Search Results 1-20 of 429

  • Rapid antibody test by fluorescence polarization immunoassay  [in Japanese]

    西山 慶音 , 火原 彰秀 , 渡慶次 学

    化学とマイクロ・ナノシステム = Journal of the Society for Chemistry and Micro-Nano Systems : 化学とマイクロ・ナノシステム研究会誌 19(2), 13-15, 2020-10

  • Efficacy of Neuraminidase Inhibitors against H5N6 Highly Pathogenic Avian Influenza Virus in a Nonhuman Primate Model.

    NGUYEN Cong Thanh , SUZUKI Saori , ITOH Yasushi , ISHIGAKI Hirohito , NAKAYAMA Misako , HAYASHI Kaori , MATSUNO Keita , OKAMATSU Masatoshi , SAKODA Yoshihiro , KIDA Hiroshi , OGASAWARA Kazumasa , 鈴木 紗織 , 伊藤 靖 , 石垣 宏仁 , 仲山 美沙子 , 林 香里 , 小笠原 一誠

    … Attention has been paid to H5N6 highly pathogenic avian influenza virus (HPAIV) because of its heavy burden on the poultry industry and human mortality. … Since an influenza A virus carrying N6 neuraminidase (NA) has never spread in humans, the potential for H5N6 HPAIV to cause disease in humans and the efficacy of antiviral drugs against the virus need to be urgently assessed. …

    Antimicrobial agents and chemotherapy 64(7), 2020-06-23

    IR 

  • Application of an Improved Micro-amount of Virion Enrichment Technique (MiVET) for the Detection of Avian Influenza A Virus in Spiked Chicken Meat Samples

    Makino Ryohei , Yamazaki Yasuko , Nagao Konomu , Apego Francis Victor , Mekata Hirohisa , Yamazaki Wataru

    … The "micro-amount of virion enrichment technique" (MiVET) was recently developed, which is a new method combining virus concentration with immunomagnetic beads and simple RNA extraction with sodium dodecyl benzenesulfonate (SDBS) for the specific and sensitive detection of avian influenza viruses (AIVs). …

    Food and Environmental Virology (12), 167-173, 2020-06

    IR 

  • Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.

    SUZUKI Saori , SHICHINOHE Shintaro , ITOH Yasushi , NAKAYAMA Misako , ISHIGAKI Hirohito , MORI Yuya , Ogata-Nakahara Ayako , NGUYEN Cong Thanh , OKAMATSU Masatoshi , SAKODA Yoshihiro , KIDA Hiroshi , OGASAWARA Kazumasa , 鈴木 紗織 , 七戸 新太郎 , 仲山 美沙子 , 石垣 宏仁 , 森 優也 , 小笠原 一誠

    … Human cases of H7N9 influenza A virus infection have been increasing since 2013. … The first choice of treatment for influenza is neuraminidase (NA) inhibitors (NAIs), but there is a concern that NAI-resistant viruses are selected in the presence of NAIs. …

    Antiviral research (178), 104790, 2020-04-06

    IR 

  • Recognition specificity of influenza virus for sialo-sugar chains with branched structure  [in Japanese]

    Hiramatsu Hiroaki , Matsumoto Kazuhiko , Kudkyal Vyankatesh , Kawahara Toshio , Suzuki Yasuo , Hayashi Kyoko , Nakakita Shin-Ichi , Watanabe Yohei , Ono Takao , Kanai Yasushi

    <p>糖鎖を用いたインフルエンザイルスの変異検出系に対し、ばらつきを抑え反応活性の高い糖鎖プローブを探索するため、足場タンパク質BSAに糖鎖を固定化したNeoglycoprotein（NGP）を合成し、糖鎖の分岐の有無に対するインフルエンザウイルスの結合性について比較した。その結果、ヒト及び鳥インフルエンザ、いずれウイルスも分岐を持たない糖鎖を固定化したNGPの方が高い結合性を有してい …

    Abstract book of Annual Meeting of the Japan Society of Vacuum and Surface Science 2020(0), 182, 2020

    J-STAGE 

  • Virucidal efficacy of acidic electrolyzed water (AEW) against African swine fever virus and avian influenza virus

    RHEE Chae Hong , KIM Soohee , KANG Young Eun , HAN Bokhee , SEO Sang-Ji , KIM Young Wook , HER Moon , JEONG Wooseog

