Search Results 1-18 of 18

  • Genome-wide association studies of allergic diseases  [in Japanese]

    廣田 朝光 , 玉利 真由美

    臨床免疫・アレルギー科 = Clinical immunology & allergology 71(1), 24-28, 2019-01

  • Association analyses of eQTLs of the <i>TYRO3</i> gene and allergic diseases in Japanese populations

    Kanazawa Jun , Noguchi Emiko , Hirota Tomomitsu , Tamari Mayumi , Hizawa Nobuyuki , Masuko Hironori , Yatagai Yohei , Sakamoto Tohru , Yamada Hideyasu , Kitazawa Haruna , Iijima Hiroaki , Naito Takashi , Saito Takefumi

    <p><i>Background:</i> <i>TYRO3</i> is a member of the TAM (<i>TYRO3</i>, <i>AXL</i>, <i>MERTK</i>) receptor tyrosine kinase family and …

    Allergology International 68(1), 77-81, 2019

    J-STAGE 

  • The Cutting-edge of Medicine : An overview of functional aenomics and omics research for autoimmune diseases  [in Japanese]

    藤尾 圭志

    日本内科学会雑誌 107(11), 2338-2343, 2018-11-10

    Ichushi Web 

  • Genome-wide Association Analysis of Eye Movement Dysfunction in Schizophrenia

    Kikuchi Masataka , Miura Kenichiro , Morita Kentaro , Yamamori Hidenaga , Fujimoto Michiko , Ikeda Masashi , Yasuda Yuka , Nakaya Akihiro , Hashimoto Ryota

    … Moreover, we performed an analysis of expression quantitative trait loci (eQTL) in human brain tissues using a public database. … Finally, we identified significant eQTL effects for all of the SNPs at 1q21.3 and 20q13.12 in particular brain regions. …

    Scientific reports 8(1), 2018-08-17

    IR 

  • Understanding the mechanism of autoimmune diseases through disease risk genes  [in Japanese]

    高地 雄太

    医学のあゆみ 266(5), 449-453, 2018-08-04

    Ichushi Web 

  • NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population

    Nishida Nao , Aiba Yoshihiro , Hitomi Yuki , Kawashima Minae , Kojima Kaname , Kawai Yosuke , Ueno Kazuko , Nakamura Hitomi , Yamashiki Noriyo , Tanaka Tomohiro , Tamura Sumito , Mori Akira , Yagi Shintaro , Soejima Yuji , Yoshizumi Tomoharu , Takatsuki Mitsuhisa , Tanaka Atsushi , Harada Kenichi , Shimoda Shinji , Komori Atsumasa , Eguchi Susumu , Maehara Yoshihiko , Uemoto Shinji , Kokudo Norihiro , Nagasaki Masao , Tokunaga Katsushi , Nakamura Minoru

    … In addition, eQTL analysis and in silico functional analysis indicated that genotypes of rs163800 or variants in strong LD with rs163800 influence expression levels of both NELFCD and CTSZ mRNA. …

    Scientific reports (8), 2018-05-23

    IR 

  • eQTLs Regulating Transcript Variations Associated with Rapid Internode Elongation in Deepwater Rice

    Kuroha Takeshi , Nagai Keisuke , Kurokawa Yusuke , Nagamura Yoshiaki , Kusano Miyako , Yasui Hideshi , Ashikari Motoyuki , Fukushima Atsushi , 草野 都

    … To elucidate the genetic and molecular basis controlling their deepwater response we used microarrays and performed expression quantitative trait loci (eQTL) and phenotypic QTL (phQTL) analyses of internode samples of 85 recombinant inbred line (RIL) populations of non-deepwater (Taichung 65)- and deepwater rice (Bhadua). …

    Frontiers in plant science (8), 1753, 2017-10

    IR 

  • ES3-1 ヒトT細胞のゲノム解析が明らかにした自己免疫疾患の病因  [in Japanese]

    石垣 和慶 , 高地 雄太 , 山本 一彦

    … て何らかの遺伝子の発現制御に異常を来すことが自己免疫疾患の発症リスクになることが示された.この現象を詳細に解析するため,我々はヒトT細胞を用いたexpression quantitative trait loci(eQTL)解析を実施した.eQTL解析は各SNPがどの遺伝子の発現をどのように調整しているかを網羅的に評価する解析手法である.本研究により,自己免疫疾患の原因遺伝子,原因パスウェイに関する新規知見を得るこ …

