Search Results 1-16 of 16

  • Islet transplantation in Japan—Report from the Japanese Islet Transplantation Registry—  [in Japanese]

    Working Group for Islet Transplantation The Japanese Pancreas and Islet Transplantation Association

    … <p>Islet transplantation is promising to be capable of relieving glucose instability and improving the QOL of type 1 diabetic patients with uncontrollable severe hypoglycemic unawareness. … A phase II clinical trial of islet transplantation for type 1 diabetes patients has been under way using ATG induction and TNF-α inhibition protocol since 2012 in Japan. …

    Japanese Journal of Transplantation 54(2-3), 121-127, 2019

    J-STAGE 

  • Islet transplantation in Japan —Report from Japanese Islet Transplantation Registry—  [in Japanese]

    The Japanese Pancreas and Islet Transplantation Association

    … <p>Islet transplantation is promising to be capable of relieving glucose instability and improving QOL of type 1 diabetic patients whose severe hypoglycemic unawareness cannot be controlled. … In Japan, a phase II clinical trial of islet transplantation for type 1 diabetes patients has been started using ATG induction and a TNF-α inhibition protocol. …

    Japanese Journal of Transplantation 53(2-3), 149-156, 2018

    J-STAGE  Ichushi Web 

  • Islet Replacement Therapy in Patients with Type 1 Diabetes  [in Japanese]

    MORI Tomomi , TANAKA Nobue , KOYAMA Ichiro , NAKAJIMA Ichiro , TSUCHIYA Ken , FUCHINOUE Shohei , BABAZONO Tetsuya , YOKOYAMA Yoichi , NISHIWAKI Yui , TAUCHI Eriko , YAMASHITA Shinpei , TAKEMURA Shunsuke , YOSHIDA Naoshi , NYUMURA Izumi , HANAI Ko

    … In these patients, pancreas and pancreatic islet transplantation can be a therapeutic option.</p><p>As of July 2017, a total of 302 patients received pancreas transplantation from brain-dead donors in Japan. …

    Journal of Tokyo Women's Medical University 87(Extra2), E168-E174, 2017

    IR  J-STAGE  Ichushi Web 

  • Islet transplantation in Japan ―Report from Japanese Islet Transplantation Registry―  [in Japanese]

    The Japanese Pancreas and Islet Transplantation Association

    … <p>Islet transplantation is promising to be capable of relieving glucose instability and improving QOL of type 1 diabetic patients who cannot be controlled of severe hypoglycemic unawareness. … In Japan, the phase II clinical trial of islet transplantation for type 1 diabetes patients has been started by using ATG induction and TNF-α …

    Japanese Journal of Transplantation 52(2-3), 169-177, 2017

    J-STAGE  Ichushi Web 

  • Curent status and the future prospects of islet transplantation  [in Japanese]

    Anazawa Takayuki , Uemoto Shinji , Okajima Hideaki , Iwanaga Yasuhiro , Masui Toshihiko , Ito Tatsuo , Tada Seiichiro , Yamane Kei , Takaori Kyoichi , Kaido Toshimi

    … Pancreatic islet transplantation is a minimally invasive therapy for type1 diabetes mellitus patients with severe hypoglycemic unawareness despite adequate insulin therapy. … Result of recent clinical trials had revealed that short-term results were promising, however, function of the transplanted islets had been decreased over time. …

    Organ Biology 23(2), 186-188, 2016

    J-STAGE  Ichushi Web 

  • Islet transplantation in Japan ―Report from Japanese Islet Transplantation Registry―  [in Japanese]

    The Japanese Pancreas and Islet Transplantation Association

    … <p>Islet transplantation promises to be capable of relieving glucose instability and improving QOL of type 1 diabetic patients who suffer from uncontrolled severe hypoglycemic unawareness. … In Japan, the phase II clinical trial of islet transplantation for type 1 diabetes patients has been started using ATG induction and TNF-α inhibition protocol. …

    Japanese Journal of Transplantation 51(2-3), 178-186, 2016

    J-STAGE  Ichushi Web 

  • Current Status and Agenda for Islet Transplantation  [in Japanese]

    Matsumoto Shinichi

    Islet transplantation has been performed for the treatment of unstable type 1 diabetic patients. … In year 2000, the University Alberta group demonstrated seven out of seven patients who received islet transplantations became insulin independence that triggered to spread clinical islet transplantation worldwide. …

