Search Results 1-20 of 211

  • Positive Association Between Small Dense Low-Density Lipoprotein Cholesterol Concentration and Biomarkers of Inflammation, Thrombosis, and Prediabetes in Non-Diabetic Adults

    Hsu Sandy Huey-Jen , Jang Men-Hwang , Torng Pao-Ling , Su Ta-Chen

    … This study aims to prospectively investigate the association between sdLDL-C concentration and traditional and nontraditional CHD risk markers to explore the underlying roles of sdLDL-C in atherogenic processes.</p><p><b>Methods:</b> … All participants fasted for 12–14 h, and venous blood samples were collected in the morning to measure serum lipid profiles and other CHD-related markers. …

    Journal of Atherosclerosis and Thrombosis 26(7), 624-635, 2019

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  • Towards accurate measurement of optical blood alcohol concentration for elimination of drunk driving  [in Japanese]

    Kabashima Shogo , Lee Jihyoung , Harada Ippei , Koga Honoka , Hashimoto Atsushi , Fujimoto Satomi , Yokode Mizuki , Yamakoshi Takehiro

    <p>道路交通法の改正により飲酒運転に関する罰則が強化され,諸外国では飲酒運転防止装置の実用化が進み,呼気ガス式手法が一般的になってきたが様々な問題点がある.そこで,その問題点を解決できる可能性がある光学的手法に着目した.すなわち光電容積脈波(PPG; photo-plethysmogram)を利用し,血中成分の吸光特性から指尖部の入射光に対して散乱された光を検出する方法である.近年, …

    Transactions of Japanese Society for Medical and Biological Engineering Annual56(Proc), 48-48, 2018

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  • Towards accurate measurement of optical blood alcohol concentration for elimination of drunk driving  [in Japanese]

    KABASHIMA SHOGO , LEE JIHYOUNG , HARADA IPPEI , KOGA HONOKA , HASHIMOTO ATUSHI , FUJIMOTO SATOMI , YOKODE MIZUKI , YAMAKOSHI TAKEHIRO

    <p>道路交通法の改正により飲酒運転に関する罰則が強化され,諸外国では飲酒運転防止装置の実用化が進み,呼気ガス式手法が一般的になってきたが様々な問題点がある.そこで,その問題点を解決できる可能性がある光学的手法に着目した.すなわち光電容積脈波(PPG; photo-plethysmogram)を利用し,血中成分の吸光特性から指尖部の入射光に対して散乱された光を検出する方法である.近年, …

    Transactions of Japanese Society for Medical and Biological Engineering Annual56(Abstract), S324-S324, 2018

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  • The Use of All-You-Can-Drink System, <i>Nomihodai</i>, Is Associated with the Increased Alcohol Consumption among College Students: A Cross-Sectional Study in Japan

    Kawaida Kyoko , Yoshimoto Hisashi , Goto Ryohei , Saito Go , Ogai Yasukazu , Morita Nobuaki , Saito Tamaki

    <p>Excessive drinking by college students is a major public health problem in Japan. However, data on heavy episodic drinking (HED) and <i>nomihodai</i>, a several-hour all-you-can- …

    The Tohoku Journal of Experimental Medicine 245(4), 263-267, 2018

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  • Association of N-Terminal Pro B-Type Natriuretic Peptide With Blood Pressure and Pulse Pressure in Elderly People ― A Cross-Sectional Population Study ―

    Sasaki Nobuo , Yamamoto Hideya , Ozono Ryoji , Fujiwara Saeko , Kihara Yasuki

    … However, data regarding the association of NT-proBNP with blood pressure (BP) and pulse pressure (PP) in the elderly population are limited.</p><p><b><i>Methods and Results:</i></b>The present cross-sectional study involved 6,529 participants, aged ≥70 years, without cardiovascular disease (CVD), who underwent general health examinations. …

    Circulation Journal 82(8), 2049-2054, 2018

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  • Associations between bloodalcoholconcentration and clinical symptoms  [in Japanese]

