Search Results 1-20 of 680

  • Transport of docosahexaenoic acid across the blood–brain barrier is decreased in aged mice  [in Japanese]

    Iwao Takuro , Takata Fuyuko , Matsumoto Junichi , Kataoka Yasufumi , Dohgu Shinya

    … </p><p>In the whole brain of aged mice, DHA uptake was significantly decreased by 52.5%, without any change to the expression level of Mfsd2a protein in brain microvasculature compared with young mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-41, 2021


  • Factors characterizing gait performance of patients before and soon after knee arthroplasty

    Ito Hideyuki , Ichihara Kiyoshi , Tamari Kotaro , Amano Tetsuya , Tanaka Shigeharu , Uchida Shigehiro

    … Factors (gender, age, and surgical mode) that might influence changes in test results were evaluated by multiple regression analysis and a two-factor stratification diagram. … [Results] Multiple regression analysis revealed that postsurgical changes in comfortable/maximum Timed Up and Go and maximum walking speed results were associated with age and surgical mode after adjustment for preoperative values. …

    Journal of Physical Therapy Science 33(3), 274-282, 2021


  • Aging of the Vascular System and Neural Diseases.

    WATANABE Chisato , IMAIZUMI Tsutomu , KAWAI Hiromi , SUDA Kazuma , HONMA Yoichi , ICHIHASHI Masamitsu , EMA Masatsugu , MIZUTANI Ken-Ichi , 渡部 千里 , 依馬 正次

    … Each capillary network is critical for maintaining proper brain function because age-related and disease-related impairment of cognitive function is associated with the loss or diminishment of brain capillaries. … This review article highlights how structural and functional alterations in the brain vessels may change with age and neurogenerative diseases. …

    Frontiers in Aging Neuroscience (12), 2020-09-29


  • A venous mechanism of ventriculomegaly shared between traumatic brain injury and normal ageing

    Aso Toshihiko , Sugihara Genichi , Murai Toshiya , Ubukata Shiho , Urayama Shin-ichi , Ueno Tsukasa , Fujimoto Gaku , Thuy Dinh Ha Duy , Fukuyama Hidenao , Ueda Keita

    ヒト脳の新しい加齢バイオマーカーを発見 --脳萎縮のメカニズム解明へ向けて--. 京都大学プレスリリース. 2020-05-21.

    Brain 143(6), 1843-1856, 2020-06


  • The Effect of a Multicomponent Dual-Task Exercise on Cortical Thickness in Older Adults with Cognitive Decline: A Randomized Controlled Trial

    Bae Seongryu , Harada Kenji , Lee Sangyoon , Harada Kazuhiro , Makino Keitaro , Chiba Ippei , Park Hyuntae , Shimada Hiroyuki

    … Cortical thickness changes were significantly associated with change in trail making test (TMT)-A, TMT-B, and story memory after a 10-month multicomponent exercise intervention. … This study suggests that multicomponent exercise programs combining physical exercise and cognitive training have important implications for brain health, especially in providing protection from age-related cortical thinning. …

    Journal of Clinical Medicine 9(5), 1312, 2020-05


  • The age-related change of gut microbiota and anti-aging function of Bifidobacterium  [in Japanese]

    大野 和也 , 吉本 真 , 小田巻 俊孝 , 清水 金忠

    Anti-aging medicine 16(2), 162-166, 2020-04

    Ichushi Web 

  • Age related change of the swing velocity in different batting trials in youth baseball players  [in Japanese]

    筒井 俊春 , 前道 俊宏 , 飯塚 哲司 , 鳥居 俊

    日本成長学会雑誌 26(1), 5-10, 2020-04

  • Efficacy and Safety of Intravitreal Aflibercept Treat-and-Extend Regimens in Exudative Age-Related Macular Degeneration: 52- and 96-Week Findings from ALTAIR : A Randomized Controlled Trial.

    OHJI Masahito , TAKAHASHI Kanji , OKADA Annabelle Ayame , Kobayashi Masato , MATSUDA Yoshimi , TERANO Yasuhiro , HANEMOTO Tsukasa , KAGA Tatsushi , KOUNO Takeya , KITAMEI Hirokuni , SATO Shinpei , YANAI Ryoji , Uchio Eiichi , MIYATA Kazunori , 若林 賢彦 , MAENO Takatoshi , YASUKAWA Tsutomu , HORIGUCHI Masayuki , NISHIMURA Tetsuya , KAWAHARA Akiteru , KURIMOTO Yasuo , MURAI Kenichi , KOBAYASHI Namie , KIMURA Wataru , MATSUSHITA Eriko , SONODA Kohei , ALTAIR Investigators , 大路 正人

    … PURPOSE:To evaluate efficacy and safety of intravitreal injections of aflibercept (IVT-AFL) treat-and-extend (T&E) dosing regimens in treatment-naïve patients with exudative age-related macular degeneration (AMD).RESULTS:Baseline characteristics were comparable between the groups (n = 123 each). … From baseline, mean change in BCVA was + 9.0 and + 8.4 letters (week 52) and + 7.6 and + 6.1 letters (week 96); …

    Advances in therapy 37(3), 1173-1187, 2020-03


  • Color vision in elderly individuals and in color-deficient individuals  [in Japanese]

    Shinomori Keizo

    <p>本稿では,特に加齢による視覚系の変化に伴う色覚の変化に焦点をあて,色の認識の問題についても考える。加齢変化により水晶体濃度が増加し,高齢者は短波長である青領域での光量が中波長領域と比べて1 log程度減少する。分光的な変化はディスプレイ利用の色覚検査にも影響を与える一方,アノマロスコープ検査は影響されない。解剖学的な要因による錐体感度低下もあり色弁別能力は低下する。同時に,色の見 …

