Search Results 1-20 of 4156

  • A Prospective Multicenter Observational Study of Venous Thromboembolism after Gastric Cancer Surgery (SHISA-1601).

    KAIDA Sachiko , MIYAKE Toru , MURATA Satoshi , YAMAGUCHI Tsuyoshi , TATSUTA Takeshi , MURAKAMI Koichiro , OKAUCHI Hiroshi , NISHIMURA Shoichi , OHTA Hiroyuki , TSUCHIHASHI Hiroshi , KAWASAKI Masayasu , TAKEBAYASHI Katsushi , SHIMIZU Tomoharu , TANI Masaji , 貝田 佐知子 , 三宅 亨 , 村田 聡 , 山口 剛 , 龍田 健 , 村上 耕一郎 , 岡内 博 , 西村 彰一 , 太田 裕之 , 土橋 洋史 , 川崎 誠康 , 竹林 克士 , 清水 智治 , 谷 眞至

    Results:A total of 126 patients were eligible to participate. VTE occurred within 9 days postoperatively in 5 cases (4.0%; 2 symptomatic and 3 asymptomatic). Postoperative day (POD) 1 plasma D-dimer a …

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1-10, 2021-03-03

    IR 

  • A systematic review of direct oral anticoagulant-induced adverse events using adverse event databases  [in Japanese]

    西塚 典仁 , 池田 俊也

    近年,有害事象の自発報告システム(Spontaneous Reporting System : SRS)による医薬品副作用情報データベー スを活用した研究が増加してきている.そこで今回,直接作用型経口抗凝固薬(Direct oral anticoagulants :DOAC)に関する SRS を活用した研究論文を収集し系統的レビューを行うことを計画した.PubMed と医中誌においてデータベース検 …

    国際医療福祉大学学会誌 = Journal of the International University of Health and Welfare 26(1), 99-112, 2021-02-20

    IR 

  • Antithrombotic therapy in dental practice  [in Japanese]

    小松 祐子 , 川井 忠 , 山田 浩之 , 千葉 俊美

    岩手医科大学歯学雑誌 = Dental journal of Iwate Medical University 45(3), 105-119, 2021-02

    IR 

  • Investigation of Effects of Concomitant Capecitabine on Warfarin Anticoagulant Activity  [in Japanese]

    齋藤 豪 , 赤嶺 由美子 , 三浦 昌朋 , 平泉 達哉

    日本病院薬剤師会雑誌 = Journal of Japanese Society of Hospital Pharmacists 57(1), 79-85, 2021-01

    Ichushi Web 

  • Prospective Randomized Study of the Safety and Efficacy of Interrupted Anticoagulant's Therapy in the Perioperative Period of Catheter Ablation for Atrial Fibrillation: The SEACOAST Rhythm AF Trial

    WATANABE Norikazu , OGAWA Kou , NAKAMURA Yuuya , INOGUCHI Kouichirou , OCHI Akinori , CHIBA Yuuta , OONISHI Yoshimi , KAWASAKI Shirou , OONUMA Masayoshi , ITOU Takayuki , ONUKI Tatsuya , ADACHI Tarou , KOBAYASHI Youichi

    No prospective, randomized study has been conducted to date in Japan comparing the use of warfarin and rivaroxaban for preventing thrombotic and bleeding events in the perioperative period of catheter …

    The Showa University journal of medical sciences 32(4), 221-232, 2021-01

    IR 

  • Effectiveness and Safety of Rivaroxaban by General Practitioners ― A Multicenter, Prospective Study in Japanese Patients With Non-Valvular Atrial Fibrillation (GENERAL) ―

    Kusano Kengo , Miyamoto Koji , Ogawa Hisao , Sugishita Nobuyoshi , Akao Masaharu , Tsuji Hikari , Matsui Kunihiko , Hiramitsu Shinya , Hatori Yutaka , Odakura Hironori , Kamada Hiroyuki

    <p><b><i>Background:</i></b>Direct oral anticoagulants have become a standard therapy for non-valvular atrial fibrillation (NVAF). However, little is known about their ef …

    Circulation Journal, 2021

    J-STAGE 

  • Management of a COVID-19 Patient during ECMO: Paying Attention to Acquired von Willebrand Syndrome

    Hayakawa Masaki , Takano Keisuke , Kayashima Michinori , Kasahara Kei , Fukushima Hidetada , Matsumoto Masanori

    … Bleeding found in this patient might be caused by AVWS and DIC.</p><p>Severe COVID-19 patients are in a thrombotic state and need to receive anticoagulant therapy. …

    Journal of Atherosclerosis and Thrombosis 28(4), 396-401, 2021

    J-STAGE 

  • COVID-19-Related Thrombosis in Japan: Final Report of a Questionnaire-Based Survey in 2020