    YOKOTA Mari , NISHIDA Masamichi , NAKAHARA Shinji , SAKAMOTO Tetsuya

    <p>急性アルコール中毒での救急搬送件数は,年々増加傾向にある。2015年1月1日〜2016年12月31日までに当院救急外来を受診した患者のうちエタノール血中濃度を測定した1,265例を対象とし臨床所見(意識レベル・嘔吐の有無,帰宅までに要する時間,輸液量)について検討を行った。男781例,年齢中央値30歳,エタノール血中濃度の中央値は219mg/dlであった。エタノール血中濃度と意識 …

    Journal of Japanese Society for Emergency Medicine 21(3), 498-503, 2018

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  • Association of N-Terminal Pro B-Type Natriuretic Peptide With Blood Pressure and Pulse Pressure in Elderly People ― A Cross-Sectional Population Study ―

    Sasaki Nobuo , Yamamoto Hideya , Ozono Ryoji , Fujiwara Saeko , Kihara Yasuki

    … However, data regarding the association of NT-proBNP with blood pressure (BP) and pulse pressure (PP) in the elderly population are limited.</p><p><b><i>Methods and Results:</i></b>The present cross-sectional study involved 6,529 participants, aged ≥70 years, without cardiovascular disease (CVD), who underwent general health examinations. …

    Circulation Journal, 2018

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  • Influence of Polysorbate 60 on Formulation Properties and Bioavailability of Morin-Loaded Nanoemulsions with and without Low-Saponification-Degree Polyvinyl Alcohol

    Ikeuchi-Takahashi Yuri , Kobayashi Ayaka , Ishihara Chizuko , Matsubara Takumi , Matsubara Hiroaki , Onishi Hiraku

    … Nanoemulsions were prepared using Tween 60 and polyvinyl alcohol (PVA) as emulsifiers, and medium chain triglycerides (MCT) as the lipid base. … However, the area under the blood concentration–time curve (<i>AUC</i>) of MCT-LL810 (0.18) nanoemulsion containing a small amount of Tween 60 did not increase because the absorption of morin was limited by P-glycoprotein (P-gp)-mediated efflux. …

    Biological and Pharmaceutical Bulletin 41(5), 754-760, 2018

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  • Detection of Acetaldehyde in the Esophageal Tissue among Healthy Male Subjects after Ethanol Drinking and Subsequent L-Cysteine Intake

    Okata Hideki , Masamune Atsushi , Shimosegawa Tooru , Hatta Waku , Iijima Katsunori , Asanuma Kiyotaka , Tsuruya Atsuki , Asano Naoki , Koike Tomoyuki , Hamada Shin , Nakayama Toru

    … <p>Ethanol is oxidized by alcohol dehydrogenase to acetaldehyde, a recognized carcinogen for the esophagus. … however, it is unknown whether L-cysteine intake affects the acetaldehyde concentration in the esophageal tissue. … The aim of this study was to measure the acetaldehyde concentration in the esophageal tissue after ethanol drinking and evaluate the effect of L-cysteine intake on the acetaldehyde levels in the esophagus. …

    The Tohoku Journal of Experimental Medicine 244(4), 317-325, 2018

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  • Effects of ethanol intake on pathophysiology of diabetes: a study using db mice, an animal model of diabetes with a leptin receptor deficiency  [in Japanese]

    牛飼 美晴 , 川口 博明 , 阿部 正治 , 堀内 正久

    … Purpose: We evaluated the influence of ethanol intake on pathophysiology of diabetes using db mice, an animal model of type 2 diabetes.Methods: The concentration of ethanol used was evaluated by the preference test. … Finally, they were anesthetized by after 6 h fasting, and organs were removed after blood collection from the heart.Results: The ethanol concentration used was determined as 5%, which was not discriminated from water by db and control mice. …

    鹿児島大学医学雑誌 = Medical journal of Kagoshima University 69, 1-8, 2017-12

    IR  Ichushi Web 

  • Analysis of fatal bicyclists in Shiga Prefecture  [in Japanese]