    … <p>This study evaluated the virucidal efficacy of acidic electrolyzed water (AEW) against African swine fever virus (ASFV) and avian influenza virus (AIV), according to the Animal and Plant Quarantine Agency (APQA) guidelines for efficacy testing of veterinary disinfectants. …

    Journal of Veterinary Medical Science, 2020

    J-STAGE 

  • Comparison of Virulence and Lethality in Mice for Avian Influenza Viruses of Two A/H5N1 and One A/H3N6 Isolated from Poultry during Year 2013-2014 in Indonesia

    Yudhawati Resti , Wulandari Laksmi , Lusida Maria I , Soetjipto , Soegiarto Gatot , Shimizu Yohko K , Mori Yasuko , Shimizu Kazufumi , Prasetya Rima R , Dewantari Jezzy R , Nastri Aldise M , Rahardjo Krisnoadi , Novianti Arindita N , Amin Muhammad , Rantam Fedik A , Poetranto Emmanuel D

    … <p>In Indonesia, the highly pathogenic avian influenza A/H5N1 virus has become endemic and has been linked with direct transmission to humans. … From 2013 to 2014, we isolated avian influenza A/H5N1 and A/H3N6 viruses from poultry in Indonesia. … The Av154 virus was highly virulent and lethal in mice without prior adaptation, suggesting its high pathogenic potential in mammals. …

    Japanese Journal of Infectious Diseases 73(5), 336-342, 2020

    J-STAGE 

  • Characterization of Myxovirus resistance protein in birds showing different susceptibilities to highly pathogenic influenza virus

    HAGIWARA Katsuro , NAKAYA Takaaki , ONUMA Manabu

    … We observed different mortalities associated with highly pathogenic avian influenza virus (HPAIV) infection to understand the relationship between <i>Mx</i> … were observed among the different bird species after virus infection. … The lowest virus copy numbers were observed in rock dove. …

    Journal of Veterinary Medical Science 82(5), 619-625, 2020

    J-STAGE  Ichushi Web 

  • The latest trend about the conformity acquisition of bird type influenza virus infected to the humans  [in Japanese]

    Nakajima Isao , Otsuka Hiroyuki , Ichimura Atsushi , Honda Yumie , Umezawa Kazuo , Seki Tomoko , Nakagawa Yoshihide , Inoguchi Sadaki

    <p>家禽や野鳥が保有する低病原性鳥インフルエンザウイルスであってもヒトが死に至る例が報告されており, これまで定説となっていた豚由来のウイルス感染とは違うルートが推測される。鳥からヒトへの感染に関する最近の文献調査, およびモンゴルへの調査視察を踏まえ鳥から直接感染するインフルエンザの動向を本稿では報告する。アザラシのインフルエンザ, 日本のイノシシのインフルエンザ, 豚便所, 北米 …

    KANTO Journal of Japanese Association for Acute Medicine 41(2), 219-224, 2020

    J-STAGE  Ichushi Web 

  • A series of the studies on countermeasure for arthropod-borne infectious diseases in Japan —Focus on highly pathogenic avian influenza and dengue outbreaks in Japan—  [in Japanese]

    Sawabe Kyoko

    … In 2004, the highly pathogenic avian influenza occurred in Kyoto. … The H5N1 influenza A virus was isolated from the blow fly, <i>Calliphora nigribarbis</i>, collected around a poultry farm. … Exposure experiments showed that the H5N1 virus survived in <i>C. … was suggested to possibly transport the H5N1 virus over a distance of 2 km, which they can access within 24 h. …

    Medical Entomology and Zoology 71(1), 1-13, 2020

    J-STAGE  Ichushi Web 

  • Role of neuropeptides in lung  [in Japanese]

    Imai Yumiko

    … <p>Severe influenza infection is characterized by a strong inflammatory response and profuse viral replication. … These viruses, such as H5N1 avian flu, have a high rate of death and to date there are no effective treatments. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S34-4, 2020

    J-STAGE 

  • Simulation of leukopenia developed with influenza A/H5N1 and its recovery with treatment of an antibody to influenza A/H5N1 virus

    Yasuda Hidenori , Kawachi Shohji , Suzuki Kazuo

    … For highly pathogenic avian influenza A/H5N1, white blood cell count rapidly decreases after onset and then engender leukopenia. … To elucidate the pathogenesis of leukopenia associated with highly pathogenic avian influenza A/H5N1 infection, simulations were conducted using a mathematical model of mice. …

    ADC Letter for Infectious Disease Control 7(1), 29-33, 2020

    J-STAGE 

  • Genetic Characterization of a Novel Reassortant H5N6 Avian Influenza Virus Identified from a 10-Year-Old Girl

