Search Results 1-20 of 559

  • Management of side effects induced by angiogenesis inhibitors  [in Japanese]

    平井 章浩 , 大木 遼佑 , 内野 慶太

    腫瘍内科 = Clinical oncology 25(3), 251-256, 2020-03

    Ichushi Web 

  • MiR-134-5p Regulates Myocardial Apoptosis and Angiogenesis by Directly Targeting KDM2A After Myocardial Infarction

    Li Xue , Wei Caiwen , Zhang Zhaozhi , Jin Qu , Xiao Xue

    … The promotion effect on the protein level of KDM2A and VEGF induced by miR-134-5p inhibitor can be reversed by shKDM2A in cardiomyocytes. … Further, silencing of miR-134-5p promoted myocardial angiogenesis and inhibited myocardial apoptosis via upregulating KDM2A in MI mice. … Taken together, our research revealed that knockdown of miR-134-5p increased KDM2A expression, thereby suppressing myocardial apoptosis and promoting myocardial angiogenesis.</p> …

    International Heart Journal, 2020

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  • A Long-term Survival Case of Pulmonary Tumor Thrombotic Microangiopathy due to Gastric Cancer Confirmed by the Early Diagnosis based on a Transbronchial Lung Biopsy

    Imakura Takeshi , Tezuka Toshifumi , Inayama Mami , Miyamoto Ryota , Abe Akane , Otsuka Kanako , Yoshida Seiji , Kudo Eiji , Haku Takashi

    … The patient was administered chemotherapy, including angiogenesis inhibitors, against gastric cancer at an early age and survived for a long time. …

    Internal Medicine 59(13), 1621-1627, 2020

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  • Clinicopathological Study of the Immunohistological Expression of mTOR and Phosphorylated mTOR in Renal Cell Carcinoma

    MIZUKAMI SAINOSUKE , NAGATA MASAYOSHI , TAKAHASHI HIROYUKI , HORIE SHIGEO

    … Activation of its pathway has been found to enhance cancer cell growth, apoptosis inhibition and angiogenesis. …

    Juntendo Medical Journal 66(3), 206-212, 2020

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  • Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice

    Shi Xiaowei , Luo Xueting , Xu Xin

    … <p>Dimethylarginine dimethylaminohydrolase-1 (DDAH1) maintains nitric oxide (NO) bioavailability by degrading asymmetric dimethylarginine (ADMA), which is an endogenous inhibitor of nitric oxide synthase (NOS). … It has been well established that DDAH1 and exercise play crucial roles in promoting cardiac angiogenesis under pathological conditions. … However, the role of DDAH1 in exercise-induced cardiac angiogenesis remains unclear. …

    BioScience Trends 14(2), 115-122, 2020

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  • Treatment Strategy for Advanced Non-small-cell Lung Cancer with Interstitial Lung Disease  [in Japanese]

    Nokihara Hiroshi , Nishioka Yasuhiko

    <p>血管新生阻害薬,ドライバー遺伝子変異に対する阻害薬,免疫チェックポイント阻害薬の登場により進行非小細胞肺癌に対する薬物療法は大きく変貌した.一方,間質性肺炎合併非小細胞肺癌に対する薬物療法は限られた薬物の使用にとどまり,そのエビデンスは乏しい.間質性肺炎合併非小細胞肺癌に対する血管新生阻害薬や免疫チェックポイント阻害薬の有効性や安全性の情報は乏しく,臨床医にとってclinical …

    Haigan 60(2), 74-80, 2020

    J-STAGE 

  • Change of serum cytokine profiles by propranolol treatment in patients with infantile hemangioma

    Tani Sayaka , Takeuchi Takashi , Suzuki Hiroyuki , Jinnin Masatoshi , Kunimoto Kayo , Inaba Yutaka , Mikita Naoya , Kaminaka Chikako , Kanazawa Nobuo , Yamamoto Yuki , Kakimoto Nobuyuki , Suenaga Tomohiro

