Search Results 1-20 of 103

  • Toll-Like Receptor 7 Stimulation Promotes the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice

    O. Krogmann Alexander , Lüsebrink Enzo , Lahrmann Catharina , Flender Anna , Nickenig Georg , Zimmer Sebastian

    … subcutaneous stimulation of TLR7 in apolipoprotein E-deficient (ApoE<sup>−/−</sup>) mice increased aortic production of reactive oxygen species (ROS), the number of circulating EMPs, and most importantly, augmented the formation of atherosclerotic plaque when compared with vehicle-treated animals.</p><p>Systemic stimulation of TLR7 leads to impaired reendothelialization upon acute vascular injury and is associated with the production of pro-inflammatory cytokines and increased levels of circulating EMPs and Sca1/Flk1 …

    International Heart Journal, 2020


  • Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis

    Sasaki Yuichi , Ikeda Yoshiyuki , Miyauchi Takahiro , Uchikado Yoshihiro , Akasaki Yuichi , Ohishi Mitsuru

    … The present study aims to investigate whether SIRT1 is involved in the etiology of menopause-induced arterial senescence and atherosclerotic development.</p><p><b>Methods</b>: Twelve-week old female apolipoprotein E-knockout (ApoE-KO) mice underwent ovariectomy (OVX) or sham surgery.</p><p><b>Results</b>: SIRT1 expression and endothelial nitric oxide synthase (eNOS) activation in the aorta were significantly lower in OVX mice than they were in sham mice (OVX vs. sham, <i>n</i>=5 per group). …

    Journal of Atherosclerosis and Thrombosis 27(1), 47-59, 2020


  • Role of Toll-Like Receptor 9 in Atherogenesis

    Fukuda Daiju , Nishimoto Sachiko , Aini Kunduziayi , Tanaka Atsushi , Nishiguchi Tsuyoshi , Kim-Kaneyama Joo-ri , Lei Xiao-Feng , Masuda Kiyoshi , Naruto Takuya , Tanaka Kimie , Higashikuni Yasutomi , Hirata Yoichiro , Yagi Shusuke , Kusunose Kenya , Yamada Hirotsugu , Soeki Takeshi , Imoto Issei , Akasaka Takashi , Shimabukuro Michio , Sata Masataka

    … BackgroundToll-like receptor (TLR) 9 recognizes bacterial DNA, activating innate immunity, whereas it also provokes inflammation in response to fragmented DNA released from mammalian cells. …

    Journal of the American Heart Association 8(7), e010860, 2019-03-23


  • Preparation of Lipid Nanodisks Containing Apolipoprotein E-Derived Synthetic Peptides for Biocompatible Delivery Vehicles Targeting Low-Density Lipoprotein Receptor

    Tanaka Masafumi , Hasegawa Mariko , Yoshimoto Natsumi , Hoshikawa Kozue , Mukai Takahiro

    … Apolipoprotein E (apoE), one of the HDL constituent proteins, serves as a ligand for the low-density lipoprotein (LDL) receptor. … Thus, it is considered that biocompatible delivery vehicles targeting LDL receptors could be prepared by incorporating apoE as the protein component of lipid nanodisks. …

    Biological and Pharmaceutical Bulletin 42(8), 1376-1383, 2019


  • Roles of PAR-2 in atherogenesis

    Hara Tomoya , Phuong Pham Tran , Fukuda Daiju , Yamaguchi Koji , Murata Chie , Nishimoto Sachiko , Yagi Shusuke , Kusunose Kenya , Yamada Hirotsugu , Soeki Takeshi , Wakatsuki Tetsuzo , Imoto Issei , Shimabukuro Michio , Sata Masataka

    … Recent studies show that protease-activated receptor (PAR)-2, a major receptor of activated factor X (FXa), are expressed in both vascular cells and leukocytes, suggesting that PAR-2 may contribute to the pathogenesis of inflammatory diseases. … Here we investigated the role of PAR-2 in vascular inflammation and atherogenesis.Methods: We generated apolipoprotein E-deficient (ApoE-/-) mice lacking systemic PAR-2 expression (PAR-2-/-ApoE-/-). …

