Search Results 1-20 of 101

  • Mitochondrial Uncouplers Confer Protection by Activating AMP-Activated Protein Kinase to Inhibit Neuroinflammation Following Intracerebral Hemorrhage

    Pan Xiaofan , Song Yanmei , He Meijun , Yan Xiaoling , Huang Caiyun , Li Jie , Dong Wanli , Cheng Jian , Jia Jia

    … Microglia-mediated neuroinflammation substantially exacerbates brain damage following ICH. … Here, we investigated whether mitochondrial uncouplers conferred protection by suppressing neuroinflammation following ICH. … To mimic ICH-induced neuroinflammation <i>in vitro</i>, we treated microglia with red blood cell (RBC) lysate. …

    Biological and Pharmaceutical Bulletin 43(8), 1210-1219, 2020


  • Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

    Radad Khaled , Amir Yassmin El , Al-Emam Ahmed , Al-Shraim Mubarak , Bin-Jaliah Ismaeel , Krewenka Christopher , Moldzio Rudolf

    … Rats in group I and V showed normal locomotor behavior and normal histology of the brain and testes. … Acrylamide was also seen to cause a significant increase of malondialdehyde levels in the brain and testes. … Decreasing lipid peroxidation by minocycline might play a role in such protection.</p> …

    Journal of Toxicologic Pathology 33(2), 87-95, 2020


  • Protection mechanism of gadolinium trichloride against hemorrhagic brain injury  [in Japanese]

    Ohnishi Masatoshi , Tasaka Shunpei , Kai Takao , Shimizu Yuki , Urabe Yuui , Yano Yukino , Akagi Marina , Inoue Atsuko

    … increased after 3 days. Gd administration decreased these M1 and M2 markers. Arginase1 and iNOS protein levels also increased 3 days after ICH, and Gd decreased them because of the decrease of cell number due to apoptosis. Next, we investigated whether Gd had an anti-inflammatory effect in an ICH model. Three days after ICH, brain edema was formed, and the number of NeuN-positive cells, which indicates neuronal nuclei, decreased in the peripheral region inside the hematoma. Gd improved the edema, neuron loss, and …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-047, 2020


  • Pathophysiological changes of progranulin in active microglia after cerebral ischemia  [in Japanese]

    Usui Akane , Horinokita Ichiro , Hayashi Hideki , Takagi Norio

    … <p>Progranulin (PGRN) is implicated in neuronal protection and anti-inflammation. … Thus, the increase in PGRN level and inhibition of GRN production after ME caused by siverestat treatment would prevent ischemic brain injury.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-045, 2020


  • Transcriptome analysis of the effect of C-C chemokine receptor 5 deficiency on cell response to Toxoplasma gondii in brain cells

    Kobayashi Kaoru , Umeda Kousuke , Ihara Fumiaki , Tanaka Sachi , Yamagishi Junya , Suzuki Yutaka , Nishikawa Yoshifumi

    … Background: Infection with Toxoplasma gondii is thought to damage the brain and be a risk factor for neurological and psychotic disorders. … The immune response-participating chemokine system has recently been considered vital for brain cell signaling and neural functioning. … gondii infection, on gene expression in the brain during T. … gondii infection in the brain. …

    BMC Genomics 20(1), 705, 2019-09


  • The mammalian pigmentary system - a model experimental system for exploring the functional divergence of a differentiated cell type  [in Japanese]

    山本 博章

    … There are two cell lineages of mammalian melanin pigment cells, one that leads to retinal pigment epithelium (RPE) cells in the eye from the optic cup and the other leading to melanocytes from vertebrate-specific neural crest cells. … Melanocyte precursors have high mobility and migrate and settle into various tissues and organs, including the skin, choroid, inner ear, heart, brain, adipose tissue, lung, etc. …

    岡山実験動物研究会報 (35), 2-8, 2019-06

    IR  Ichushi Web 

  • Non-cell autonomous mechanisms of proliferation and differentiation of oligodendrocyte precursor cells

    Arai Ken

    … The neurovascular unit emphasizes that cell-cell interaction between neuronal, glial, and vascular elements is critical for brain function. … For example, astrocytes produce brain-derived neurotrophic factor that promotes oligodendrogenesis (i.e. OPC proliferation and differentiation) to ease white matter damage under pathological conditions. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), SY8-1, 2018


  • The Microbiome: A Key Regulator of the Gut-Brain Axis in Visceral Pain

    Cryan John F.