    … Signals for angiogenin, epidermal growth factor (EGF), platelet-derived growth factor-BB (PDGF-BB), regulated on activation, normal T-cell expressed and secreted chemokine (RANTES), tissue inhibitor of metalloproteinases 1 (TIMP-1), and tissue inhibitor of metalloproteinases 2 (TIMP-2) were evident in all five cases before treatment. …

    Drug Discoveries & Therapeutics 14(2), 89-92, 2020

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  • Abnormal Vascular Phenotypes Associated with the Timing of Interruption of Retinal Vascular Development in Rats

    Kondo Ryo , Nakano Ayuki , Asano Daiki , Morita Akane , Arima Shiho , Mori Asami , Sakamoto Kenji , Nagamitsu Tohru , Nakahara Tsutomu

    … <p>Pathological angiogenesis is a leading cause of blindness in several retinal diseases. … The key driving factor inducing pathological angiogenesis is the pronounced hypoxia leading to a marked, increased production of vascular endothelial growth factor (VEGF). … Vascular defects of two different degrees were created in the retina by subcutaneously treating neonatal rats with the VEGF receptor (VEGFR) tyrosine kinase inhibitor KRN633 on postnatal day (P) 4 and P5 (P4/5) or P7 and P8 (P7/8). …

    Biological and Pharmaceutical Bulletin 43(5), 859-863, 2020

    J-STAGE 

  • PRC2 Components Maintain DNA Hypermethylation of the Upstream Promoter and Regulate Robo4 Expression in Endothelial Cells

    Izawa Kohei , Shirakura Keisuke , Kakiuchi Koji , Funahashi Nobuaki , Maekawa Naoki , Hino Nobumasa , Tanaka Toru , Doi Takefumi , Okada Yoshiaki

    … <p>Roundabout4 (Robo4) is an endothelial cell-specific protein that stabilizes the vasculature in pathological angiogenesis and inflammation. … An inhibitor for the PRC2 component, EZH2, induced the promoter activity and expression of Robo4 in endothelial cells treated with or without TNFα. …

    Biological and Pharmaceutical Bulletin 43(4), 742-746, 2020

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  • Impaired endothelium-dependent vasodilator responses of retinal blood vessels in adult rats with a history of retinopathy of prematurity  [in Japanese]

    Mori Asami , Nakano Ayuki , Sumida Daiki , Kondo Rho , Asano Daiki , Morita Akane , Sakamoto Kenji , Nakahara Tsutomu

    … We reported that short-term interruption of retinal vascular development with blockade of vascular endothelial growth factor (VEGF) signaling pathway in neonatal rats induces ROP-like retinal blood vessels, such as aggressive angiogenesis and tortuous arteries. … ROP was induced in rats by the subcutaneous injection of the VEGF receptor tyrosine kinase inhibitor KRN633 on postnatal day (P) 7 and P8. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-322, 2020

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  • The role of Prostaglandin D<sub>2 </sub>synthase in retinal angiogenesis  [in Japanese]

    Erika Sekihachi , Omori Keisuke , Kobayashi Koji , Nagata Nanae , Nakamura Tatsuro , Kurata Kaori , Uemura Akiyoshi , Murata Takahisa

    … (PGD<sub>2</sub>) represents anti-angiogenic role in tumor model, its role in physiological and pathological angiogenesis still remain unknown. … on retinal angiogenesis using genetically modified mice. … Gene deficiency of L-PGDS impaired the physiological angiogenesis of retina, accompanied with increased mRNA expression of pro-angiogenic factor VEGF. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-YIA-35, 2020

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  • Valproic acid prevents retinal angiogenesis via a proteasome-dependent mechanism in neonatal mice  [in Japanese]

    Morita Akane , Takahashi Kanako , Iizuka Naoto , Saito Keigo , Asano Daiki , Mori Asami , Sakamoto Kenji , Nakahara Tsutomu

    … <p>Pathological retinal angiogenesis contributes to the development and progression of vision-threatening eye diseases, such as retinopathy of prematurity and diabetic retinopathy. … We previously reported that valproic acid and vorinostat, a HDAC inhibitor, suppress pathologic retinal angiogenesis in mice with oxygen-induced retinopathy. … At P4, the delayed retinal angiogenesis was observed in mice treated with valproic acid or vorinostat. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-073, 2020