    Japanese Journal of Clinical Immunology 40(4), 280a-280a, 2017

    J-STAGE  Ichushi Web 

  • Association of HLA-G 3' Untranslated Region Polymorphisms with Systemic Lupus Erythematosus in a Japanese Population: A Case-Control Association Study

    Hachiya Yuki , Kawasaki Aya , Oka Shomi , Kondo Yuya , Ito Satoshi , Matsumoto Isao , Kusaoi Makio , Amano Hirofumi , Suda Akiko , Setoguchi Keigo , Nagai Tatsuo , Shimada Kota , Sugii Shoji , Okamoto Akira , Chiba Noriyuki , Suematsu Eiichi , Ohno Shigeru , Katayama Masao , Kono Hajime , Hirohata Shunsei , Takasaki Yoshinari , Hashimoto Hiroshi , Sumida Takayuki , Nagaoka Shouhei , Tohma Shigeto , Furukawa Hiroshi , Tsuchiya Naoyuki , 川﨑 綾 , 近藤 裕也 , 松本 功 , 住田 孝之 , 古川 宏 , 土屋 尚之

    eQTL analysis showed reduced HLA-G mRNA level in 14bp ins/ins individuals. …

    PLOS ONE 11(6), e0158065, 2016-06

    IR 

  • Functional genomics in human immunology  [in Japanese]

    高地 雄太

    医学のあゆみ 252(1), 33-38, 2015-01-03

    Ichushi Web 

  • Expression Quantitative Trait Loci Analysis of Carotenoid Metabolism-related Genes in Citrus

    Sugiyama Aiko , Omura Mitsuo , Shimada Takehiko , Fujii Hiroshi , Endo Tomoko , Shimizu Tokurou , Nesumi Hirohisa , Nonaka Keisuke , Ikoma Yoshinori

    … 明らかにするため,交雑集団を用いて eQTL 解析を行った.この交雑集団において,フィトエン合成酵素(<i>PSY</i>),フィトエン不飽和化酵素(<i>PDS</i>),ς- カロテン不飽和化酵素,β- 環水酸化酵素(<i>HYb</i>),ゼアキサンチン・エポキシ化酵素(<i>ZEP</i>)の eQTL が検出された.これら検出された eQTL は,これらカロテノイド代謝酵素遺伝 …

    Journal of the Japanese Society for Horticultural Science 83(1), 32-43, 2014

    J-STAGE 

  • A reference database of genetic variations in Japanese population  [in Japanese]

    日笠 幸一郎 , 松田 文彦

    医学のあゆみ 245(5), 352-357, 2013-05-04

    Ichushi Web 

  • A major quantitative trait locus for cold-responsive gene expression is linked to frost-resistance gene Fr-A2 in common wheat

    MOTOMURA Yoichi , KOBAYASHI Fuminori , IEHISA Julio C. M. , TAKUMI Shigeo

    … In expression quantitative trait locus (eQTL) analysis, accumulated transcripts of <i>Cor</i>/<i>Lea</i> … Four eQTLs controlling five cold-responsive genes were found, and the major eQTL with the greatest effect was located on the long arm of chromosome 5A. …

    Breeding Science 63(1), 58-67, 2013-03-01

    IR  J-STAGE  References (58)

  • Identification of Single Nucleotide Polymorphisms Regulating Peripheral Blood mRNA Expression with Genome-Wide Significance: An eQTL Study in the Japanese Population

    Sasayama Daimei , Hori Hiroaki , Nakamura Seiji , Miyata Ryo , Teraishi Toshiya , Hattori Kotaro , Ota Miho , Yamamoto Noriko , Higuchi Teruhiko , Amano Naoji , Kunugi Hiroshi

    … In the current study, a genome-wide eQTL analysis was performed in whole blood samples collected from 76 Japanese subjects. … We identified 102 cis-acting and 5 trans-acting eQTL regions. … The cis-eQTL regions were widely distributed both upstream and downstream of the gene, as well as within the gene. … The eQTL SNPs identified were examined for their influence on the expression levels in lymphoblastoid cell lines by using a public database. …