    Organ Biology 22(2), 213-218, 2015

    J-STAGE  Ichushi Web 

  • Problems and perspectives of islet transplantation based on the experience of clinical trial  [in Japanese]

    Anazawa Takayuki , Kenjo Akira , Kimura Takashi , Sato Naoya , Saito Takuro , Goto Mitsukazu

    … Pancreatic islet transplantation has emerged as an eff ective treatment for type 1 diabetes patients with severe hypoglycemic unawareness. … Islet transplants, though signifi cantly improving, are still mostly done on an experimental basis. …

    Organ Biology 22(2), 176-180, 2015

    J-STAGE  Ichushi Web 

  • Islet transplantation in Japan ―Report from Japanese Islet Transplantation Registry―  [in Japanese]

    The Japanese Pancreas and Islet Transplantation Association

    Islet transplantation can relieve glucose instability and problems with hypoglycemia while the graft is functioning. … Islet transplants, though significantly improving, are still mostly done on an experimental basis. …

    Japanese Journal of Transplantation 50(2-3), 186-190, 2015

    J-STAGE  Ichushi Web 

  • Islet transplantation in Japan ―Report from Japanese Islet Transplantation Registry―  [in Japanese]

    The Japanese Pancreas and Islet Transplantation Association

    Islet transplantation can relieve glucose instability and problems with hypoglycemia while the graft is functioning. … However, the long-term results of islet transplantation pointed to the need for progress improving islet graft function. …

    Japanese Journal of Transplantation 49(2-3), 292-297, 2014

    J-STAGE  Ichushi Web 

  • Islet transplantation in Japan:―Report from Japanese Islet Transplantation Registry―  [in Japanese]

    The Japanese Pancreas and Islet Transplantation Association

    Islet transplantation employing donors after cardiac death (DCD) can relieve glucose instability and problems with hypoglycemia while the graft is functioning. … We started the phase II clinical trial with type 1 diabetes patients for islet transplantation using both brain-dead donors and DCD to evaluate ATG induction and TNF inhibition protocol. …

    Japanese Journal of Transplantation 48(6), 384-389, 2013

    J-STAGE  Ichushi Web 

  • Immunosuppressive therapy for pancreas and islet transplantation  [in Japanese]

    Maruyama Michihiro , Kenmochi Takashi , Ito Taihei , Akutsu Naotake , Asano Takehide

    … Immunosuppressive regimen for pancreas transplantation is currently almost the same as that for kidney transplantation in Japan. … A number of clinical trials, such as avoidance or withdrawal of steroids, use of mTOR inhibitor, etc, have been carried out abroad. … For islet transplantation, various clinical trials in immunosuppressive therapy have been carried out after Edmonton protocol. …

    Organ Biology 20(2), 218-221, 2013

    J-STAGE 

  • From mouse islet isolation to clinical islet transplantation trial in Japan  [in Japanese]

    Gotoh Mitsukazu

    … I then had the opportunity to study pancreas islet transplantation in 1984, when I worked as a research fellow with Prof. A. … The first success of establishment of islet isolation method in mouse facilitated research process on the studies of islet immunology and tolerance induction. …

    Organ Biology 20(2), 89-96, 2013

    J-STAGE 

  • Islet transplantation in Japan : Report from Japanese Islet Transplantation Registry  [in Japanese]

    穴澤 貴行 , 後藤 満一

    移植 46(6), 552-558, 2011-12-10

    References (3)

  • Current status of islet transplantation in Japan  [in Japanese]

    ANAZAWA Takayuki , GOTOH Mitsukazu

    … The program of islet transplantation in Japan was started in 2004. … Sixty-five islet isolations were performed for 34 transplantations in 18 patients with insulin-dependent diabetes mellitus. … Clinical islet transplantation will resume as a clinical trial using mammalian-free enzyme to assess a new immunosuppression protocol.<br> …

    Suizo 26(2), 169-175, 2011

    J-STAGE 

  • <Topics>Islet and Hybrid Islet Iransplantaion : Clinical Trial and Future Prospect  [in Japanese]

    井上 一知

    日本外科宝函 63(2), 45-46, 1994-03-01

    IR  Ichushi Web 

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