    Japanese Journal of Visual Science 41(4), 56-65, 2020


  • Age-Related Change in Muscle Characteristics and Resistance Training for Older Adults

    IKEZOE Tome

    … This review shows the age-related changes in muscle mass and muscle quality, which were measured by muscle echo intensity on ultrasound images, and low-intensity resistance training effects on muscle volume and muscle quality.</p> …

    Physical Therapy Research 23(2), 99-105, 2020


  • Hearing Change After Shunt Placement in Elderly Patients with Idiopathic Normal-Pressure Hydrocephalus  [in Japanese]

    Sugiura Saiko , Bundo Masahiko , Suzuki Hirokazu , Nakada Takafumi , Uchida Yasue , Sone Michihiko , Nakashima Tsutomu

    <p> 水頭症患者における聴力変化がしばしば報告されており, 相対的内リンパ水腫によると推測されている. 今回われわれは2012年1月~2018年3月の間に正常圧水頭症に対するシャント手術を受け, 術前後で聴力検査を行った高齢者53名において聴力変化についての検討を行った. 術前の聴力は半数以上に中等度以上の感音難聴を認めた. 術後の聴力は53名全体では一部の低音域において有意な低下を …

    Nippon Jibiinkoka Gakkai Kaiho 123(8), 737-744, 2020

    J-STAGE  Ichushi Web 

  • The Role of Tropomyosin in Lens Epithelial Mesenchymal Transition and Differentiation  [in Japanese]

    Shibata Teppei

    <p>もっとも一般的な白内障術後の合併症は, 後囊混濁 (posterior capsule opacification:PCO) である. 筆者らは, PCOの発症にトロポミオシン (tropomyosin:Tpm) がかかわっている可能性があることに注目した. 本研究では, <i>Tpm1</i>の水晶体特異的ノックアウトマウス (<i>Tpm1 …

    The Journal of The Japanese Society for Cataract Research 32(1), 7-10, 2020

    J-STAGE  Ichushi Web 

  • Attenuation of core temperature elevation and interleukin-6 excretion during head-out hot water immersion in elderly people

    Yamashiro Mami , Nishimura Yukihide , Mikami Yukio , Kouda Ken , Sakurai Yuta , Yoshioka Izumi , Kinoshita Tokio , Kojima Daisuke , Tajima Fumihiro

    … however, serum interleukin-6 levels did not change in elderly participants. … We assert that these differences are likely to be related to age-related changes in core temperature regulation and muscle fibers.</p> …

    Journal of Physical Therapy Science 32(7), 444-448, 2020


  • Does left-right discrimination ability of adults change with age?  [in Japanese]

    Yoshizaki Kazuhito , Kato Kimiko , Hatta Takeshi

    Age-related changes in left-right discrimination, which mainly reflect visuospatial processing, were investigated. … Healthy middle-aged (N = 236, 55-64 years of age), young-old (N = 129, 65-74 years of age) and old-old (N = 252, 75-92 years of age) participants responded to a modified version of the MRMT comprising of 12 turns, each of which could be assigned to one of the three categories of mental rotation proposed by Vingerhoets et al. …

    Journal of Human Environmental Studies 18(1), 43-48, 2020


  • Process of Hikikomori during Adolescence to a Support Organization  [in Japanese]

    Tamada Satoshi , Matsushita Toshiko , Katayama Noriko

    <p>本研究は,情報伝達手段の多様化した昨今において,思春期にひきこもった当事者が,支援機関に通所するまでのプロセス明らかにすることを目的とした.研究対象者7名にインタビューを行い,修正版グラウンデッド・セオリー・アプローチにて分析した.また,分析の過程でスマートフォンやSNSなど,近年の情報伝達手段の多様化に伴う対人関係の変化を加味した.その結果,コアカテゴリである《同年代から受ける …

    Journal of Japan Academy of Psychiatric and Mental Health Nursing 29(1), 13-22, 2020


  • Age-Dependent Increase of IGFBP-4 Causes Skin Aging  [in Japanese]

    Okuno Ryosuke , Tanaka Hiroshi , Hasegawa Seiji , Nakata Satoru

    <p>IGF-1(インスリン様成長因子1)は細胞の増殖や分化にさまざまな役割を果たしている。皮膚においてはケラチノサイトの増殖促進効果や線維芽細胞におけるコラーゲン産生促進効果,分解抑制効果などを有することがしられている。加齢によってIGF-1 の産生量が減少することによりIGF-1 の機能発現が低下することはよくしられているが,IGF-1 を受容する細胞側の加齢変化は十分には明らかに …

    Journal of Society of Cosmetic Chemists of Japan 54(1), 33-41, 2020


  • Age-related change of the pulmonary and bronchial circulation  [in Japanese]

    重田 文子 , 田邉 信宏

    Anti-aging medicine 15(4), 421-425, 2019-08

    Ichushi Web 

  • Posture Age Model Based on Anteversion of Elderly People and Proposal of its Reduction Method  [in Japanese]

    武藤 剛 , 千葉 智也 , 柴 喜崇 , 上出 直人 , 坂本 美喜 , 村田 修平 , 鈴木 愛理 , 福本 将也 , 武藤 ゆみ子

    電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 119(86), 37-40, 2019-06-16

  • Muscle atrophy in the lower extremity and abdominal muscle with aging, and the correlation of muscle atrophy and stiffness with low back pain  [in Japanese]

    市橋 則明 , 池添 冬芽

    日本整形外科学会雑誌 93(4), 253-259, 2019-04

    Ichushi Web 

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