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  • Fibrinolytic Activity of Circulating Microvesicles Is Associated with Progression of Breast Cancer

    Valente-Acosta Benjamín , Flores-García Mirthala , González-Zárate Georgina , Gerson-Cwilich Raquel , Maldonado-Méndez Marai , Juárez-Vega Guillermo , Anglés-Cano Eduardo , Peña-Díaz Aurora de la

    … <p>The fibrinolytic system plays an important role in breast cancer, favoring progression through extracellular-matrix degradation, angiogenesis, apoptosis and cellular proliferation. … However, fibrinolytic activity associated with uPA cannot be reliably measured in the blood because of the rapid inhibition of uPA by plasminogen activator inhibitor-1 (PAI-1). …

    The Tohoku Journal of Experimental Medicine 250(2), 121-128, 2020

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  • Exploration of Potential Prognostic Biomarkers in Aflibercept Plus FOLFIRI in Japanese Patients With Metastatic Colorectal Cancer

    森脇 俊和 , Tetsuya Hamaguchi , Tadamichi Denda , Toshihiro Kudo , Naotoshi Sugimoto , Takashi Ura , Kentaro Yamazaki , Hirofumi Fujii , Takeshi Kajiwara , Takako Eguchi Nakajima , Shin Takahashi , Satoshi Otsu , Yoshito Komatsu , Fumio Nagashima , Toshikazu MORIWAKI , Taito Esaki , Takeo Sato , Michio Itabashi , Eiji Oki , Toru Sasaki , Marielle Chiron , Takayuki Yoshino

    … Seventy‐eight potential protein biomarkers were chosen for analysis based on their roles in angiogenesis, tumor progression, and tumor‐stroma interaction. …

    Cancer Science 110(11), 3565-3572, 2019-12

    IR 

  • Standard therapy including immune checkpoint inhibitor for renal cell carcinoma  [in Japanese]

    髙橋 俊二

    腫瘍内科 = Clinical oncology 24(3), 244-252, 2019-09

    Ichushi Web 

  • Angiogenesis inhibitors and hypertension  [in Japanese]

    門脇 裕 , 赤澤 宏

    腎臓内科・泌尿器科 = Nephrology & urology 10(1), 31-37, 2019-07

    Ichushi Web 

  • 2nd-line antiangiogenic therapy in advanced colorectal carcinoma : RAISE trial and its subgroup analyses  [in Japanese]

    梁 幾勇 , 谷澤 欣則 , 廣田 晋也 , 吉野 孝之

    腫瘍内科 = Clinical oncology 24(1), 97-106, 2019-07

    Ichushi Web 

  • (Pro)renin receptor in the pathogenesis of diabetic retinopathy and development of inhibitor  [in Japanese]

    神田 敦宏

    内分泌・糖尿病・代謝内科 = Endocrinology, diabetology & metabolism 48(5), 368-371, 2019-05

    Ichushi Web 

  • Novel regulatory mechanism of gene expression by nitric oxide  [in Japanese]

    Uehara Takashi

    … NO also has a variety of physiological functions such as neurotransmission, inflammatory reaction, vasodilation, and stimulates both angiogenesis and cell proliferation. … In addition, we attempted to develop a specific inhibitor of <i>S</i>-nitrosylation of this substrate by the hierarchical virtual screening approaches. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-S21-1, 2019

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  • The involvement of advanced glycation end products in angiogenesis  [in Japanese]

    Yamazaki Yui , Nishinaka Takashi , Niwa Atsuko , Mori Shuji , Wake Hidenori , Liu Keyue , Nishibori Masahiro , Takahashi Hideo

    … Advanced glycation end products (AGEs) accumulating under hyperglycemic conditions are acknowledged to play a causative role in the vascular complications of diabetes including retinopathy associated with excessive angiogenesis. … However, the detailed mechanism of AGEs-mediated excessive angiogenesis is poorly understood. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-O-03, 2019

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