Search Results 1-20 of 155

  • Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis

    Takahashi Mari , Takahashi Genki , Tanaka Jun , Takiguchi Hiroto , Niimi Kyoko , Ito Yoko , Hayama Naoki , Oguma Tsuyoshi , Asano Koichiro , Horio Yukihiro , Takihara Takahisa , Enokida Keito , Miyaoka Masashi , Hirabayashi Kenichi , Ohshinden Kana , Hattori Shigeaki , Takahashi Fuminari

    Anti-cancer treatments were not performed because of the presence of advanced interstitial pneumonia and chronic respiratory failure. … Cyclosporine A was tapered to avoid suppression of anti-tumor immunity, and pirfenidone was initiated. … Within 2 months, the tumor had shrunk to 10 mm in diameter and remained regressed for 9 months. …

    Internal Medicine, 2021


  • Sinomenine Can Inhibit the Growth and Invasion Ability of Retinoblastoma Cell through Regulating PI3K/AKT Signaling Pathway

    Zheng Qian , Zhu Qin , Li Cuiping , Hao Shuang , Li Jianguo , Yu Xin , Qi Dengmei , Pan Yu

    … <p>Sinomenine was found to play anti-cancer functions in different type of cancers, while the mechanisms underlying the anticancer effects of sinomenine in retinoblastoma (RB) remains unclear. … Sinomenine can exert anti-tumor function on RB cells <i>in vitro</i>, therefore sinomenine might be a potential alterative medication for the treatment for RB.</p> …

    Biological and Pharmaceutical Bulletin 43(10), 1551-1555, 2020


  • Development of antibody-drug conjugates that target vascular endothelial cells to promote anti-tumor activity  [in Japanese]

    Gao Shangze , Nishibori Masahiro

    … <p>Antibody drugs have revolutionised and strongly impacted therapy in the 21st century, especially in the field of cancer and inflammation-related diseases. … Although anti-cancer therapies pay much attention to the induction of cancer cell death, the cancer microenvironment and the functional roles of vascular endothelial cells in metastasis are also important to understand to regulate the growth of cancer cells. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S32-1, 2020


  • Effect of probenecid on 3D-cultured prostate cancer spheroids  [in Japanese]

    Uwada Junsuke , Yazawa Takashi , Mukai Shoichiro , Terada Naoki , Taniguchi Takanobu

    … Therefore, probenecid might support the effect of anti-cancer drugs via inhibition of efflux of these drugs from tumor cells.</p><p>Conventionally, cancer cell lines have been cultured as two-dimensional (2D) monolayer. … However, such condition does not reflect the real tumor situation in vivo. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-347, 2020


  • Anti-tumor Activities of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors and Bisphosphonates in Pancreatic Cell Lines Which Show Poor Responses to Gemcitabine

    Kawashiri Takehiro , Tokunaga Ayumi , Kobayashi Daisuke , Shimazoe Takao

    … <p>Few therapeutic options exist for gemcitabine-resistant pancreatic cancer. … In this study, we investigated the anti-cancer effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors and bisphosphonates in pancreatic cancer cell lines (SUIT-2 and MIA PaCa-2) which show poor responses to gemcitabine, established through long-term culture in nutrient-deprived or gemcitabine-containing media. …

    Biological and Pharmaceutical Bulletin 43(1), 49-52, 2020

    J-STAGE  Ichushi Web 

  • The effect of PHD inhibitor on tumor microenvironment and tumor immune response  [in Japanese]

    Matsunaga Shinji , Tomita Shuhei

    <p>組織内に走行する血管は,組織内の細胞へ酸素や栄養などを供給する重要な組織構造である.一方,腫瘍組織では異常な血管形成が認められる.これらの背景には血管透過性の亢進,不規則な血管新生,未成熟な血管形成があると考えられている.また,これらは腫瘍血管構造の特徴でもある.したがって,腫瘍組織は血流が乏しく,組織内間質圧が高く,低酸素,低栄養,低pHの組織環境に曝されている.このような組織 …

    Folia Pharmacologica Japonica 155(1), 35-39, 2020

    J-STAGE  Ichushi Web 

  • Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities

    Zahra Maram Hussein , Salem Tarek A. R. , El-Aarag Bishoy , Yosri Nermeen , EL-Ghlban Samah , Zaki Kholoud , Marei Amel H. , Abd El-Wahed Aida , Saeed Aamer , Khatib Alfi , AlAjmi Mohamed F. , Shathili Abdulrahman M. , Xiao Jianbo , Khalifa Shaden A. M. , El-Seedi Hesham R.

