Search Results 1-20 of 5192

  • Cancer stem cells and drug resistance  [in Japanese]

    馬島 哲夫 , 清宮 啓之

    医学のあゆみ 273(5), 356-361, 2020-05-02

  • Novel approach for management of endometrial cancer : drug repositioning of metformin


    … [SUMMARY] Metformin, a mainstay drug used clinically for over 60 years, improves insulin sensitivity and is widely prescribed for type 2 diabetes mellitus. … Endometrial cancer(EC) is the most common gynecological cancer and exhibits the strongest association with obesity and insulin resistance, and as such, is hypothesized as a suitable target cancer for metformin evaluation. …

    Chiba medical journal = 千葉医学 96E(2), 33-40, 2020-04-10


  • A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants

    Makau Juliann Nzembi , Watanabe Ken , Otaki Hiroki , Mizuta Satoshi , Ishikawa Takeshi , Kamatari Yuji O. , Nishida Noriyuki

    … The emergence of resistance to currently available anti-influenza drugs has heightened the need for antivirals with novel mechanisms of action. … Our data demonstrate that NUD-1 interferes with the oligomerization of NP and less likely induces drug-resistant variants than oseltamivir; …

    Viruses 12(3), 337, 2020-03-19


  • Genetic epidemiological analysis of influenza virus detected in Aichi Prefecture during 2016/17 and 2018/19 seasons  [in Japanese]

    齋藤 友睦 , 齋藤 典子 , 尾内 彩乃 , 皆川 洋子 , 伊藤 雅 , 安井 善宏 , 松本 昌門

    愛知県衛生研究所報 (70), 1-10, 2020-03

  • Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3

    Sogawa Chiharu , Eguchi Takanori , Tran Manh Tien , Ishige Masayuki , Trin Kilian , Okusha Yuka , Taha Eman Ahmed , Lu Yanyin , Kawai Hotaka , Sogawa Norio , Takigawa Masaharu , Calderwood Stuart K. , Okamoto Kuniaki , Kozaki Ken-Ichi

    … Tumor growth, progression, and therapy resistance are crucial factors in the prognosis of cancer. … The properties of three-dimensional (3D) tumor-like organoids (tumoroids) more closely resemble in vivo tumors compared to two-dimensionally cultured cells and are therefore effectively used for assays and drug screening. … We here established a repurposed drug for novel anticancer research and therapeutics using a 3D tumoroid-based screening system. …

    Cancers 12(2), 523, 2020-02-24


  • SNP Discrimination by Tolane-Modified Peptide Nucleic Acids: Application for the Detection of Drug Resistance in Pathogens

    Takagi Kenji , Hayashi Tenko , Sawada Shinjiro , Okazaki Miku , Hori Sakiko , Ogata Katsuya , Kato Nobuo , Ebara Yasuhito , Kaihatsu Kunihiro

    … During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. … An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in pathogens. …

    Molecules 25(4), 769, 2020-02-02


  • JMJD2A sensitizes gastric cancer to chemotherapy by cooperating with CCDC8

    Nakagawa Tadahiko , Sato Yasushi , Tanahashi Toshihito , Mitsui Yasuhiro , Kida Yoshifumi , Fujino Yasuteru , Hirata Misato , Kitamura Shinji , Miyamoto Hiroshi , Okamoto Koichi , Muguruma Naoki , Bando Yoshimi , Takayama Tetsuji

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 23(3), 426-436, 2020

  • Treatment and Diagnosis of Childhood Acute Otitis Media with Drug Resistance to Antimicrobials: Reading and Interpreting "Childhood Acute Otitis Treatment Guidelines 2018 Edition"  [in Japanese]

    Uno Yoshifumi

    <p>薬剤耐性菌による感染症の難治化に対し,薬剤耐性菌対策として抗微生物薬の適正使用が提言されている.耳鼻咽喉科領域の感染症の中でも特に小児急性中耳炎はその起炎菌である肺炎球菌,インフルエンザ菌の薬剤耐性化が進むに従い難治化が問題となっている.今回「小児急性中耳炎診療ガイドライン2018年版」が作成されたが,今回のガイドラインにおいてはこの薬剤耐性の問題に応えるべくClinical Q …

    The Journal of Japan Society for Infection and Aerosol in Otorhinolaryngology 8(2), 142-150, 2020


