Search Results 1-20 of 9510

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Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy, including FoxO1 and its targets

Ajima Haruka , Kai Yuko , Fujimaki Junya , Akashi Shiori , Morita Akihito , Ezaki Osamu , Kamei Yasutomi , Miura Shinji

… Besides its lipid-lowering effect, the side effect of muscle atrophy after fibrate administration to humans has been demonstrated in some studies. … FoxO1, a member of the FoxO forkhead type transcription factor family, is markedly upregulated in skeletal muscle in energy-deprived states and induces muscle atrophy via the expression of E3-ubiquitine ligases. …

The Journal of Toxicological Sciences 46(1), 11-24, 2021

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2

Effects of conservative treatment of 2-week rigorous bed rest on muscle disuse atrophy in osteoporotic vertebral fracture patients

Ikumi Akira , Funayama Toru , Terajima Sho , Matsuura Satoshi , Yamaji Akihiro , Nogami Yuko , Okuwaki Shun , Kawamura Haruo , Yamazaki Masashi

… Osteoporotic vertebral fracture (OVF) is conventionally treated with conservative management such as bed rest, but a relatively prolonged bed rest has the potential risk of muscle disuse atrophy. … This study aimed to examine whether the 2-week of rigorous bed rest affects muscle disuse atrophy in OVF patients.Patients and Methods: …

Journal of Rural Medicine 16(1), 8-13, 2021

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3

Intra-rater reliability of measurement of abdominal perimuscular connective tissue thickness on ultrasound images

Nanikawa Wataru , Miyazaki Junya

… [Purpose] The thickness of the perimuscular connective tissue (PMCT) reflects muscular atrophy and decreased flexibility that may cause low back pain. …

Journal of Physical Therapy Science 33(1), 32-36, 2021

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4

Effects of neuromuscular electrical stimulation on pulmonary alveola and cytokines in chronic obstructive pulmonary disease (COPD) and skeletal muscle atrophy model mice

Maruoka Hiroshi , Tanaka Ken-ichi , Takayanagi Masaaki , Zenda Masashi

… [Conclusion] On the basis of these findings, our study reveals that NMES affects cytokines and macrophages in COPD skeletal muscle atrophy. …

Journal of Physical Therapy Science 33(1), 1-8, 2021

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5

Prospective Memory Deficits in Multiple Sclerosis: Voxel-based Morphometry and Double Inversion Recovery Analysis

Toko Megumi , Maruyama Hirofumi , Kitamura Juri , Ueno Hiroki , Ohshita Tomohiko , Nemoto Kiyotaka , Ochi Kazuhide , Higaki Toru , Akiyama Yuji , Awai Kazuo

… Gray matter (GM) atrophy and plaques have been attracting attention for various cognitive impairments in MS patients. … Regardless of the location of plaques on DIR, both PM deficit and GM atrophy should be detected using neuropsychological tests and VBM in MS patients. …

Internal Medicine 60(1), 39-46, 2021

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6

Juzentaihoto Suppresses Muscle Atrophy and Decreased Motor Function in SAMP8 Mice

Morita Yasuyo , Ishida Tomoaki , Morisawa Shumpei , Jobu Kohei , Ou Yangran , Fujita Hiroko , Hanazaki Kazuhiro , Miyamura Mitsuhiko

… In addition, increased levels of ubiquitin ligases cause skeletal muscle atrophy. … In this study, we evaluated the effect that juzentaihoto hot water extract (JTT) has on skeletal muscle atrophy and motor function by administering it to senescence-accelerated mouse prone-8 (SAMP8). … The results of this study suggested that JTT administration suppresses skeletal muscle atrophy and motor function decline in SAMP8 mice. …

Biological and Pharmaceutical Bulletin 44(1), 32-38, 2021

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7

The simplified Kyoto classification score is consistent with the ABC method of classification as a grading system for endoscopic gastritis

Nishizawa Toshihiro , Koike Kazuhiko , Toyoshima Osamu , Kondo Ryo , Sekiba Kazuma , Tsuji Yosuke , Ebinuma Hirotoshi , Suzuki Hidekazu , Tanikawa Chizu , Matsuda Koichi

… The Kyoto classification score, which ranges from 0 to 8, is based on the following findings: atrophy, intestinal metaplasia, diffuse redness, nodularity, and enlarged folds. … Furthermore, we defined a simplified Kyoto classification score as the sum of scores of just atrophy and intestinal metaplasia. …

Journal of Clinical Biochemistry and Nutrition 68(1), 101-104, 2021

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8

A single nucleotide polymorphism in Prostate Stem Cell Antigen is associated with endoscopic grading in Kyoto classification of gastritis

Toyoshima Osamu , Matsuda Koichi , Nishizawa Toshihiro , Sekiba Kazuma , Matsuno Tatsuya , Kondo Ryo , Watanabe Hidenobu , Suzuki Hidekazu , Tanikawa Chizu , Koike Kazuhiko

… The Kyoto score is the sum of scores obtained from endoscopy-based atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness. … Atrophy, enlarged folds, and diffuse redness scores were higher in T allele carriers (risk allele) than in CC genotype individuals. …

Journal of Clinical Biochemistry and Nutrition 68(1), 73-77, 2021

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9

Endoscopic and Upper Gastrointestinal Barium X-ray Radiography Images of Early-stage Autoimmune Gastritis: A Report of Two Cases

Ayaki Maki , Aoki Rika , Mastunaga Tae , Manabe Noriaki , Fujita Minoru , Kamada Tomoari , Kobara Hideki , Masaki Tsutomu , Haruma Ken

… We herein report two patients with early-stage autoimmune gastritis who did not exhibit complete atrophy. …

