Search Results 1-20 of 3016

  • Local perspectives on Ebola during its tenth outbreak in DR Congo: A nationwide qualitative study

    Muzembo Basilua Andre , Ntontolo Ngangu Patrick , Ngatu Nlandu Roger , Khatiwada Januka , Ngombe Kabamba Leon , Numbi Oscar Luboya , Nzaji Kabamba Michel , Maotela Kabinda Jeff , Ngoyi Mukonkole Jean , Suzuki Tomoko , Wada Koji , Ikeda Shunya

    … Participant responses were categorized in terms of their themes and subthemes.</br> … Ebola was interpreted as (2) a plot by multinational corporations (fears of genocide, Ebola understood as a biological weapon, concerns over organ trafficking, and Ebola was taken to be the result of business actions). …

    PLoS ONE 15(10), e0241120, 2021-10-22


  • Biological Stress Responses to Acute Respiratory Distress Syndrome and Treatment Strategy  [in Japanese]

    小谷 透 , 森 麻衣子

    The Japanese journal of rehabilitation medicine = リハビリテーション医学 58(4), 352-356, 2021-04

  • Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, and Therapeutic Outcomes

    Ando Hidenori , Emam Sherif E. , Kawaguchi Yoshino , Shimizu Taro , Ishima Yu , Eshima Kiyoshi , Ishida Tatsuhiro

    … or KNa-cit increased responses to anti-programmed cell death-1 (PD-1) antibody, an immune checkpoint inhibitor, in a murine B16 melanoma model. …

    Biological and Pharmaceutical Bulletin 44(6), 844-852, 2021


  • Nanosecond Pulsed Electric Fields: Biological Actions and Potential Applications  [in Japanese]

    YANO Ken-ichi

    … Instead, nsPEFs can elicit various cellular responses in an intensity-dependent manner. … nsPEFs are increasingly recognized as a novel physical means with unique biological actions. … This review provides an overview of cellular responses to nsPEFs and possible biomedical applications of nsPEFs.</p> …

    Seibutsu Butsuri 61(3), 162-165, 2021


  • Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 Melanoma

    Nomura Daichi , Abe Ryo , Tsukimoto Mitsutoshi

    … <p>Radiation is an effective cancer treatment, but cancer cells can acquire radioresistance, which is associated with increased DNA damage response and enhanced proliferative capacity, and therefore, it is important to understand the intracellular biochemical responses to γ-irradiation. …

    Biological and Pharmaceutical Bulletin 44(5), 642-652, 2021


  • Pharmacological Interaction between Diets and Commensal Bacteria for the Creation of Lipid Environment in the Control of Health and Diseases  [in Japanese]

    Saika Azusa , Kunisawa Jun

    … As such, the intestinal immune system is important for the regulation of immunological homeostasis and biological defense. … Among the important dietary components are fatty acids, which are metabolized to lipid mediators that act as signaling molecules and regulate immune responses. … In addition, we revealed that lipid mediators play key roles in the enhancement of intestinal Immunoglobulin A responses, which provide the first line of defense against viral and bacterial infectious diseases. …

    YAKUGAKU ZASSHI 141(5), 681-688, 2021


  • Continuous Measurement of Greenhouse Ventilation Rate in Summer and Autumn via Heat and Water Vapor Balance Methods

    TUSI Ahmad , SHIMAZU Teruaki , OCHIAI Masaki , SUZUKI Katsumi

    … Continuous monitoring of canopy photosynthetic rates in a naturally ventilated greenhouse requires a method of measuring ventilation rates that can record accurate short-term responses throughout the day. …

    Environment Control in Biology 59(2), 41-48, 2021


  • Eye-tracker-based Evaluation of Saccadic Deficits in Young Children with Developmental Disorders

    Ono Yumie , Niida Takahiro , Shinomiya Yuma , Suzuki Kenji , Hara Naoto , Azegami Yasuhiko , Sato Taeko , Mimori Chigusa , Shimoizumi Hideo

    … Four saccade responses were measured, consisting of eye movement to the instantaneously shifted visual target either to the right or left (step condition), to the visual target that appeared 200 ms after turning off the fixation point (gap condition), to the visual target while the fixation point remained (overlap condition), and in the direction opposite to the visual target (anti-saccade condition). …

    Advanced Biomedical Engineering 10(0), 70-79, 2021


  • Increase in Blood Pressure by Local Injection of Ketamine into the Amygdala in Rats

    Morimoto Issei , Koyama Yoshimasa , Murakawa Masahiro

    … In a total of 11 responses, an increase in blood pressure started with a mean latency of 193.5 ± 43.0 s, reached its peak 180.2 ± 23.3 s after the response onset, then gradually returned to the baseline with mean duration of 706.7 ± 113.5 s. …

    Biological and Pharmaceutical Bulletin 44(4), 544-549, 2021


  • Multiple inflammatory responses to chronic stress and their roles in emotional disturbances  [in Japanese]

    Nie Xiang , Furuyashiki Tomoyuki

    過酷な環境によるストレスは抑うつや不安など情動変容を誘導し,うつ病など精神疾患のリスクを高める。マウスの慢性ストレスは自然免疫受容体TLR2/4を介して内側前頭前皮質のミクログリアで炎症性サイトカインを誘導し,うつ様行動を促す。また神経細胞由来の2AGがミクログリアに発現するプロスタグランジン(PG)合成酵素COX1を介して代謝され,皮質下領域でのPGE2産生を増強し,EP1受容体を介してうつ様行 …

