Search Results 1-20 of 85

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  • A Case of Primary Pulmonary Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma, Not Otherwise Specified  [in Japanese]

    Takenaka Hirofumi , Kawasaki Naruaki , Ishiguro Futoshi , Enomoto Atsushi , Abe Takashi , Shigemitsu Kikuo

    <p><b>背景.</b>Epstein-Barr virus(EBV)陽性びまん性大細胞型B細胞性リンパ腫・非特定型(diffuse large B-cell lymphoma,not otherwise specified:DLBCL,NOS)の患者のほとんどは,50歳以上の成人で,自己免疫疾患や免疫不全を示唆する既往歴を持たない.この疾患は稀であり,高齢者 …

    Haigan 59(2), 142-146, 2019

    J-STAGE

  • Transcriptional Regulation of CD4+ T Cell Differentiation in Experimentally Induced Arthritis and Rheumatoid Arthritis

    Kondo Yuya , Yokosawa Masahiro , Kaneko Shunta , Furuyama Kotona , Segawa Seiji , Tsuboi Hiroto , Matsumoto Isao , Sumida Takayuki

    … Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation of the joint synovium and infiltration by activated inflammatory cells. … CD4+ T cells form a large proportion of the inflammatory cells invading the synovial tissue, and are involved in the RA pathologic process. …

    Arthritis & rheumatology 70(5), 653-661, 2018-05

    IR

  • Distinct Regulation of CXCL10 Production by Cytokines in Human Salivary Gland Ductal and Acinar Cells

    Aota Keiko , Kani Koichi , Yamanoi Tomoko , Nakashiro Koh-ichi , Ishimaru Naozumi , Azuma Masayuki

    … CXCL10, a CXC chemokine induced by interferon-gamma [IFN-γ], has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions. …

    Inflammation 41(4), 1172-1181, 2018-03-17

    IR

  • Treatment of multiple sclerosis and neuromyelitis optica–spectrum disorders  [in Japanese]

    Nakahara Jin

    … More than 20,000 Japanese patients are suffering from demyelinating diseases of the central nervous system (CNS), including multiple sclerosis (MS) and neuromyelitis optica–spectrum disorders (NMOSD). … Similarly to other autoimmune diseases, the use of systemic steroids or immunosuppressive medicines mainstay as a therapeutic strategy to halt the production of such autoantibodies. …

    Neurological Therapeutics 35(3), 214-218, 2018

    J-STAGE

  • Primary immunodeficiencies and hematological malignancies  [in Japanese]

    KANEGANE Hirokazu , HOSHINO Akihiro , TAKAGI Masatoshi

    <p>原発性免疫不全症は免疫系の内因的破綻によって生ずる疾患であり,反復,重症または日和見感染といった易感染性を特徴とするが,悪性腫瘍や自己免疫疾患の合併も少なくない。特に獲得免疫系の異常によってそれらのリスクが高まる。原発性免疫不全症における悪性腫瘍の発症メカニズムはさまざまであり,細胞傷害性リンパ球による腫瘍監視機構の欠陥,アポトーシスの異常,発がん性を有する物質に対する高感受性, …

    Rinsho Ketsueki 59(11), 2459-2467, 2018

    J-STAGE

  • Involvement of innate immunity in chronic fibro-inflammatory responses of the pancreas  [in Japanese]

    WATANABE Tomohiro , MINAGA Kosuke , KAMATA Ken , KUDO Masatoshi

    <p>慢性炎症性膵臓疾患は慢性膵炎と自己免疫性膵炎に大別される.これらの慢性炎症性膵臓疾患の炎症局所においては,免疫細胞の浸潤と線維化が認められる.自然免疫反応と獲得免疫反応の双方が慢性膵炎と自己免疫性膵炎の発症に必要であると考えられているがその詳細は解明されていない.最近,我々は慢性膵炎と自己免疫性膵炎が共通の自然免疫反応経路を背景に,発症することを見出した.慢性膵炎では膵臓の腺房細 …

    Suizo 33(4), 737-742, 2018

    J-STAGE Ichushi Web

  • Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection

    Uchida Tetsuro , Hamasaki Azumi , Kuroda Yoshinori , Sadahiro Mitsuaki , Tamazawa Nobuyuki , Ohe Rintaro , Yamakawa Mitsunori

