検索結果 12381件中 1-20 を表示

  • 電波型腹腔鏡アンテナシステムの検討 (放送技術)

    真鳥 拓也 , 藤本 孝文 , 川島 慶也 , 田中 俊幸

    映像情報メディア学会技術報告 = ITE technical report 42(1), 5-8, 2018-01

  • Loss of angiotensin converting enzyme II (ACE2) accelerates the development of liver injury induced by thioacetamide

    Wu Hsi-Tien , Chuang Ya-Wen , Huang Cheng-Pu , Chang Ming-Huang

    … Eight-weeks-old wild-type (WT; … The physiological and pathological examinations demonstrated higher serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels, infiltration of white blood cells and fibrotic lesions within liver in the <i>Ace2</i> …

    Experimental Animals 67(1), 41-49, 2018


  • A Case of <i>Helicobacter pylori</i>-negative Advanced Gastric Cancer with Massive Eosinophilia

    Takagi Atsushi , Ozawa Hideki , Oki Masayuki , Yanagi Hidetaka , Nabeshima Kazuhito , Nakamura Naoto

    … The laboratory data revealed prominent eosinophilia, with a white blood cell count of 7,900/μl and increased eosinophil granulocyte level of 1,659/μl. … After an examination for secondary eosinophilia, esophagogastroduodenoscopy showed an enlarged gastric fold in the corpus, suggesting type 4 gastric cancer. …

    Internal Medicine, 2018


  • Time-Dependent Changes in Increased Levels of Plasma Irisin and Muscle PGC-1<i>α</i> and FNDC5 after Exercise in Mice

    Pang Minhui , Yang Jianwei , Rao Jiaming , Wang Haiqing , Zhang Jiayi , Wang Shengyong , Chen Xiongfei , Dong Xiaomei

    … <p>Exercise induces the expression of peroxisome proliferator-activated receptor gamma co-activator 1-α (PGC-1α) in skeletal muscle, which promotes the cleavage of fibronectin type III domain-containing protein 5 (FNDC5) to irisin. … Male C57BL/6J mice underwent a treadmill exercise (60% of VO<sub>2max</sub>) for 30 min or one hour (h), and blood and gastrocnemius samples were collected before exercise (pre-exercise), immediately after exercise, and during 24-h recovery after 1-h exercise. …

    The Tohoku Journal of Experimental Medicine 244(2), 93-103, 2018


  • Composite Lymphoma as Co-occurrence of Advanced Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Carrying Trisomy 12 and t(14;18) and Peripheral T-cell Lymphoma

    Aoyama Yumi , Kodaka Taiichi , Zushi Yuriko , Goto Yuta , Tsunemine Hiroko , Itoh Tomoo , Takahashi Takayuki

    … <p>Composite lymphoma is defined as the co-occurrence of two types of lymphoma, comprising 1-4% of lymphomas, and the association of B-cell-type chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma and peripheral T-cell lymphoma (PTCL) is rare. … Five years after the onset of B-CLL, large abnormal cells with convoluted nuclei appeared in the peripheral blood and rapidly increased in number. …

    Journal of Clinical and Experimental Hematopathology, 2018


  • Altered immune responses in broiler chicken husbandry workers and their association with endotoxin exposure

    GAUTAM Ravi , HEO Yong , LIM GyeongDong , SONG EunSeob , ROQUE Katharine , LEE JaeHee , KIM YeonGyeong , CHO AhRang , SHIN SoJung , KIM ChangYul , BANG GiHwan , BAHNG JiYun , KIM HyoungAh

    Blood taken from the farmers and controls was subjected to plasma IgE and IgG subclass measurements. … Isolated peripheral blood mononuclear cells (PBMC) were stimulated and cytokine production was measured. … The cytokines released by PBMC from farmers indicated skewing toward Type-2 helper T-cell responses: interferon (IFN)-γ:interleukin (IL)-4 and IFNγ:IL-13 ratios were significantly lower than for control PBMC. …

    Industrial health 56(1), 10-19, 2018


  • Increased hepatic triglyceride level induced by a glucokinase activator in mice

    Namekawa Junichi , Yasui Mari , Katayanagi Atsuko , Shirai Mitsuyuki , Asai Fumitoshi

    … Recently, GK activators are expected as a novel therapeutic agent for Type 2 diabetes mellitus (T2DM). … Next, CD-1 mice received oral doses of vehicle or GKA50 (20 or 60 mg/kg) once daily for 4 days, and clinical signs, body weight, food consumption, blood chemistry, and hepatic TG were evaluated. …

