Search Results 1-20 of 14750

  • Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases

    Zhang Meiyu , Miura Taro , Suzuki Shunsuke , Chiyotanda Masako , Tanaka Sachiko , Sugiyama Kentaro , Kawashima Hisashi , Hirano Toshihiko

    … We examined the molecular targets of vitamin K2 to suppress proliferation and cytokine production in T-cell mitogen-activated PBMCs of atopic dermatitis patients from the viewpoint of mitogen-activated protein kinase signaling molecules. … The effect of vitamin K2 on concanavalin A-activated PBMC proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and cell counting assays. …

    Biological and Pharmaceutical Bulletin 44(1), 7-17, 2021

    J-STAGE 

  • Long Noncoding RNA SNHG16 Facilitates Abdominal Aortic Aneurysm Progression through the miR-106b-5p/STAT3 Feedback Loop

    Yang Baihui , Wang Xi , Ying Chenyong , Peng Fei , Xu Ming , Chen Feiyun , Cai Bing

    … </b></p><p><b>Methods: </b>We investigated the functional role of STAT3 in AAA by evaluating vascular smooth muscle cell (VSMC) apoptosis and proliferation via terminal deoxynucleotidyl transferase dUTP nick end labeling, western blotting, 5-ethynyl-2´-deoxyuridine, and Cell Counting Kit-8 assays. … Inhibition of STAT3 facilitated VSMC proliferation and repressed VSMC apoptosis. …

    Journal of Atherosclerosis and Thrombosis 28(1), 66-78, 2021

    J-STAGE 

  • Growth Rate-dependent Cell Death of Diatoms due to Viral Infection and Their Subsequent Coexistence in a Semi-continuous Culture System

    Tomaru Yuji , Yamaguchi Haruo , Miki Takeshi

    … <p>Viral infections are a major factor in diatom cell death. … These results suggested that the host physiological status related to the growth rate affected viral infection and proliferation. … This may be partially explained by defective interference particles from viruses and cell debris. … Moreover, diatom populations with a low growth rate may partially sustain higher growth populations through nutrient recycling following virus-induced cell death. …

    Microbes and Environments 36(1), n/a, 2021

    J-STAGE 

  • Identification of Phenolic Constituents and Inhibitory Activity of Persimmon Calyx and Shiteito against Tumor Cell Proliferation

    Yoshimura Morio , Mochizuki Akira , Amakura Yoshiaki

    … We therefore isolated the ingredients and investigated their anti-tumor cell proliferative activity, together with Shiteito and Shitei extracts. … As a result, Shiteito showed weak inhibition of hepatocellular carcinoma (Hep3B) cell proliferation at a high concentration. …

    Chemical and Pharmaceutical Bulletin 69(1), 32-39, 2021

    J-STAGE 

  • Massive Ascites Caused by Primary Diffuse Large B-cell Lymphoma of the Jejunum: A Case of a Rare Initial Symptom

    Ota Kazuhiro , Takeuchi Toshihisa , Higuchi Kazuhide , Nishida Shinya , Akutagawa Hiroshi , Imai Yoshiro , Tani Kiri , Shinohara Yoshinori , Iwatsubo Taro , Shimpei Kawaguchi , Kojima Yuichi

    … Histological examination showed dense proliferation of large lymphoid atypical cells, and immunohistochemistry showed CD20 and CD10 positivity, CD3 negativity, and Ki67 labeling index >80%. … These findings suggest that small intestine primary diffuse large B-cell lymphoma (DLBCL) caused the ascites. …

    Internal Medicine, 2021

    J-STAGE 

  • Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model

    Tatsuoka Hisato , Sakamoto Satoko , Yabe Daisuke , Kabai Ryotaro , Kato Unyanee , Okumura Tatsuya , Botagarova Ainur , Tokumoto Shinsuke , Usui Ryota , Ogura Masahito , Nagashima Kazuaki , Mukai Eri , Fujitani Yoshio , Watanabe Akira , Inagaki Nobuya

    … Heterogeneity of gene expression and rarity of replication hamper molecular analysis of β-cell mass restoration in adult pancreas. … Here, we show transcriptional dynamics in β-cell replication process by single-cell RNA sequencing of murine pancreas with or without partial pancreatectomy. …

    iScience 23(12), 2020-12-18

    IR 

  • Circulating tumor cells with FGFR2 expression might be useful to identify patients with existing FGFR2-overexpressing tumor

