Search Results 1-20 of 4377

  • An outbreak of rabbit hemorrhagic disease (RHD) caused by <i>Lagovirus europaeus</i> GI.2/rabbit hemorrhagic disease virus 2 (RHDV2) in Ehime, Japan

    KATAYAMA Akiho , MIYAZAKI Ayako , OKAZAKI Naohito , NAKAYAMA Teruko , MIKAMI Osamu

    … Necropsy revealed liver discoloration and fragility, hemorrhage of some organs and blood coagulation failure. …

    Journal of Veterinary Medical Science, 2021

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  • Acquired hemophilia A with reappearance of inhibitor 10 years after the completion of immunosuppressive therapy  [in Japanese]

    OSHIDA Koichi , ITO Takuma , SHIRAYAMA Rie , KUSUHARA Koichi , SATO Tetsuji , SAKAI Michio

    <p>後天性血友病A（AHA）は血液凝固第VIII因子（FVIII）に対するインヒビター（FVIII-INH）出現に伴い重篤な出血を来す疾患である。発症頻度は年間約100～400万人に1人と稀ではあるが，疾患概念が浸透したことで診断例は近年増加しており，高齢者に突然発症する出血性疾患として留意すべきである。AHA治療は出血に対する止血治療とFVIII-INH除去を目的とした免疫抑制療法 …

    Rinsho Ketsueki 62(3), 186-189, 2021

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  • Management of a COVID-19 Patient during ECMO: Paying Attention to Acquired von Willebrand Syndrome

    Hayakawa Masaki , Takano Keisuke , Kayashima Michinori , Kasahara Kei , Fukushima Hidetada , Matsumoto Masanori

    … To date, no study has examined ECMO-related bleeding and AVWS in COVID-19 patients.</p><p>We report a COVID-19 patient who experienced bleeding from AVWS in addition to disseminated intravascular coagulation (DIC) during ECMO. …

    Journal of Atherosclerosis and Thrombosis 28(4), 396-401, 2021

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  • COVID-19-Related Thrombosis in Japan: Final Report of a Questionnaire-Based Survey in 2020

    Horiuchi Hisanori , Morishita Eriko , Urano Tetsumei , Yokoyama Kenji , the Questionnaire-survey Joint Team on The COVID-19-related thrombosis

    <p>A questionnaire on COVID-19-related thrombosis in patients hospitalized before Aug 31, 2020, was sent to 399 hospitals throughout Japan. Responses were received from 111 (27.8%) with informat …

    Journal of Atherosclerosis and Thrombosis 28(4), 406-416, 2021

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  • Modulation of Host Immune System by Staphylococcal Superantigen-like (SSL) Proteins  [in Japanese]

    Tsuji Tsutomu

    … This family is composed of 14 members (SSL1-SSL14), and recent studies have revealed that these members exhibit various immunomodulatory activities: <i>e.g</i>., inhibition of antibody and complement functions, impairment of leukocyte trafficking, modulation of receptor functions, inappropriate activation of immunocytes, and inhibition of blood coagulation. …

    YAKUGAKU ZASSHI 141(4), 579-589, 2021

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  • Vitamin K intake and health, consideration from the epidemiological studies  [in Japanese]

    Kuwabara Akiko , Uenishi Kazuhiro , Tanaka Kiyoshi

    … <p>The most fundamental function of vitamin K is to activate the blood coagulation factors in the liver. … Despite the recent recognition of its extra-hepatic actions, the current Dietary Reference Intakes for vitamin K is based on the amount necessary for maintaining the normal blood coagulation in many countries. …

    Journal of Clinical Biochemistry and Nutrition, 2021

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  • The physiological alteration of histidine-rich glycoprotein on the mice perinatal period.  [in Japanese]

    Teshigawara Kiyoshi , Liu Keyue , Wang Dengli , Wake Hidenori , Mori Shuji , Takahashi Hideo , Nishibori Masahiro

