Search Results 1-20 of 19406

  • Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice

    Kiyasu Yoshiyuki , Kawada Kenji , Hirai Hideyo , Ogawa Ryotaro , Hanada Keita , Masui Hideyuki , Nishikawa Gen , Yamamoto Takamasa , Mizuno Rei , Itatani Yoshiro , Kai Masayuki , Taketo Mark Makoto , Sakai Yoshiharu

    … Although CCR1 expression in myeloid cells could be associated with pro-tumor activity, it remains elusive whether disruption of CCR1-mediated myeloid cell accumulation can suppress tumor progression. … Mice reconstituted with Ccr1-/- BM exhibited marked suppression of MC38 tumor growth and CMT93 liver metastasis, compared with control mice. …

    Cancer letters (487), 53-62, 2020-09-01

    IR 

  • Role of CGRP in Neuroimmune Interaction via NF-κB Signaling Genes in Glial Cells of Trigeminal Ganglia

    Afroz Shaista , Arakaki Rieko , Iwasa Takuma , Waskitho Arief , Oshima Masamitsu , Matsuka Yoshizo

    … It affects the inflammatory responses and pain sensitivity by modulating the activity of glial cells. … The effect on various genes involved in NF-κB signaling pathway was analyzed compared to no treatment control condition using a PCR array analysis. …

    International Journal of Molecular Sciences 21(17), 6005, 2020-08-20

    IR 

  • Neuroprotective Effects of Casein-Derived Peptide Met-Lys-Pro (MKP) in a Hypertensive Model.

    TADA-MATSUZAKI Asuka , HAMEZAH Hamizah Shahirah Binti , YANAGISAWA Daijiro , MORIKAWA Shigehiro , TOOYAMA Ikuo , 多田 明日翔 , 柳沢 大治郎 , 森川 茂廣 , 遠山 育夫

    … We have previously reported that casein hydrolysate, CH-3, from bovine milk and casein-derived tripeptide Met-Lys-Pro (MKP) has ACE inhibitory activity and reduces blood pressure. … MRI study demonstrated that hemorrhagic lesions were observed in two of five rats in the control group, while no hemorrhagic lesions were observed in the MKP group. …

    Frontiers in Neuroscience, 2020-08-14

    IR 

  • Step-by-Step Procedure to Test Photoelectric Dye-Coupled Polyethylene Film as Retinal Prosthesis to Induce Light-Evoked Spikes in Isolated Retinal Dystrophic Tissue of rd1 Mice

    Matsuo Toshihiko , Terada Keiko , Sakurai Mikako , Liu Shihu , Yamashita Koichiro , Uchida Tetsuya

    … Purpose: Multielectrode array recording for electric activity in cardiac and neuronal cells has been developed as preclinical tests for drug screening. …

    Clinics in Surgery (5), 2903, 2020-08-10

    IR 

  • Switching from originator infliximab to biosimilar infliximab in Japanese patients with rheumatoid arthritis achieving clinical remission (the IFX-SIRIUS study I)

    Kawashiri Shin-ya , Shimizu Toshimasa , Sato Shuntaro , Morimoto Shimpei , Kawazoe Yurika , Sumiyoshi Remi , Hosogaya Naoki , Fukushima Chizu , Yamamoto Hiroshi , Kawakami Atsushi

    … METHODS/DESIGN: This study is an interventional, multicenter, open-label, single-arm against historical control and noninferiority clinical trial with a 24-week follow-up. … We will evaluate disease activity by measuring clinical disease activity indices and by using musculoskeletal ultrasound (MSUS). …

    Medicine 99(30), e21151, 2020-07-24

    IR 

  • Higher Risk Taking and Impaired Probability Judgment in Behavioral Addiction

    Asaoka Yui , Won Moojun , Morita Tomonari , Ishikawa Emi , Goto Yukiori

    行動依存症の認知特性を解明 --なぜ行動依存症はリスクを犯すのか--. 京都大学プレスリリース. 2020-07-07.

    International Journal of Neuropsychopharmacology, 2020-07-23

    IR 

  • Baseline Cognitive Performance Moderates the Effects of Physical Activity on Executive Functions in Children

    Ishihara Toru , Drollette Eric S. , Ludyga Sebastian , Hillman Charles H. , Kamijo Keita

    … Findings regarding the effects of regular physical activity on cognition in children have been inconsistent due to a number of demographic factors and experimental considerations. … The present study was designed to examine baseline cognitive performance and executive function demands, as possible factors underlying the lack of consensus in the literature, by investigating the moderating role of those factors on the effects of physical activity on cognition. …

    Journal of Clinical Medicine 9(7), 2071, 2020-07

    IR 

  • Mechanisms of Audio-Motor Integration during Keyboard Instrument Playing  [in Japanese]

