Search Results 1-20 of 1075

  • Differentiation of Cultured Meibocytes through the Activation of Peroxisome Proliferator-activated Receptor γ  [in Japanese]

    唐沢 容子 , 伊藤 正孝 , 西尾 佳明 , 竹内 大

    日本眼科学会雑誌 124(1), 7-14, 2020-01

  • Role of neuropeptides in lung  [in Japanese]

    Imai Yumiko

    … These viruses, such as H5N1 avian flu, have a high rate of death and to date there are no effective treatments. … Here we investigated whether phagocytes are capable of de novo production of NPY, as has been described for CA. We show that synthesis of NPY and its Y1-receptor (Y1R) were increased in phagocytes in lungs following severe influenza virus infection. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S34-4, 2020

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  • Pharmacological aspects of Respiratory Diseases  [in Japanese]

    Yatera Kazuhiro

    … <p>With the recent aging population, pneumonia, lung cancer, and chronic obstructive pulmonary disease (COPD) are leading death causes, and asthma and interstitial pneumonia are common. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S34-2, 2020

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  • Regenerative Medicine and Drug Development using Stem Cells  [in Japanese]

    Okano Hideyuki

    … </p><p>I will also talk about our new clinical trial for ALS using a drug named ropinirole (ROPI: known as D2 receptor agonist), which was identified in the iPSCs-based phenotypic screening of ALS patients-derived motor neurons with FDA-approved drug library (Fujimori et al., Nat Med, 2018). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-JPS-4, 2020

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  • Tumor necrosis factor alpha protects retinal ganglion cells against excitotoxicity via reduction of oxidative stress in the mice  [in Japanese]

    Sakamoto Kenji , Haginoya Yuki , Sakai Hiroki , Asano Daiki , Morita Akane , Mori Asami , Nakahara Tsutomu

    … <p>Excitotoxicity is thought to be involved in the neuronal cell death induced by glaucoma. … We reported that tumor necrosis factor alpha (TNFα) was involved in the protective effects of a Toll-like receptor 9 agonist on the retinal ganglion cell loss induced by excitotoxicity in the mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-266, 2020

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  • TLR4-activated p38 and NF-κB and GM-CSF receptor-mediated JAK2/STAT5 pathways are important for microglial long-term survival  [in Japanese]

    Kamigaki Mayumi , Hide Izumi , Kodama Yasushi , Sakai Norio , Ishihara Kumatoshi

    … <p>We have previously reported that the activation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induced rapid death of primary cultured rat microglia. … Furthermore, we examined the involvement of GM-CSF receptor downstream signaling intermediates, JAK2 and STAT5, which are known to regulate the transcription of survival genes. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-273, 2020

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  • Protective effect of endogenous apelin against age-related loss of retinal ganglion cells in mice  [in Japanese]

    Ishimaru Yuki , Sumino Akihide , Shibagaki Fumiya , Chitose Hikari , Miura Reina , Tanimura Akinori , Yamamuro Akiko , Yoshioka Yasuhiro , Maeda Sadaaki

    … Recently, it has been reported that deficiency of apelin, an endogenous peptide ligand of the G protein-coupled receptor APJ, enhances several tissues aging. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-215, 2020

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  • TRPC3-Nox2 complex formation mediates nutritional deficiency-induced cardiomyocyte atrophy  [in Japanese]

    Tanaka Tomohiro , Binti Sudi Suhaini , Oda Sayaka , Numaga-Tomita Takuro , Nishiyama Kazuhiro , Nishimura Akiyuki , Sunggip Caroline , Mangmool Superchoke , Nishida Motohiro

    … Here, we report that ATP induces atrophy of neonatal rat cardiomyocytes (NRCMs) without cell death through P2Y2 receptors. … ATP led to overproduction of reactive oxygen species (ROS) through increased amount of NADPH oxidase (Nox) 2 proteins, due to increased physical interaction between Nox2 and canonical transient receptor potential 3 (TRPC3). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-YIA-36, 2020

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  • Induction of reactive oxygen species by activation of the EP2 receptor contributes to prostaglandin E2-induced cytotoxicity in motor neuron-like NSC-34 cells  [in Japanese]

    Nango Hiroshi , Kosuge Yasuhiro , Miyagishi Hiroko , Ito Yoshihisa , Ishige Kumiko

    … <p>We have shown previously that prostaglandin E2 (PGE2) directly induces neuronal death through activation of the E-prostanoid (EP) 2 receptor in differentiated NSC-34 cells, motor neuron-like cell line. … MTT reduction assay and lactate dehydrogenase release assay revealed that PGE2- and butaprost-induced cell death were each suppressed by pretreatment with a cell permeable antioxidant, N-acetylcysteine (NAC). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-193, 2020

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  • An APJ agonist suppresses the loss of retinal neuronal cells in diabetes model mouse fed a high-fat diet  [in Japanese]

    Shibagaki Fumiya , Ishimaru Yuki , Akai Kiichi , Tokuda Kana , Yamamuro Akiko , Yoshioka Yasuhiro , Maeda Sadaaki

    … <p>Diabetic retinopathy is a leading cause of blindness and leads to retinal neuronal cell death at the early stage. … We have previously shown that an apelin receptor (APJ) agonist suppresses the reduction of the retinal neuronal function observed in a mouse model of diabetes fed a high-fat diet (HFD). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-213, 2020

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  • Derivatives of calmodulin-like skin protein, named CLSP(1-61) and CLSPCOL, as anti-Alzheimer disease agents  [in Japanese]

    Hashimoto Yuichi , Matsuoka Masaaki

    … <p>Calmodulin-like skin protein (CLSP), a secreted peptide, likely protect neurons from toxicity linked to Alzheimer disease (AD) via the heterotrimeric humanin receptor. … By conducting an <i>in vitro</i> AD-related death assay, we have characterized endogenous CLSP interactors. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-191, 2020

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  • Effects of a novel RyR1 inhibitor on malignant hyperthermia model mice  [in Japanese]

    Murayama Takashi , Allen Paul D. , Sakurai Takashi , Yamazawa Toshiko , Kobayashi Takuya , Kurebayashi Nagomi , Noguchi Satoru , Nishino Ichizo , Mori Shuichi , Kagechika Hiroyuki , Lopez Jose R.

