Search Results 1-20 of 1122

  • Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice

    Mizushige Takafumi , Uchida Tomoki , Ohinata Kousaku

    … Moreover, other aromatic amino acid-leucines, Phe-Leu and Trp-Leu, also exhibited antidepressant-like activities, suggesting that the structure of aromatic amino acid-leucine may be important for antidepressant activity. …

    Scientific Reports (10), 2020-02-10


  • New variants of AADC deficiency expand the knowledge of enzymatic phenotypes

    Riccardo Montioli , Giovanni Bisello , Mirco Dindo , Giada Rossignoli , Carla Borri Voltattorni , Mariarita Bertoldi

    … AADC deficiency is a rare genetic disease caused by mutations in the gene of aromatic amino acid decarboxylase, the pyridoxal 5'-phosphate dependent enzyme responsible for the synthesis of dopamine and serotonin. …

    Archives of Biochemistry and Biophysics (682), 108263, 2020-01-15


  • Chronic glyphosate exposure elicits neuronal cell death and microglia activation in developing rat cerebellum  [in Japanese]

    FUTAGAMI Ken , TIONG Thomas Kwong Soon , LEE Christine Li Mei , HUANG Yong Lin , NOMURA Yoko , KANDA Yasunari , YOSHIDA Sachiko

    … however, the safeties of glyphosate or aminomethylphosphonic acid (AMPA), a metabolite in the soil, are unknown. … The primary herbicidal function of glyphosate is to inhibit a key plant enzyme, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), which participates in the biosynthesis of aromatic amino acids (including phenylalanine, tyrosine, and tryptophan) via the shikimate pathway in bacteria, fungi, and plants. …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-5S, 2020


  • Critical moieties of aromatic amino acid probes causing renal accumulation in tumor imaging  [in Japanese]

    Jin Chunhuan , Wei Ling , Ohgaki Ryuichi , Okuda Suguru , Nagamori Shushi , Kanai Yoshikatsu

    … <p>As molecular probes for cancer diagnosis, [<sup>18</sup>F]FAMT (3-[<sup>18</sup>F]fluoro-α-methyl-l-tyrosine) and [<sup>123</sup>I]IMT (3-[<sup>123</sup>I]iodo-α-methyl-l-tyrosine) have been used clinically due to their high selectivity to cancer-specific amino acid transporter LAT1 (SLC7A5). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-YIA-17, 2020


  • Divergent and Scalable Synthesis of α-Hydroxy/Keto-β-amino Acid Analogues by the Catalytic Enantioselective Addition of Glyoxylate Cyanohydrin to Imines

    Nanjo Takeshi , Zhang Xuan , Tokuhiro Yusuke , Takemoto Yoshiji

    … The catalytic enantioselective addition of glyoxylate cyanohydrin to imines to afford α-keto-β-amino acid equivalents is reported. … Sterically tuned aminobenzothiadiazine catalysts provided high yields and stereoselectivities (up to 100% yield, 99% ee, >99:1 dr) for both aromatic and aliphatic imines, and the stereodivergent synthesis of both diastereomers was achieved. …

    ACS Catalysis 9(11), 10087-10092, 2019-11-01


  • Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties

    Murakami Kazuma , Irie Kazuhiro

    … Based on NMR and MS spectroscopic analysis, we propose three structural characteristics found in natural products required for the suppressive activity against Aβ42 aggregation (i.e., oligomerization by targeting specific amino acid residues on this protein). … (2) non-catechol-type flavonoids with planarity due to α, β-unsaturated carbonyl groups that can interact with the intermolecular β-sheet region in Aβ42 aggregates, especially aromatic rings such as those of Phe19 and 20; …

    Molecules 24(11), 2019-06-05


  • Critical moieties of aromatic amino acids for the interaction with organic anion transporter OAT1: Implications for reducing the renal background in tumor imaging  [in Japanese]

    Jin Chunhuan , Wei Ling , Ohgaki Ryuichi , Tominaga Hideyuki , Okuda Suguru , Nagamori Shushi , Kanai Youshikatsu

    … <p>The excellent tumor selectivity of amino acid-based imaging probes, [<sup>18</sup>F]FAMT (3-[<sup>18</sup>F]fluoro-a-methyl-l-tyrosine) and [<sup>123</sup>I]IMT (3-[<sup>123</sup>I]iodo-a-methyl-l-tyrosine), is supported by their selectivity for LAT1 (L-type amino acid transporter 1) which is specifically expressed in tumor cells. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-SS-02, 2019