    Horiuchi Hisanori , Morishita Eriko , Urano Tetsumei , Yokoyama Kenji , the Questionnaire-survey Joint Team on The COVID-19-related thrombosis

    Anticoagulant therapy was provided to 893 patients (14.6% of the 6,119 patients with available data), the main reasons being provided as elevated D-dimer levels and worsening clinical condition.</p> …

    Journal of Atherosclerosis and Thrombosis 28(4), 406-416, 2021

    J-STAGE 

  • Antithrombotic therapy in dental practice  [in Japanese]

    KOMATSU Yuko , KAWAI Tadashi , YAMADA Hiroyuki , CHIBA Toshimi

    <p>抗血栓療法とは, 血栓症の発症予防を目的とする治療法であり, 主に抗血小板療法と抗凝固療法が挙げられる.抗血小板薬としてはアスピリンが, 抗凝固薬としてはワルファリンが広く知られるところである. 近年,抗凝固薬として直接作用型経口抗凝固薬の内服をしている患者が歯科外来を受診する機会も増えてきた.また, 抗血栓療法患者が術後出血や, 外傷性もしくは突発的な出血を主訴に口腔外科を受診 …

    Dental Journal of Iwate Medical University 45(3), 105-119, 2021

    J-STAGE 

  • Efficacy of Erector Spinae Plane Block after Trunk Surgery: A Stratified Randomized Observer-Blinded Comparative Study

    KUMEMURA MASATERU , OMAE TAKESHI , YANAGISAWA NAOTAKE , SAKURABA SONOKO , KOH KEITO

    … Although epidural anesthesia and paravertebral blocks are routinely administered to achieve postoperative analgesia after trunk surgery, the use of anticoagulant therapy has increased the number of cases in which these procedures are contraindicated. …

    Juntendo Medical Journal, 2021

    J-STAGE 

  • A Novel Risk Stratification System for Ischemic Stroke in Japanese Patients With Non-Valvular Atrial Fibrillation

    Okumura Ken , Yamashita Takeshi , Fukuda Keiichi , Ogawa Hisashi , Tsuda Toyonobu , Isobe Mitsuaki , Toyoda Kazunori , Miyamoto Yoshihiro , Miyata Hiroaki , Okamura Tomonori , Sasahara Yusuke , Tomita Hirofumi , for the J-RISK AF Research Group , Nakai Michikazu , Kodani Eitaro , Akao Masaharu , Suzuki Shinya , Hayashi Kenshi , Sawano Mitsuaki , Goya Masahiko

    … Significant risk factors were: being elderly (aged 75–84 years [E], HR=1.74), extreme elderly (≥85 years [EE], HR=2.41), having hypertension (H, HR=1.60), previous stroke (S, HR=2.75), type of AF (persistent/permanent) (T, HR=1.59), and low body mass index <18.5 kg/m<sup>2</sup>(L, HR=1.55) after adjusting for oral anticoagulant treatment. …

    Circulation Journal, 2021

    J-STAGE 

  • Late results of Maze and pulmonary vein isolation procedures for atrial fibrillation  [in Japanese]

    YAMAUCHI Masanobu , HANADA Tomoki , KAMIHIRA Satoshi , KANETSUKI Kazuma

    心房細動(AF)に対する外科手術であるメイズ手術や肺静脈隔離術(PVI)後のリズム維 持の有効性は明らかで,それに加え生存率の改善や脳梗塞発症予防効果も示されている.今回,当 院でのメイズ,PVI術後の遠隔成績について検討した。対象は1999年から2019年の6月までの77例 で,慢性AF 54例,発作性心房細動23例,平均年齢は70才,62%(48例)が男性であった.術式は, 両心房メイズ50例 …

    Medical Journal of Shimane Prefectural Central Hospital 45(0), 19-26, 2021

    J-STAGE 

  • Recombinant soluble thrombomodulin reduces lipopolysaccharide-induced endothelial cellular stiffening  [in Japanese]

    Okamoto Takayuki , Usuda Haruki , Tanaka Tetsuya , Wada Koichiro

    <p>Recent studies have indicated that endothelial cell increases cellular stiffness upon inflammation and that stiff endothelium of atherosclerotic region and aged vessels is favor to monocyte a …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-O-F5-1, 2021

    J-STAGE 

  • A thrombin inhibitor aggravates HMGB1-dependent colonic and bladder pain: Role of the thrombomodulin/thrombin system in visceral pain modulation  [in Japanese]

    Yamagata Ayumu , Matsui Kazuki , Tsubota Maho , Nishibori Masahiro , Kawabata Atsufumi