    Circulation 138(16), 1706-1719, 2018-04-26


  • The Novel Apolipoprotein E Mutation ApoE Chengdu (c.518T>C, p.L173P) in a Chinese Patient with Lipoprotein Glomerulopathy

    Wu Hongyan , Yang Yuan , Hu Zhangxue

    … Several apolipoprotein E (apoE) mutations have been reported to be related to LPG. … Herein, we report a case of a LPG patient with a novel apoE mutation.</p><p><b>Methods</b><b>: </b>A 45-year-old Chinese female was diagnosed as LPG by renal biopsy. … APOE gene was sequenced. … A fasting lipid panel showed mild hyperlipidemia and elevated serum apoE (5.6 mg/dL). …

    Journal of Atherosclerosis and Thrombosis 25(8), 733-740, 2018

    J-STAGE  Ichushi Web 

  • MicroRNA-134 Promotes the Development of Atherosclerosis Via the ANGPTL4/LPL Pathway in Apolipoprotein E Knockout Mice

    Ye Qiong , Huang Chong , Pan Yan-Jun , Zhang Jie , Chen Ling-Yan , Zhao Zhen-Wang , Xie Wei , Li Liang , Zhang Min , Xia Xiao-Dan , Zheng Xi-Long , Tian Guo-Ping , Tang Chao-Ke , Cheng Hai-Peng , Zhang Xin , Ou Xiang , Yu Xiao-Hua , Tan Ru-Qi , Yang Feng-Yun , Gong Duo

    ApoE KO male mice on a C57BL/6 background were fed a high-fat/high-cholesterol Western diet, from 8 to 16 weeks of age. … After 8 weeks we measured aortic atherosclerosis, LPL Activity, mRNA and protein levels of ANGPTL4 and LPL, LPL/ low-density lipoprotein receptor related protein 1 Complex Formation, proinflammatory cytokine secretion and lipid levels.</p><p><b><i>Results</i>:</b> …

    Journal of Atherosclerosis and Thrombosis 25(3), 244-253, 2018

    J-STAGE  Ichushi Web 

  • Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis

    Kasahara Kazuyuki , Tanoue Takeshi , Yamashita Tomoya , Yodoi Keiko , Matsumoto Takuya , Emoto Takuo , Mizoguchi Taiji , Hayashi Tomohiro , Kitano Naoki , Sasaki Naoto , Atarashi Koji , Honda Kenya , Hirata Ken-ichi

    … Germ-free (GF) or conventionally raised (Conv) Apolipoprotein E deficient (ApoE(-/-)) mice were fed chow diet and sacrificed at twenty weeks of age. … We found lack of gut microbiota in ApoE(-/-) mice caused a significant increase in the plasma and hepatic cholesterol levels compared to ConvR ApoE(-/-) mice. …

    Journal of Lipid Research 58(3), 519-528, 2017-03


  • Identification of apolipoprotein E as a target gene in cadmium-mediated cancer cell invasion  [in Japanese]

    SUZUKI Masayo , TAKEDA Shuso , NAKAMURA Yuta , TAKIGUCHI Masufumi

    … アポリポプロテインE (ApoE)のmRNAおよびタンパク質の発現がコントロール細胞と比較して顕著に低下していた。 … Cd長期曝露した細胞をDNA脱メチル化剤である5-aza-2’-deoxycytidine (5aza-dC)で処理することにより、ApoEの発現がコントロール細胞レベルまで回復し、さらにはCd曝露によるがん細胞浸潤の抑制も確認された。 …

    Annual Meeting of the Japanese Society of Toxicology 44.1(0), P-9, 2017


  • Triglyceride Rich Lipoprotein -LPL-VLDL Receptor and Lp(a)-VLDL Receptor Pathways for Macrophage Foam Cell Formation

    Takahashi Sadao

    … <p>Very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor family. … The VLDL receptor functions as a peripheral lipoprotein receptor in concert with lipoprotein lipase (LPL) in heart, muscle, adipose tissue and macrophages. …

    Journal of Atherosclerosis and Thrombosis 24(6), 552-559, 2017

    J-STAGE  Ichushi Web 

  • Scavenger Receptor Class B Type 1 Deletion Led to Coronary Atherosclerosis and Ischemic Heart Disease in Low-density Lipoprotein Receptor Knockout Mice on Modified Western-type Diet