  • Amino Acids and Peptides as Functional Components in Arylenediimide-Based Molecular Architectonics

    Roy Bappaditya , Govindaraju Thimmaiah

    … In particular, amino acids and peptides are attractive auxiliaries to guide the controlled molecular self-assembly, coassembly, heterostructures and living assembly systems of functional molecules in the scheme of molecular architectonics. … Use of these exquisite biomolecular auxiliaries to master the art of engineering the molecular assembly of functional aromatic units viz., arylenediimides has been a continuous effort in the emerging field of molecular architectonics. …

    Bulletin of the Chemical Society of Japan 92(11), 1883-1901, 2019


  • Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice

    Iida Ayaka , Nakamura Tsuyoshi , Kuranuki Sachi , Yamamoto Ryoko , Uchida Masaya , Ohta Masanori , Ichimura Mayuko , Tsuneyama Koichi , Masaki Takayuki , Seike Masataka

    … <p>The changes in free amino acid (AA) levels in blood during the progression from non-alcoholic steatohepatitis (NASH) to hepatocellular carcinoma (HCC) are unclear. … The Fischer ratio decreased at 16 weeks in the STAM group, with increasing aromatic AA levels. …

    Experimental Animals 68(4), 417-428, 2019

    J-STAGE  Ichushi Web 

  • Effect of Traditional Processing on the Nutritional Quality and <i>in vivo</i> Biological Value of Samh (<i>Mesembryanthemum forsskalei</i> Hochst) Flour

    Alderaywsh Fahad , Osman Magdi A. , Al-Juhaimi Fahad Y. , Gassem Mustafa A. , Al- Maiman Salah A. , Adiamo Oladipupo Q. , Özcan Mehmet Musa , Ahmed Isam A. Mohamed

    … Similar amino acid content was found in both raw and treated flours with glutamic acid, glycine, arginine, and aspartic acid being predominant. … Cooking reduced the total aromatic and non-essential amino acid content whereas roasting reduced the total essential amino acid content of samh flour. …

    Journal of Oleo Science 68(10), 1033-1040, 2019


  • Effect of methotrexate on pteridine-contents and relaxation response of the aorta from <i>quinonoid</i>-dihydropteridine reductase (QDPR) knockout mice

    Sumi-Ichinose Chiho , Suganuma Yui , Kano Taiki , Ihira Noriko , Ikemoto Kazuhisa , Ichinose Hiroshi , Kondo Kazunao

    … <p>Tetrahydrobiopterin (BH4) is not only an essential cofactor for aromatic L-amino acid hydroxylases but also all types of nitric oxide (NO) synthases. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO3-3-47, 2018


  • GDNF, CDNF and MANF have divergent effects on nigrostriatal dopamine neurochemistry in rats

    Renko Juho-Matti , Piepponen Petteri , Reenila Ilkka , Saarma Mart , Tuominen Raimo

    … They were administered with an aromatic amino acid decarboxylase inhibitor 3-hydroxybenzylhydrazine (NSD1015) 100mg/kg, i.p. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO2-1-52, 2018


  • Structure activity relations of aromatic amino acid derivatives to interact with organic anion transporter OAT1 reveal critical moieties for renal accumulation of tumor imaging probes

    Jin Chunhuan , Ohgaki Ryuichi , Tominaga Hideyuki , Okuda Suguru , Nagamori Shushi , Kanai Yoshikatsu

    … <p>3-[18F]fluoro-alpha-methyl-L-tyrosine ([18F]FAMT) and 3-[123I]iodo-alpha-methyl-L-tyrosine ([123I]IMT) have been developed as amino acid probes for tumor imaging. … FAMT and IMT are accumulated specifically in tumor due to their high selectivity to amino acid transporter LAT1 (L-type amino acid transporter 1) expressed specifically in tumor cells. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-8-40, 2018


  • Past・Present・Future on Parkinson's Disease Therapeutics  [in Japanese]

    Hattori Nobutaka

    … 間以上,問題となるジスキネジアが1時間以上あれば考慮すべきである.さらに,近未来的治療方法としては,iPS細胞由来ドパミン神経細胞の移植療法や芳香族アミノ酸脱炭酸酵素(aromatic L-amino acid decarboxylase(AADC):AADC)を使った遺伝子治療が登場すると考えられる.さらに,疾患修飾療法として2型糖尿病治療薬でGLP(glucagon-like peptide)-1アナログのエキセナチドが候補として …

    Nihon Naika Gakkai Zasshi 107(4), 762-770, 2018

    J-STAGE  Ichushi Web 

  • Dibutyltin(IV) Complexes Derived from L-DOPA: Synthesis, Molecular Docking, Cytotoxic and Antifungal Activity