    … Under normal homeostatic conditions this microbial population helps maintain intestinal peristalsis, mucosal integrity, pH balance, immune priming and protection against invading pathogens. … Furthermore, these microbes can influence centrally regulated emotional behaviour through mechanisms including microbially derived bioactive molecules (amino acid metabolites, short-chain fatty acids, neuropeptides and neurotransmitters), mucosal immune and enteroendocrine cell activation, as well as vagal nerve stimulation. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), SY71-3, 2018


  • Multi-target effects of 3-n-Butylphalide, a component of Apium graveolens L., in treatment of neurodegenerative diseases

    Wang Xiaoliang , Peng Ying , Wang Ling , Li Jiang , Xu Shaofeng , Feng Nan , Wang Weiping

    … In 1990s dl-NBP was found to be potent in protection of brain injury from cerebral ischemia in animal models. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), SY40-3, 2018


  • Estrogen increases glutathione level in brain endothelial cells exposed to ischemic injury by repression of ABCG2 activity

    PARK EUN-MI , Shin Jin A , Jeong Sae Im , Kim Hye Won , Jang Gyeonghui

    … <p>The adenosine triphosphate (ATP)-binding cassette (ABC) efflux transporter ABCG2, which is located in the blood-brain barrier (BBB), limits the entry of endogenous compounds and xenobiotics into the brain. … However, the role of ABCG2 in estrogen-mediated protection in the ischemic brain is not clear. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO4-1-12, 2018


  • Nickel chloride suppresses cell proliferation and induces G<sub>2</sub>/M cell-cycle arrest in cultured human astrocytes

    Yubolphan Ruedeemars , Vivithanaporn Pornpun

    … Astrocytes, the most abundant glial cells in the brain, play a prominent role in the protection of other brain cells from toxins and oxidants. … The present study aims to determine the effect of nickel in cell proliferation and cell cycle of human astrocytes. … Cell proliferation was determined by monitoring CFSE fluorescent intensity. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO3-13-25, 2018


  • Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice

    Nishibori Masahiro , Fu Li , Wake Hidenori , Wang Dengli , Teshigawara Kiyoshi , Liu Keyue , Takahashi Hideo K , Mori Shuji

    … In the previous studies, we demonstrated the beneficial effects of anti-HMGB1 mAb on brain ischemia- and trauma-induced brain injuries in rats through the inhibition of HMGB1 translocation, protection of BBB and suppression of inflammatory responses. … injected anti-HMGB1 mAb were present on/around vascular endothelial cells of brain in pilocarpine-induced seizure mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO3-1-85, 2018


  • Neuro-protection of Encapsulated Curcumine on ischemia-reperfusion injury through Attenuating Autophagic and Apoptosis in vitro and in vivo

    Lu Xiaowei , Zhong Jie , Sun Linlin , Li Xiaolin , Wang Zhaolu

    … no agent has achieved clinical success in aspect of neuro-protection so far.Autophagy is one of the important ways to maintain cellular homeostasis.Appropriate autophagy protects cells in the condition of ischemia and hypoxia,while over-activatied autophagy followed I-R injury result in apoptosis.Curcumine (CUR) was reported to be a natural inhibitor of autophagy,however,its application was restricted by poor water solubility,short half-life and low concentration in brain.Basing on previous result that nanoparticle based drug …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO2-1-12, 2018


  • Pharmacokinetic evaluation of Xiaoxuming decoction for anti-cerebral ischemic stroke and its protection mechanism in blood-brain barrier

    Yang Zhihong , You Yuyang

    … mode for TCM prescription study in brain, via investigated the pharmacokinetic profiles of active ingredient group (31 components detected) of XXMD, evaluated the weight factor (6 cellular energy-metabolism substances) for pharmacological action (anti-cerebral ischemic stroke), then developed the mathematics models to reveal the pharmacokinetic characteristics of the integrity composition of XXMD.</p><p>During the studies, the gerbil pathological and physiological self-control brain regions model and the real-time …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-11-39, 2018