    … In more severe inflammatory condition such as sepsis syndrome, the reduced level of plasma HRG is exacerbating the mortality by inducing to the neutrophil hyperactivity, the promotion of blood coagulation cascade, the vascular endothelial dysfunction, and so on. … Moreover, HRG KO mice showed hypertension by the gestation, whereas rise in blood pressure did not observed in the healthy gestational C57BL/6 mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-O-D1-1, 2021

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  • Translational research targeting inflammatory responses and development of novel drugs  [in Japanese]

    Nishibori Masahiro

    <p>High mobility group box-1 (HMGB1) は、核内に局在するクロマチンDNA結合タンパクである。HMGB1はストレス刺激や細胞障害により、細胞質を経由して細胞外へ分泌・放出されると、神経突起伸展活性や起炎性活性を発揮する。このような局在、動態、活性の特徴は、既存の活性物質群とは全く異なっている。演者は、HMGB1に対する特異的単クローン抗体を作製し、抗体 …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-SL8, 2021

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  • Hypercholesterolemia may attenuate cerebral aneurysm  [in Japanese]

    Hokamura Kazuya , Makino Hiroshi , Iwaki Takayuki , Imai Ryou , Kimura Tetsuro , Nakajima Yoshiki , Umemura Kazuo

    … <p>[Introduction] Subarachnoid hemorrhage (SAH) is a life-threatening type of stroke and can be frequently caused by a ruptured aneurysm of cerebrovascular blood vessels. … It is well accepted that lowering blood cholesterol levels is mandatory in the prevention of cerebral circulatory disorder. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-37, 2021

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  • The perifollicular zone of the spleen as a distributor and filter of blood components

    Sasou Shunichi

    Journal of Clinical and Experimental Hematopathology 61(1), 58-60, 2021

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  • The Pathophysiology of COVID-19 (Coronavirus Disease 2019) Caused by the Infection of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)  [in Japanese]

    Nakamura Fumio , Nakamura-Ishizu Ayako

    … <p>Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a wide range of clinical manifestations, including acute respiratory distress syndrome, severe inflammation, abnormal blood coagulation, and cytokine storm syndrome. …

    Journal of Tokyo Women's Medical University 91(1), 11-18, 2021

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  • Challenges in the Management of Cardiopulmonary Bypass Using Argatroban in a Patient With Heparin-induced Thrombocytopenia: A Case Report  [in Japanese]

    OTA Yusuke , NAGAHASHI Kiwamu , KOJIMA Yasuhiro , UEHARA Hirokazu

    72歳，女性。大動脈弁狭窄症による心不全のため大動脈弁置換術を予定していたが，血小板減少を認めヘパリン起因性血小板減少症Ⅱ型と診断された。手術の延期が考慮されたが，循環動態が不安定であったため予定通り大動脈弁置換術を施行した。<br>　手術開始時にアルガトロバンを4μg/kg/minで持続静注を開始し，人工心肺開始時にメシル酸ナファモスタットを30mg/hで開始した。活性化凝固時間の推 …

    JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE 69(5), 530-534, 2021

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  • Hematological phenotype of COVID-19-induced coagulopathy: Far from typical sepsis-induced coagulopathy  [in Japanese]

    UMEMURA Yutaka

    Japanese Journal of Thrombosis and Hemostasis 32(1), 51-54, 2021

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  • Refractory Duodenal Bleeding Ulcers Successfully Treated with Factor XIII Transfusion

    Yamada Yusuke , Abe Tomohiro , Ochiai Hidenobu , Ashizuka Shinya

    … Despite the administration of proton pump inhibitor and red blood cells, her black stool and anemia progressed, and she was therefore transferred to our hospital. … On the 21st day of admission, an endoscopic examination showed the oozing of blood from the duodenal mucosa. …

    Internal Medicine, 2021

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  • Analyses of hemorrhagic diathesis in high-iron diet-fed rats

    Inai Yohei , Izawa Takeshi , Mori Mutsuki , Atarashi Machi , Tsuchiya Seiichirou , Kuwamura Mitsuru , Yamate Jyoji

