検索結果 964件中 1-20 を表示

  • The Efficacy of Reduced-dose Dasatinib as a Subsequent Therapy in Patients with Chronic Myeloid Leukemia in the Chronic Phase: The LD-CML Study of the Kanto CML Study Group

    Iriyama Noriyoshi , Ohashi Kazuteru , Hashino Satoshi , Kimura Shinya , Nakaseko Chiaki , Takano Hina , Hino Masayuki , Uchiyama Michihiro , Morita Satoshi , Sakamoto Junichi , Sakamaki Hisashi , Inokuchi Koiti

    … </p><p><b>Methods </b>Patients with chronic myeloid leukemia in the chronic phase (CML-CP) who were being treated with low-dose imatinib (≤200 mg/day), but were resistant to this agent were enrolled in the current study (referred to as the LD-CML study). … </p><p><b>Conclusion </b>Low-dose dasatinib can attain MMR and DMR without severe toxicity in patients with CML-CP who are unable to achieve MMR with low-dose imatinib. …

    Internal Medicine 57(1), 17-23, 2018

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  • Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis

    Takaki Hiroko , Akazawa Yuko , Kido Youko , Morishita Mami , Honda Takuya , Shibata Hidetaka , Miuma Satoshi , Miyaaki Hisamitsu , Taura Naota , Kondo Hisayoshi , Nakao Kazuhiko

    … CONCLUSIONS: These findings suggest that during lipoapoptosis, HCV infection may enhance hepatocyte toxicity by increasing JNK phosphorylation. …

    Medical Science Monitor 23, 4526-4532, 2017-09-21

    機関リポジトリ DOI

  • Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity

    Ogihara Takuo , Arakawa Hiroshi , Jomura Tomoko , Idota Yoko , Koyama Satoshi , Yano Kentaro , Kojima Hajime

    … Sph(f-) and spheroids cultured on feeder cells (Sph(f+)) were exposed to the hepatotoxic drugs flutamide, diclofenac, isoniazid and chlorpromazine at various concentrations for 14 days, and albumin secretion and cumulative leakages of toxicity marker enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and γ-glutamyl transpeptidase (γ-GTP), were measured. … In the case of Sph(f-), significant correlations among all the toxicity markers except for γ-GTP were observed. …

    The Journal of Toxicological Sciences 42(4), 499-507, 2017-08-01

    機関リポジトリ DOI

  • 水生生物への複合毒性のスクリーニング評価における急性慢性毒性比の検討

    大西 洋平 , 竹田 宜人

    環境毒性学会誌 20(1), 21-33, 2017-07

  • Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells

    Sawa Kenta , Uematsu Takumi , Korenaga Yusuke , Hirasawa Ryuya , Kikuchi Masatoshi , Murata Kyohei , Zhang Jian , Gai Xiaoqing , Sakamoto Kazuichi , Koyama Tomoyuki , Satoh Takumi

    … Here we found that pyruvate, oxaloacetate, and α-ketoglutarate, but not lactate, citrate, iso-citrate, succinate, fumarate, or malate, protected HT22 cells against hydrogen peroxide-mediated toxicity. … Because these protective KCIs did not have any toxic effects (at least up to 10 mM), they have potential use for therapeutic intervention against chronic neurodegenerative diseases. …

    Antioxidants 6(1), 21, 2017-03

    機関リポジトリ DOI

  • 2,4-D (Pesticides)

    Food Safety Commission of Japan

    … No adverse effects were detected in carcinogenicity, reproductive toxicity, teratogenicity and genotoxicity relevant to human health. …

    Food Safety 5(4), 171-177, 2017

    J-STAGE

  • 天然の無機系ナノ粒子

    黒田 章裕 , 杉林 堅次 , 藤堂 浩明 , 伊藤 公紀 , 雨宮 隆 , 安部 隆 , 宮城 磯治

    <p>無機系ナノ粒子の生体に対する影響が危惧されて以来,数多くの論文が発表されてきたが,安全なのか,そうでないのかの結論に対しては,いずれも決め手に欠け,結論が見えない状態が継続している。われわれは,無機系ナノ粒子のヒトに対する長期曝露試験や世代をまたいだ安全性の評価結果が存在していないことがこの問題の原因の1つであると考えている。現在,規制議論の中では無機系ナノ粒子は人工起源のものし …