    西村 杏香 , 田村 明由奈 , 村井 翔太 , 小林 耕太 , Momoka Nishimura , Ayuna Tamura , Shota Murai , Kohta I Kobayasi

    MIDIキーボードと機能的磁気共鳴画像法(fMRI)を用い,聴覚フィードバックによって指先の力を調整するときの脳活動を検討した.本研究は,指の力のコントロールにおける聴覚フィードバックの効果と,その時の脳活動について明らかにすることを目的として行った.実験の結果,指先の力を制御する際に音圧と力が対応する聴覚フィードバックが返ってくる場合(Normal条件)の方が,対応していない場合(Reverse …

    同志社大学ハリス理化学研究報告 = The Harris science review of Doshisha University 61(2), 62-68, 2020-07

    IR  DOI 

  • Relationship between metformin use and vitamin B-12 status in patients with type 2 diabetes in Japan

    Sugawara Kenji , Okada Yuko , Hirota Yushi , Sakaguchi Kazuhiko , Ogawa Wataru

    … Materials and Methods This cross‐sectional study was carried out with type 2 diabetes mellitus patients treated (Met group, n = 122) or not treated (control group, n = 63) with metformin. … The primary end-point was the difference in the serum concentration of homocysteine, a marker of VB12 activity, between the two groups. …

    Journal of Diabetes Investigation 11(4), 917-922, 2020-07

    IR 

  • Functional Analysis of Transcriptional Factor, KpeA, in Aspergillus oryzae during Rice and Seed koji Making  [in Japanese]

    荒川 弦矢 , 進藤 斉 , 穂坂 賢 , 徳岡 昌文 , Genya Arakawa , Hitoshi Shindo , Masaru Hosaka , Masafumi Tokuoka

    麹菌の転写因子KpeAは平板培養でのコウジ酸生産の制御因子として見出されたが,その後,広く二次代謝と分生子形成の制御に関わることが明らかとなった。種麹製造及び製麹は分生子形成の制御を伴う醸造工程であり,また,米麹中の二次代謝物は醸造物の品質や安全性に影響する。そこで本研究では,実際の醸造における培養工程である種麹製造と製麹において,KpeAの遺伝子破壊株と高発現株の形質を調べることでKpeAの醸造 …

    東京農業大学農学集報 = Journal of agriculture science, Tokyo University of Agriculture 65(1), 25-32, 2020-06

    IR 

  • Risk Factors for Chronic Damage Accumulation Across Different Onset Eras in Systemic Lupus Erythematosus: A Cross-sectional Analysis of a Lupus Registry of Nationwide Institutions (LUNA)

    Ohashi Keiji , Sada Ken-Ei , Asano Yosuke , Hayashi Keigo , Yamamura Yuriko , Asano Sumie Hiramatsu , Miyawaki Yoshia , Morishita Michiko , Katsuyama Eri , Watanabe Haruki , Tatebe Noriko , Narazaki Mariko , Matsumoto Yoshinori , Sunahori-Watanabe Katsue , Kawabata Tomoko , Yajima Nobuyuki , Wada Jun

    … In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; … Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity. …

    Acta Medica Okayama 74(3), 191-198, 2020-06

    IR  DOI 

  • Moxibustion stimulation of the extremities: its effects ondeep body temperatures and autonomic nervous system during sleep in healthy subjects  [in Japanese]

    松熊 秀明 , 大月 隆史 , 堀川 奈央 , 鍋田 理恵 , 鍋田 智之

    【目的】入眠前の四肢末梢皮膚温度上昇が放熱を促し、深部温度が低下することで睡眠に移行すると されている。そこで、市販されているスモークレスの台座灸を四肢末梢に行い入眠時の深部温度および 自律神経活動にどのような影響を与えるのかについて検討した。【方法】実験にはインフォームドコンセントの得られた本学学生・教職員 8 名 ( 平均年齢 35.6±12.1 歳 ) を用いた。研究デザイ …

    森ノ宮医療大学紀要 = Bulletin of Morinomiya University of Medical Sciences (14), 17-26, 2020-05-01

    IR 

  • Remarkable improvement and weight reduction in obese diabetic patient by continuation of super low carbohydrate diet (LCD)

    Bando Hiroshi

    … She had a strong hope to receive Laparoscopic sleeve gastrectomy (LSG), but she could not take the operation of LSG because of severe diabetic control (HbA1c 11.4%). … In our activity of Japan LCD Promotion Association (JLCDPA), super-LCD has been effective with 12% of carbohydrate. …

    Advances in Obesity, Weight Management & Control 10(2), 40-42, 2020-04-30

    IR 

  • Inhalation administration of the bicyclic ethers 1,8- And 1,4-cineole prevent anxiety and depressive-like behaviours in mice