  • Drug Development Based on Intracellular Pharmacokinetic Analysis of Molecular Target Drug in Mice Bearing Patient-derived Xenograft Model  [in Japanese]

    Hamada Akinobu

    … <p>Traditionally, anticancer drug discovery research has been conducted based on immortalized cancer cell lines, either cultured <i>in vitro</i> … Furthermore, a significant association was also reported between drug responses in patient and corresponding PDX as high as 87%. … We are preparing a PDX model for Japanese cancer patients including drug resistance examples and rare cancers. …

    YAKUGAKU ZASSHI 140(5), 641-648, 2020


  • Monitoring Quinolone Resistance Due to Mutations in GyrA and ParC in <i>Haemophilus Influenzae</i>(2012-17)

    NAGATOMO Yasuhiro , SHIRAKURA Tetsuro , FUKUCHI Kunihiko , TAKUMA Takahiro , TOKIMATSU Issei , NIKI Yoshihito

    … Knowing recent drug-resistant bacteria trends is important for proper antibacterial drug use to improve the prognosis of patients with infectious diseases and for public health. … Amino acid mutations in the quinolone resistance-determining regions were analyzed in the isolates showing an MIC value ≥ … This screening procedure may be effective for reducing the inappropriate use of quinolones and controlling the emergence of drug-resistant <i>H. …

    The Showa University Journal of Medical Sciences 32(1), 81-90, 2020


  • Nanogel antigen DDS toward overcoming immune resistance of cancer  [in Japanese]

    Harada Naozumi , Muraoka Daisuke , Shiku Hiroshi , Akiyoshi Kazunari

    がん治療用ワクチンでは、主要なリンパ器官(リンパ節や脾臓など)に局在する抗原提示細胞(樹状細胞やマクロファージ)にワクチン抗原を高効率かつ適切なタイミングで送達することが、ワクチンによる免疫応答誘導に極めて重要である。筆者らは、コレステロール置換プルラン(CHP)ナノゲルを抗原デリバリーシステムとしたがん治療ワクチンの有用性を示してきた。また、CHPナノゲルを利用した腫瘍内マクロファージの機能調節 …

    Drug Delivery System 35(1), 64-69, 2020


  • NADH peroxidase plays a crucial role in consuming H<sub>2</sub>O<sub>2</sub> in <i>Lactobacillus casei</i> IGM394

    NARAKI Shingo , IGIMI Shizunobu , SASAKI Yasuko

    … IGM394 is used as a host for drug delivery systems, and it exhibits the same growth rate under aerobic and anaerobic conditions. … IGM394, we constructed 23 deficient mutants targeting genes that confer oxidative stress resistance. … resistance than the wild-type strain. …

    Bioscience of Microbiota, Food and Health 39(2), 45-56, 2020


  • Detection and Isolation of a Drug-Resistant Influenza Virus Using a Sialidase Fluorescence Imaging Technique

    Kurebayashi Yuuki , Takahashi Tadanobu , Otsubo Tadamune , Minami Akira , Ikeda Kiyoshi , Suzuki Takashi

    … The method has been applied to the detection and isolation of a drug-resistant influenza virus. … A drug-resistant influenza virus, which has become a problem in recent years, is a virus that has acquired by mutation resistance to a sialidase inhibitor and retains its activity even in the presence of a sialidase inhibitor. … The authors have therefore developed a method for selective detection of a drug-resistant influenza virus. …

    Trends in Glycoscience and Glycotechnology 32(186), E37-E43, 2020


  • Detection and Isolation of a Drug-Resistant Influenza Virus Using a Sialidase Fluorescence Imaging Technique  [in Japanese]

    Kurebayashi Yuuki , Takahashi Tadanobu , Otsubo Tadamune , Minami Akira , Ikeda Kiyoshi , Suzuki Takashi

    <p>インフルエンザウイルスの膜表面に存在するノイラミニダーゼ(NA)は、シアリダーゼ活性を示すウイルスの増殖に重要なタンパク質であり、治療薬の標的にもなっている。著者らはシアリダーゼ活性を蛍光イメージング可能な基質BTP3-Neu5Acを開発し、シアリダーゼ活性の蛍光イメージングによるインフルエンザウイルス検出法を開発し、薬剤耐性インフルエンザウイルスの検出分離法への応用を展開してき …