    日本化粧品技術者会誌 51(4), 317-325, 2017

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  • A case report of ventricular septal defect in an adult Sprague Dawley rat

    Kurotaki Tetsuro , Tomonari Yuki , Sato Junko , Kanno Takeshi , Tsuchitani Minoru

    … A 20-week-old male Sprague Dawley rat noted with decreased body weight, dyspnea, and anorexia beginning 2 days before death was necropsied in the recovery period of a sub-chronic toxicity study. …

    Journal of Toxicologic Pathology 30(4), 327-332, 2017

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  • Pyraziflumid (Pesticides)

    Food Safety Commission of Japan

    … Increased incidences of thyroid follicular cell adenomas and carcinomas in males, and also of hepatocellular adenomas in females were identified in a two-year combined chronic toxicity/carcinogenicity study in rats. … The lowest no-observed-effect level (NOAEL) obtained from all the studies was 2.15 mg/kg bw/day in a two-year combined chronic toxicity/carcinogenicity study in rats. …

    Food Safety 5(3), 118-119, 2017

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  • A Case of Unilateral Posterior Reversible Encephalopathy Syndrome Occurring after Carotid Artery Stenting

    Kikuchi Osamu , Ishizaki Kenichi

    … Temporary disruption of the blood–brain barrier due to blood pressure fluctuations in chronic unilateral hypoperfusion caused by stenosis of the right internal carotid artery or toxicity of the contrast medium was suspected.</p><p><b>Conclusion:</b> …

    脳神経血管内治療 11(8), 403-408, 2017

    J-STAGE

  • Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity

    Ogihara Takuo , Arakawa Hiroshi , Jomura Tomoko , Idota Yoko , Koyama Satoshi , Yano Kentaro , Kojima Hajime

    … Sph(f-) and spheroids cultured on feeder cells (Sph(f+)) were exposed to the hepatotoxic drugs flutamide, diclofenac, isoniazid and chlorpromazine at various concentrations for 14 days, and albumin secretion and cumulative leakages of toxicity marker enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and γ-glutamyl transpeptidase (γ-GTP), were measured. … In the case of Sph(f-), significant correlations among all the toxicity markers except for γ-GTP were observed. …

    The Journal of Toxicological Sciences 42(4), 499-507, 2017

    J-STAGE

  • 肝細胞肥大の毒性学的特徴の解明に向けた農薬のラット反復投与毒性試験結果データベースの構築

    増田 茜 , 増田 雅美 , 川野 拓歩 , 橘内 陽子 , 中山 晴香 , 中島 宏之 , 小島 弘幸 , 北村 繁幸 , 浦丸 直人 , 保坂 卓臣 , 佐々木 崇光 , 吉成 浩一

    … Using risk assessment reports of pesticides that are publicly available from the Food Safety Commission of Japan, we extracted all observations/findings that were based on 90-day subacute toxicity tests and 2-year chronic toxicity and carcinogenicity tests in rats. …

    薬学雑誌 137(5), 611-622, 2017

    J-STAGE 医中誌Web

  • Isofetamid (Pesticides)

    Food Safety Commission of Japan

    … None of neurotoxicity, carcinogenicity, reproductive toxicity, teratogenicity, immunotoxicity and genotoxicity were observed. … The lowest no-observed-adverse-effect level (NOAEL) obtained in all the toxicity studies was 5.34 mg/kg bw/day in a one-year chronic toxicity study in dogs. …

    Food Safety 5(1), 31-33, 2017

    J-STAGE

  • Cyclaniliprole (Pesticides)

    Food Safety Commission of Japan

    … None of neurotoxicity, carcinogenicity, reproductive toxicity, teratogenicity, immunotoxicity and genotoxicity were observed. … The lowest no-observed-adverse-effect level (NOAEL) obtained in all the toxicity studies was 1.29 mg/kg bw/day in a one-year chronic toxicity study in dogs. …

    Food Safety 5(1), 29-30, 2017

    J-STAGE

  • Oral acute and chronic toxicity studies of β, β-dimethylacrylalkannin in mice and rats