    … BACKGROUND/AIM:Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. … zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. … zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). …

    Molecules 24(13), 2495, 2019-07-08


  • Taurine and its anti-cancer functions: a mini review

    Ma Ning , He Feng , Takenori Yamashita , Kato Toshihiro , Murata Mariko

    … Since ancient times, natural products have been used intraditional medicine to prevent and treat various diseases, including cancer. … Several studies have demonstrated that taurine has anti-inflammatory6, antioxidant7, and hypoglycemic8 effects. …

    Japanese Journal of Taurine Research 5(1), 23-26, 2019

    J-STAGE  Ichushi Web 

  • Explore the effect of PHD inhibitor on innate immune systems in tumor mouse model.  [in Japanese]

    Nishide Shunji , Matsunaga Shinji , Shiota Masayuki , Yamaguchi Takehiro , Uchida Junji , Nakatani Tatsuya , Miura Katsuyuki , Tomita Shuhei

    … <p>Tumor microenvironment (TME) is hypoxic and low pH. TME confer not only resistance of anti-cancer drug therapy on tumor cells, but also impair the activity of immune cells. … Under TME condition, tumor-infiltrated macrophages (Mfs) change phenotype from anti-tumor (M1) phenotype to tumor progressive (M2) phenotype. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-YIA-28, 2019


  • The effect of PHD inhibitor on tumor microenvironment and tumor immune response  [in Japanese]

    Matsunaga Shinji , Tomita Shuhei

    … An abnormal blood vessel formation is a common feature of tumor tissue that were characterized by hyper-permeability, irregular vascularization, immature vessels and intravasation. … Therefore, tumor tissue is exposed to low oxygen nutrition depletion and low pH due to hypoperfusion and elevated interstitial pressure. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-S13-2, 2019


  • Anti-tumor effects of L-type amino acid transporter 1 (LAT1) inhibitor in a syngeneic and orthotropic mouse model for melanoma  [in Japanese]

    Shi Zitong , Ohgaki Ryuichi , Kaneda Kazuko , Okuda Suguru , Nagamori Shushi , Endou Hitoshi , Kanai Yoshikatsu

    … <p>Melanoma is the most malignant form of skin cancer, which originates from the pigment-producing melanocytes in the basal layer of epidermis. … LAT1 is upregulated in various cancers, including melanoma, and contributes to supporting cancer cell proliferation. … Therefore, LAT1 is regarded as a promising molecular target of novel anti-cancer therapeutics. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-SS-49, 2019


  • The Synergistic Antitumor Effect of Combined Anti-Human Epidermal Growth Factor Receptor 2 Antibody and Gamma Interferon Therapy on Antibody-resistant Breast Cancer Cells

    GOCHO Toshihiko , TSUCHIYA Hiromichi , KAMIJO Shotaro , YAMAZAKI Yoshitaka , SASAKI Akiko , KIUCHI Yuji

    … The anti-human epidermal growth factor receptor 2 (HER2) antibody (Ab) is a molecularly targeted Ab for cancer therapy. … In the field of breast cancer, approximately 20% overexpress HER2 protein. … However, the recurrence rate is 30% and the metastasis rate is 18% one year after treatment of anti-HER2 Ab for HER2 positive breast cancer. …

    The Showa University Journal of Medical Sciences 31(3), 237-252, 2019

    IR  J-STAGE  Ichushi Web 

  • Design and synthesis of novel histone deacetylase 6 inhibitors with benzyl-triazole as the core skeleton

    Mou Zishuo , Gao Jianjun , Miao He , Zhang Li , Su Li , Wang Baolei , Luan Yepeng

    … <p>In the field of epigenetics, histone deacetylases (HDACs) are important members and well validated targets for anti-cancer drugs discovery. … This series of compounds is worthy for further anti-cancer activity evaluation and structural optimization works.</p> …

    BioScience Trends 13(3), 267-272, 2019

    J-STAGE  Ichushi Web 

  • Design, synthesis and biological evaluation of 4-piperidin-4-yl-triazole derivatives as novel histone deacetylase inhibitors

    Miao He , Gao Jianjun , Mou Zishuo , Wang Baolei , Zhang Li , Su Li , Han Yantao , Luan Yepeng