    Fundamental Toxicological Sciences 5(1), 13-20, 2018


  • 侵襲性肺炎球菌感染症を繰り返すIgG-<i>κ</i>型くすぶり型骨髄腫

    千葉 雅尋 , 押味 和夫 , 松川 敏大 , 岡田 耕平 , 宮城島 拓人

    <p>患者はIgG-<i>κ</i>型くすぶり型骨髄腫の68歳女性。全身倦怠感,発熱,右下肢痛のため入院。入院翌日に血圧が低下し,血液培養で肺炎球菌が分離されたことから,侵襲性肺炎球菌感染症(IPD)による敗血症性ショックと診断した。抗菌薬と免疫グロブリン大量療法を開始し,数日で改善した。患者は以前にもIPDに罹患し,23価肺炎球菌莢膜ポリサッカライドワクチン( …

    臨床血液 59(1), 40-44, 2018


  • Evaluation of Two Commercial Enzyme-linked Immunosorbent Assay Kits for the Detection of Human Circulating Metrnl

    Zheng Si-Li , Li Zhi-Yong , Zhang Zheng , Wang Dong-Sheng , Xu Jian , Miao Chao-Yu

    … The DY7867-05 kit showed superiority over the SK00478-02 kit since it generated better curve fitting degree, smaller variation among tests, higher inter-assay reproducibility and better specificity, and could effectively detect human Metrnl in six types of blood samples. … No gender difference in circulating Metrnl levels was found, while people with newly diagnosed type 2 diabetes mellitus (T2DM) had significantly lower Metrnl levels compared to the healthy controls.</p> …



  • Newly Developed Rat Model of Chronic Kidney Disease–Mineral Bone Disorder

    Watanabe Kentaro , Fujii Hideki , Goto Shunsuke , Nakai Kentaro , Kono Keiji , Watanabe Shuhei , Shinohara Masami , Nishi Shinichi

    … We used male Sprague–Dawley (SD) rats and spontaneously diabetic Torii (SDT) rats, which are used as models for nonobese type 2 diabetes. … blood and urinary biochemical analyses and histological analysis of the aorta were performed.</p><p><b><i>Results</i>:</b> … At 20 weeks, hemoglobin A1c (HbA1c) levels, blood pressure, and renal function were not significantly different among the six groups. …

    Journal of Atherosclerosis and Thrombosis 25(2), 170-177, 2018


  • 2型糖尿病経過中に抗GAD抗体陽転を伴って発症した自己免疫性多内分泌腺症候群3型の1例

    伊藤 弘紀 , 戸巻 寛章 , 吉田 秀彦 , 福澤 正光

    <p>症例は66歳男性.47歳時に体調不良で近医受診し,糖尿病が判明し当院へ紹介.インスリン分泌の保たれた2型糖尿病として経口薬で治療し,HbA1c 6~8 %で推移.その後HbA1c上昇あり,54歳で中間型インスリンを導入.58歳でBasal-Bolus-Therapyに変更.この時抗GAD抗体は陰性.62歳でHbA1c上昇し再入院.その際抗GAD抗体の陽性とインスリン分泌能低下を認 …

    糖尿病 61(1), 9-14, 2018


  • ソフトドリンクケトーシスとの鑑別が困難であった肥満1A型糖尿病の1例

    栗山 恵里沙 , 福山 貴大 , 内田 あいら , 相良 陽子 , 玉井 秀一 , 中野 優子 , 當時久保 正之 , 川﨑 英二

    <p>症例は45歳,男性.叔父に2型糖尿病あり.10日前より続く全身倦怠感,口渇,多飲(1 L/日以上の清涼飲料水)を主訴に当院初診.受診時BMI 25.7 kg/m<sup>2</sup>,血糖1,260 mg/dL,HbA1c 12.4 %,動脈血ガスpH 7.156,尿ケトン3+.DKAの診断で入院し輸液とインスリン静脈内投与を開始した.病歴および肥満の存 …

    糖尿病 61(1), 22-27, 2018


  • Ability of B-Type Natriuretic Peptide Testing to Predict Cardioembolic Stroke in the General Population ― Comparisons With C-Reactive Protein and Urinary Albumin ―

    Nakamura Motoyuki , Ishibashi Yasuhiro , Tanaka Fumitaka , Omama Shinichi , Onoda Toshiyuki , Takahashi Tomohiro , Takahashi Shuko , Tanno Kozo , Ohsawa Masaki , Sakata Kiyomi , Koshiyama Makoto , Ogasawara Kuniaki , Okayama Akira , on behalf of the Iwate-KENCO Study Group

    … <p><b><i>Background:</i></b>The ability of cardiovascular biomarkers to predict the incidence of stroke subtypes remains ill-defined in the general population.</p><p><b><i>Methods and Results:</i></b>The blood levels of B-type natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) and urinary albumin corrected by urinary creatinine (UACR) were determined in a general population (n=13,575). …