Internal Medicine, 2021

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10

Anemia in Diabetic Patients Reflects Severe Tubulointerstitial Injury and Aids in Clinically Predicting a Diagnosis of Diabetic Nephropathy

Ito Kenji , Masutani Kosuke , Nakashima Hitoshi , Yokota Soichiro , Watanabe Maho , Inoue Yori , Takahashi Koji , Himuro Naoko , Yasuno Tetsuhiko , Miyake Katsuhisa , Uesugi Noriko

… The tissues of patients in the DN group demonstrated more severe interstitial fibrosis and tubular atrophy (IF/TA) than those in the NDKD group (p<0.05) regardless of the rate of global glomerulosclerosis, and IF/TA was related to the prevalence of anemia (odds ratio: 7.31, 95% confidence interval: 2.33 - 23.00, p<0.01) according to a multivariable regression analysis. …

Internal Medicine, 2021

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11

Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy

Miyashita Kaname , Hongo Yui , Nakashima Akihiko , Kato Seiya , Kusano Hironori , Morizono Shusuke , Higashi Nobuhiko

… Ten months after treatment, he rapidly developed massive ascites and atrophy of the liver, and we detected HCV RNA in his serum using real time polymerase chain reaction. …

Internal Medicine, 2021

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12

An Adult Case of Hemiplegia, Aphasia, and Hemispheric Atrophy Associated with Febrile Status Epilepticus

Naoi Tameto , Morita Mitsuya , Koyama Kansuke

A 43-year-old man with a preceding infection was transferred to our hospital for febrile status epilepticus (SE). Although treatment for SE was immediately initiated, it failed. Therefore, co …

Internal Medicine, 2021

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13

Prevalence of Barrett's Epithelium Shown by Endoscopic Observations with Linked color Imaging in Subjects with Different H. pylori Infection Statuses

Adachi Kyoichi , Ishimura Norihisa , Kishi Kanako , Notsu Takumi , Mishiro Tomoko , Sota Kazunari , Ishihara Shunji

… The degree of gastric mucosal atrophy was higher in cases with BE (p<0.001), although negativity for H. … infection and mild gastric mucosal atrophy were significant factors for the development of longer BE. … infection and mild gastric mucosal atrophy were not correlated with SSBE prevalence. …

Internal Medicine, 2021

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14

Effectiveness of Levodopa in Patients with Multiple System Atrophy and Associated Clinicopathological Features

Ishida Chiho , Takahashi Kazuya , Kato-Motozaki Yuko , Tagami Atsuro , Komai Kiyonobu

… Objective To determine the clinicopathological features of levodopa or dopamine agonist (DA) responders with multiple system atrophy (MSA), an autopsy-confirmed diagnosis is vital due to concomitant cases of MSA and Parkinson's disease (PD). …

Internal Medicine, 2021

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15

A Case of Celiac Disease Complicated by Rhabdomyolysis

Fujisawa Mia , Nakahara Fumio , Suzuki Hidekazu , Suzuki Takayoshi , Matsushima Masashi , Ueda Takashi , Kaneko Motoki , Fujimoto Ryutaro , Sano Masaya , Teramura Erika , Monma Makiko , Mizukami Hajime

… Endoscopy detected prominent atrophy of the intestinal villi. …

Internal Medicine, 2021

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16

Treatment of Refractory Hypertension with Timely Angioplasty in Total Renal Artery Occlusion with Atrophic Kidney

Sasaki Yuri , Ito Sadayoshi , Takase Kei , Abe Takaaki , Mishima Eikan , Kikuchi Koichi , Toyohara Takafumi , Suzuki Takehiro , Ota Hideki , Seiji Kazumasa , Miyazaki Mariko , Harigae Hideo

… We here report a 57-year-old man who presented with renin-mediated refractory hypertension caused by occlusion of a unilateral renal artery leading to kidney atrophy (length: 69 mm). …

Internal Medicine, 2021

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17

A case in which the manifestation of fasciculations in the tongue led to a diagnosis of amyotrophic lateral sclerosis (ALS) : associated disease [in Japanese]

石濱嵩統 , 阿部厚 , 松浦有紗 , 長谷川博亮 , 林宏紀 , 古田浩史

日本口腔外科学会雑誌 = Japanese journal of oral and maxillofacial surgery 66(11), 577-582, 2020-11
18

Recovery from developmental delay associated with severe atopic dermatitis in an infant : a case report with examination of prognostic factors [in Japanese]

佐藤健 , 菅原祐之 , 滝島茂 , 田中由美 , 松田希 , 三上健太郎 , 長谷川毅

小児科臨床 = Japanese journal of pediatrics 73(11), 1559-1565, 2020-11
19

Pathologically Proven Intraocular Infiltration With Adult T-Cell Leukemia/Lymphoma: Two New Cases With Either Vitreous Opacity or Aqueous Hypopyon and Literature Review of 16 Cases

Matsuo Toshihiko , Shimizu Takehiro , Tanaka Takehiro , Yamamoto Akira , Takasuka Hiroki

… She had bilateral optic disc atrophy and localized retinal white infiltrates in both eyes. …

Journal of Investigative Medicine High Impact Case Reports (8), 2324709620966843, 2020-10-20

IR
20

Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis

Yamashita Toru , Kushida Yoshihiro , Wakao Shohei , Tadokoro Koh , Nomura Emi , Omote Yoshio , Takemoto Mami , Hishikawa Nozomi , Ohta Yasuyuki , Dezawa Mari , Abe Koji

… Relative to the vehicle groups, the Muse group significantly improved scores in the rotarod, hanging-wire and muscle strength of lower limbs, recovered the number of motor neurons, and alleviated denervation and myofiber atrophy in lower limb muscles. …

Scientific Reports 10(1), 17102, 2020-10-13

IR

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