    Kuroda Kenji , Yashiro Masakazu , Miki Yuichiro , Sera Tomohiro , Yamamoto Yurie , Sugimoto Atsushi , Nishimura Sadaaki , Kushiyama Shuhei , Togano Shingo , Okuno Tomohisa , Ohira Masaichi

    … Fibroblast growth factor receptor (FGFR) is associated with proliferation, migration, and angiogenesis of carcinomas, and FGFR signaling inhibitors are considered a key drug for the treatment of solid tumors with FGFR overexpression. … The relapse-free survival of the patients with FGFR2-positive CTCs (≥5 cells/10 mL blood) was significantly poorer (P = .018, log-rank) than that of the patients without FGFR2-positive CTCs (<5 cell/10 mL blood). …

    Cancer Science 111(12), 4500-4509, 2020-12

    IR 

  • Cigarette smoke, but not novel tobacco vapor products, causes epigenetic disruption and cell apoptosis

    Hattori Naoko , Nakagawa Takeya , Yoneda Mitsuhiro , Nakagawa Kaori , Hayashida Hiromi , Ito Takashi

    … Here we examined differences in the biological effects of conventional cigarette smoke (CS) and two HNB products, Ploom TECH and Ploom TECH+, using the cultured cancer cell line A549 and the normal bronchial epithelium cell line BEAS-2B. … The conventional CS 3R4F extract (0.5%) markedly decreased cell proliferation of both A549 and BEAS-2B cells; … however, 0.5% extracts of these commercially available HNB products did not affect cell growth. …

    Biochemistry and Biophysics Reports (24), 100865, 2020-11-21

    IR 

  • Gold Nanoparticles Enhance EGFR Inhibition and Irradiation Effects in Head and Neck Squamous Carcinoma Cells

    Kashin Masahiko , Kakei Yasumasa , Teraoka Shun , Hasegawa Takumi , Yamaguchi Akinobu , Fukuoka Takao , Sasaki Ryohei , Akashi Masaya

    … Cetuximab, an epidermal growth factor receptor inhibitor (EI), is currently the only targeted molecular therapy used in combination with radiotherapy for head and neck squamous cell carcinoma (HNSCC). … We compared cell numbers, proliferation, apoptosis, and migration between control cells and those treated with or without 60 nm AuNP (1.0 nM), AG1478 (0.5 μM), and irradiation (4 Gy). … We found that AuNP+AG1478 inhibited proliferation more than AG1478 alone; …

    BioMed Research International (2020), 1281645, 2020-11-07

    IR 

  • The mechanism of hematopoietic stem cell proliferation in response to stress  [in Japanese]

    雁金 大樹 , 田久保 圭誉

    循環器内科 = Cardioangiology 88(5), 563-567, 2020-11

  • Tumor-like features of gene expression and metabolic profiles in enlarged pancreatic islets are associated with impaired incretin-induced insulin secretion in obese diabetes: A study of Zucker fatty diabetes mellitus rat

    Hayami Tomohide , Yokoi Norihide , Yamaguchi Takuro , Honda Kohei , Murao Naoya , Takahashi Harumi , Wang Shujie , Seino Yusuke , Kamiya Hideki , Yabe Daisuke , Sweet Ian R. , Mizoguchi Akira , Nakamura Jiro , Seino Susumu

    … Markers for β-cell differentiation were markedly decreased in the enlarged islets, but those for cell proliferation were increased. … Conclusions The enlarged islets of Zucker fatty diabetes mellitus rats, which are defective for IIIS, show tumor cell-like metabolic features, including a dedifferentiated state, accelerated aerobic glycolysis and impaired mitochondrial function. …

    Journal of Diabetes Investigation 11(6), 1434-1447, 2020-11

    IR 

  • Impact of the Stroma on the Biological Characteristics of the Parenchyma in Oral Squamous Cell Carcinoma

    Takabatake Kiyofumi , Kawai Hotaka , Omori Haruka , Qiusheng Shan , Oo May Wathone , Sukegawa Shintaro , Nakano Keisuke , Tsujigiwa Hidetsugu , Nagatsuka Hitoshi

    … Therefore, in this study, we investigated the effect of the stroma on the parenchyma in oral squamous cell carcinoma (OSCC). … We isolated tumor stroma from two types of OSCCs with different invasiveness (endophytic type OSCC (ED-st) and exophytic type OSCC (EX-st)) and examined the effect of the stroma on the parenchyma in terms of proliferation, invasion, and morphology by co-culturing and co-transplanting the OSCC cell line (HSC-2) with the two types of stroma. …