    Dong Zefeng , Ya Xuerong , Wang Di , Liu Cheng , Shen Qiang , Xia Yu

    … <p>A 10-year-old girl was confirmed, by laboratory tests, to be infected with the H5N6 subtype of the highly pathogenic avian influenza virus in Suzhou city in November, 2018 (JSSZ01). … The hemagglutinin (HA) gene of this H5N6 virus belonged to the 2.3.4.4 H5 clade, and the HA linkage peptide of the JSSZ01 strain was RERRRKR↓GLF with multiple basic amino acids. …

    Japanese Journal of Infectious Diseases 73(1), 36-43, 2020

    J-STAGE  Ichushi Web 

  • Whole-Genome Sequence of an Avian Influenza A/H9N2 Virus Isolated from an Apparently Healthy Chicken at a Live-Poultry Market in Indonesia

    Novianti Arindita N. , Rahardjo Krisnoadi , Prasetya Rima R. , Nastri Aldise M. , Dewantari Jezzy R. , Rahardjo Adi P. , Estoepangestie Agnes T. S. , Shimizu Yohko K. , Poetranto Emmanuel D. , Soegiarto Gatot , Mori Yasuko , Shimizu Kazufumi

    … We isolated an avian influenza A/H9N2 virus from an apparently healthy chicken at a live-poultry market in January 2018. … This is the first report of a whole-genome sequence of A/H9N2 virus in Indonesia. … Phylogenetic analyses indicated that intrasubtype reassortment of genome segments is involved in the genesis of the A/H9N2 virus. …

    Microbiology Resource Announcements 8(17), e01671-18, 2019-04-25

    IR 

  • Influenza as a zoonosis  [in Japanese]

    喜田 宏

    呼吸器内科 = Respiratory medicine 35(1), 6-10, 2019-01

    Ichushi Web 

  • Resuming Farm Operations after a Highly Pathogenic Avian Influenza Outbreak  [in Japanese]

    佐々木 宏

    鶏病研究会報 = Journal of the Japanese Society on Poultry Diseases 55(3), 101-104, 2019

  • Variety of influenza viruses and vaccine  [in Japanese]

    奥野 良信

    バムサジャーナル = The journal of biomedical science and biosafety 31(3), 図巻頭1p,91-96, 2019

  • Protease-dependent virus tropism and pathogenicity: The role for TMPRSS2  [in Japanese]

    TAKEDA Makoto

    宿主プロテアーゼの局在と，ウイルス膜融合タンパクのプロテアーゼに対する基質としての特異性が，ウイルスの細胞や臓器トロピズム，そしてウイルス病原性の重大な決定因子になっている．この宿主プロテアーゼ依存性ウイルストロピズムの解明は，1970年代の本間らの宿主依存性修飾という現象の解明に始まり，タンパク質解析技術の導入とともに，それがウイルス膜融合タンパクの開裂による活性化で説明ができること，そして，核 …

    Uirusu 69(1), 61-72, 2019

    J-STAGE 

  • Emerging and re-emerging infectious diseases in Japan: epidemiology and infection prevention measures

    Kutsuna Satoshi

    … <p>In recent years, emerging and re-emerging infectious diseases, such as the Ebola virus disease and Middle East Respiratory Syndrome (MERS), have been frequently reported. … Especially, for mosquito-borne infectious diseases, viral hemorrhagic fever and severe fever with thrombocytopenia syndrome, and avian Influenza and MERS, the disease features, routes of infection, and infection prevention measures are reviewed in this article. …

    Global Health & Medicine 1(2), 78-82, 2019

    J-STAGE 

  • The Clinical and Epidemiological Characteristics of Travel-Related Influenza  [in Japanese]

    MUTOH Yoshikazu , KATO Yasuyuki , HAYAKAWA Kayoko , KUTSUNA Satoshi , KATANAMI Yuichi , OHMAGARI Norio

    <p> インフルエンザは地域毎に流行状況が異なり，渡航者によって国内に持ち込まれる輸入感染症としての側面も持ち合わせている．近年，パンデミックインフルエンザ対策の重要性が指摘されているが，渡航者による国外からのインフルエンザの持ち込みについては基礎的なデータが不足している．今回，2012年4月1日から2016年3月31日の期間に海外でインフルエンザに罹患し日本へ入国・帰国した患者の臨床 …

    Kansenshogaku Zasshi 93(2), 132-138, 2019

    J-STAGE 

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