    ASUKE Jun , TANAKA Katsunori , INOUE Takuya , HITOSUGI Masahito

    平成25年と26年に滋賀県で発生した全自転車死亡事故28例(平成25年14例、平成26年14例)を対象に、損傷内容、各死亡事故状況、事故原因を総合的に検討した。さらに、検討結果を全国で発生した自転車死亡事故例と比較した。対象は男性が21人、女性が7人で平均年齢は66.9歳(±18.4歳)であった。60歳以上の事故死亡率は75.0%(21人)であり、全国における60歳以上の事故死亡率72. …

    Journal of the Japanese Council of Traffic Science 16(2), 29-37, 2017

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  • Effects of bleeding on the volatile flavor compounds in skipjack tuna  [in Japanese]

    HIRATSUKA SEIICHI , HANEDA YOSHITAKA , KOIZUMI KYOKO

    船上で脱血した冷凍カツオの揮発性成分を非脱血群と比較した。脱血群は非脱血群に比べて,アルデヒド類とアルコール類が有意に少なかった。緩衝液中で血液と脂質を混合させると,アルデヒド類とアルコール類の生成が顕著であり,血液のみ,脂質のみではそれらはほとんど生成されなかった。脂質 100 mg に血液 0-100 μL を反応させると,それらの生成は血液の濃度依存的に増加した。カツオ魚肉の臭い成分であるア …

    NIPPON SUISAN GAKKAISHI 82(1), 28-32, 2016

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  • Is the serum L-arginine level during early pregnancy a predictor of pregnancy-induced hypertension?

    Wang Jingwen , Niwa Yoshimitsu , Mitsui Takashi , Yoshida Shigeru , Yamashita Mamoru , Tamakoshi Koji , Kikkawa Fumitaka , Kotani Tomomi , Tsuda Hiroyuki , Mano Yukio , Sumigama Seiji , Li Hua , Komatsu Koji , Miki Rika , Maruta Ei

    … The objective of this study was to determine the concentration of serum <span style="font-variant: small-caps;">l</span>-arginine in healthy pregnant women and infant cord blood and to compare them with those in patients with pregnancy-induced hypertension (PIH). …

    Journal of Clinical Biochemistry and Nutrition 57(1), 74-81, 2015

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  • Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency—A Double-Blind, 3-Way Crossover Study—

    SUNAGAWA Yoichi , YOKOJI Tsunehiro , MORIMOTO Eriko , TAKAHASHI Tsukasa , OZAWA Hitomi , IMAIZUMI Atsushi , UENO Morio , KAKEYA Hideaki , SHIMATSU Akira , WADA Hiromichi , HASEGAWA Koji , HIRANO Sae , MORIMOTO Tatsuya , KATANASAKA Yasufumi , MIYAZAKI Yusuke , FUNAMOTO Masafumi , OKAMURA Nobuko , HOJO Yuya , SUZUKI Hidetoshi , DOI Osamu

    … Curcumin is a major constituent of the spice turmeric and has various biological activities, including anticancer, antioxidant, and anti-inflammatory properties, as well as alcohol detoxification. … However, because of its poor absorption efficiency, it is difficult for orally administered curcumin to reach blood levels sufficient to exert its bioactivities. … The maximal plasma curcumin concentration (0-24 h) of Theracurmin was 10.7 to 5.6 times higher than those of BCM-95 and Meriva, respectively. …

    Journal of Nutritional Science and Vitaminology 61(1), 37-44, 2015

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  • Associations between the Serum 25(OH)D Concentration and Lipid Profiles in Japanese Men

    Sun Xiaomin , Cao Zhen-Bo , Tanisawa Kumpei , Ito Tomoko , Oshima Satomi , Ishimi Yoshiko , Tabata Izumi , Higuchi Mitsuru

    … <b><i>Aim</i></b>: Low circulating 25-hydroxyvitamin D [25(OH)D] concentration has been linked to a high prevalence of cardiovascular disease. … We thus aimed to evaluate the association between the serum 25(OH)D concentration and lipid profiles in Japanese men taking into consideration confounding factors, including the visceral fat area (VFA) and cardiorespiratory fitness.<br><b><i>Methods</i></b>: A total of 136 men (age range: 20-79 years) participated in our study. …