    Zhang Piao-Piao , Yan Xiao-Dan , Fan Xiao-Yu , Ling Ya-Hao , Li Chao , Lin Lin , Qin Dan , Liu Tian-Tian , Li Ye , Li Hui , Zhang Qianqian , Mu Wen-Bo , Wang Ai-Ping , Jin Hong-Tao , Wei Jin-Feng

    … However, its potential toxicity has not been rigorously studied. … To confirm its safety, the oral toxicity of β, β-dimethylacrylalkannin was evaluated <i>in vivo</i>. … An acute oral toxicity study in mice demonstrated that β, β-dimethylacrylalkannin was practically nontoxic based on its high median lethal dose (LD<sub>50 </sub>> …

    Fundamental Toxicological Sciences 4(2), 45-56, 2017

    J-STAGE

  • Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

    Satarug Soisungwan , Vesey David A. , Gobe Glenda C.

    … <p>Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity. … Dietary Cd intake of 10-30 µg/day has been linked with reduced tubular reabsorption, chronic kidney disease, hypertension, coronary arterial and peripheral arterial diseases, macular degeneration, obesity-independent diabetes, and cancer. … This review adds to these connections by presenting the synergism of kidney Cd toxicity on blood pressure control and glucose homeostasis. …

    The Tohoku Journal of Experimental Medicine 241(1), 65-87, 2017

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  • Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD

    Matsukawa Toshihiro , Hashimoto Daigo , Sugita Junichi , Nakazawa Seitarou , Matsushita Takae , Kashiwazaki Haruhiko , Goto Hideki , Onozawa Masahiro , Kahata Kaoru , Fujimoto Katsuya , Endo Tomoyuki , Kondo Takeshi , Hashino Satoshi , Yamazaki Yutaka , Teshima Takanori

    … In the present study, we compared the efficacy and toxicity of 15-10-10 MTX (day +1: 15 mg/m2; … The cumulative incidence rates of grades II-IV acute GVHD, grades III-IV acute GVHD and chronic GVHD in the 15-10-10 MTX and 10-7-7 MTX groups did not differ to a statistically significant extent. …

    International journal of hematology 104(1), 117-124, 2016-07

    機関リポジトリ DOI

  • Control Efficacy of Pongam (Pongamia pinnata L.) Leaf Extract against the Turnip Aphid Lipaphis pseudobrassicae (Davis) (Hemiptera: Aphididae)

    Tran Dang Hoa , Le Khac Phuc , Tran Hoang Dong Thi , Ueno Takatoshi

    … In laboratory tests, pongam leaf extract showed acute toxicity to the turnip aphid; … Pongam leaf extract has thus nonlethal chronic toxicity. …

    九州大学大学院農学研究院紀要 61(1), 141-145, 2016-02-29

    機関リポジトリ

  • 慢性期CMLに対するTKI療法

    高橋 直人

    <p>BCR-ABLチロシンキナーゼ阻害剤(TKI)は慢性骨髄性白血病(CML)の予後を劇的に改善させ,今やCML患者の予後を規定する最大の要因は合併症の有無となった。これまでTKIの有害事象は可逆的でマネージメント可能と考えられてきた。ところが臨床試験の長期観察から第二世代TKIに関連した心血管障害の頻度が予想以上に高いことが明らかになってきた。本事象の発症機序は正確にはわかっていな …

    臨床血液 57(10), 1956-1961, 2016

    J-STAGE

  • 尿路結石を認めなかった2,8-DHA結晶尿の1症例

    永田 勝宏 , 田中 佳 , 松本 正美 , 田中 千津 , 新田 恭子 , 宮澤 克人 , 飯沼 由嗣

    <p>2,8-ジヒドロキシアデニン結晶(2,8-dihydroxyadenine; 2,8-DHA)は,黄~黄褐色で大小不同の球状結晶であり,アデニンホスホリボシルトランスフェラーゼ(adenine phosphoribosyl transferase; APRT)欠損症で生じる異常結晶である。症例は60歳代男性で,2012年に糖尿病と診断され糖尿病性腎症による慢性腎不全のため通院中で …

    医学検査 65(6), 695-699, 2016

    J-STAGE

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