CiNii Articles - acyclic retinoid

1

Supplementation with geranylgeranoic acid during mating, pregnancy and lactation improves reproduction index in C3H/HeN mice

Tabata Yuki , Uematsu Sayaka , Shidoji Yoshihiro

<p><tt>ジテルペノイドの一種であるゲラニルゲラノイン酸（GGA）はウコンなどの植物に含まれる天然の化合物である。我々は以前AKR/J系マウスの繁殖期間中にGGAを摂取させると、再生産指数（RI）が対照群の3倍まで向上することを見出し、特許を取得している。GGAによるRIの向上が他の齧歯類や哺乳動物でも有効か調べるために、本研究では以前とは他系統のC3H系マウスを用いR …

Journal of Pet Animal Nutrition 23(1), 1-8, 2020

J-STAGE Ichushi Web
2

Chemoprevention of hepatocellular carcinoma by acyclic retinoid : clinical trials [in Japanese]

清水雅仁 , 森脇久隆

医学のあゆみ 249(11), 1159-1163, 2014-06-14

Ichushi Web
3

Chemoprevention of hepatocellular carcinoma by acyclic retinoid : basic research [in Japanese]

秦咸陽 , 小嶋聡一

医学のあゆみ 249(11), 1153-1158, 2014-06-14

Ichushi Web
4

The acyclic retinoid peretinoin inhibits hepatitis C virus replication and infectious virus release in vitro

Shimakami Tetsuro , Honda Masao , Shirasaki Takayoshi , Takabatake Riuta , Liu Fanwei , Murai Kazuhisa , Shiomoto Takayuki , Funaki Masaya , Yamane Daisuke , Murakami Seishi , Lemon Stanley M. , Kaneko Shuichi

… Clinical studies suggest that the oral acyclic retinoid Peretinoin may reduce the recurrence of hepatocellular carcinoma (HCC) following surgical ablation of primary tumours. …

Scientific Reports (4), 4688, 2014-04-15

IR
5

Combination of Bevacizumab and Acyclic Retinoid Inhibits the Growth of Hepatocellular Carcinoma Xenografts

KUBOTA Masaya , SHIMIZU Masahito , BABA Atsushi , OHNO Tomohiko , KOCHI Takahiro , SHIRAKAMI Yohei , MORIWAKI Hisataka

… This study examined the possible combined inhibitory effects of bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody, and acyclic retinoid (ACR), which can prevent the development of HCC, on the growth of Huh7 human HCC cells. …

Journal of Nutritional Science and Vitaminology 60(5), 357-362, 2014

J-STAGE Ichushi Web
6

Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development [in Japanese]

OKADA H , HONDA M , CAMPBELL JS , SAKAI Y , YAMASHITA T , TAKEBUCHI Y , HADA K , SHIRASAKI T , TAKANATAKE R , NAKAMURA M , SUNAGOZAKA H , TANAKA T , FAUSTO N , KANEKO S

… Although recent evidence suggests that peretinoin, a member of the acyclic retinoid family, may be an effective chemopreventive drug for HCC, published data about its effects on hepatic mesenchymal cells, such as stellate cells and endothelial cells, remain limited. …

金沢大学十全医学会雑誌 = Journal of the J◆U00FB◆zen Medical Society 122(2), 35-36, 2013-06-01

IR References (3)
7

CXCR4-Tropic, But Not CCR5-Tropic, Human Immunodeficiency Virus Infection Is Inhibited by the Lipid Raft-Associated Factors, Acyclic Retinoid Analogs, and Cholera Toxin B Subunit

Kamiyama Haruka , Kakoki Katsura , Shigematsu Sayuri , Izumida Mai , Yashima Yuka , Tanaka Yuetsu , Hayashi Hideki , Matsuyama Toshifumi , Sato Hironori , Yamamoto Naoki , Sano Tetsuro , Shidoji Yoshihiro , Kubo Yoshinao

… Retinoid analogs have been shown to modulate ceramide levels in the cell membrane, while cholera toxin B subunit (CT-B) specifically binds to the ganglioside GM1. … In this study, we found that the acyclic retinoid analogs geranylgeranoic acid (GGA) and NIK-333 as well as CT-B efficiently attenuate CXCR4-tropic, but not CCR5-tropic, HIV-1 vector infection. …

AIDS Research and Human Retroviruses 29(2), 279-288, 2013-01-21

IR
8

Adjuvant systemic drug therapy and recurrence of hepatocellular carcinoma following curative resection