    Dougnon Godfried , Ito Michiho

    … The results showed that 1, 8-cineole at 4 × 10⁻⁴ mg, and 1, 4-cineole at 4 × 10⁻⁴ and 4 × 10⁻³ mg significantly increased the amount of time spent in the light box and the number of entries in the light box in the LDB as well as reduced the number of marbles buried in the MBT relative to those in the control, suggesting an anxiolytic effect. …

    Molecules 25(8), 2020-04-18

    IR 

  • Association of Fine Particulate Matter Exposure With Bystander-Witnessed Out-of-Hospital Cardiac Arrest of Cardiac Origin in Japan

    Kojima Sunao , Michikawa Takehiro , Matsui Kunihiko , Ogawa Hisao , Yamazaki Shin , Nitta Hiroshi , Takami Akinori , Ueda Kayo , Tahara Yoshio , Yonemoto Naohiro , Nonogi Hiroshi , Nagao Ken , Ikeda Takanori , Sato Naoki , Tsutsui Hiroyuki , the Japanese Circulation Society With Resuscitation Science Study (JCS-ReSS) Group

    … Design, Setting, and Participants: This case-control study used data from cases registered between January 1, 2005, and December 31, 2016, in the All-Japan Utstein Registry, a prospective, nationwide, population-based database for OHCAs across all 47 Japanese prefectures. … However, an initial nonshockable rhythm, such as pulseless electrical activity and asystole, was associated with PM2.5 exposure (% increase, 1.4; …

    JAMA Network Open 3(4), 2020-04-17

    IR 

  • Protective effects of a cystine and theanine mixture against acute radiation injury in rats

    Matsuu-Matsuyama Mutsumi , Shichijo Kazuko , Tsuchiya Takashi , Kondo Hisayoshi , Miura Shiro , Matsuda Katsuya , Sekine Ichiro , Nakashima Masahiro

    … CT pre-treatment (280 mg/kg for 5 days) significantly improved weight loss and survival rate of rats as compared with the control group after 5 Gy. … CT pre-treatment significantly increased the rate of mucosa and crypt length, and decreased the number of apoptotic cells, TUNEL and cleaved caspase-3 positive cells, while increasing the number of mitotic cells and Ki-67 positive cells in jejunal crypts and villi compared to control rats post-irradiation. …

    Environmental Toxicology and Pharmacology (78), 103395, 2020-04-17

    IR 

  • Software Analytics for Manual Activities using Developer Work Elements

    Peraphon Sopahtsathit

    … Unfortunately, existing state-of-the-practice software engineering development models do not take human effort into consideration since there are no applicable metrics to gauge the associated manual activity. … The proposed technique classifies three manual activity domains, namely, abstract, concrete, and unclassified. …

    情報処理学会論文誌 61(4), 2020-04-15

    IPSJ 

  • Curcumin β‐D‐glucuronide exhibits anti‐tumor effects on oxaliplatin‐resistant colon cancer with less toxicity in vivo

    Ozawa‐Umeta Hitomi , Kishimoto Atsuhiro , Imaizumi Atsushi , Hashimoto Tadashi , Asakura Tadashi , Kakeya Hideaki , Kanai Masashi

    水溶性プロドラッグ型抗がん剤CMGの治療抵抗性大腸がんに対する抗腫瘍効果を解明 --難治性がん治療薬の開発に期待--. 京都大学プレスリリース. 2020-03-16.

    Cancer Science, 2020-04-07

    IR 

  • Distinct sensorimotor feedback loops for dynamic and static control of primate precision grip

    Oya Tomomichi , Takei Tomohiko , Seki Kazuhiko

    動的・静的筋力発揮に脊髄と大脳皮質一次運動野の帰還信号のループが別々に関わっていることを発見 --脊髄と脳の役割分担--. 京都大学プレスリリース. 2020-04-10.

    Communications Biology (3), 2020-04-02

    IR 

  • 〈Research Notes〉Screening of antifungal volatile compounds derived from microorganisms  [in Japanese]

    大池 達矢 , 江邉 正平 , 松川 哲也 , 岡南 政宏 , 梶山 慎一郎 , 阿野 貴司

    [要旨]本研究では、環境土壌から単離した細菌が生産する揮発性有機化合物(Microbial Volatile OrganicCompounds :MVOCs)に着目し、 MVOCsによる植物病原菌に対する抗真菌活性を試験した。また、植物病原菌に対して強い抗真菌活性を示した細菌を4株選抜し、それらのMVOCsのGC/MS分析を試みた。MVOCsによる抗真菌活性の結果、Monilinia fructi …

    近畿大学生物理工学部紀要 = Memoirs of the Faculty of Biology-Oriented Science and Technology of Kindai University (43), 63-72, 2020-03-31

    IR 

Page Top