Antibody Specific for Tenascin-C

    Ageyama Naohide , Kurosawa Hiroyuki , Fujimoto Ousuke , Uehara Tomoya , Hiroe Michiaki , Arano Yasushi , Yoshida Toshimichi , Yasutomi Yasuhiro , Imanaka-Yoshida Kyoko

    … Tenascin-C (TNC) is an extracellular matrix molecule not normally expressed, but it is strongly upregulated when associated with active inflammation. … Dual autoradiography was used to compare the uptake of <sup>111</sup>In-TNC Fab' … Dual-isotope SPECT showed the regional myocardial uptake of <sup>111</sup>In-TNC Fab' …

    International Heart Journal 60(1), 151-158, 2019

    J-STAGE  Ichushi Web 

  • Apical-to-basolateral transepithelial transport of cow's milk caseins by intestinal Caco-2 cell monolayers : MS-based quantitation of cellularly degraded α- and β-casein fragments

    Sakurai Nao , Nishio Shunsuke , Akiyama Yuka , Miyata Shinji , Oshima Kenzi , Nadano Daita , Matsuda Tsukasa

    … Casein (CN) is the major milk protein to nourish infants but, in certain population, it causes cow's milk allergy, indicating the uptake of antigenic CN and their peptides through the intestinal epithelium. … These results suggest that CNs are partially degraded by cellular proteases and/or peptidases and immunologically active CN fragments are transported to basal side of the cell monolayers.ファイル公開日: 2019/08/01 …

    The journal of biochemistry 164(2), 113-125, 2018-08

    IR  Ichushi Web 

  • Effects of work-matched moderate- and high-intensity warm-up on power output during 2-min supramaximal cycling

    Fujii Naoto , Nishida Yuya , Ogawa Takeshi , Tanigawa Satoru , Nishiyasu Takeshi , 西保 岳 , 谷川 聡 , 藤井 直人

    … Nine active young males performed a 120-s supramaximal cycling exercise consisting of 90 s of constantworkload cycling at a workload that corresponds to 110% peak oxygen uptake (VO2peak) followed by 30 s ofmaximal cycling. …

    Biology of sport 35(3), 223-228, 2018-04


  • A study on the inhibitory effect of aspartic acid salt on skeletal muscle atrophy  [in Japanese]

    山田 茂 , 我妻 玲 , 木崎 恵梨子 , 中川 美桜 , 岩田 華苗

    … Initially, inactivity causes a decrease in capillary and oxygen supply, inhibits ATP synthesis, and produces active oxygen. … We have described the effect of aspartic acid magnesium uptake on the suppression mechanism of muscle atrophy, and the imbalance of the intracellular mineral with the inactive proteolysis system. …

    実践女子大学生活科学部紀要 = Bulletin of Jissen Women's University Faculty of Human Life Sciences (55), 1-7, 2018-03-09

    IR  Ichushi Web 

  • Correlation between the Ratio of Transmitted Near Infrared Radiation to Photosynthetically Active Radiation and Rice Growth Indicators  [in Japanese]

    HIRAI Yasumaru , MOE Kyi , NAGAMATSU Akina , YAMAKAWA Takeo , INOUE Eiji , OKAYASU Takashi , MITSUOKA Muneshi

    … This study focused on the ratio of transmitted near infrared radiation (700-1000 nm, NIR) to photosynthetically active radiation (400-700 nm, PAR), that is, NIRt/PARt (t represents transmitted). … The objective of this study was to investigate correlation between NIRt/PARt and rice growth indicators, which were leaf nitrogen content (LNC), dry matter weight (PDW), and nitrogen uptake (PNU) of rice plant, to examine the possibility of estimating the rice growth indicators using NIRt/PARt. …

    Journal of the Japanese Agricultural Systems Society 34(3), 59-66, 2018


  • Selective Interaction Using Extracellular Nanostructure in Bacteria  [in Japanese]

    TASHIRO Yosuke

    … MV is biologically active and contain various components including genetic materials and proteins. … However, it is not fully understood which bacterial cells uptake MV in microbial community. …

    Oleoscience 18(5), 221-225, 2018

    J-STAGE  Ichushi Web 

  • Surgical Management of Regorafenib-tolerant Progressing Metastatic Gastrointestinal Stromal Tumor—Report of a Case—  [in Japanese]

    SAKANO Yoshihiro , SAITO Takuro , KISHI Kentaro , MASUZAWA Toru , HIROTA Seiichi , AKAMATSU Hiroki

    … Positron emission tomography-computed tomography revealed abnormal fluorodeoxyglucose (FDG) uptake only in the two lesions, and we diagnosed that only these two lesions were tolerant to regorafenib and still in active status. … No obvious active lesions and new metastatic lesions have been observed at one year after the resection of the metastatic lesions. …

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 79(10), 2053-2057, 2018

    J-STAGE  Ichushi Web 

  • Investigation of Intracellular Delivery of NuBCP-9 by Conjugation with Oligoarginines Peptides in MDA-MB-231 Cells

    Wang Wei , Suga Tadaharu , Hagimori Masayori , Kuroda Naotaka , Fuchigami Yuki , Kawakami Shigeru

    … <p>Oligoarginines (Rn) are becoming promising tools for the intracellular delivery of biologically active molecules. … NuBCP-9, a peptide that induces apoptosis in B-cell lymphoma 2 (Bcl-2)-expressing cancer cells, has been reported to promote the uptake and non-specific cytotoxicity of R8, also called octaarginine. … In this study, we conjugated NuBCP-9 with various Rn (<i>n</i>=8, 10, 12, 14) to investigate and compare their cellular uptake characteristics. …

    Biological and Pharmaceutical Bulletin 41(9), 1448-1455, 2018

    IR  J-STAGE  Ichushi Web 

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