    Rocha-Del Castillo Erika , Gómez-García Omar , Andrade-Pavón Dulce , Villa-Tanaca Lourdes , Ramírez-Apan Teresa , Nieto-Camacho Antonio , Gómez Elizabeth

    … The potency of this cytotoxic activity depended on the nature of the substituent bonded to the aromatic ring. … Molecular docking studies demonstrated that the organotin(IV) complexes bind at the active site of topoisomerase I in a similar manner to topotecan, sharing affinity for certain amino acid side chains (Ile535, Arg364 and Asp533), as well as for similar DNA regions (DA113, DC112 and DT10).</p> …

    Chemical and Pharmaceutical Bulletin 66(12), 1104-1113, 2018

    J-STAGE  Ichushi Web 

  • Denaturation of Lysozyme with Visible-light-responsive Photocatalysts of Ground Rhodium-doped and Ground Rhodium-antimony-co-doped Strontium Titanate

    Usuki Sho , Nakata Kazuya , Yamatoya Kenji , Kawamura Yuki , Yamaguchi Yuichi , Suzuki Norihiro , Katsumata Ken-ichi , Terashima Chiaki , Fujishima Akira , Kudo Akihiko

    … BCA and Bradford protein assays indicated that the peptide bonds and basic, aromatic and N-terminal amino acid residues in lysozyme were denaturated by g-STO:Rh photocatalysis. … The denaturation of those amino acids, as quantified by the decreased solubility of lysozyme, was estimated to be more severe by Bradford protein assay than by BCA protein assay. …

    Journal of Oleo Science 67(12), 1521-1533, 2018


  • Detection and estimation of urinary fluorescent substances using a portable ultraviolet lamp (black light) (II)  [in Japanese]

    TAKIZAWA Akira , SASAKI Fumio , OOSAWA Nobutaka , OKUDA Shunji

    … Using the fluorescent spot test on filter papers and TLC plates, we have defined 12 fluorescent substances, namely, amino acids (tryptophan and histidine), flavine compounds (FMN and FAD), aromatic amino acid metabolites (gentisic acid, tryptamine, serotonin, 5-hydroxyindole acetic acid, skatole, and indole) and hemoglobin metabolites (coproporphyrin and urobilin) in urine specimens.</p> …

    Japanese Journal of Medical Technology 67(2), 204-209, 2018

    J-STAGE  Ichushi Web 

  • Design of Dication-Type Amino Acid Ionic Liquids and Their Application to Self-Assembly Media of Amphiphiles

    Fujiwara Saki , Ohno Hiroyuki , Yoshio Masafumi , Kato Takashi , Ichikawa Takahiro

    … <p>Dication-type amino acid ionic liquids have been prepared and their physicochemical properties, such as viscosity, glass transition temperature, Kamlet-Taft parameter, ionic conductivity, and refractive index, have been examined. … Comparing these properties of the dication-type amino acid ionic liquids with those of corresponding monocation-type ones, we have investigated the effects of the cation-bridging. …

    Bulletin of the Chemical Society of Japan 91(1), 1-5, 2018


  • Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives

    Shoji Osami , Yanagisawa Sota , Kyle Stanfield Joshua , Suzuki Kazuto , Cong Zhiqi , Sugimoto Hiroshi , Shiro Yoshitsugu , Watanabe Yoshihito

    … The selective hydroxylation of benzene to phenol, without the formation of side products resulting from overoxidation, is catalyzed by cytochrome P450BM3 with the assistance of amino acid derivatives as decoy molecules. … This work shows that amino acid derivatives with a totally different structure from fatty acids can be used as decoy molecules for aromatic hydroxylation by wild-type P450BM3. …

    Angewandte Chemie International Edition (56), 10324-10329, 2017-08-21


  • First characterization of an archaeal amino acid racemase with broad substrate specificity from the hyperthermophile Pyrococcus horikoshii OT-3

    Kawakami Ryushi , Sakuraba Haruhiko , Ohmori Taketo , Ohshima Toshihisa

    … A novel amino acid racemase with broad substrate specificity was recently isolated from the hyperthermophilic archaeon Pyrococcus horikoshii OT-3. … The purified enzyme retained its full activity after incubation at 80°C for at least 2 h in buffer (pH 7-10), making this enzyme the most thermostable amino acid racemase so far known. …

    Journal of bioscience and bioengineering 124(1), 23-27, 2017-07

    IR  DOI 

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