  • Studies on neuroprotective role of RIP kinase inhibitors and their interaction with omega-3 fatty acid in MPTP induced Parkinson disease

    Pal Rishi , Kartik Shipra , Tiwari Prafulla C , Jain Mayank , Nath Rajendra , Pant Kamlesh K

    … <p>Parkinson disease (PD) characterized by inflammation of dopaminergic neurons leading to cell death. … Programmed cell death (PCD) is a mechanism of cell demises includes apoptosis, autophagy or necroptosis. … Signal transaction pathways involved in cell death mediated through inflammation of dopaminergic neurons is not well understood. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), OR5-3, 2018


  • Networks and targets analyses of hypoxia preconditioning via systemic omics

    Xue Ming , Xia Zhengchao , Xia Binbin , Zhou Tao , Cui Can , Cheng Haiting , Wang Mingming , Su Su , Ma Yi , Li Jingyi

    … In this study, the acute and repetitive hypoxia and HPC models using mice, zebrafish and PC12 cell were successfully constructed. … The aminobutyric acid was markedly decreased in HPC brain. … Our data provided an important insight to further reveal the protection mechanism of HPC.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), OR12-2, 2018


  • Boron Neutron Capture Therapy Combined with Early Successive Bevacizumab Treatments for Recurrent Malignant Gliomas – A Pilot Study

    SHIBA Hiroyuki , SUZUKI Minoru , ONO Koji , OUE Shiro , ISHIKAWA Eiichi , MICHIUE Hiroyuki , MIYATAKE Shin-Ichi , TAKEUCHI Koji , HIRAMATSU Ryo , FURUSE Motomasa , NONOGUCHI Naosuke , KAWABATA Shinji , KUROIWA Toshihiko , KONDO Natsuko , SAKURAI Yoshinori

    … However, despite the cell-selectivity of BNCT, brain radiation necrosis (BRN) may develop and cause severe neurological complications and sometimes death. … We herein used extended BV treatment beginning just after BNCT to confer protection against or ameliorate BRN, and evaluated; … In one case, uncontrollable brain edema occurred and ultimately led to death after BV was interrupted due to meningitis. …

    Neurologia medico-chirurgica 58(12), 487-494, 2018

    IR  J-STAGE  Ichushi Web 

  • Secondary thyroid cancer after diagnosis of childhood cancer: hospital-based case series  [in Japanese]

    Ishida Yasushi , Yoshinaga Shinji , Goto Hiroaki , Fujimoto Junichiro , Kuroda Tatsuo , Maeda Miho , Okamura Jun , Kawaguchi Hiroshi , Sato Maho , Tokuyama Mika , Kiyotani Chikako , Hori Hiroki , Kobayashi Ryoji

    <p>治療終了後の小児がん経験者の晩期合併症の中で生命予後に直接影響する最も深刻なものは二次がんであり,二次性甲状腺がんに関して検討した.</p><p>方法:研究デザインはケースシリーズ研究で,対象は1980年1月1日~2009年12月31日に15病院で小児がんと診断され,2010年3月31日現在の時点で2か月以上生存していた10,069人の中で,病理組織学的に …

    The Japanese Journal of Pediatric Hematology / Oncology 55(3), 261-268, 2018

    J-STAGE  Ichushi Web 

  • Application of the active ingredients extracted from Hericium Erinaceus to mental health  [in Japanese]

    Okamura Hisayoshi , Nakamura Tomoko

    … erinaceum exerts important bioactivities, including the induction of neuronal growth factor (NGF) synthesis, the inhibition of beta-amyloid peptide cytotoxicity, and protection against neuronal cell death caused by endoplasmic reticulum stress. …

    Journal of Health Psychology Research 30(Special_issue), 231-236, 2018


  • Protection of Cultured Cortical Neurons by Luteolin against Oxidative Damage through Inhibition of Apoptosis and Induction of Heme Oxygenase-1

    Kim Sunyoung , Chin Young-Won , Cho Jungsook

    … These results indicate that luteolin exhibits neuroprotective effect through the inhibition of ROS and apoptotic cell death. …

    Biological and Pharmaceutical Bulletin 40(3), 256-265, 2017

    J-STAGE  Ichushi Web 

Page Top