    … <p>Histone deacetylase is an important member of epigenetics and a well validated target for anti-cancer drug discovery. … We found that MH1-18 and MH1-21 moderately inhibited the proliferation of four human cancer cell lines SGC-7901, NCI-H226, MCF-7, and HL-60. … Results obtained in the current study shed light on designing potent HDAC6 inhibitors as anti-cancer agents.</p> …

    BioScience Trends 13(2), 197-203, 2019

    J-STAGE  Ichushi Web 

  • The mechanisms of taxodione-induced apoptosis in BCR-ABL-positive leukemia cells  [in Japanese]

    Uchihara Yuki , Tago Kenji , Funakoshi-Tago Megumi

    <p>BCR-ABLは,慢性骨髄性白血病(CML)や急性リンパ芽球性白血病(ALL)の原因遺伝子産物であり,転写因子STAT5やキナーゼAktの活性化を介して強力な形質転換能を示す.BCR-ABLを標的とした分子標的薬イマチニブの開発により,CMLやALLに対する治療効果は劇的に改善された.しかしながら,イマチニブの継続的な投与により,bcr-abl遺伝子にイマチニブ耐性を示す二次的な …

    Folia Pharmacologica Japonica 153(4), 147-154, 2019

    J-STAGE  Ichushi Web 

  • Screening of a growth inhibitor library of sarcoma cell lines to identify potent anti-cancer drugs

    Qiao Zhiwei , Kondo Tadashi

    … In the present study, to identify inhibitors with potential therapeutic utility in sarcomas, we screened the growth inhibitory effects of 361 inhibitors, including experimental reagents and anti-cancer drugs approved for use in non-sarcoma malignancies and those under clinical trials. …

    Journal of Electrophoresis 63(1), 1-7, 2019

    J-STAGE  Ichushi Web 

  • Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine

    Terasaki Masaru , Matsumoto Naoya , Hashimoto Ryuichi , Endo Tetsuya , Maeda Hayato , Hamada Junichi , Osada Kazumi , Miyashita Kazuo , Mutoh Michihiro

    … <p>Fucoxanthin and its major metabolite, fucoxanthinol, have potent anti-cancer properties in carcinogenic model mice and against cancer cells. … We recently demonstrated that glycine was an effective predictor of the suppression of sphere formation and epithelial mesenchymal transition by fucoxanthinol in human colorectal cancer stem-like spheroids (colonospheres) under normoxia and hypoxia. …

    Journal of Clinical Biochemistry and Nutrition 64(1), 52-58, 2019

    J-STAGE  Ichushi Web 

  • Anti-tumor growth effect of STIM1 suppression

    Han Chong , Yoneyama Tohru , Toyama Yuichi , Yonekura Manabu , Ohyama Chikara , Murakami Manabu

    … Prostate cancer (PCa) progresses into an androgen-independent stage, resistance to apoptosis has been implicated in moderate efficiency or failure of a number of anti-cancer treatments. … Thus, targeting apoptosis represents a promising strategy in urologic cancer treatments.</p><p>The ubiquitous second messenger Ca2+ regulates various cellular processes such as proliferation and migration. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO4-6-18, 2018


  • ABCB1-mediated multi-drug resistance in leukemic K562/ADR cells was reversed by Matrine, the main ingredient from <i>Sophora alopecuroides</i>

    Chen Zhi , Nishimura Nobuhiro , Okamoto Takayuki , Wada Koichiro , Naora Kohji

    … It has been concerned in recent years because of the reversing effect on chemotherapeutic-resistant cancer cells. … In this research, the effects of matrine on sensitivity of anti-cancer agents as well as mRNA and protein expression of ABCB1 (P-glycoprotein) were examined in human leukemia K562 cells and the chemo-resistant subtype K562/ADR cells.</p><p>[Methods] K562 and K562/ADR cells were purchased from RIKEN Cell Bank (Japan). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO3-7-14, 2018


  • Highly Selective HDAC6 inhibitor targets glioblastoma promoting HDAC6 degradation via autophagy inhibition and immune modulation

    Liu Jia-Rong , Yu Chao-Wu , Chern Ji-Wang

    … <p>Glioblastoma is the most fatal type of primary brain tumor and current treatments for glioblastoma are insufficient. … The decrease of HDAC6 expression by J22352 treatment is as a consequence of anti-migration effect, autophagic cancer cell death and significant tumor growth inhibition in glioblastoma. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-8-23, 2018


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