    … however, little is known about the effects of iron overload on the blood coagulation system. … Six-week-old F344/DuCrlCrlj male rats were fed a standard (containing 0.02% iron) or a high-iron diet (containing 1% iron) for 6 weeks and were then sampled for hematological, blood biochemical, coagulation, and pathological examinations. …

    Journal of Toxicologic Pathology 34(1), 33-41, 2021

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  • Acute infectious purpura fulminans due to <i>E. coli</i> in a hemodialysis patient  [in Japanese]

    Ito Furano , Oyama Satoko , Saito Kaiji , Hori Kenichiro , Sasaki Natsue , Tamura Hiroyuki , Tomita Kimio

    <p>【症例】81歳，女性．4年前に維持透析導入となる．透析中に呼吸困難，ショック，汎血球減少，DICをきたし，入院となる．第1病日より抗菌薬にて治療を開始した．血液培養にて大腸菌が検出された．第5病日に上下肢，鼠径，背部に辺縁に紫斑を伴う灰白色斑を認め，徐々に壊死が進行し電撃性紫斑病（purpura fulminans： PF）と診断した．第8病日にはプロテインC活性35％と低値であ …

    Nihon Toseki Igakkai Zasshi 54(1), 45-49, 2021

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  • Characteristics of atypical lymphocytes in peripheral blood in a tsutsugamushi disease patient: Tsutsugamushi disease with atypical lymphocytes  [in Japanese]

    TAKEDA Hikaru , YAMADA Takahiro , HASEGAWA Tsuyoshi , SUZUKI Yu , TANAKA Kiwa , MORIYA Mika , UEKI Tetsuya , TAJIMA Katsushi

    <p>発熱性疾患のツツガムシ病は，臨床上他の急性感染症との見分けがつかない場合がある。患者は75歳女性，めまいと寒気でibuprofenを内服した後，全身に紅斑様皮疹が出現した。翌日，皮疹は増悪傾向を示し，意識障害を伴ったため治療精査目的に当院に紹介となった。入院時，末梢血液像で異型リンパ球を認めたこと以外，リンパ節腫脹や明らかな痂皮形成は認めなかった。第4病日，播種性血管内凝固症候群 …

    Japanese Journal of Medical Technology 70(1), 176-181, 2021

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  • Perioperative Bypassing Agent Therapy for Pulmonary Pleomorphic Carcinoma with Acquired Hemophilia

    Sakai Takashi , Azuma Yoko , Sano Atsushi , Sadamoto Sota , Tochigi Naobumi , Nagase Daisuke , Iyoda Akira

    … <p>A 74-year-old man was admitted with lung cancer, and preoperative blood test showed abnormal activated partial thromboplastin time (APTT). … Coagulation factor screening and APTT mixing test achieved a diagnosis of acquired hemophilia A (AHA). …

    Annals of Thoracic and Cardiovascular Surgery, 2021

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  • Acute Myeloid Leukemia Developing with Acute Pancreatitis Mimicking Autoimmune Pancreatitis

    Sumitani Ryohei , Miki Hirokazu , Kagawa Kumiko , Abe Masahiro , Nakamura Shingen , Hori Taiki , Murai Jumpei , Kawata Shiyori , Oura Masahiro , Sogabe Kimiko , Takahashi Mamiko , Harada Takeshi , Fujii Shiro

    … A blood analysis revealed pancytopenia and increased serum pancreatic enzymes with disseminated intravascular coagulation. …

    Internal Medicine, 2021

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  • Urinary Thrombin as a Marker of Glomerular Inflammation Associated with Renal Injury in Type 2 Diabetes

    Kitamoto Yasunori , Imamura Takahisa , Taguma Yoshio , Iwaoka Taisuke , Yorinaka Hoichi , Arizono Kenji

    … To investigate the implications of urinary thrombin in the nephropathy, we compared urinary thrombin with expression of tissue factor, the trigger of blood coagulation activation, in glomeruli and with markers of renal injury (estimated glomerular filtration rate (eGFR) and proteinuria). …

    The Tohoku Journal of Experimental Medicine 253(1), 41-49, 2021

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