    Liao Jiawei , Wang Fan , Huang Wei , Liu George , Guo Xin , Wang Mengyu , Dong Chengyan , Gao Mingming , Wang Huan , Kayoumu Abudurexiti , Shen Qiang , Wang Yuhui

    … <p><b><i>Aim</i></b><b>: </b>Atherosclerosis-prone apolipoprotein E (apoE) or low-density lipoprotein receptor (LDL-R) knockout (KO) mice are generally resistant to developing coronary atherosclerosis (CA) and ischemic heart disease (IHD). …

    Journal of Atherosclerosis and Thrombosis 24(2), 133-146, 2017

    J-STAGE  Ichushi Web 

  • The role of single-nucleotide variants of the energy metabolism-linked genes <i>SIRT3</i>, <i>PPARGC1A</i> and <i>APOE</i> in amyotrophic lateral sclerosis risk

    Albani Diego , Pupillo Elisabetta , Bianchi Elisa , Chierchia Armando , Martines Rosalba , Forloni Gianluigi , Beghi Ettore

    … The genes selected were sirtuin 3 (<i>SIRT3</i>), peroxisome proliferator-activated receptor-γ coactivator-1α (<i>PPARGC1A</i>) and apolipoprotein E (<i>APOE</i>). … single-nucleotide polymorphism rs4980329 in ALS risk, and a contribution of the <i>APOE</i>-ε2 allele, which was more frequent in ALS patients than in controls. …

    Genes & Genetic Systems 91(6), 301-309, 2016

    J-STAGE  Ichushi Web 

  • Intermedin<sub>1–53</sub> Protects Against Myocardial Fibrosis by Inhibiting Endoplasmic Reticulum Stress and Inflammation Induced by Homocysteine in Apolipoprotein E-Deficient Mice

    Zhang Jin-Sheng , Hou Yue-Long , Lu Wei-Wei , Ni Xian-Qiang , Lin Fan , Yu Yan-Rong , Tang Chao-Shu , Qi Yong-Fen

    … Myocardial fibrosis in apolipoprotein E-deficient (ApoE -/-) mice and neonatal rat cardiac fibroblasts (CFs) were induced using homocysteine (Hcy).</p><p><i><b>Results</b></i><b>: </b>IMD<sub>1-53</sub> … reduced myocardial interstitial collagen deposition in ApoE-/- mice treated with Hcy and decreased the expression of myocardial collagen I and III, which was further verified in rat CFs. …

    Journal of Atherosclerosis and Thrombosis 23(11), 1294-1306, 2016


  • A Dipeptidyl Peptidase-4 Inhibitor but not Incretins Suppresses Abdominal Aortic Aneurysms in Angiotensin II-Infused Apolipoprotein E-Null Mice

    Kohashi Kyoko , Hirano Tsutomu , Hiromura Munenori , Mori Yusaku , Terasaki Michishige , Watanabe Takuya , Kushima Hideki , Shinmura Kyoko , Tomoyasu Masako , Nagashima Masaharu

    … We reported that incretins [glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP)] or a dipeptidyl peptidase-4 inhibitor (DPP-4I) suppressed atherosclerosis in apolipoprotein E-null (Apoe-/-) mice. …

    Journal of Atherosclerosis and Thrombosis 23(4), 441-454, 2016

    J-STAGE  Ichushi Web 

  • Reduction of Intracellular Chloride Concentration Promotes Foam Cell Formation

    Wu Qian-Qian , Yang Chao , Wang Yan-Li , Zhou Ping , Lv Xiao-Fei , Liu Jie , Zhou Jia-Guo , Liang Si-Jia , Liu Xiao-Yun , Xiong Li-Xiong , Shang Jin-Yan , Mai Xiao-Yi , Pang Rui-Ping , Su Ying-Xue , Yu Bei-Xin , Yuan Jia-Ni