    Trends in Glycoscience and Glycotechnology 32(186), J35-J41, 2020


  • Prevalence of Multidrug Resistant Salmonellae with Increasing Frequency of <i>Salmonella enterica</i> Serovars Kentucky and Virchow among Hospitalized Diarrheal Cases in and around Delhi, India

    Sharma Naresh Chand , Kumar Dhirendra , Sarkar Anirban , Chowdhury Goutam , Mukhopadhyay Asish K , Ramamurthy Thandavarayan

    … <p>Non-typhoidal salmonellae (NTS) are a major cause of acute diarrhea with characteristic multidrug resistance (MDR). … In a hospital-based study, 81 NTS were isolated and tested for serotypes and antimicrobial resistance (AMR). … Most of the NTS isolates displayed resistance to nalidixic acid (NA) (73%), ciprofloxacin (CIP) (48%), ampicillin (AM) and norfloxacin (NOR) (36% each), and gentamicin (CN) (31%). …

    Japanese Journal of Infectious Diseases 73(2), 119-123, 2020


  • The Usefulness of Prasugrel as Rescue Medication in Neuroendovascular Therapy  [in Japanese]

    Niimi Jun , Naito Hiromichi , Takahashi Yurika , Ueda Kotaro , Tasaka Kenta , Tsuruoka Atsushi , Nemoto Fumio , Moriwaki Takuya , Hatayama Kazumi , Otake Mitsuhiro

    … In neuroendovascular therapy, clopidogrel resistance and thrombosis are common problems. …

    Journal of Neuroendovascular Therapy 14(3), 90-95, 2020


  • Effect of probenecid on 3D-cultured prostate cancer spheroids  [in Japanese]

    Uwada Junsuke , Yazawa Takashi , Mukai Shoichiro , Terada Naoki , Taniguchi Takanobu

    … On the other hand, probenecid can also inhibit multiple channels and transporters including multidrug resistance protein-1 (MRP-1). … In this study, we evaluated the effect of probenecid on prostate cancer cell lines which cultured as multicellular tumor spheroids by culturing in ultra-low attachment plate.</p><p>Prostate cancer cell line 22Rv1 cultured as spheroid showed lower sensitivity against anti-cancer drug doxorubicin, compared to cells cultured as monolayer. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-347, 2020


  • Chronic exposure to hypoxia facilitates chemotherapy sensitivity with downregulation of MDR1.  [in Japanese]

    Miyamoto Licht , Yagi Yuko , Hatano Aya , Ikeda Yasumasa , Abe Shinji , Tamaki Toshiaki , Tsuchiya Koichiro

    … However, the tumor acquires resistance to such cytotoxic compounds. … Especially, the facilitation of drug efflux often causes therapeutic failure, which is known as multidrug resistance. … Multidrug resistance protein1 (MDR1, also known as p-glycoprotein) is a typical transporter relevant to the adaptive drug resistance. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-O-121, 2020


  • Elucidation of mechanism of growth inhibition of human colorectal stem cell by dietary polyphenol antioxidant.  [in Japanese]

    Hayashi Kimika , Suzuki Nobuaki , Nagano Hiroaki , Shibutani Makoto , Nakano Tomohiro , Koyanagi Mihoko , Hayashi Shinmo , Kaneda Masahiro , Usui Tatsuya , Sasaki Kazuaki , Elbadawy Mohamed , Goto Yuta , Yamanaka Megumi , Shinohara Yuta , Hazama Syoichi , Takenouchi Hiroko , Nakashima Masao , Tsunedomi Ryouichi

    … Since cancer stem cells are related to drug resistance and recurrence of colorectal cancer, a new remedy that targets cancer stem cells is needed. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-232, 2020


  • Histamine receptor antagonists inhibited proton regulators in oral cancer cell lines Introduction  [in Japanese]

    Ogasawara Masahito , Kon Masashi , Yamada Hiroyuki , Tamura Haruki , Yamada Arisa

    … Clinical studies suggested that in combination with anti-cancer drugs, histamine type 2 receptor antagonists (H2R ant) and omeprazole could become more sensitive to anti-cancer drug treatment. … Furthermore, cancer associated microenvironments (TMEs) play pivotal roles in cancer proliferation and drug resistance. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-234, 2020


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