Zhong Yuesi , Liu Bo , Deng Meihai , Xu Ruiyun

… however, no other studies have reported polyprenoicacid (acyclic retinoid) to be effective. …

Drug Discoveries & Therapeutics 7(4), 164-166, 2013

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9

Chemoprevention of Hepatocellular Carcinoma by Acyclic Retinoid [in Japanese]

Shimizu Masahito , Moriwaki Hisataka

… A malfunction of the retinoid X receptor-α (RXRα) due to phosphorylation by the Ras-MAPK signaling pathway is profoundly involved in liver carcinogenesis and thus may be a promising target for HCC chemoprevention. … Acyclic retinoid (ACR), which inhibits Ras-MAPK activation and RXRα phosphorylation, successfully improves the survival of HCC patients by preventing the recurrence of the tumor and the formation of secondary tumors. …

VITAMINS 87(2), 90-94, 2013

J-STAGE Ichushi Web References (26)
10

Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J-+Lepr^<db>/+Lepr^<db> mice [in Japanese]

SHIMIZU Masahito , MORIWAKI Hisataka

ビタミン 86(5), 309-312, 2012-06-25

References (9)
11

Prediction and prevention of intrahepatic recurrence of hepatocellular carcinoma

IZUMI Namiki

Hepatology research : the official journal of the Japan Society of Hepatology 42(3), 226-232, 2012-03-01

Ichushi Web References (61)
12

Combination of acyclic retinoid with branched-chain amino acids inhibits xenograft growth of human hepatoma cells in nude mice

SHIMIZU M.

Hepatol Res 42, 1241-1247, 2012

Ichushi Web Cited by (2)
13

Study on clinical effects and basic action mechanisms of acyclic retinoid for chemoprevention of liver cancers [in Japanese]

Moriwaki Hisataka

… Retinoid X receptor (RXR) is a key nuclear receptor and regulates cellular differentiation and programmed cell death. … Acyclic retinoid is a synthetic RXR-ligand, restores the RXR malfunction, and actually induces differentiation and apoptosis in liver cancer cells. … Phase II/III clinical trials of acyclic retinoid demonstrated significant preventive effect on second primary liver carcinogenesis. …

VITAMINS 86(12), 665-670, 2012

J-STAGE Ichushi Web References (22)
14

Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand [in Japanese]

Ohno Tomohiko , Shirakami Yohei , Shimizu Masahito , Kubota Masaya , Sakai Hiroyasu , Yasuda Yoichi , Kochi Takahiro , Tsurumi Hisashi , Moriwaki Hisataka

VITAMINS 86(10), 539-541, 2012

J-STAGE References (14)
15

Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +Lepr^<db>/+Lepr^<db> mice [in Japanese]

Shimizu Masahito , Moriwaki Hisataka

VITAMINS 86(5-6), 309-312, 2012

J-STAGE
16

Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand [in Japanese]

大野智彦 , 清水雅仁 , 久保田全哉 [他] , 河内隆宏 , 白上洋平 , 鶴見寿 , 森脇久隆

VITAMINS 86(4), 241, 2012

J-STAGE Ichushi Web
17

Phase I and pharmacokinetic clinical trial of oral administration of the acyclic retinoid NIK-333

OKUSAKA Takuji , UENO Hideki , IKEDA Masafumi , MORIZANE Chigusa

Hepatology research : the official journal of the Japan Society of Hepatology 41(6), 542-552, 2011-06-01

Ichushi Web References (13)
18

Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells

TATSUKAWA Hideki , SANO Tetsuro , FUKAYA Yayoi , ISHIBASHI Naoto , WATANABE Makiko , OKUNO Masataka , MORIWAKI Hisataka , KOJIMA Soichi

Molecular Cancer (10), 4, 2011-01-09

IR
19

Acyclic retinoid NIK-333 accelerates liver regeneration and lowers serum transaminase activities in 70% partially hepatectomized rats, in vivo

木村光利 , Watanabe Makiko , Ishibashi Naoto , Yanagida Shingo , 荻原政彦

… The effect of an acyclic synthetic retinoid analogue NIK-333, on the restoration of liver mass and recovery of liver function after 70% partial hepatectomy, was compared with natural retinoids in rats in vivo. …

European Journal of Pharmacology 643(2-3), 267-273, 2010-09

IR
20

Chemoprevention of hepatocellular carcinoma by acyclic retinoid [in Japanese]

清水雅仁 , 森脇久隆

Japanese journal of clinical medicine 67(-), 240-244, 2009-05

Ichushi Web

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