    Journal of Atherosclerosis and Thrombosis 22(4), 355-362, 2015

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  • Relationship Between Shift Work and Clustering of the Metabolic Syndrome Diagnostic Components

    Kawabe Yuri , Ueshima Hirotsugu , HIPOP-OHP Research Group , Nakamura Yasuyuki , Kikuchi Sayuri , Murakami Yoshitaka , Tanaka Taichiro , Takebayashi Toru , Okayama Akira , Miura Katsuyuki , Okamura Tomonori

    … We defined the four MetS-DC in this study as follows: 1) high blood pressure(BP): systolic BP ≥130 mmHg, or diastolic BP ≥85 mmHg, or the use of antihypertensive drugs; … 2) dyslipidemia: high-density lipoprotein-cholesterol concentration <40 mg/dl or triglyceride concentration ≥150 mg/dl, or on medication for dyslipidemia; …

    Journal of Atherosclerosis and Thrombosis 21(7), 703-711, 2014

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  • A case of sepsis caused by intraabdominal infection with <i>Mycoplasma hominis</i> after Caesarean section  [in Japanese]

    IKEGAYA Kazuko , NONAKA Haruna , KASEZAWA Yuri , TSUCHIYA Ken , FUJITA Yuichi

    31歳の妊婦において,帝王切開後に<i>Mycoplasma hominis</i>による腹腔内感染から敗血症に進行した症例を経験した.発育菌は血液寒天培地,チョコレート寒天培地およびPEA加ブルセラHK寒天培地(ウサギ)上で3日目に微小なコロニーを形成した.コロニーをグラム染色するも菌体は確認できず,顆粒状のものが観察されるのみであった.菌株は遺伝子解析により<i& …

    Japanese Journal of Medical Technology 63(3), 311-316, 2014

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  • Preliminary Observation of Dynamic Changes in Alcohol Concentration in the Human Brain with Proton Magnetic Resonance Spectroscopy on a 3T MR Instrument

    KUBO Hitoshi , HARADA Masafumi , SAKAMA Minoru , MATSUDA Tsuyoshi , OTSUKA Hideki

    … Purpose: Our purposes were to establish suitable conditions for proton magnetic resonance spectroscopy (MRS) to measure dynamic changes in alcohol concentration in the human brain, to evaluate these changes, and to compare the findings with data from analysis of breath vapor and blood samples.<br> … Continuous measurements of MRS, breath vapor, and blood samples were conducted before and after the subjects drank alcohol with a light meal. …

    Magnetic Resonance in Medical Sciences 12(3), 235-240, 2013-09-01

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  • Onset of a Declining Trend in Fatal Motor Vehicle Crashes Involving Drunk-driving in Japan

    NAKAHARA Shinji , KATANODA Kota , ICHIKAWA Masao

    … Background: In Japan, introduction of severe drunk-driving penalties and a lower blood alcohol concentration (BAC) limit in June 2002 was followed by a substantial reduction in fatal alcohol-related crashes. …

    Journal of Epidemiology 23(3), 195-204, 2013-05-01

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  • Driving Behavior Analysis Related with Blood Alcohol Concentration by Driving Simulator Experiment  [in Japanese]

    Takae Yasuhiko , Kuge Nobuyuki , Sakuma Tsuyoshi , Higuchi Susumu , Matsushita Sachio , Hara Sachiko

    アルコール摂取状態での運転行動を解明するためドライビングシミュレータ実験を行った.本実験はアルコールクランプ法により実験参加者の血中アルコール濃度を高精度で管理して実施した.実験の結果,アルコール摂取状態では車線逸脱に対する操舵遅れや急操舵が観察され,ふらつき運転が起こる仕組みを分析できた.

    Transactions of Society of Automotive Engineers of Japan 44(2), 635-640, 2013

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