    <p>Endothelial thrombomodulin (TM) is capable of causing thrombin-dependent degradation of high mobility group box 1 (HMGB1), a damage-associated molecular pattern protein. We have shown that HM …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-O-B2-2, 2021

    J-STAGE 

  • Coagulation Assay and Stroke Severity upon Admission of Patients with Cardioembolic Cerebral Infarction during Direct Oral Anticoagulant Use

    Deguchi Ichiro , Osada Takashi , Takao Masaki , Takahashi Shinichi

    <p>Although the severity of acute cerebral infarction varies in patients receiving direct oral anticoagulants (DOACs), no practical method to predict the severity has been established. We analyz …

    The Keio Journal of Medicine, 2021

    J-STAGE 

  • A technique of revascularization in mediastinal tumor surgery with superior vena cava resection  [in Japanese]

    Nawashiro Ayako , Takenaka Masaru , Matsumiya Hiroki , Mori Masataka , Kuroda Koji , Tanaka Fumihiro

    <p>77歳男性.動悸と息切れを主訴に近医を受診し,前縦隔腫瘤と心囊水貯留を指摘された.胸部CTでは前縦隔に12 cmのmassを認め,左右腕頭静脈~上大静脈合流部への浸潤が疑われた.浸潤性胸腺腫が疑われ,有症状であり手術加療を行う方針とした.手術はまず右後側方切開で開始した.肉眼的に心膜と上中葉に広く腫瘍の浸潤を認め,上中葉合併切除を行った.次に胸骨正中切開を行った.左右腕頭静脈の合 …

    The Journal of the Japanese Association for Chest Surgery 35(2), 207-212, 2021

    J-STAGE 

  • Examination of Epistaxis  [in Japanese]

    Yoshimi Nobuhiro , Matsui Kazuo , Mineta Hiroyuki , Ishikawa Ryuji , Sone Masataka , Ikeba Hiroshi , Uchiyama Koudai , Shimodaira Yuki , Matsuda Shigeru , Yamaguchi Yuki , Hosokawa Seiji

    … In regard to relationships of the age, sex, antiplatelet/anticoagulant drug therapy, bleeding site, blood pressure, presence of allergic rhinitis, etc., with the risk of rebleeding, there was a significant association between the site of bleeding (especially high risk in cases with posterior bleeding and bleeding from the middle turbinate and middle nasal passages) and the risk of rebleeding (P <0.01).</p> …

    Practica oto-rhino-laryngologica. Suppl. 156(0), 139-143, 2021

    J-STAGE 

  • Comparison of Edoxaban and Warfarin for the Treatment of Cancer-Associated Venous Thromboembolism ― A Retrospective Observational Study ―

    Goto Hitoshi , Umetsu Michihisa , Akamatsu Daijirou , Sugawara Hirofumi , Tsuchida Ken , Yoshida Yoshitaro , Suzuki Shunya , Kamei Takashi

    … <p><b><i>Background:</i></b>Because anticoagulant drugs for ambulatory patients with cancer-associated venous thromboembolism (CAT) are limited to warfarin and direct oral anticoagulants (DOACs) in Japan, it is important to assess the outcomes of both drugs.</p><p><b><i>Methods and Results:</i></b>We retrospectively assessed the outcomes of CAT patients who were treated with warfarin or edoxaban between 2011 and 2017. …

    Circulation Journal, 2021

    J-STAGE 

  • Purification, characterization and anticoagulant activity <i>in vitro</i> of polysaccharides from the seeds of <i>Toona sinensi</i>s (A.Juss) Roem

    Cai Wei-Rong , Wen Zhi-Ying , Ding Bo-Le , Yue Dan-Wei , Xu Yong , Jia Zhi-Fei , Zhu Han

    … Moreover, their in vitro anticoagulant activities were evaluated by activated partial thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT) assays. … STSP-3 exhibited potent anticoagulant activity and would be explored as a natural potential anticoagulant.</p> …

    Food Science and Technology Research 27(1), 151-159, 2021

    J-STAGE 

  • Incidence of adverse clinical events during anticoagulant therapy in patients with nonvalvular atrial fibrillation associated with renal dysfunction  [in Japanese]

    Nakajima Kazuo , Naka Motoji , Nishiyama Osamu , Takahama Miki , Nishimori Eita

    <p><b>要旨</b>:【目的および方法】腎機能障害(推定糸球体濾過量 <60 ml/min/1.73 m2)を有する非弁膜症性心房細動(NVAF)患者中,ワルファリン(Wa)投与166例(79±8歳)および直接阻害型経口抗凝固薬(DOAC)投与196例(80±10 歳)の有害臨床イベント発症率を後ろ向きに検討した.【結果】WaおよびDOAC投与群の虚血 …

    Japanese Journal of Stroke, 2021

    J-STAGE 

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