    … <p>Type 1 ryanodine receptor (RyR1) is a Ca<sup>2+</sup> release channel in the sarcoplasmic reticulum and plays an important role in excitation-contraction coupling. Genetic mutations in RyR1 cause various skeletal muscle diseases including malignant hyperthermia (MH). Since the main underlying mechanism of MH is hyperactive Ca<sup>2+</sup> release by gain-of-function of the RyR1 channel, inhibition of RyR1 is a promising treatment for the disease. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-O-056, 2020

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  • Analysis of CICR control mechanism using molecular dynamics simulation and malignant hyperthermia model mouse  [in Japanese]

    Yamazawa Toshiko

    … <p>Mutations in type 1 ryanodine receptor (<i>RyR1</i>) gene cause severe muscle diseases, such as malignant hyperthermia (MH), which is a disorder of Ca<sup>2+</sup>-induced Ca<sup>2+</sup> … Pre-administration of RyR1 inhibitor completely prevented rise in the body temperature and death. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-S14-2, 2020

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  • Glial cells and pharmacological targets in Sandhoff disease  [in Japanese]

    Ogawa Yasuhiro , Sakuraba Hitoshi , Oishi Kazuhiko

    … In the most severe form, the onset begins during early infancy, and death usually occurs within 2-5 years of age. … Inhibiting this receptor with istradefylline decreases the number of activated microglial cells and inflammatory cytokines/chemokines. … receptor as a sensor, in regulating microglial activation in the late phase of inflammation.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-S13-2, 2020

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  • Development of Retrievable Molecular Target Drug using Intelectin  [in Japanese]

    Obata Shotaro , Moriwaki Yasuhiro , Misawa Hidemi , Tsuji Shotaro

    … </p><p>In this study, we used ITLN-fused TNF receptor (TNFR-ITLN) instead of antibody because it doesn't need humanization. … TNFR-ITLN is a soluble TNF receptor replacing Fc of etanercept with ITLN. … Furthermore, these rats were prevented from death by endotoxin shock.</p><p>According to these results, we considered that the apheresis using TNFR-ITLN plus diol column could selectively remove plasma TNF-α. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-095, 2020

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  • Novel conjugates of endoperoxide and 4-anilinoquinazoline induce myeloma cell apoptosis by inhibiting the IGF1-R/AKT/mTOR signaling pathway

    Xu Yujia , Zeng Yuanying , Mao Xinliang , Zeng Kun , Wang Xiaoge , Zhang Jieyu , Cao Biyin , Zhang Zubin , Qiao Chunhua , Xu Xiaofeng , Wang Qi

    … <p>4-anilinoquinazoline-containing inhibitors of the epidermal growth factor receptor (EGFR) are widely used in non-small cell lung cancer patients with mutated EGFR, but they are less effective in multiple myeloma (MM), a fatal malignancy derived from plasma cells. …

    BioScience Trends, 2020

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  • Dexmedetomidine Protects SK-N-SH Nerve Cells from Oxidative Injury by Maintaining Iron Homeostasis

    Qiu Lingqin , Ge Li , Hu Qionghua

    … Ferroptosis causes neuronal death in multiple neurological disorders. … <i>t</i>-BHP increased the expression of iron importers, transferrin receptor-1 and divalent metal transporter-1, and iron regulatory protein 1 and 2. …

    Biological and Pharmaceutical Bulletin 43(3), 424-431, 2020

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  • Pathogenesis, clinical course, and recent issues in HIV-1-infected Japanese hemophiliacs: a three-decade follow-up

    Oka Shinichi , Ikeda Kazuko , Takano Misao , Ogane Miwa , Tanuma Junko , Tsukada Kunihisa , Gatanaga Hiroyuki

    … Switching to the second receptor agents proved critical in subsequent disease progression. … Prognosis improved dramatically and cause of death changed from AIDS-related opportunistic infections and malignancies before 1997, to hepatitis C virus-related cirrhosis and hepatocellular carcinoma (HCC) around 2010, and again to non-AIDS defining malignancies recently. …

    Global Health & Medicine, 2020

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  • Dependence and Cytotoxicity of Components of Cannabis  [in Japanese]

    Funada Masahiko , Tomiyama Ken-ichi

    receptor type antagonist AM251. … Δ<sup>9</sup>-THC and synthetic cannabinoids caused cell death in a dose-dependent manner. … receptor. …

    YAKUGAKU ZASSHI 140(2), 205-214, 2020

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  • Fat-specific protein 27b is regulated by hepatic peroxisome proliferator-activated receptor γ in hepatic steatosis

    Aibara Daisuke , Matsuo Kohei , Yamano Shigeru , Matsusue Kimihiko

    … <p>The fat-specific protein 27 gene (<i>Fsp27</i>) belongs to the cell death-inducing DNA fragmentation factor 45-like effector family. … is directly regulated by peroxisome proliferator-activated receptor γ (PPARγ) in fatty livers of genetically obese leptin deficient <i>ob/ob</i> …

    Endocrine Journal 67(1), 37-44, 2020

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