    … <p>Immunoglobulin G subclass 4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disease characterized by an elevated serum IgG4 level and an IgG4-positive lymphocyte infiltrate mainly in exocrine tissues. … Previous reports documented IgG4-RD in several cardiovascular disorders. …

    Annals of Thoracic and Cardiovascular Surgery 24(4), 208-210, 2018

    J-STAGE Ichushi Web

  • Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel K<sub>Ca</sub>3.1 as a Therapeutic Target for Immune Disorders

    Ohya Susumu , Kito Hiroaki

    … K<sub>Ca</sub>3.1 is therefore an attractive therapeutic target for allergic, inflammatory, and autoimmune disorders. …

    Biological and Pharmaceutical Bulletin 41(8), 1158-1163, 2018

    J-STAGE Ichushi Web

  • Are there early signs that predict development of temporomandibular joint disease?

    Fredricson Adrian Salinas , Khodabandehlou Farid , Weiner Carina Krüger , Naimi-Akbar Aron , Adami Johanna , Rosén Annika

    … <p>Temporomandibular joint disorders (TMJD) involve orofacial pain and functional limitations that may limit important daily activities such as chewing and speaking. … In conclusion, autoimmune diseases and inflammatory conditions are associated with increased risk of TMJD. … Moreover, certain lung disorders may predict subsequent development of TMJD.</p> …

    Journal of Oral Science 60(2), 194-200, 2018

    J-STAGE

  • Viewing sepsis and autoimmune disease in relation with infection and NETs-formation  [in Japanese]

    MATSUHISA Akio , OKUI Akira , HORIUCHI Yoshiyuki

    <p>感染に対する最初のディフェンスラインである好中球が, NETosisという細胞死をとる事が2004年に報告され, アポトーシス, ネクローシスと区別された。この現象は既に基礎と臨床領域において示唆されていた。NETosisはPMA等の化学物質, IL-8等のサイトカイン, PAMPsまたはDAMPs, 細菌等の微生物, ANCA等の自己抗体とその抗原複合体の刺激によって誘導される …

    Nippon Saikingaku Zasshi 73(2), 171-191, 2018

    J-STAGE Ichushi Web

  • IgG4-related Disease - A Systemic Disease that Deserves Attention Regardless of One's Subspecialty

    Hamano Hideaki , Tanaka Eiji , Ishizaka Nobukazu , Kawa Shigeyuki

    … <p>IgG4-related disease (IgG4-RD) is an inflammatory condition characterized by a high serum IgG4 concentration and the abundant infiltration of lymphocytes and IgG4-positive plasma cells in the tissue, as well as spatial (diverse clinical manifestations) and temporal (the possibility of recurrence) multiplicities. …

    Internal Medicine 57(9), 1201-1207, 2018

    J-STAGE

  • Cepharanthine Inhibits IFN-γ-Induced CXCL10 by Suppressing the JAK2/STAT1 Signal Pathway in Human Salivary Gland Ductal Cells

    Aota Keiko , Yamanoi Tomoko , Kani Koichi , Azuma Masayuki

    … Cepharanthine, a biscolaurine alkaloid isolated from the plant Stephania cephalantha Hayata, has been reported to have potent anti-inflammatory properties. … Here we investigated the effects of cepharanthine on the expression of CXCL10 (a CXC chemokine induced by interferon-gamma [IFN-γ] that has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions) in IFN-γ-treated human salivary gland cell lines. …

    Inflammation 41(1), 50-58, 2017-09-06

    IR DOI

  • Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection

    Uchida Tetsuro , Hamasaki Azumi , Kuroda Yoshinori , Sadahiro Mitsuaki , Tamazawa Nobuyuki , Ohe Rintaro , Yamakawa Mitsunori

    … <p>Immunoglobulin G subclass 4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disease characterized by an elevated serum IgG4 level and an IgG4-positive lymphocyte infiltrate mainly in exocrine tissues. … Previous reports documented IgG4-RD in several cardiovascular disorders. …

    Annals of Thoracic and Cardiovascular Surgery, 2017

    J-STAGE

  • The interface between the immune system and autonomic nervous system  [in Japanese]

    NAKANE Shunya , MUKAINO Akihiro , ANDO Yukio

    … <p>  神経系と免疫系はヒトを支えるふたつの広大なシステムである.両者の相関はこれまでにも研究がなされてきているが,神経系による免疫系制御が昨今注目を集めている.自律神経系に関してはinflammatory reflex仮説をベースに迷走神経刺激による幅広い抗炎症作用が臨床への応用という視点からも期待されている.また交感神経系によるリンパ球動態制御については,近年その分子基盤が解明され,さらなる研 …

    Japanese Journal of Clinical Immunology 40(5), 352-360, 2017

    J-STAGE Ichushi Web

  • Are there early signs that predict development of temporomandibular joint disease?