    International Journal of Molecular Sciences 21(20), 7714, 2020-10-18

    IR 

  • Combination of rAd-p53 in situ gene therapy and anti-PD-1 antibody immunotherapy induced anti-tumor activity in mouse syngeneic urogenital cancer models

    Kunimura Naoto , Kitagawa Koichi , Sako Ryota , Narikiyo Keita , Tominaga Shoko , Bautista Diosdado S. , Xu Wei , Fujisawa Masato , Shirakawa Toshiro

    … Three mouse syngeneic tumor cell lines, TRAMP-C2 (prostate cancer derived from C57BL/6 mice), MBT-2 (bladder cancer derived from C3H mice) and Renca (kidney cancer derived from BALB/c mice) were used in this study. … Consistent with the CAR expressions, rAd-p53 at 160 multiplicity of infection (MOI) significantly inhibited the cell proliferation of TRAMP-C2 and Renca cells, but not MBT-2 cells. …

    Scientific Reports 10(1), 17464, 2020-10-15

    IR 

  • Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes

    Kumagai-Takei Naoko , Nishimura Yasumitsu , Maeda Megumi , Hayashi Hiroaki , Matsuzaki Hidenori , Lee Suni , Yoshitome Kei , Ito Tatsuo , Otsuki Takemi

    Environmental Health and Preventive Medicine 25(1), 2020-10-08

    DOI 

  • Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin

    Kawara Akina , Mizuta Ryo , Fujisawa Masayoshi , Ito Toshihiro , Li Chunning , Nakamura Kaoru , Sun Cuiming , Kuwabara Masaki , Kitabatake Masahiro , Yoshimura Teizo , Matsukawa Akihiro

    … Compared to WT mice, Spred2−/− mice developed milder PF with increased proliferation of bronchial epithelial cells. … Spred2−/− and WT macrophages produced similar levels of TNFα and MCP-1 in response to BLM or lipopolysaccharide and myeloid cell-specific deletion of Spred2 in mice had no effect. …

    Scientific Reports 10(1), 16490, 2020-10-05

    IR 

  • β-cell proliferation through humoral factors  [in Japanese]

    白川 純

    糖尿病・内分泌代謝科 = Diabetology, endocrinology & metabolology 51(4), 260-265, 2020-10

  • Effect of surface roughness of titanium formed by angled fine particle peening on cell adhesion and proliferation  [in Japanese]

    鈴木 李奈 , 桃沢 愛 , 照月 大悟 , 亀山 雄高 , 遠山 沙良 , 高橋 玄宇

    Abrasive technology : 砥粒加工学会誌 : journal of the Japan Society for Abrasive Technology 64(10), 527-532, 2020-10

  • Caspase Recruitment Domain-Containing Protein 9 Expression is a Novel Prognostic Factor for Lung Adenocarcinoma

    Miwa Nanako , Nagano Tatsuya , Jimbo Naoe , Dokuni Ryota , Kiriu Tatsunori , Mimura Chihiro , Yasuda Yuichiro , Katsurada Masahiro , Yamamoto Masatsugu , Tachihara Motoko , Tanaka Yugo , Kobayashi Kazuyuki , Itoh Tomoo , Maniwa Yoshimasa , Nishimura Yoshihiro

    … The role of CARD9 in cancer cells was analyzed using lung cancer cell lines treated with CARD9 siRNA. … Knockdown of CARD9 in lung adenocarcinoma cells inhibited proliferation but did not increase apoptosis. … In addition, CARD9 activated the NF-κB pathway in a lung adenocarcinoma cell line. …

    OncoTargets and Therapy (13), 9005-9013, 2020-09-10

    IR 

  • A role of vitamin B6 in the cell proliferation of acute myeloid leukemia  [in Japanese]

    山口 博樹

    血液内科 = Hematology 81(3), 390-393, 2020-09

  • Regulation of colonic epithelial cell homeostasis by mTORC1

    Kotani Takenori , Setiawan Jajar , Konno Tasuku , Ihare Noriko , Okamoto Saki , Saito Yasuyuki , Murata Yoji , Noda Tetsuo , Matozaki Takashi

    Cell signaling important for homeostatic regulation of colonic epithelial cells (CECs) remains poorly understood. … Mammalian target of rapamycin complex 1 (mTORC1), a protein complex that contains the serine-threonine kinase mTOR, mediates signaling that underlies the control of cellular functions such as proliferation and autophagy by various external stimuli. …

    Scientific Reports 10(1), 13810, 2020-08-14

    IR 

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