    PLOS ONE 8(1), e54967, 2013-01-24

    IR  DOI 

  • A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese

    Okada Yukinori , Shimane Kenichi , Kochi Yuta , Tahira Tomoko , Suzuki Akari , Higasa Koichiro , Takahashi Atsushi , Horita Tetsuya , Atsumi Tatsuya , Ishii Tomonori , Okamoto Akiko , Fujio Keishi , Hirakata Michito , Amano Hirofumi , Kondo Yuya , Ito Satoshi , Takada Kazuki , Mimori Akio , Saito Kazuyoshi , Kamachi Makoto , Kawaguchi Yasushi , Ikari Katsunori , Mohamme Osman Wael , Matsuda Koichi , Terao Chikashi , Ohmura Koichiro , Myouzen Keiko , Hosono Naoya , Tsunoda Tatsuhiko , Nishimoto Norihiro , Mimori Tsuneyo , Matsuda Fumihiko , Tanaka Yoshiya , Sumida Takayuki , Yamanaka Hisashi , Takasaki Yoshinari , Koike Takao , Horiuchi Takahiko , Hayashi Kenshi , Kubo Michiaki , Kamatani Naoyuki , Yamada Ryo , Nakamura Yusuke , Yamamoto Kazuhiko

    … Considering that expression quantitative trait loci (eQTLs) have been implicated in genetic risks for autoimmune diseases, we integrated an eQTL study into the results of the GWAS. … We observed enrichments of cis-eQTL positive loci among the known SLE susceptibility loci (30.8%) compared to the genome-wide SNPs (6.9%). … The risk A allele of rs340630 demonstrated a cis-eQTL effect on the AFF1 transcript with enhanced expression levels (P<0.05). …

    PLoS Genetics 8(1), e1002455, 2012-01-26

    IR 

  • Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study

    LANGBERG Kurt A , MA Lijun , SHARMA Neeraj K , HANIS Craig L , ELBEIN Steven C , HASSTEDT Sandra J , DAS Swapan K , the American Diabetes Association GENNID Study Group

    Journal of human genetics 57(1), 57-61, 2012-01-01

    Ichushi Web  References (37) Cited by (2)

  • A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese

    Okada Yukinori , Shimane Kenichi , Kochi Yuta , Tahira Tomoko , Suzuki Akari , Higasa Koichiro , Takahashi Atsushi , Horita Tetsuya , Atsumi Tatsuya , Ishii Tomonori , Okamoto Akiko , Fujio Keishi , Hirakata Michito , Amano Hirofumi , Kondo Yuya , Ito Satoshi , Takada Kazuki , Mimori Akio , Saito Kazuyoshi , Kamachi Makoto , Kawaguchi Yasushi , Ikari Katsunori , Mohammed Osman Wael , Matsuda Koichi , Terao Chikashi , Ohmura Koichiro , Myouzen Keiko , Hosono Naoya , Tsunoda Tatsuhiko , Nishimoto Norihiro , Mimori Tsuneyo , Matsuda Fumihiko , Tanaka Yoshiya , Sumida Takayuki , Yamanaka Hisashi , Takasaki Yoshinari , Koike Takao , Horiuchi Takahiko , Hayashi Kenshi , Kubo Michiaki , Kamatani Naoyuki , Yamada Ryo , Nakamura Yusuke , Yamamoto Kazuhiko

    … Considering that expression quantitative trait loci (eQTLs) have been implicated in genetic risks for autoimmune diseases, we integrated an eQTL study into the results of the GWAS. … We observed enrichments of cis-eQTL positive loci among the known SLE susceptibility loci (30.8%) compared to the genome-wide SNPs (6.9%). … The risk A allele of rs340630 demonstrated a cis-eQTL effect on the AFF1 transcript with enhanced expression levels (P&0.05). …

    PLoS Genetics 8(1), e1002455, 2012-01

    IR  DOI 

  • Haplotype in the IBD5 region is associated with refractory Crohn's disease in Slovenian patients and modulates expression of the SLC22A5 gene

    REPNIK Katja , POTOCNIK Uros

    Journal of gastroenterology 46(9), 1081-1091, 2011-09-01

    References (44)

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