    Fredricson Adrian Salinas , Khodabandehlou Farid , Weiner Carina Krüger , Naimi-Akbar Aron , Adami Johanna , Rosén Annika

    … <p>Temporomandibular joint disorders (TMJD) involve orofacial pain and functional limitations that may limit important daily activities such as chewing and speaking. … In conclusion, autoimmune diseases and inflammatory conditions are associated with increased risk of TMJD. … Moreover, certain lung disorders may predict subsequent development of TMJD.</p> …

    Journal of Oral Science, 2017

    J-STAGE

  • Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice

    Suzuki Akari , Kochi Yuta , Shoda Hirofumi , Seri Yu , Fujio Keishi , Sawada Tetsuji , Yamada Ryo , Yamamoto Kazuhiko

    … The expression of various inflammatory cytokines and Padi genes in immune cells was detected by the real-time TaqMan assay. … In the Padi4−/−mice, serum anti-type II collagen (CII) immunoglobulin M (IgM), IgG, and inflammatory cytokine levels were significantly decreased compared with those in the wild-type mice. … [Conclusions]Padi4 affected disease severity in the CIA mice and was involved in the enhancement of the collagen-initiated inflammatory responses. …

    BMC Musculoskeletal Disorders (17), 2016-05-05

    IR

  • Comparative analysis of mediastinal fat-associated lymphoid cluster development and lung cellular infiltration in murine autoimmune disease models and the corresponding normal control strains

    Elewa Yaser Hosny Ali , Ichii Osamu , Kon Yasuhiro

    … In the present study, we compared the morphological features of MFALCs in 4-month-old male murine autoimmune disease models (MRL/MpJ-lpr mice and BXSB/MpJ-Yaa mice) with those of the corresponding control strains (MRL/MpJ and BXSB/MpJ, respectively). … The spleen weight to body weight ratios and anti-double-stranded DNA autoantibody titres were found to be significantly higher in the autoimmune models than in the control strains. …

    Immunology 147(1), 30-40, 2016-01

    IR DOI

  • Resident memory T cells in mouse and human  [in Japanese]

    WATANABE Rei

    <p>  生体内のmemory T細胞分画に関して,近年一旦組織に移行した後循環に戻らずその組織に留まり続けるresident memory T細胞(T<sub>RM</sub>)の存在が明らかになり,研究が活発に進められている.T<sub>RM</sub>は細胞表面にCD69,CD103を発現し強いエフェクター機能を有する分画としての報 …

    Japanese Journal of Clinical Immunology 39(6), 505-512, 2016

    J-STAGE Ichushi Web

  • Limbic Encephalitis Associated with Sjögren's Syndrome: Report of Three Cases

    Çoban Arzu , Özyurt Selen , Meriç Kaan , Mısırlı Handan , Tüzün Erdem , Türkoğlu Recai

    … The 26-year-old patient also developed acute motor axonal neuropathy one week after autoimmune encephalitis. … All three patients showed contrast-enhanced MRI lesions and inflammatory cerebrospinal fluid findings, while not displaying any anti-neuronal antibodies and showing a remarkable response to immunotherapy. … Therefore, in LE cases with no identifiable cause, serological screening for rheumatologic disorders is recommended. …

    Internal Medicine 55(16), 2285-2289, 2016

    J-STAGE

  • The relationship between serum adipocytokines and Graves’ ophthalmopathy: A hospital-based study

    Kim Bo-Yeon , Mok Ji-Oh , Kang Sung-Koo , Jang Sun-Young , Jung Chan-Hee , Kim Chul-Hee

    … Adipocytokines are thought to be associated with inflammatory disorders and autoimmune diseases. … These results suggest that adipocytokines, such as leptin and resistin, may play a role in inflammatory and autoimmune processes of GD and GO. …

    Endocrine Journal 63(5), 425-430, 2016

    J-STAGE

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