    Japanese Journal of Biological Psychiatry 32(1), 13-17, 2021


  • Pain regulation by noradrenaline : a new mechanism through glial cells  [in Japanese]

    Tsuda Makoto

    青斑核のノルアドレナリン(NA)神経は,恐怖や不安,覚醒,ストレスなどへの関連性が示されている。加えて,同神経は末梢からの痛覚刺激で興奮する。青斑核NA神経は上行性だけでなく,脊髄後角へ下行性に軸索を投射し,同部位で放出されたNAが末梢からの痛覚伝達を抑制すると考えられている。脊髄後角には,脳と同様に神経だけでなく,グリア細胞が豊富に存在する。最近筆者らは,脊髄後角の表層に限局したアストロサイトサ …

    Japanese Journal of Biological Psychiatry 32(1), 2-5, 2021


  • KAv-1 is Better Suited to Chick Fibroblast Culture than DMEM or 199 Media

    Katayama Masafumi , Onuma Manabu , Fukuda Tomokazu

    … <p>Cultured cells are a useful resource for poultry scientists, since these cells allow scientists to evaluate biological responses to conditions such as infectious diseases <i>in vitro </i>while mimicking<i> …

    The Journal of Poultry Science, 2021


  • Novel physiological functions of free fatty acid receptors  [in Japanese]

    Ichimura Atsuhiko

    … <p>Fatty acids are produced through various biological processes. … In this symposium, I will introduce recent advances on the key physiological functions of the FFARs-mediated signaling transduction pathways in the regulation of metabolism and immune responses. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-S25-3, 2021


  • Novel Reporter Systems Monitoring NFkB activation Can Be Applied toHigh-Throughput Screening.  [in Japanese]

    Tomo Yonezawa

    … <p>Transcriptional regulation is a very important and pivotal function in myriad biological responses. … The modified cells secreted SEAP in response to treatment with human recombinant IL-18 in a concentration-dependent manner. </p><p> Finally, in order to identify drugs mimicking IL-18 biological activity or possessing inhibitory effects on IL-18-induced NFkB, we demonstrated drug screening using number of extracts derived from marine bacteria and synthetic compounds.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-P2-LB50, 2021


  • Multiple spatiotemporal patterns of social stress-induced epigenetic regulations in microglia  [in Japanese]

    Taniguchi Masayuki , Matsushita Kazutoshi , Mishima Rei , Kitaoka Shiho , Kuraku Shigehiro , Kadota Mitsutaka , Furuyashiki Tomoyuki

    … Furthermore, these epigenetic responses were concordant with the expression of adjacent genes associated with different biological functions. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-O-E2-3, 2021


  • Translational research targeting inflammatory responses and development of novel drugs  [in Japanese]

    Nishibori Masahiro

    <p>High mobility group box-1 (HMGB1) は、核内に局在するクロマチンDNA結合タンパクである。HMGB1はストレス刺激や細胞障害により、細胞質を経由して細胞外へ分泌・放出されると、神経突起伸展活性や起炎性活性を発揮する。このような局在、動態、活性の特徴は、既存の活性物質群とは全く異なっている。演者は、HMGB1に対する特異的単クローン抗体を作製し、抗体 …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-SL8, 2021


  • Role of TRPM2 expressed in macrophages in TNBS-induced colonic fibrosis in mice  [in Japanese]

    Tomohiro Nakamoto , Matsumoto Kenjiro , Yasuda Hiroyuki , Mori Yasuo , Kato Shinichi

    … The colonic fibrosis was evaluated by measuring the length of colon, fibrosis score under Masson's-trichrome staining, mRNA expression of COL1A1, ACTA2, TIMP1 and TRPM2 by quantitative RT-PCR.</p><p><b>Results</b>: Repeated colorectal injection of TNBS induced shortening of colon length, increasing fibrosis score, and upregulating COL1A1,ACTA2,TIMP1 mRNA expressions in WT mice, but these responses were significantly attenuated in KO mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P2-15, 2021


  • Regulation of redox signaling by reactive sulfur species  [in Japanese]

    Kasamatsu Shingo , Ihara Hideshi

    … Accumulating evidence has suggested that persulfides may be involved in a variety of biological processes, such as antioxidant and anti-inflammatory responses, biosynthesis of sulfur-containing molecules, mitochondrial energy metabolism via sulfur respiration, and cytoprotection via regulation of redox signal transduction induced by endogenous and exogenous electrophiles. …

    Journal of Clinical Biochemistry and Nutrition 68(2), 111-115, 2021


  • <i>Streptococcus thermophilus</i> MN-ZLW-002 Can Inhibit Pre-adipocyte Differentiation through Macrophage Activation

    Kang Xiaohong , Liang Huijing , Luo Yating , Li Zhouyong , He Fang , Han Xue , Zhang Lanwei

    … Recent studies indicate that some selected probiotics can modulate the immune responses of the host animal, thereby altering its lipid metabolism. …

    Biological and Pharmaceutical Bulletin 44(3), 316-324, 2021


  • Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model

    Ando Hidenori , Eshima Kiyoshi , Ishida Tatsuhiro

    … Acidic TME impairs the responses of tumors to some anti-cancer chemotherapies. …

    Biological and Pharmaceutical Bulletin 44(2), 266-270, 2021


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