    Circulation Journal, 2018


  • New insights into the pharmacological treatment of pediatric patients with type 2 diabetes

    Urakami Tatsuhiko

    … <p>The principal treatment for children and adolescents with type 2 diabetes is dietary and exercise management. … However, the blood glucose levels of some patients receiving this treatment fail to improve; … The pathophysiology of type 2 diabetes in pediatric patients appears to be similar to that in adults; …

    Clinical Pediatric Endocrinology 27(1), 1-8, 2018


  • Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients

    Okawa Tomoko , Yamaguchi Yukie , Kou Kenzen , Ono Junya , Azuma Yoshinori , Komitsu Noriko , Inoue Yusuke , Kohno Masumi , Matsukura Setsuko , Kambara Takeshi , Ohta Shoichiro , Izuhara Kenji , Aihara Michiko

    … Recent studies have indicated that serum levels of squamous cell carcinoma antigen (SCCA) 1 and 2 induced by type 2 cytokines such as IL-4 and IL-13, are increased in patients with atopic dermatitis (AD). …

    Allergology International 67(1), 124-130, 2018


  • クエン酸ナトリウムを用いて調製した魚肉加熱ゲルの摂取がラットの血圧および脂質濃度に及ぼす影響

    桑原 浩一 , 井上 舞 , 安本 早穂子 , 鳥巣 雄洋 , 野口 絵理香 , 久保 久美子 , 田丸 静香 , 永田 保夫 , 田中 一成

    <p> 食塩の代わりにクエン酸塩を用いて調製する魚肉の新たな加熱ゲル化方法を開発し,本方法で調製した加熱ゲルがラットの血圧や脂質濃度に及ぼす影響を検討した。新規または従来法で調製した加熱ゲルをAIN-76組成の食餌に添加した。新規加熱ゲルの摂取は,高血圧自然発症ラットの血圧上昇を抑制させた。また,調製方法に関わらず加熱ゲルの摂取は,血清コレステロールおよび肝臓トリグリセリド濃度を減少さ …

    日本水産学会誌, 2018


  • The interplay between neuroendocrine activity and psychological stress-induced exacerbation of allergic asthma

    Miyasaka Tomomitsu , Dobashi-Okuyama Kaori , Takahashi Tomoko , Takayanagi Motoaki , Ohno Isao

    … In particular, stress-induced enhanced type 2 T-helper (Th2)-type lung inflammation is strongly associated with asthma pathogenesis. … This is followed by the secretion of stress hormones into the blood, including glucocorticoids, epinephrine, and norepinephrine, which enhance Th2 and type 17 T-helper (Th17)-type asthma profiles in humans and rodents. …

    Allergology International 67(1), 32-42, 2018


  • Dietary interventions to prevent and manage diabetes in worksite settings: a meta-analysis

    Shrestha Archana , Karmacharya Biraj Man , Khudyakov Polyna , Weber Mary Beth , Spiegelman Donna

    … The objective of this meta-analysis is to summarize the evidence for the effectiveness of dietary interventions in worksite settings on lowering blood sugar levels. …

    journal of Occupational Health 60(1), 31-45, 2018


  • Effect of <i>Lactobacillus casei</i> strain Shirota-fermented milk on metabolic abnormalities in obese prediabetic Japanese men: a randomised, double-blind, placebo-controlled trial

    NAITO Eiichiro , YOSHIDA Yasuto , KUNIHIRO Satoru , MAKINO Kumiko , KASAHARA Kohei , KOUNOSHI Yuu , AIDA Masanori , HOSHI Ryotaro , WATANABE Osamu , IGARASHI Tomoki , MIYAZAKI Kouji , ITO Hideki

    … <p>An obesity-related prediabetic state is characterised by metabolic abnormalities such as post-glucose load hyperglycaemia and dyslipidaemia and consequently increases the risk for type 2 diabetes and cardiovascular disease. … The post-load PG and fasting blood markers were evaluated. …

    Bioscience of Microbiota, Food and Health 37(1), 9-18, 2018


  • Tolvaptan Improves Prognosis in Responders with Acute Decompensated Heart Failure by Reducing the Dose of Loop Diuretics

    Nakamura Makiko , Sunagawa Osahiko , Kinugawa Koichiro

    … As a control group, we selected 25 patients from 100 consecutive ADHF patients who were not treated with TLV by propensity score matching for age, serum sodium level, serum creatinine level, plasma B-type natriuretic peptide (BNP) level, systolic blood pressure, heart rate, and dose of loop diuretics. …

    International Heart Journal 59(1), 87-93, 2018