    … The results showed that [Cl<sup>−</sup>]<sub>i</sub>was decreased in monocytes/macrophages from patients with hypercholesterolemia and from apoE<sup>−/−</sup>mice fed with a high-fat diet. … Lowering [Cl<sup>−</sup>]<sub>i</sub>upregulated scavenger receptor A (SR-A) expression, increased the binding and uptake of oxLDL, enhanced pro-inflammatory cytokine production and subsequently accelerated foam cell formation in macrophages from humans and mice. …

    Circulation Journal 80(4), 1024-1033, 2016

    J-STAGE  Ichushi Web 

  • Multifarious effects of 17-β-estradiol on apolipoprotein E receptors gene expression during osteoblast differentiation <i>in vitro </i>

    Gui Yuyan , Duan Zhongliang , Qiu Xuemin , Tang Wei , Gober Hans-Jürgen , Li Dajin , Wang Ling

    … Apolipoprotein E (ApoE) regulated bone metabolism in mice might mediate uptake of lipid particles into target cells such as osteoblasts <i>via</i> … receptor-mediated endocytosis by apoE receptors, which includes the low-density lipoprotein receptor (LDLR) family and heparan sulfate proteoglycans (HSPGs). …

    BioScience Trends 10(1), 54-66, 2016

    J-STAGE  Ichushi Web 

  • Metabolism and Modification of Apolipoprotein B-Containing Lipoproteins Involved in Dyslipidemia and Atherosclerosis

    Morita Shin-ya

    … The hepatic uptake of these remnants is facilitated by apolipoprotein E (apoE), but is inhibited by apolipoproteins C-I, C-II and C-III. … LDL receptor, LDL receptor-related protein and heparan sulfate proteoglycans are involved in the hepatic clearance of lipoproteins containing apoB-100 and/or apoE. …

    Biological and Pharmaceutical Bulletin 39(1), 1-24, 2016

    J-STAGE  Ichushi Web 

  • High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice

    Uetake Y , Ikeda H , Irie R , Tejima K , Matsui H , Ogura S , Wang H , Mu SY , Hirohama D , Ando K , Sawamura T , Yatomi Y , Fujita T , Shimosawa T

    … steatohepatitis (NASH), which is frequently associated with metabolic syndrome.Methods: We examined the exacerbating effect of high-salt diet on high-fat diet-induced liver injury in a susceptible model to oxidative stress, apoE knockout and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transgenic mice.Results: High-salt diet led to NASH in high-fat diet-fed LOX-1 transgenic/apoE knockout mice without affecting high-fat diet-induced dyslipidemia or hepatic triglyceride …

    LIPIDS IN HEALTH AND DISEASE (14), 6, 2015-02-13


  • UFM1 Protects Macrophages from oxLDL-Induced Foam Cell Formation Through a Liver X Receptor α Dependent Pathway

    Pang Qi , Xiong Jie , Hu Xiao-Lei , He Jiang-Ping , Liu Hui-Fang , Zhang Guang-Ya , Li Yuan-Yuan , Chen Feng-Ling

    … Using real-time quantitative PCR (qRT-PCR) and western blot analysis, we first analyzed the UFM1 expression in mouse peritoneal macrophages (MPMs) from ApoE-/- mice <i>in vivo</i> … Furthermore, the upregulation of ABCA1 and ABCG1 by UFM1 resulted from liver X receptor α (LXRα) activation, which was confirmed by the observation that LXRα siRNA prevented the expression of ABCA1 and ABCG1. …

    Journal of Atherosclerosis and Thrombosis 22(11), 1124-1140, 2015

    J-STAGE  Ichushi Web 

  • Chitosan Oligosaccharides Attenuate Atherosclerosis and Decrease Non-HDL in ApoE-/- Mice

    Yu Yang , Luo Tian , Liu Shuai , Song Guohua , Han Jiju , Wang Yun , Yao Shutong , Feng Lei , Qin Shucun

    … In this study, we investigated the effects of COS treatment on atherosclerosis (AS) in apolipoprotein E deficient mice (apoE-/-).<br><b><i>Methods</i>:</b> … The COS treatment decreased the lesion areas of aortic enface, plaque areas in aortic root, and increased plaque stability in apoE-/-. …

    Journal of Atherosclerosis and Thrombosis 22(9), 926-941, 2015

    J-STAGE  Ichushi Web 

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